Greenspan's basic & clinical endocrinology:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
McGraw-Hill Medical
2011
|
| Ausgabe: | 9. ed. |
| Schriftenreihe: | A Lange medical book
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 880 S. Ill., graph. Darst. |
| ISBN: | 9780071622431 0071622438 |
Internformat
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| 245 | 1 | 0 | |a Greenspan's basic & clinical endocrinology |c ed. by David G. Gardner ... |
| 246 | 1 | 3 | |a Basic & clinical endocrinology |
| 246 | 1 | 3 | |a Basic and clinical endocrinology |
| 250 | |a 9. ed. | ||
| 264 | 1 | |a New York [u.a.] |b McGraw-Hill Medical |c 2011 | |
| 300 | |a XIII, 880 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a A Lange medical book | |
| 650 | 2 | |a Endocrine Glands |a physiology | |
| 650 | 2 | |a Endocrine Diseases | |
| 650 | 2 | |a Hormones |a physiology | |
| 650 | 0 | 7 | |a Physiologie |0 (DE-588)4045981-0 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804147972784521216 |
|---|---|
| adam_text | Titel: Greenspan s basic clinical endocrinology
Autor: Gardner, David G.
Jahr: 2011
Authors
Preface
XI
xv
1. Hormones Hormone Action 1
David G. Gardner, MD, Mark Anderson, MD, PhD,
Robert A. Nissenson, PhD
Relationship to the Nervous System 2
Chemical Nature of Hormones 3
Endocrine Glands Target Organs 4
Regulation of Hormone Levels in Plasma 4
Hormone Action 5
Receptors 5
Neurotransmitter Peptide Hormone Receptors 6
G Protein-Coupled Receptors 7
G Protein Transducers 8
Effectors 9
Disorders of G Proteins G Protein-Coupled
Receptors 11
Growth Factor Receptors 13
Cytokine Receptors 14
Guanylyl Cyclase-Linked Receptors 16
Nuclear Action of Peptide Hormones 18
Nuclear Receptors 18
Steroid Receptor Family 18
Thyroid Receptor Family 21
Nongenomic Effects of the Steroid Hormones 25
Steroid 8c Thyroid Hormone Receptor Resistance
Syndromes 25
Endocrine Autoimmunity
Juan Carlos Jaume, MD
27
Immune Recognition Response 28
Tolerance 31
T-Cell Tolerance 31
B-Cell Tolerance 35
Autoimmunity is Multifactorial 35
Genetic Factors in Autoimmunity 36
Environmental Factors in Autoimmunity 36
Single-Gland Autoimmune Syndromes 37
Autoimmune Aspects of Thyroid Disease 37
Genes Environment 37
Autoimmune Response 37
Animal Models of Autoimmune Thyroid Disease 38
Autoimmune Aspects of Type 1 Diabetes 38
Genes Environment 39
Autoimmune Response 39
Animal Models of Autoimmune Diabetes Mellitus 40
Autoimmune Aspects of Other Endocrinopathies 40
Autoimmune Adrenal Failure 40
Autoimmune Oophoritis Orchitis 41
Autoimmune Hypophysitis 41
Autoimmune Hypoparathyroidism 41
Autoimmune Polyglandular Syndromes 42
Autoimmune Polyglandular Syndrome I (APS-I) 42
Autoimmune Polyglandular Syndrome II
(APS-II) 43
Management of Autoimmune Polyglandular
Syndromes 44
Immunodeficiency, Polyendocrinopathy, Enteropathy,
X-Linked Syndrome 44
POEMS Syndrome (Osteosclerotic Myeloma) 44
3. Evidence-Based Endocrinology
Clinical Epidemiology 47
David C. Aron, MD, MS
Diagnostic Testing: Test Characteristics 47
Sensitivity Specificity 48
Receiver-Operating Characteristic Curves 50
Predictive Values, Likelihood Ratios, Diagnostic
