Kainate receptors: novel signaling insights
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Springer Science+Business Media [u.a.]
2011
|
| Schriftenreihe: | Advances in experimental medicine and biology
717 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | "This volume critically examines the functional actions of the kainate type glutamate receptors (KARs). Following on from the larger body of work on the NMDA and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions"--Provided by publisher. |
| Beschreibung: | XX, 131 S. Ill., graph. Darst. |
| ISBN: | 9781441995568 |
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| 245 | 1 | 0 | |a Kainate receptors |b novel signaling insights |c ed. by Antonio Rodriguez-Moreno ... |
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| 490 | 1 | |a Advances in experimental medicine and biology |v 717 | |
| 500 | |a "This volume critically examines the functional actions of the kainate type glutamate receptors (KARs). Following on from the larger body of work on the NMDA and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions"--Provided by publisher. | ||
| 650 | 4 | |a Kainic acid |x Physiological effect | |
| 650 | 4 | |a Kainic acid |x Receptors | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Receptors, Kainic Acid |x physiology | |
| 650 | 4 | |a Cerebrum |x physiology | |
| 650 | 4 | |a Signal Transduction |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804147987885064192 |
|---|---|
| adam_text | Titel: Kainate receptors
Autor: Rodríguez-Moreno, Antonio
Jahr: 2011
CONTENTS
1. METABOTROPIC ACTIONS OF KAINATE RECEPTORS
IN THE CONTROL OF GABA RELEASE...........................................1
Talvinder S. Sihra and Antonio Rodriguez-Moreno
Abstract.................................................................................................................................1
Introduction--------------.___.........___..........___...............................................................1
Presynaptic Modulation of GABA Release by Metabotropic Actions of KARs_____..2
Conclusion............................................................................................................................8
2. IN THE DEVELOPING HIPPOCAMPUS KAINATE
RECEPTORS CONTROL THE RELEASE OF GABA
FROM MOSSY FIBER TERMINALS VIA
A METABOTROPIC TYPE OF ACTION............................................11
Enrico Cherubini, Maddalena D. Caiati and Sudhir Sivakumaran
Abstract...............................................................................................................................11
Introduction........................................................................................................................12
Presynaptic Kainate Receptors Control the Release of Glutamate and GABA.....____12
Kainate Receptors Modulate Cell Excitability via a Metabotropic
Type of Action.............................................................................................................13
Kainate Receptors in the Immature Hippocampus........................................................14
GABAergic Phenotype of Immature MF Terminals.......................................................15
GluKl KARs Down Regulate GABA Release by from Immature
MF Terminals.............................................................................................................17
Modulation of Spike-Time Dependent Plasticity by GluKl KARs...............................21
Conclusion..........................................................................................................................22
3. LOCALIZATION AND FUNCTIONS OF KAINATE
RECEPTORS IN THE BASAL GANGLIA.........................................27
Xiao-Tao Jin and Yoland Smith
Abstract...............................................................................................................................27
Introduction...._______.----------.....--------------------.-........-.................................27
xvii
xviii Contents
Striatum..............................................................................................................................28
Globus Pallidus...................................................................................................................29
Substantia Nigra Pars Compacta.....................................................................................33
Subthalamic Nucleus.........................................................................................................36
Conclusion..........................................................................................................................36
4. METABOTROPIC ACTIONS OF KAINATE RECEPTORS
IN THE CONTROL OF GLUTAMATE RELEASE
IN THE HIPPOCAMPUS......................................................................39
Antonio Rodriguez-Moreno and Talvinder S. Sihra
Abstract...............................................................................................................................39
Introduction........................................................................................................................39
KARs on Schaffer Collateral (SC) Terminals Suppress Glutamate Release
at Schaffer Collateral (SC)-CAl Pyramidal Cell (PC)...........................................40
KARs on Granule Cells (Dentate Gyrus) Mossy Fibre (MF) Terminals
Effect Bimodal Modulation of Glutamate Release at Mossy Fibre
(MF)-CA3 Pyramidal Cell (PC) Synapses...............................................................42
Conclusion..........................................................................................................................46
5. METABOTROPIC ACTIONS OF KAINATE RECEPTORS
IN THE REGULATION OF ISAHP AND EXCITABILITY
IN CAÍ PYRAMIDAL CELLS..............................................................49
Zara Melyan and Howard V. Wheal
Abstract...............................................................................................................................49
Introduction........................................................................................................................49
Direct Postsynaptic Activation of KAR Inhibits IsAHP on C Al Pyramidal Cell...............50
KARs Responsible for IsAHp Inhibition Involve Metabotropic Action...........................53
Signal Transduction Mechanisms for Metabotropic KAR-Induced
Inhibition of IsAHPin CAÍ Pyramidal Cells..............................................................54
Conclusion..........................................................................................................................57
6. KAINATE RECEPTORS WITH A METABOTROPIC
SIGNATURE ENHANCE HIPPOCAMPAL
EXCITABILITY BY REGULATING THE SLOW
AFTER-HYPERPOLARIZATION IN CA3
PYRAMIDAL NEURONS.....................................................................59
Arnaud Ruiz
Abstract...............................................................................................................................59
Introduction........................................................................................................................59
High-Affinity Postsynaptic KAR Subunits in the Hippocampus...................................60
Action of KAR Agonists on the Slow After-Hyperpolarization
in Hippocampal Pyramidal Neurons........................................................................61
