The molecular biology of cancer: a bridge from bench to bedside
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley-Blackwell
2013
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XII, 620 S. Ill., graph. Darst. |
| ISBN: | 9781118008812 1118008812 9781118022870 |
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| 245 | 1 | 0 | |a The molecular biology of cancer |b a bridge from bench to bedside |c ed. by Stella Pelengaris ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Chichester [u.a.] |b Wiley-Blackwell |c 2013 | |
| 300 | |a XII, 620 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cancer - Aspect moléculaire | |
| 650 | 4 | |a Cancer |x Molecular aspects | |
| 650 | 4 | |a Neoplasms |x genetics | |
| 650 | 4 | |a Molecular Biology | |
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Datensatz im Suchindex
| _version_ | 1804148014961393664 |
|---|---|
| adam_text | Contents
Contributors,
vii
Preface to the Second
Edition,
ix
Reviews
oí
the First Edition,
χ
Acknowledgments and. Dedication,
xi
About the Companion Website,
xii
Introduction,
1
1
Overview of Cancer Biology,
3
Michael Khan and Stella Pelengans
Introduction,
5
Cancer incidence and epidemiology,
8
Towards a definition of cancer,
8
Causes of cancer,
16
Cancer is a genetic disease,
2]
Cancers (and Darwin s finches) evoJve by mutation and
natural· selection,
21
Blame the parents
-
inherited single gene defects and
susceptibility to cancer,
21
The cancer roadmap
-
What kinds of genes are
epimutated in cancer9,
23
Viruses and the beginnings of cancer biology,
25
Hens arid teeth or bears and woods? The hens have
it
-
cancer is rare,
25
The barriers to cancer,
25
What is the secret of cancer developme
...
timing ,
28
Location, location, location
-
the cancer environment·.
nanny or spartan state,
28
Cancer goes agricultural,
29
Cancer superhighways
-
blood vessels and lymphatics,
31
On your bike and turn the lights off before you go,
31
Catching cancer,
31
Hammering the hallmarks,
32
Painting a portrait of cancer,
33
The drugs don t work,
34
Mechanism of origin rather than cell of origin
-
towards a
new functional taxonomy of cancer,
3 5
ís
it worth it?,
36
Conclusions and future directions,
36
Bibliography,
37
Appendix
}. 1
History of cancer,
40
2
The Burden of Cancer,
43
William P. Steward and Anne L. Thomas
Introduction,
43
Lung cancer,
45
Breast cancer,
49
Colorectal cancer,
53
Carcinoma of
lhe
prostate,
56
Renal
cai ano ma,
57
Skin cancer,
58
Carcinoma of the cervix,
60
Hematológica)
malignancies,
60
Conclusions and future directions,
63
Outstanding questions,
63
Bibliography,
64
Questions for student review,
66
3
Nature and Nurture in Oncogenesis,
67
Michael Khan and Stella Pelengaris
Introduction,
69
Risk factors,
73
Preventing cancers,
76
Cancei genetics
--
in depth,
78
Cancer genomics,
87
Gene-
en vu
onme.nl. interactions,
89
Mutations and treatment,
89
Chem.oprevention of cancer,
90
Risk factors act in combination,
90
Environmental causes of cancer,
93
The clinical staging and
histológica!
examination
of cancer,
101
Screening and
biomarkers,
102
Somatic gene mutations, epigenetic alterations and
multistage tumongenesis,
105
Conclusions and future directions,
107
Outstanding questions,
107
Bibliography,
107
Questions for student review,
109
4 DNA
Replication and the Cell Cycle, 111
Stella Pelengaris and Michael Khan
Introduction,
112
The cell cycle
-
overview,
114
Phases of the cell cycle,
120
The cell-cycle engine: cydms and krnases,
123
Regulation by degradation,
126
Regulation by transcription,
129
MicroRNAs and the cell cycle,
131
Chromatm,
131
DNA
replication and mitosis,
1 31
Checkpoints
-
putting breaks on the eel)-cycle
engine,
135
The
DNA
damage response (DDR),
136
(.óment·.
The
checkpoints.
1 36
Cell-o
eli·
entry and its control by extracellular signals.
138
Changes in global gene expression during the cell
ode.