Accuracy 51
An Approach to Diagnosis in Practice 52
Clinical Epidemiologic Principles Applied to Treatment
Decisions 54
Decision Analysis 55
Determine the Probability of Each Chance Event 57
Deciding on a Strategy: Averaging Out
Folding Back the Tree 58
Discounting Future Events 58
Sensitivity Analysis 58
Cost-Effectiveness Analysis Using Decision
Analysis 58
Other Aspects of Clinical Epidemiology 58
Evidence-Based Endocrinology 58
Step One: Translation of the Clinical Problem into
Answerable Questions 61
Step Two: Finding the Best Evidence 61
Step Three: Appraising the Evidence for Its Validity
Usefulness 61
Steps Four Five: Applying the Results in Practice
Evaluating Performance 62
4. Hypothalamus Pituitary Gland 65
Bradley R. Javorsky, MD, David C. Aron, MD, MS,
James W. Findling, MD, J. Blake Tyrrell, MD
Anatomy Embryology 66
Blood Supply 68
Pituitary Development Histology 68
Hypothalamic Hormones 70
Hypophysiotropic Hormones 70
Neuroendocrinology: The Hypothalamus as Part of a
Larger System 73
iv CONTENTS
The Hypothalamus the Control of Appetite 74
The Pineal Gland the Circumventricular
Organs 75
Anterior Pituitary Hormone 75
Adrenocorticotropic Hormone Related Peptides 76
Growth Hormone 78
Prolactin 80
Thyrotropin 82
Gonadotropins: Luteinizing Hormone Follicle-
Stimulating Hormone 83
Endocrinologie Evaluation of the Hypothalamic-Pituitary
Axis 85
Evaluation of Adrenocorticotropic Hormone 85
Evaluation of Growth Hormone 88
Evaluation of Prolactin 88
Evaluation of Thyroid-Stimulating Hormone 88
Evaluation of LH FSH 89
Problems in Evaluation of the Hypothalamic-Pituitary
Axis 89
Effects of Pharmacologic Agents on Hypothalamic-Pituitary
Function 89
Endocrine Tests of Hypothalamic-Pituitary Function 90
Neuroradiologic Evaluation 90
Pituitary Hypothalamic Disorders 91
Empty Sella Syndrome 92
Hypothalamic Dysfunction 93
Hypopituitarism 94
Pituitary Adenomas 99
Tall Stature due to Nonendocrine Causes
Tall Stature due to Endocrine Disorders
7. The Thyroid Gland
David S. Cooper, MD
Paul W. Ladenson, MA (Oxon.), MD
158
159
5. The Posterior Pituitary
(Neurohypophysis)
Alan G. Robinson, MD
Physiology of Hormone Function 115
Anatomy of Hormone Synthesis Release 117
Pathophysiology 117
Diagnostic Tests of Diabetes Insipidus 120
Treatment of Diabetes Insipidus 121
Treatment of Hyponatremia in SIADH 125
Summary 126
6. Growth
Dennis Styne, MD
Normal Growth 129
Intrauterine Growth 129
The Placenta 130
Classic Hormones of Growth Fetal Growth 130
Growth Factors Oncogenes in Fetal Growth 130
Insulin-like Growth Factors, Receptors, 8c Binding
Proteins 130
Insulin 131
Epidermal Growth Factor 131
Fetal Origins of Adult Disease 132
Postnatal Growth 132
Measurement of Growth 139
Skeletal (Bone) Age 142
Disorders of Growth 142
Short Stature due to Nonendocrine Causes 142
Short Stature due to Endocrine Disorders 146
115
129
163
Embryology, Anatomy, 8c Histology 163
Physiology 163
Structure Synthesis of Thyroid Hormones 163
Iodine Metabolism 164
Thyroid Hormone Synthesis Secretion 164
Abnormalities in Thyroid Hormone Synthesis
Release 168
Thyroid Hormone Transport 169
Metabolism of Thyroid Hormones 171