Contents xix
Synaptically Released Glutamate Modulates I,AHp in Hippocampal
Pyramidal Neurons....................................................................................................62
Candidate Mechanisms Linking KAR Activation and Enhanced
Cellular Excitability...................................................................................................63
Conclusion..........................................................................................................................63
7. METABOTROPIC ACTIONS OF KAINATE RECEPTORS
IN DORSAL ROOT GANGLION CELLS...........................................69
Jose Luis Rozas
Abstract...............................................................................................................................69
Introduction........................................................................................................................69
Expression and Subunit Composition..............................................................................70
Kainate Receptors Physiology and Plasticity at Dorsal Root
Ganglion Neurons......................................................................................................72
Kainate Receptors and Pain..............................................................................................75
Conclusion..........................................................................................................................76
8. ROLE OF KAINATE RECEPTORS IN NETWORK ACTIVITY
DURING DEVELOPMENT..................................................................81
Sari E. Lauri and Tomi Taira
Abstract...............................................................................................................................81
Introduction..........................................................................................................---------.81
Kainate Receptors and Network Activity in the Mature Hippocampus.......................82
Kainate Receptors in the Developing Brain....................................................................83
KAR Mediated Regulation of Network Activity in the Immature
Hippocampus..............................................................................................................84
Role of KARs in Developmental Maturation of Synaptic Connectivity.......................86
Conclusion..........................................................................................................................88
9. KAINATE RECEPTOR MODULATION BY SODIUM
AND CHLORIDE...................................................................................93
Andrew J.R. Plested
Abstract.................................................................................................---------------------93
Introduction........................................................................................................................93
Physical Characteristics of Sodium and Chloride....................................»....................93
Structural View of Glutamate Receptor Activation........................................................94
Ion Binding Sites in the Dimer Interface of Kainate Receptors....................................96
The Role of Ions in Kainate Receptor Gating...-....-....--------------.-------.-------99
Allosteric Modulation of Other Ion Channel Receptors
by Monovalent Ions..................................................................................................104
Physiological Situation with Regard to Ions..................................................................106
Conclusion........................................................................................................................109
xx Contents
10. BTB-KELCH PROTEINS AND UBIQUITINATION
OF KAINATE RECEPTORS...............................................................115
John Marshall, Leslie A.C. Blair and Jeffrey D. Singer
Abstract.............................................................................................................................115
Introduction......................................................................................................................115
KAR Regulation by the Ubiquitin-Proteasome Pathway.............................................117
AF Regulation of Shank, a Parallel Path to Regulate Surface
GluR Expression......................................................................................................119
Development of Novel Peptidomimetic Drugs for the Treatment
of Neurological Disorders........................................................................................119
Conclusion........................................................................................................................121
11. CONCLUDING REMARKS......................................................................127
Antonio Rodriguez-Moreno and Talvinder S. Sihra
INDEX................................................................................................................129
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| isbn | 9781441995568 |
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| series2 | Advances in experimental medicine and biology |
| spelling | Kainate receptors novel signaling insights ed. by Antonio Rodriguez-Moreno ... New York Springer Science+Business Media [u.a.] 2011 XX, 131 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 717 "This volume critically examines the functional actions of the kainate type glutamate receptors (KARs). Following on from the larger body of work on the NMDA and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions"--Provided by publisher. Kainic acid Physiological effect Kainic acid Receptors Cellular signal transduction Receptors, Kainic Acid physiology Cerebrum physiology Signal Transduction physiology Rodríguez-Moreno, Antonio Sonstige oth Advances in experimental medicine and biology 717 (DE-604)BV000003102 717 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024164451&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kainate receptors novel signaling insights Advances in experimental medicine and biology Kainic acid Physiological effect Kainic acid Receptors Cellular signal transduction Receptors, Kainic Acid physiology Cerebrum physiology Signal Transduction physiology |
| title | Kainate receptors novel signaling insights |
| title_auth | Kainate receptors novel signaling insights |
| title_exact_search | Kainate receptors novel signaling insights |
| title_full | Kainate receptors novel signaling insights ed. by Antonio Rodriguez-Moreno ... |
| title_fullStr | Kainate receptors novel signaling insights ed. by Antonio Rodriguez-Moreno ... |
| title_full_unstemmed | Kainate receptors novel signaling insights ed. by Antonio Rodriguez-Moreno ... |
| title_short | Kainate receptors |
| title_sort | kainate receptors novel signaling insights |
| title_sub | novel signaling insights |
| topic | Kainic acid Physiological effect Kainic acid Receptors Cellular signal transduction Receptors, Kainic Acid physiology Cerebrum physiology Signal Transduction physiology |
| topic_facet | Kainic acid Physiological effect Kainic acid Receptors Cellular signal transduction Receptors, Kainic Acid physiology Cerebrum physiology Signal Transduction physiology |
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