Essentials of biochemistry:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVIII, 364 S. Ill., graph. Darst. 235 mm x 155 mm |
| ISBN: | 3642196233 9783642196232 |
Internformat
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| 100 | 1 | |a Fromm, Herbert J. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Essentials of biochemistry |c Herbert J. Fromm ; Mark S. Hargrove |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2012 | |
| 300 | |a XVIII, 364 S. |b Ill., graph. Darst. |c 235 mm x 155 mm | ||
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| 700 | 1 | |a Hargrove, Mark S. |e Verfasser |4 aut | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-022553646 | |
Datensatz im Suchindex
| _version_ | 1809403796429733888 |
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| adam_text |
IMAGE 1
CONTENTS
1 THE CELL AND ITS COMPONENTS 1
1.1 TYPICAL PROKARYOTIC CELL: ESCHERICHIA COLI 1
1.2 ARCHAEA 2
1.3 EUKARYOTIC CELL (NON-PLANT) 3
1.4 EUKARYOTIC CELL COMPONENTS (PLANT) 4
2 INTRODUCTION TO BIOMOLECULES 5
2.1 AMINO ACIDS 5
2.1.1 ESSENTIAL AMINO ACIDS 9
2.1.2 OPTICAL PROPERTIES 10
2.2 CARBOHYDRATES 13
2.2.1 MONOSACCHARIDES 13
2.2.2 DISACCHARIDES 18
2.2.3 POLYSACCHARIDES 19
2.3 LIPIDS 22
2.3.1 FATTY ACIDS 23
2.3.2 TRIACYLGLYCEROLS 24
2.3.3 PHOSPHOACYLGLYCEROLS 24
2.3.4 SPHINGOLIPIDS 25
2.3.5 WAXES 26
2.3.6 TERPENES 26
2.3.7 STEROLS 27
2.3.8 PROSTAGLANDINS 27
2.3.9 MEMBRANES 27
2.4 NUCLEOTIDES 29
2.4.1 THEBASES 30
2.4.2 THESUGARS 30
2.4.3 THE NUCLEOSIDES 31
2.4.4 THE NUCLEOTIDES 32
REFERENCE 34
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1009990160
DIGITALISIERT DURCH
IMAGE 2
XUE CONTENTS
3 PROTEIN STRUCTURE AND FUNCTION 35
3.1 PROTEINS ARE POLYMERS OF AMINO ACIDS, CHARACTERIZED BY FOUR "LEVELS"
OF STRUCTURE 36
3.2 THE PROTEIN "MAIN CHAIN" CONTROLS CONFORMATIONAL FLEXIBILITY 37 3.3
COMMON SECONDARY STRUCTURAL ELEMENTS THE ALPHA HELIX AND THE BETA SHEET
40
3.4 TERTIARY STRUCTURE: PROTEINS EXHIBIT COMMON FOLDS 42
3.5 QUATERNARY STRUCTURE 44
3.6 WHAT ARE PROTEIN STRUCTURES AND HOW ARE PROTEIN STRUCTURES MEASURED?
44
3.7 HEMOGLOBIN: AN EXAMPLE OF PROTEIN STRUCTURE AND FUNCTION 46 3.8
PROTEIN FOLDING AND STABILITY 51
FURTHER READING 52
4 ENZYMES 53
4.1 CHARACTERISTICS OF ENZYMES 53
4.2 ENZYME CLASSIFICATION 55
4.3 MECHANISMS OF ENZYME ACTION 56
4.4 NUCLEOPHILIC SUBSTITUTION REACTIONS 64
4.4.1 S N 1 (SUBSTITUTION, NUCLEOPHILIC, FIRST ORDER REACTION) 64 4.4.2
S N 2 (SUBSTITUTION, NUCLEOPHILIC, SECOND ORDER) 65 4.4.3
STEREOCHEMISTRY OF NUCLEOPHILIC SUBSTITUTION REACTIONS 65 4.5
PHOSPHOROUS COMPOUNDS AND THEIR CHEMISTRY 65
4.5.1 OXIDATION STATES OF PHOSPHOROUS 66
4.5.2 TYPES OF REACTION INVOLVING PHOSPHOROUS 66
4.6 STUDYING THE STEREOCHEMISTRY OF ENZYME-CATALYZED REACTIONS 67 4.6.1
THE USE OF CHIRAL PHOSPHOROUS COMPOUNDS 67
4.6.2 ISOTOPE SCRAMBLING (POSITIONAL ISOTOPE EXCHANGE) 68 4.7 STUDIES ON
THE MECHANISM OF ENZYME ACTION USING TRANSITION STATE ANALOGS 69
4.7.1 PROLINE RACEMASE 69
4.7.2 ADENYLATE KINASE 70