Control of Thyroid Function 8c Hormone Action 173
Physiologic Changes in Thyroid Function 181
Thyroid Autoimmunity 183
Tests of Thyroid Function 184
Tests of Thyroid Hormones in Blood 184
Assessment of Thyroid Iodine Metabolism 8c Biosynthetic
Activity 187
Thyroid Imaging 188
Thyroid Ultrasonography Other Imaging
Techniques 189
Thyroid Biopsy 189
Test of Peripheral Thyroid Hormone Actions 190
Measurement of Thyroid Autoantibodies 190
Disorders of the Thyroid 190
Hypothyroidism 191
Hyperthyroidism 8c Thyrotoxicosis 198
Nontoxic Goiter 209
Thyroiditis 211
Effects of Ionizing Radiation on the Thyroid Gland 214
Thyroid Nodules 8c Thyroid Cancer 214
8. Metabolic Bone Disease
Dolores Shoback, MD, Deborah Sellmeyer, MD,
Daniel D. Bikle, MD, PhD
227
Cellular 8c Extracellular Calcium Metabolism 227
Parathyroid Hormone 228
Vitamin D 234
How Vitamin D 8c PTH Control Mineral Homeostasis 241
Medullary Carcinoma of the Thyroid 241
Hypercalcemia 242
Disorders Causing Hypercalcemia 244
Treatment of Hypercalcemia 252
Hypocalcemia 252
Causes of Hypocalcemia 254
Treatment of Hypocalcemia 258
Bone Anatomy 8c Remodeling 258
Functions of Bone 258
Structure of Bone 259
Bone Remodeling 261
Osteoporosis 262
Treatment of Osteoporosis 266
Glucocorticoid-Induced Osteoporosis 270
Osteomalacia Rickets 271
CONTENTS
Nephrotic Syndrome 273
Hepatic Osteodystrophy 274
Drug-Induced Osteomalacia 274
Hypophosphatemic Disorders 274
Calcium Deficiency 276
Primary Disorders of the Bone Matrix 276
Osteogenesis Imperfecta 276
Inhibitors of Mineralization 277
Paget Disease of Bone (Osteitis Deformans) 277
Etiology 277
Renal Osteodystrophy 280
Hereditary Forms of Hyperphosphatemia 281
9. Glucocorticoids Adrenal
Androgens
Ty B. Carroll, MD, David C. Aron, MD, MS,
James W. Findling, MD, J. Blake Tyrrell, MD
Embryology 8c Anatomy 285
Biosynthesis of Cortisol 8c Adrenal
Androgens 287
Circulation of Cortisol 8c Adrenal
Androgens 292
Metabolism of Cortisol Adrenal
Androgens 292
Biologic Effects of Adrenal Steroids 294
Adrenal Androgens 299
Laboratory Evaluation 299
Disorders of Adrenocortical Insufficiency 303
Primary Adrenocortical Insufficiency
(Addison Disease) 303
Secondary Adrenocortical Insufficiency 308
Diagnosis of Adrenocortical Insufficiency 308
Treatment of Adrenocortical Insufficiency 310
Prognosis of Adrenocortical Insufficiency 312
Cushing Syndrome 312
Hirsutism 8c Virilism 323
Incidental Adrenal Mass 323
Glucocorticoid Therapy for Nonendocrine
Disorders 324
10. Endocrine Hypertension
William F. Young, Jr, MD, MSc
285
329
11. Adrenal Medulla Paraganglia 345
Paul A. Fitzgerald, MD
Anatomy 346
Hormones of the Adrenal Medulla Paraganglia 347
Catecholamines 347
Catecholamine (Adrenergic) Receptors 352
Disorders of the Adrenal Medulla Paraganglia 357
Epinephrine 8c Norepinephrine Deficiency 357
Pheochromocytoma Paraganglioma 358
Incidentally Discovered Adrenal Masses 381
12. Testes 395
Glenn D. Braunstein, MD
Anatomy Structure-Function Relationships 395
Testes 395
Physiology of The Male Reproductive System 397
Accessory Structures 397
Gonadal Steroids 397
Control of Testicular Function 399