1 39
Cell cycle and cancer,
139
Drugging the cell cycle in cancer therapies,
141
Conclusions and future directions,
142
Outstanding questions,
143
Bibliography,
143
Questions for student review,
144
5
Growth Signaling Pathways and the New Era
of Targeted Treatment of Cancer,
146
Stella Pelencjaris and Michael Khan
Introduction,
147
Growth factor regulation of the cell cycle,
150
Growth homeostasis and tissue repair and
regeneration,
151
Regulated and deregulated growth,
155
Cellular differentiation,
157
Tissue growth and the angiogenic switch ,
158
Cancers and nutrients,
158
Growth factor signaling pathways,
160
A detailed description of signal transduction pathways and
their subversion in cancer,
160
Translational control and growth,
184
Conclusions and future directions,
185
Outstanding questions,
185
Bibliography,
186
Questions for student review,
187
6
Oncogenes,
188
Stella Pelengaris and Michael Khan
Introduction, I
89
The oncogenes,
189
The discovery of oncogenes ushers in the new era of
the molecular biology
oí
cancer,
191
Overview of oncogenes,
191
Types of oncogenes,
193
Oncogene
collaboration
-
from cell culture to animal
models,
199
The c-MYC
oncogene,
199
The
RAS superfamüy,
213
SRC
-
the oldest
oncogene,
228
BCR-ABL and the Philadelphia chromosome,
232
The BCL-2 family,
23 5
Biologically targeted therapies in cancer and the concept
of
oncogene
addiction ,
23 5
Conclusions and future directions,
235
Outstanding questions,
236
Bibliography,
236
Questions for student review,
238
7
Tumor Suppressors,
239
Martine F. Roussel
Introduction,
239
The two-hits hypothesis: loss of heterozygosity
(LOH), 240
Haploinsufficiency in cancer.
240
Epigenetic events.
242
Definition of a tumor suppressor,
242
The retinoblastoma protein family,
242
P53/TP53,
250
INK^a/ARF.
2 54
The p5 3 and RB pathways in cancer,
257
Senescence and immortalization: Role of RB and p53,
258
Tumor suppressors and the control of cell proliferation,
258
Tumor suppressors and control
oí
the
DNA
damage
response and genomic stability,
260
The microRNAs and tumor suppressors,
260
Conclusions and future directions,
263
Acknowledgments,
263
Outstanding questions,
264
Bibliography,
264
Questions for student review,
265
8
Cell Death,
266
Stella Pelengans and Michael Khan
Introduction,
267
An historical perspective,
267
Apoptosis in context,
267
Apoptosis as a barrier to cancer formation,
271
Apoptosis versus necrosis,
271
Cell death by necrosis
-
not just inflammatory,
272
The pathways to apoptosis,
272
The apoptosome
-
wheel of death ,
274
Caspases the initiators and executioners of
apoptosis,
274
The IA.P family
-
inhibitors of apoptosis and much
more,
276
The central role of MOMP and its regulators in apoptosis
-
the BCL-2 family,
279
Mitochondria) outer membrane permeabilization
(MOMP),
281
Endoplasmic reticulum. stress,
282
Suess-indiicible heat shock proteins,
282
Tumor suppressor p5 3,
282
Oncogemc stress: MYC-induced apoptosis,
283
Autophagy
-
a different kind of cell death and
survival,
287
Cell death in response to cancer therapy,
290
Exploiting cell death (and senescence) in cancer
control,
290
Conclusions and future directions,
292
Outstanding questions,
293
Bibliography,
293
Questions
foi
student review,
294
9
Senescence, Telomeres, and Cancer
Stem Cells,
295
Mana A Blasco
and Michael Khan
Introduction,
296
Senescence,
298
Conclusions and future directions,
Outstanding questions,
310
Bibliography,
311
Questions for student review,
312
310
Contents
10
Genetic
Instability, Chromosomes, and
Repair,
314
Michael Khan
Introduction,
316
Telomere attrition and genomie instability,
32.1
Sensing
DNA.
damage,
323
Repairing
DNA
damage,
32.5
Checkpoints,
336
MiaOsal.ellir.es and rnirusatellites,
343
Chaperones and genomie instability,
344
Cancer susceptibility syndromes involving genetic
instability,
345
Genomie instability and colon cancer,
34.6
Conclusions and future directions,
346
Outstanding questions,
347
Bibl.iogra.phy,
347
Questions for student review,
349
11
There Is More to Cancer than Genetics:
Regulation of Gene and Protein Expression
by Epigenetic Factors, Small Regulatory RNAs,
and Protein Stability,
350
Stella Pelengaris and Michael Khan
Introduction,
351
The language of epigenetics,
353
Ep¡.genetics,
353
Methylation of
DNA, 359
Acetylarion of
tristones
and other posttranslahonaf
modifications,
360
Epigenetics and cancer,
362
CIMP and
MIN
and the mutalor phenotype ,
363
Imprinting and. loss of imprinting,
366
Clinical use of epigenetics,
367
Regulation of translation,
368
Noncodmg
RNA
and
RNA
interference,
369
Therapeutic and research potential
oí
RN
Ai,
371
Treatments based on rruRNA,
373
Regulating the proteins,
373
Therapeutic inhibition of the proteasome,
376
Receptor degradation,
377
Wrestling with protein transit
-
the role of SUMO and.
