Pharmacology and pharmacokinetics: a basic reader
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Springer
2010
|
| Schriftenreihe: | Competency-based critical care
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 70 S. Ill., graph. Darst. |
| ISBN: | 9781849961455 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804145706025353216 |
|---|---|
| adam_text | V
CONTRIBUTORS
...............................................................................................
IX
CHAPTER 1 PHARMACOLOGY
..........................................................................
1
SUE HILL
INTRODUCTION
.............................................................................
1
MECHANISM OF DRUG ACTION
.................................................... 2
RECEPTOR INTERACTIONS
......................................................... 2
ION CHANNELS
........................................................................
2
VOLTAGE-GATED IONIC CHANNELS ....................................... 3
LIGAND-GATED ION CHANNELS
........................................... 3
IONOTROPIC GLUTAMATE RECEPTORS
.................................... 5
IONOTROPIC PURINERGIC RECEPTORS: P2X SUBTYPES
.......... 5
TRANSMEMBRANE TRANSDUCING RECEPTORS
.......................... 5
G-PROTEIN COUPLED RECEPTORS (GPCRS)
........................ 5
TYROSINE KINASE RECEPTORS (TKR)
................................. 7
GUANYLYL CYCLASE RECEPTORS............................................ 7
INTRACELLULAR MEMBRANE-BOUND RECEPTORS
....................... 7
CYTOSOLIC RECEPTORS
........................................................ 7
CYTOPLASMIC HORMONE RECEPTORS
.................................. 7
ADRENOSTEROID HORMONES .............................................. 8
PHARMACODYNAMICS
................................................................ 8
INTRODUCTION TO DRUG*RECEPTOR INTERACTION
.................... 8
PROPERTIES OF RECEPTOR SYSTEMS
......................................... 9
TYPES OF DRUG*RECEPTOR INTERACTION
................................ 9
TYPES OF AGONIST
.............................................................. 9
CHAPTER 2 PHARMACOKINETIC PRINCIPLES
................................................... 13
DAVID BROWN AND MARK TOMLIN
INTRODUCTION
.............................................................................
13
DRUG ABSORPTION
..................................................................... 14
LIPID DIFFUSION
..................................................................... 14
MEMBRANE TRANSPORT MOLECULES........................................ 15
P-GLYCOPROTEIN
................................................................. 15
OTHER FACTORS AFFECTING DRUG ABSORPTION
........................ 16
DRUG ABSORPTION FROM THE LUNG
........................................ 17
CONTENTS
V
I C
O
N
T
E
N
T
S
DRUG ABSORPTION THROUGH THE SKIN
.................................. 17
IM AND SC ABSORPTION
........................................................ 17
BIOAVAILABILITY
......................................................................
18
DRUG DISTRIBUTION
................................................................... 19
VOLUME OF DISTRIBUTION (
V
D
) .............................................. 21
USE OF
V
D
...............................................................................
23
CAUTION WHEN USING
V
D
...................................................... 23
DRUG BINDING: TYPES OF INTERMOLECULAR BONDS
................ 23
PLASMA PROTEIN BINDING
...................................................... 24
SIGNIFICANCE OF PROTEIN BINDING IN DRUG INTERACTIONS ..... 25
THE BLOOD-BRAIN
BARRIER..................................................... 26
DRUG METABOLISM
.................................................................... 27
STEREOISOMERS
......................................................................
29
PHASE 1 METABOLISM
............................................................ 29
ENZYME INDUCTION
.............................................................. 31
ENZYME INHIBITION
.................................................................. 31
DRUG*FOOD INTERACTIONS
..................................................... 32
METABOLISM AT NONHEPATIC SITES
........................................ 32
PHASE 2 METABOLISM
............................................................ 32
FIRST-PASS METABOLISM
........................................................ 32
DRUG EXCRETION (ELIMINATION)
................................................ 32
RELATIONSHIP BETWEEN EXCRETION AND CLEARANCE
.............. 33
USING THE CONCEPT OF CLEARANCE AND HALF-LIFE
IN PHARMACOKINETIC EQUATIONS
...................................... 34
NONLINEAR PHARMACOKINETICS
............................................. 36
CLEARANCE BY SPECIFIC ORGANS
............................................. 37
RENAL CLEARANCE
............................................................... 37
GLOMERULAR FILTRATION (PASSIVE DIFFUSION)
.................... 37
TUBULAR SECRETION (ACTIVE)
............................................. 37
TUBULAR REDIFFUSION
........................................................ 37
MEASURES OF RENAL CLEARANCE
............................................. 37
BILIARY EXCRETION AND ENTEROHEPATIC EXCRETION
............... 39
HEPATIC CLEARANCE
............................................................... 39
INFLUENCE OF PHARMACOKINETICS ON THE
CHOICE OF DOSE REGIMEN
.................................................... 40
FACTORS AFFECTING PHARMACOKINETICS
..................................... 41
PHYSIOLOGICAL FACTORS
.......................................................... 41
AGE
....................................................................................
41
BODY WEIGHT
..................................................................... 43
GENDER
..............................................................................
43
PREGNANCY
........................................................................
43
GENETIC POLYMORPHISM
................................................... 43
ETHNICITY
...........................................................................