Evaluation of Male Gonadal Function 400
Clinical Evaluation 400
Laboratory Tests of Testicular Function 401
Pharmacology of Drugs used to Treat Male Gonadal
Disorders 403
Androgens 403
Gonadotropins 405
Gonadotropin-Releasing Hormone 405
Clinical Male Gonadal Disorders 405
Klinefelter Syndrome (XY Seminiferous Tubule
Dysgenesis) 405
Bilateral Anorchia (Vanishing Testes Syndrome) 407
Leydig Cell Aplasia 408
Cryptorchidism 409
Noonan Syndrome (Male Turner
Syndrome) 410
Myotonic Dystrophy 411
Adult Seminiferous Tubule Failure 411
Adult Leydig Cell Failure (Andropause) 412
Male Infertility 413
Erectile Dysfunction 415
Gynecomastia 417
Testicular Tumors 420
Renin-Angiotensin-Aldosterone System 329
Renin 8c Angiotensin 329
Aldosterone 331
Primary Aldosteronism 332
Other Forms of Mineralocorticoid Excess or Effect 340
Hyperdeoxycorticosteronism 340
Apparent Mineralocorticoid Excess Syndrome 340
Liddle Syndrome-Abnormal Renal Tubular Ionic
Transport 341
Hypertension Exacerbated by Pregnancy 341
Other Endocrine Disorders Associated with
Hypertension 341
Cushing Syndrome 341
Thyroid Dysfunction 342
Acromegaly 342
13. Female Reproductive Endocrinology
Infertility
Mitchell P. Rosen, MD
Marcelle I. Cedars, MD
Embryology Anatomy 424
Ovarian Steroidogenesis 426
Physiology of Folliculogenesis the Menstrual
Cycle 427
Amenorrhea 436
Hypothalamic Amenorrhea 437
Pituitary Amenorrhea 440
Ovarian Amenorrhea 442
Anovulation 445
423
CONTENTS
Obesity 452
Outflow Tract Disorders 454
Menopause 455
Oocyte Depletion 455
Endocrine System Changes with Aging 456
Menopausal Consequences 458
Infertility 461
Diagnosis of Infertility 461
Management of the Infertile Couple 463
Contraception 464
Oral Contraceptives 464
Contraception: Long-Acting Contraceptives 470
Emergency Contraception 475
14. Disorders of Sex Determination
Differentiation
Felix A. Conte, MD, Melvin M.
Grumbach, MD
Human Sex Differentiation 480
Testicular 8c Ovarian Differentiation 485
Psychosexual Differentiation 489
Classification Nomenclature of Disorders of Sex
Determination (8c Differentiation) 489
Klinefelter Syndrome 8c Its Variants: Seminiferous
Tubule Dysgenesis-Sex Chromosome DSD 493
Syndrome of Gonadal Dysgenesis: Turner Syndrome
8c Its Variants 495
Ovotesticular DSD (Individuals with Both Ovarian 8c
Testicular Tissue) 500
46,XY DSD Androgen Induced (Female
Pseudohermaphroditism) 502
P450 Aromatase Deficiency 509
Maternal Source Androgens 8c Progestogens 509
Unclassified Forms of Abnormal Sexual Development in
Males 517
Unclassified Forms of Abnormal Sexual Development in
Females 519
Management of Patients with DSD 519
Incomplete Isosexual Precocious Puberty in Boys 547
Incomplete Contrasexual Precocity in Boys 547
Incomplete Isosexual Precocious Puberty in Girls 547
Incomplete Contrasexual Precocity in Girls 548
Variations in Pubertal Development 548
Differential Diagnosis of Precocious Puberty 549
Treatment of Precocious Puberty 549
15. Puberty
Dennis Styne, MD
Physiology of Puberty 527
Physical Changes Associated with Puberty 527
Endocrine Changes from Fetal Life to Puberty 531
Ovulation Menarche 534
Adrenarche 534
Miscellaneous Metabolic Changes 535