the proniyelocyhc leukemia (PML) body,
377
Conclusions and future directions,
380
Outstanding questions,
380
Bibliography,
381
Questions for student review,
382
12
Cell Adhesion in Cancer,
383
Charles H. Streuli
Introduction,
383
Adhesive interactions with the extracellular matrix,
384
Cell -ceil interactions,
393
Critical steps in the dissemination of
métastases,
395
E-cadlierin downregulation in cancer leads to
migration,
399
Eptthelial-mesenchymaJ transitions,
401
Integrins, metalloprotemases,
and cell invasion,
402
Survival in an inappropriate environment,
404
Conclusions,
406
Outstanding questions,
406
Bibliography,
407
Questions for student review,
409
13
Tumor Immunity and Immunotherapy,
410
Cass ian Yee
Introduction,
410
Endogenous .immune response,
411
Effector cells in tumoi immunity,
413
Tumor antigens,
417
Antigen specific therapy of cancer,
420
Clinical trials in vaccine therapy,
422
CytoMne therapy of cancer,
423
Tumor immune evasion,
424
Clinical trials in irnrnunornod
ula tory
therapy,
425
Conclusions,
42 5
Bibiiog.ra.phy,
4.26
Questions for student review,
427
14
Tumor Angiogenesis,
429
Christiana
Ruhrberg
Introduction,
429
General principles of new vessel growth,
430
Pathological neovascularization: tumor vessels,
430
Basic concepts
m
tumor angiogenesis: the angiogenic
switch,
432
Vascular growl
h
and differentiation factors: stimulators
of the angiogenic switch,
432
Role of inhibitors in angiogenesis,
436
Clinical outcomes and fufure directions,
436
Acknowledgments,
437
Bibliography,
4 37
Questions lor student review,
437
15
Cancer Chemistry: Designing New Drugs for
Cancer Treatment,
438
Ana
M
Pizarro and Peter
j
Saaier
Introduction,
439
Historical perspective,
439
The drug discovery process and predinical development
of a. drug,
442
Questions remaining,
457
Conclusions and future directions,
457
Bibliography,
458
Questions for student review,
459
16
Biologically Targeted Agents from Bench
to Bedside,
461
Michael Khan, Peter Sadler, Ana M. Pizarro, and Stella Pelengaris
Introduction,
463
Targeted therapies,
463
Cancer cell heterogeneity,
466
Finding the molecular largets,
468
Tumor regression in mice by maclivating single
oncogenes,
468
Targeted cancer therapies,
473
Targeting oncogenes to treat cancer?,
473
Contents
The concept of synthetic lethality and collateral
vulnerability,
47 5
Clinical progress in biological and molecular targeted
therapies,
476
Molecular targeted drugs an inventory,
479
DNA
damage responses,
490
Transcription factors,
491
Targeting epigenetic regulation of gene expression,
492
Hitting the extrinsic support network and preventing
spread,
493
Gene therapy, antisense, and siRNA,
495
Resistance to targeted therapies
-
intrinsic resistance
and emergence of secondary pathways and tumor
escape,
497
Negative feedback loops and failure of targeted
thérapies,
500
Biomarkers
to identify optimal treatments and
tailored therapies,
501
Pharmacogenetics and pharmacogenornics,
505
Clinical trials in cancer,
506
Conclusions and future directions,
506
Bibliography,
507
Questions for student review,
508
17
The Diagnosis of Cancer,
509
Anne Ĺ
Thomas, Bruno Morgan, and William P. Steward
Introduction,
509
Clinical manifestations,
510
Investigations in oncological practice,
511
Non
invasive imaging techniques,
516
Future novel uses of imaging,
521
Proteomics and microarrays,
523
Circulating tumor cells,
523
Disease staging,
523
Conclusions and future directions,
524
Bibliogiaphy,
524
Questions for student review,
525
18
Treatment of Cancer: Chemotherapy and
Radiotherapy,
526
Anne L. Thomas, J.P. Sage, and William P. Steward
Introduction,
526
Radiotherapy physics,
526
Radiobiology,
527
Treatment planning,
528
Recent advances,
529
Chemoradiation,
5 30
Conclusion,
540
Bibliography,
542
Questions for student review,
543
19
Caring for the Cancer Patient,
544
Nicky Rudd and Esther Waterhouse
Introduction,
544
Key concepts,
544
Communication with the cancer patient,
544
When is palliative care appropriate for
cancer patients7,
545
Palliative care assessment,
545
Symptom control,
545
Respiratory symptoms,
547
Nausea and vomiting,
547
Bowel obstruction,
548
Constipation,
549
Fatigue,
549
Cachexia and anorexia,
549
Psychological problems,
549
The dying patient,
5 50
Supportive care,
5 50
An example of the care of a cancer patient,
551
Questions remaining,
551
Conclusions and. future directions,
551
Underlying problems,
551
Comment,
551
Underlying problems,
5 52
Bibliography,
5 52
Questions for student review,
553
20
Systems Biology of Cancer,
554
Walter Schubert,
Norbert C.J.