44
EFFECTS OF DISEASE ON PHARMACOKINETICS
........................... 44
RENAL DISEASE
................................................................... 44
DOSAGE MODIFICATION IN RENAL DISEASE .......................... 45
RENAL REPLACEMENT THERAPY
.......................................... 47
LIVER DISEASE
.................................................................... 47
CONGESTIVE HEART FAILURE (CHF)
.................................... 48
THYROID DISEASE
............................................................... 48
VII
C
O
N
T
E
N
T
S
DRUG INTERACTIONS WITH A PHARMACOKINETIC BASIS
................ 48
DRUG ABSORPTION
................................................................. 49
DRUG DISTRIBUTION
............................................................... 49
DRUG METABOLISM
............................................................ 49
DRUG EXCRETION
.................................................................... 49
RULES OF THUMB WHEN DEALING WITH
POTENTIALLY INTERACTING DRUGS
............................................ 50
DECIDING TO EMBARK ON THERAPEUTIC DRUG
MONITORING
...............................................................................
50
SUMMARY
..................................................................................
51
CHAPTER 3 INTRODUCTION TO SPECIALIST
THERAPEUTICS................................ 53
KENWYN JAMES, SPIKE BRIGGS, ROB LEWIS, AND MIKE CELINSKI
DRUGS TARGETING THE GASTROINTESTINAL TRACT
IN CRITICAL
CARE.........................................................................
53
STRESS-RELATED MUCOSAL DAMAGE
........................................ 53
ANTACIDS
...........................................................................
53
SUCRALFATE..........................................................................
54
H
2
BLOCKERS
......................................................................
54
PROTON PUMP INHIBITORS (PPIS)
...................................... 54
GASTROINTESTINAL HYPOMOTILITY
........................................... 54
METOCLOPRAMIDE
.............................................................. 55
ERYTHROMYCIN
.................................................................. 55
OTHER PROKINETIC DRUGS
.................................................. 55
CONSTIPATION
.................................................................... 55
NOSOCOMIAL INFECTION
......................................................... 56
SELECTIVE DECONTAMINATION OF THE DIGESTIVE TRACT
....... 56
ENTERAL NUTRITION
............................................................. 56
SUMMARY
..............................................................................
57
SEDATION ON THE INTENSIVE CARE UNIT
...................................... 57
PURPOSE
................................................................................
57
OBJECTIVE
..............................................................................
57
THE IDEAL SEDATIVE AGENT
.................................................... 58
SEDATIVE AGENTS
................................................................... 58
BENZODIAZEPINES
............................................................. 58
PROPOFOL
............................................................................
59
BARBITURATES
..................................................................... 59
KETAMINE
..........................................................................
60
ISOFLURANE
.........................................................................
60
ANTIPSYCHOTICS
................................................................. 61
OPIOIDS
.............................................................................
62
NONOPIOID ANALGESIA WITHIN THE INTENSIVE CARE UNIT
.......... 62
PARACETAMOL (ACETAMINOPHEN)
.......................................... 62
CLONIDINE
.........................................................................
62
DEXMEDETOMIDINE...........................................................
63
TRAMADOL
..............................................................................
63
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ........................... 63
OPIATES IN CRITICAL CARE
........................................................... 64
INTRODUCTION
.................................................................... 64
VIII C
O
N
T
E
N
T
S
PHARMACODYNAMICS
............................................................ 64
CENTRAL NERVOUS SYSTEM (CNS)
...................................... 64
CARDIOVASCULAR SYSTEM
................................................... 64
GASTROINTESTINAL TRACT
..................................................... 64
IMMUNE SYSTEM
............................................................... 64
PHARMACOKINETICS
............................................................... 65
ROUTE OF ADMINISTRATION
..................................................... 65
MORPHINE
.........................................................................
65
FENTANYL
............................................................................
65
ALFENTANIL
.........................................................................
65
REMIFENTANIL
.................................................................... 65
CONCLUSION
...............................................................................
66
INDEX
..................................................................................................
67
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| illustrated | Illustrated |
| indexdate | 2024-07-09T23:23:42Z |
| institution | BVB |
| isbn | 9781849961455 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022561907 |
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| spelling | Pharmacology and pharmacokinetics a basic reader Mark E. Tomlin (ed.) Pharmacology & pharmacokinetics London Springer 2010 IX, 70 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Competency-based critical care Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmakologie (DE-588)4045687-0 s Pharmakokinetik (DE-588)4115557-9 s DE-604 Tomlin, Mark E. Sonstige oth SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022561907&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacology and pharmacokinetics a basic reader Pharmakologie (DE-588)4045687-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4115557-9 |
| title | Pharmacology and pharmacokinetics a basic reader |
| title_alt | Pharmacology & pharmacokinetics |
| title_auth | Pharmacology and pharmacokinetics a basic reader |
| title_exact_search | Pharmacology and pharmacokinetics a basic reader |
| title_full | Pharmacology and pharmacokinetics a basic reader Mark E. Tomlin (ed.) |
| title_fullStr | Pharmacology and pharmacokinetics a basic reader Mark E. Tomlin (ed.) |
| title_full_unstemmed | Pharmacology and pharmacokinetics a basic reader Mark E. Tomlin (ed.) |
| title_short | Pharmacology and pharmacokinetics |
| title_sort | pharmacology and pharmacokinetics a basic reader |
| title_sub | a basic reader |
| topic | Pharmakologie (DE-588)4045687-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Pharmakologie Pharmakokinetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022561907&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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