Delayed Puberty or Absent Puberty (Sexual
Infantilism) 535
Constitutional Delay in Growth
Adolescence 535
Hypogonadotropic Hypogonadism 535
Hypergonadotropic Hypogonadism 540
Differential Diagnosis of Delayed Puberty 542
Treatment of Delayed Puberty 543
Precocious Puberty (Sexual Precocity) 545
Central (Complete or True) Precocious
Puberty 545
16. The Endocrinology of Pregnancy
Robert N. Taylor, MD, PhD
Martina L. Badell, MD
Conception Implantation 553
Fertilization 553
Implantation 8c hCG Production 554
479 Ovarian Hormones of Pregnancy 555
Symptoms 8c Signs of Pregnancy 555
Fetal-Placental-Decidual Unit 555
Polypeptide Hormones 555
Human Chorionic Gonadotropin 555
Human Placental Lactogen 555
Other Chorionic Peptide Hormones
Growth Factors 558
Steroid Hormones 558
Progesterone 558
Estrogens 558
Maternal Adaptation to Pregnancy 559
Maternal Pituitary Gland 559
Maternal Thyroid Gland 559
Maternal Parathyroid Gland 559
Maternal Pancreas 559
Maternal Adrenal Cortex 561
Fetal Endocrinology 562
Fetal Pituitary Hormones 562
Fetal Thyroid Gland 562
Fetal Adrenal Cortex 562
Fetal Gonads 562
Endocrine Control of Parturition 563
Sex Steroids 563
Oxytocin 563
527 Prostaglandins 563
Preterm Labor/Birth 563
Maternal/Fetal Stress 564
Pathologic Uterine Distention 564
Infection/Inflammation 564
Decidual Hemorrhage Coagulation 564
Postterm Pregnancy 565
Management of Postterm Pregnancy 565
Endocrinology of the Puerperium 566
Physiologic 8c Anatomic Changes 566
Uterine Changes 566
Endocrine Changes 566
Lactation 566
Endocrine Disorders 8c Pregnancy 567
Hyperthyroidism in Pregnancy 567
Hypothyroidism in Pregnancy 567
Pituitary Disorders in Pregnancy 567
Obesity 8c Pregnancy 568
Parathyroid Disease Pregnancy 569
Preeclampsia/Eclampsia 569
553
CONTENTS
Pathophysiology 569
Clinical Features 570
Treatment/Management of Preeclampsia
17. Pancreatic Hormones
Diabetes Mellitus
Umesh Masharani, MB, BS, MRCP (UK)
Michael S. German, MD
570
573
The Endocrine Pancreas 574
Anatomy Histology 574
Hormones of the Endocrine Pancreas 575
Diabetes Mellitus 587
Classification 587
Type 1 Diabetes Mellitus 587
Type 2 Diabetes 590
Other Specific Types of Diabetes 593
Clinical Features of Diabetes Mellitus 599
Treatment of Diabetes Mellitus 609
Agents for the Treatment of Hyperglycemia 610
Sulfonylureas 612
Steps in the Management of the Diabetic
Patient 622
Immunopathology of Insulin Therapy 625
Acute Complications of Diabetes Mellitus 626
Transition to Subcutaneous Insulin Regimen 631
Chronic Complications of Diabetes Mellitus 634
Specific Chronic Complications of Diabetes Mellitus 636
Management of Diabetes in the Hospitalized Patient 642
Diabetes Mellitus 8c Pregnancy 644
18. Hypoglycemic Disorders 657
Umesh Masharani, MB, BS, MRCP (UK) 8c
Stephen E. Gitelman, MD
Pathophysiology of the Counterregulatory Response to
Neuroglycopenia 658
Counterregulatory Response to
Hypoglycemia 659
Maintenance of Euglycemia in the Postabsorptive
State 660
Classification of Hypoglycemic Disorders 661
Diabetes 661
Factitious Hypoglycemia 662
Drugs 662
Autoimmune Hypoglycemia 663
Pancreatic a Cell Tumors 663
Congenital Hyperinsulinism 670