de Wit,
and Peter
Walden
Introduction,
5 56
Information flow in cells,
5 56
Model organisms and cancer models,
5 57
Array-based technologies:
genomi«,
epigeriomics,
and. tianscriptomics,
559
SNPs, the HapMap, and the identification
oí
cancer genes,
559
Cancer mRNA expression analysis,
5 62
CGH arrays, CpG island microarra.ys, and
ChIP-on-Chip,
564
Next-generation sequencing,
564
Proteomics,
566
Posttranslational. modifications,
567
Protein complexes and cellular networks,
569
Clinical applications of proteomics,
570
Toponomics: investigating the protein, network code
of cells and tissues,
571
Processing the images from the cyclical imaging
procedures,
571
Structure, code, and semantics of the
toponome:
a high-dimensional combinatorial problem,
573
Detecting a cell surface protein network code:
lessons from a tumor cell,
575
The molecular face of cells in diseases,
576
Individualized medicine and tailored therapies,
576
Discussion and conclusion,
579
Bibliography,
579
Internet resources,
581
Questions for student review,
582
Appendix.
20.1
Techniques for the generation
oí
genetically altered mouse models of cancer,
582
Glossary,
585
Answers ro Questions,
597
Index,
603
Newly revised and updated for its second edition, this comprehensive text provides a detailed overview of the
molecular mechanisms underpinning the development of cancer and its treatment. Written by an international
panel of researchers, specialists, and practitioners in the field, the text discusses all aspects of cancer biology
from the molecular causes, development, and diagnosis through to the treatment of cancer patients.
■
New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested
■
Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions
for research
■
Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field
■
Highlights the direct links between cancer research and clinical applications
■
Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review
■
An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing
for higher exams, and for researchers and teachers in the field.
Stella Pelengaris PhD is Director of Pharmaiogos and previous Researcher at the Imperial Cancer Research Fund, and Senior
Research Fellow at the University of Warwick and Warwick Medical School.
iftichael Khan PhD FRCP is Associate Professor of Medicine at University Hospitals of Coventry and Warwickshire and previous
Head of Molecular Medicine at the University of Warwick.
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV039164511 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:00:24Z |
| institution | BVB |
| isbn | 9781118008812 1118008812 9781118022870 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024181910 |
| oclc_num | 745531681 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-11 DE-19 DE-BY-UBM |
| physical | XII, 620 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Wiley-Blackwell |
| record_format | marc |
| spelling | The molecular biology of cancer a bridge from bench to bedside ed. by Stella Pelengaris ... 2. ed. Chichester [u.a.] Wiley-Blackwell 2013 XII, 620 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer - Aspect moléculaire Cancer Molecular aspects Neoplasms genetics Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Molekularbiologie (DE-588)4039983-7 s DE-604 Pelengaris, Stella Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024181910&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024181910&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | The molecular biology of cancer a bridge from bench to bedside Cancer - Aspect moléculaire Cancer Molecular aspects Neoplasms genetics Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | The molecular biology of cancer a bridge from bench to bedside |
| title_auth | The molecular biology of cancer a bridge from bench to bedside |
| title_exact_search | The molecular biology of cancer a bridge from bench to bedside |
| title_full | The molecular biology of cancer a bridge from bench to bedside ed. by Stella Pelengaris ... |
| title_fullStr | The molecular biology of cancer a bridge from bench to bedside ed. by Stella Pelengaris ... |
| title_full_unstemmed | The molecular biology of cancer a bridge from bench to bedside ed. by Stella Pelengaris ... |
| title_short | The molecular biology of cancer |
| title_sort | the molecular biology of cancer a bridge from bench to bedside |
| title_sub | a bridge from bench to bedside |
| topic | Cancer - Aspect moléculaire Cancer Molecular aspects Neoplasms genetics Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Cancer - Aspect moléculaire Cancer Molecular aspects Neoplasms genetics Molecular Biology Molekularbiologie Krebs Medizin Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024181910&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024181910&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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