19. Disorders of Lipoprotein Metabolism 675
Mary J. Malloy, MD John P. Kane, MD, PhD
Atherosclerosis 675
Overview of Lipid Transport 676
Differentiation of Disorders of Lipoprotein
Metabolism 680
Clinical Descriptions of Primary 8c Secondary Disorders of
Lipoprotein Metabolism 681
The Hypertriglyceridemias 681
Primary Hypertriglyceridemia 683
Secondary Hypertriglyceridemia 685
The Primary Hypercholesterolemias 687
Familial Hypercholesterolemia 687
Familial Combined Hyperlipidemia 687
Lp(a) Hyperlipoproteinemia 688
Familial Ligand-Defective Apo B-100 688
Cholesterol 7a-Hydroxylase Deficiency 688
Hypothyroidism 688
Nephrosis 688
Immunoglobulin Disorders 688
Anorexia Nervosa 688
Cholestasis 689
The Primary Hypolipidemias 689
Primary Hypolipidemia due to Deficiency of
High-Density Lipoproteins 689
Primary Hypolipidemia due to Deficiency of
Apo B-Containing Lipoproteins 690
Secondary Hypolipidemia 691
Other Disorders of Lipoprotein Metabolism 691
The Lipodystrophies 691
Rare Disorders 692
Treatment of Hyperlipidemia 692
Dietary Factors in the Management of Lipoprotein
Disorders 693
Drugs Used in Treatment of Hyperlipoproteinemia 694
Bile Acid Séquestrants 694
Niacin (Nicotinic Acid) 695
Fibric Acid Derivatives 695
HMG-CoA Reductase Inhibitors 696
Cholesterol Absorption Inhibitors 697
Combined Drug Therapy 697
20. Obesity 699
Alka M. Kanaya, MD Christian Vaisse, MD, PhD
Definition Epidemiology 699
Definition 699
Prevalence 8c Projections 699
Possible Explanations for the Increased
Obesity Rates 700
Pathophysiology Genetics of Obesity 700
Regulation of Food Intake Energy Expenditure 700
Informing the Brain of the Energy Status: Leptin 8c
Short-Term Gastrointestinal Signals 700
Central Integration of Energy Homeostasis Signals 701
Leptin Resistance in Obesity 702
Genetics of Obesity 702
Health Consequences of Obesity 703
Mechanism Underlying Obesity Complications:
Adipose Tissue as an Endocrine Organ 703
Metabolic Complications of Obesity: Insulin Resistance
8c Type 2 Diabetes 704
Dyslipidemia 705
The Metabolic Syndrome 705
Cardiovascular Complications 705
Pulmonary Complications 705
Gastrointestinal Complications 706
Reproduction Gynecologic Complications 706
Cancer 706
Management of the Obese Patient 706
Screening 8c Prevention of Complications 706
Therapeutic Approaches for Weight Loss 706
CONTENTS
21. Humoral Manifestations
of Malignancy
Dolores Shoback, MD, 8i Janet L. Funk, MD
711
Ectopic Hormone Receptor Syndromes 711
APUD Concept of Neuroendocrine Cell Tumors 712
Hypercalcemia of Malignancy 712
Pathogenesis 712
Humoral Mediators 712
Solid Tumors Associated with Hypercalcemia of
Malignancy 713
Hematologic Malignancies Associated with
Hypercalcemia of Malignancy 714
Diagnosis 715
Treatment 715
Ectopic Cushing Syndrome 715
Differential Diagnosis 715
Clinical Features 717
Syndrome of Inappropriate Antidiuretic Hormone
Secretion 717
Etiology 8c Pathogenesis 718
Clinical 8c Laboratory Features 718
Non-Islet Cell Tumor-Induced Hypoglycemia 718
Other Hormones Secreted by Tumors 719
Oncogenic Osteomalacia 720
Etiology 8c Clinical Features 720
Pathology 8c Pathogenesis 720
Gut Hormones 721
22. Multiple Endocrine Neoplasia
David G. Gardner, MD
723
723
729
Multiple Endocrine Neoplasia Type 1
Pathogenesis 725
Treatment 726
Screening 727
Multiple Endocrine Neoplasia Type 2
Pathogenesis 730
Treatment 732
Screening 732
Other Disorders Characterized by Multiple Endocrine
Organ Involvement 733
Carney Complex 733
McCune-Albright Syndrome 734
Neurofibromatosis Type 1 734
Von Hippel-Lindau Disease 734
MEN X 734
23. Geriatric Endocrinology 737
Susan L. Greenspan, MD, Mary Korytkowski, MD,
Neil M. Resnick, MD
Thyroid Function 8c Disease 738
Disorders of the Thyroid Gland 738
Hyperthyroidism 739
Hypothyroidism 741
Multinodular Goiter 742
Thyroid Nodules 8c Cancer 743
Carbohydrate Intolerance Diabetes Mellitus 743
Osteoporosis 750
Hyperparathyroidism 757
Changes in Water Balance 757
Hypernatremia 758
Hyponatremia 758
Hyporeninemic Hypoaldosteronism 758
Glucocorticoids 8c Stress 758
Disorders of the Hypothalamic-Pituitary-Adrenal
Axis 759
Changes in Reproductive Function in Men 760
24. Endocrine Emergencies
David G. Gardner, MD
Myxedema Coma 763
Thyroid Storm 765
Thyrotoxic Periodic Paralysis 766
Amiodarone-Induced Thyrotoxicosis 767
Acute Adrenal Insufficiency 768
Pituitary Apoplexy 769
Diabetic Ketoacidosis 769
Nonketotic Hyperosmolar Coma 773
Hypercalcémie Crisis 775
Acute Hypocalcemia 777
Hyponatremia 779
Diabetes Insipidus 782
25. AIDS Endocrinopathies
Carl Grunfeld, MD, PhD Grace Lee, MD
Thyroid Disorders 787
Adrenal Disorders 789
Bone 8c Mineral Disorders 791
Gonadal Disorders 792
Pituitary Disorders 794
AIDS Wasting Syndrome 794
Abnormalities of Fat Distribution Associated with
HIV 795
Disorders of Glucose 8c Lipid Metabolism 796
Conclusion 801
26. Endocrine Surgery
Geeta Lai, MD Orlo H. Clark, MD
763
787
803
The Thyroid Gland 803
Embryology 8c Anatomy 803
Developmental Thyroid Abnormalities 804
Hyperthyroidism 804
Thyroiditis 805
Goiter (Nontoxic) 805
Thyroid Nodules 805
Thyroid Cancer 806
Conduct of Thyroidectomy 809
The Parathyroid Gland 811
Embryology 8c Anatomy 811
Primary Hyperparathyroidism 811
Persistent Recurrent Primary Hyperparathyroidism 814
Secondary Hyperparathyroidism 814
Special Consideration: Familial Hyperparathyroidism 815
Complications of Parathyroid Surgery 815
The Adrenal (Suprarenal) Gland 815
CONTENTS
Embryology 8c Anatomy 815
Primary Hyperaldosteronísm 815
Hypercortisolism 816
Adrenal Cortical Carcinoma 816
Sex Steroid Excess 817
Pheochromocytoma 817
Adrenal Incidentaloma 817
Technique of Adrenalectomy 818
The Endocrine Pancreas 818
Embryology Anatomy 818
Insulinoma 819
Gastrinoma (Zollinger-Ellison Syndrome) 820
Vipoma (Verner-Morrison) Syndrome 821
Glucagonoma 821
Somatostatinoma 821
Nonfunctioning Pancreatic Tumors 821
Appendix: Normal Hormone Reference Ranges
Index
825
845
|
| any_adam_object | 1 |
| author2 | Gardner, David G. |
| author2_role | edt |
| author2_variant | d g g dg dgg |
| author_GND | (DE-588)172104742 |
| author_facet | Gardner, David G. |
| building | Verbundindex |
| bvnumber | BV039135359 |
| classification_rvk | YC 3100 |
| ctrlnum | (OCoLC)743404784 (DE-599)HBZHT016870496 |
| discipline | Medizin |
| edition | 9. ed. |
| format | Book |
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| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV039135359 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:59:44Z |
| institution | BVB |
| isbn | 9780071622431 0071622438 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024153567 |
| oclc_num | 743404784 |
| open_access_boolean | |
| owner | DE-578 DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-578 DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XIII, 880 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | McGraw-Hill Medical |
| record_format | marc |
| series2 | A Lange medical book |
| spelling | Greenspan's basic & clinical endocrinology ed. by David G. Gardner ... Basic & clinical endocrinology Basic and clinical endocrinology 9. ed. New York [u.a.] McGraw-Hill Medical 2011 XIII, 880 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier A Lange medical book Endocrine Glands physiology Endocrine Diseases Hormones physiology Physiologie (DE-588)4045981-0 gnd rswk-swf Endokrinopathie (DE-588)4113435-7 gnd rswk-swf Endokrinium (DE-588)4152176-6 gnd rswk-swf Endokrinologie (DE-588)4014663-7 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Endokrinologie (DE-588)4014663-7 s DE-604 Endokrinium (DE-588)4152176-6 s Physiologie (DE-588)4045981-0 s Endokrinopathie (DE-588)4113435-7 s 1\p DE-604 Gardner, David G. edt Greenspan, Francis S. 1920-2016 Begründer eines Werks (DE-588)172104742 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024153567&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Greenspan's basic & clinical endocrinology Endocrine Glands physiology Endocrine Diseases Hormones physiology Physiologie (DE-588)4045981-0 gnd Endokrinopathie (DE-588)4113435-7 gnd Endokrinium (DE-588)4152176-6 gnd Endokrinologie (DE-588)4014663-7 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4113435-7 (DE-588)4152176-6 (DE-588)4014663-7 (DE-588)4151278-9 |
| title | Greenspan's basic & clinical endocrinology |
| title_alt | Basic & clinical endocrinology Basic and clinical endocrinology |
| title_auth | Greenspan's basic & clinical endocrinology |
| title_exact_search | Greenspan's basic & clinical endocrinology |
| title_full | Greenspan's basic & clinical endocrinology ed. by David G. Gardner ... |
| title_fullStr | Greenspan's basic & clinical endocrinology ed. by David G. Gardner ... |
| title_full_unstemmed | Greenspan's basic & clinical endocrinology ed. by David G. Gardner ... |
| title_short | Greenspan's basic & clinical endocrinology |
| title_sort | greenspan s basic clinical endocrinology |
| topic | Endocrine Glands physiology Endocrine Diseases Hormones physiology Physiologie (DE-588)4045981-0 gnd Endokrinopathie (DE-588)4113435-7 gnd Endokrinium (DE-588)4152176-6 gnd Endokrinologie (DE-588)4014663-7 gnd |
| topic_facet | Endocrine Glands physiology Endocrine Diseases Hormones physiology Physiologie Endokrinopathie Endokrinium Endokrinologie Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024153567&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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