4.7.3 LYSOZYME 71
4.8 MECHANISM OF CHYMOTRYPSIN 73
4.9 SPECIFICITY OF THE SERINE PROTEASES 75
4.10 LOW-BARRIER HYDROGEN BONDS 76
4.11 MECHANISM OF GLUCOAMYLASE 76
4.12 SUBSTRATE CHANNELING 77
REFERENCES 79
5 ENZYME KINETICS 81
5.1 NOMENCLATURE 81
5.2 BRIEF REVIEW OF CHEMICAL KINETICS 82
5.3 THE EVOLUTION OF ENZYME KINETICS 83
5.3.1 HISTORICAL 83
IMAGE 3
CONTENTS XUEI
5.3.2 TIME COURSE OF ENZYME-CATALYZED REACTIONS 84
5.3.3 DERIVATION OF THE HENRI-MICHAELIS-MENTEN EQUATION 85 5.3.4 THE
HALDANE EQUATION 91
5.3.5 SHORTHAND METHOD FOR DERIVING RATE EQUATIONS FOR THE REVERSE
REACTION 92
5.3.6 ENZYME INHIBITION 92
5.3.7 REVERSIBLE ENZYME INHIBITION 93
5.3.8 THE EFFECT OF PH ON ENZYME KINETICS 99
5.3.9 THE EFFECT OF TEMPERATURE ON ENZYME KINETICS 101 5.3.10 THE
INTEGRATED HENRI-MICHAELIS-MENTEN EQUATION 101 5.3.11 KINETIC ISOTOPE
EFFECTS 103
5.3.12 MISCELLANEOUS METHODS FOR STUDYING ENZYME KINETICS 105 5.3.13
COOPERATIVITY AND SIGMOIDAL KINETICS 106
REFERENCES 122
6 COENZYMES AND VITAMINS 123
6.1 COENZYMES 123
6.1.1 NAD + ANDNADP + 123
6.1.2 BIOTIN 126
6.1.3 THIAMINE PYROPHOSPHATE 127
6.1.4 COENZYMEA 129
6.1.5 PYRIDOXAL PHOSPHATE 130
6.1.6 FLAVIN COENZYMES 133
6.1.7 LIPOICACID 135
6.1.8 FOLIE ACID COENZYMES 136
6.1.9 VITAMIN B 12 COENZYMES 139
6.2 VITAMINS 143
6.2.1 VITAMINA 143
6.2.2 VITAMINC 144
6.2.3 VITAMIND 144
6.2.4 VITAMINE 145
6.2.5 VITAMINK 146
REFERENCES 148
7 INTRODUCTION TO METABOLISM 149
7.1 HIGH ENERGY COMPOUNDS 151
7.1.1 ATP (AS WELL AS OTHER NUCLEOSIDE DI-AND TRIPHOSPHATES) . 152
7.1.2 ACETYL PHOSPHATE 152
7.1.3 CREATINE PHOSPHATE 153
7.1.4 PHOSPHOENOLPYRUVATE 153
7.1.5 PYROPHOSPHATE 153
7.1.6 ACETYL-COENZYME A (ACETYL-COA) 154
7.2 INTERMEDIATE ENERGY COMPOUNDS 154
7.3 LOW ENERGY COMPOUNDS 155
IMAGE 4
XIV CONTENTS
7.4 REGENERATION OF NUCLEOSIDE DI- AND TRI-PHOSPHATES 155 7.5 METABOLIC
PATHWAYS AND THEIR REGULATION 156
7.5.1 THE CONCEPT OF THE "COMMITTED STEP" IN A METABOLIC PATHWAY 156
7.5.2 METABOLIC PATHWAYS ARE HIGHLY EXERGONIC 157
7.5.3 PATHWAYS ARE NOT THERMODYNAMICALLY REVERSIBLE, BUT THEY ARE
PHYSIOLOGICALLY REVERSIBLE 158
7.5.4 FEED FORWARD ACTIVATION AND FEED-BACK INHIBITION 158 7.5.5
EQUILIBRIUM VERSUS NONEQUILIBRIUM ENZYMES AS SITES OF REGULATION 158
7.5.6 MODULATION OF ENZYME ACTIVITY 159
REFERENCES 161
8 CARBOHYDRATE METABOLISM A: GLYCOLYSIS AND GLUCONEOGENESIS 163 8.1
GLYCOLYSIS 163
8.1.1 GLYCOLYTIC ENZYMES AND THEIR MECHANISMS OF ACTION 165 8.1.2
METABOLISM OF D-MANNOSE AND D-GALACTOSE 176
8.1.3 REGULATION OF GLYCOLYSIS 180
8.2 GLUCONEOGENESIS 183
8.2.1 PYRUVATE CARBOXYLASE 184
8.2.2 PHOSPHOENOLPYRUVATE CARBOXYKINASE 186
8.2.3 FRUCTOSE-1,6-BISPHOSPHATASEI 187
8.2.4 GLUCOSE-6-PHOSPHATASE 188
8.3 COORDINATED REGULATION BETWEEN GLYCOLYSIS AND GLUCONEOGENESIS 189
8.4 THECORI CYCLE 193
8.5 THE GLUCOSE-ALANINE CYCLE 194
8.6 SHUTTLE MECHANISMS ALLOW OXALOACETATE TRANSPORT FROM MITOCHONDRIA TO
THE CYTOSOL 195
8.7 THE PENTOSE PHOSPHATE SHUNT 196
8.7.1 THE ENZYMES OF THE PENTOSE PHOSPHATE SHUNT 197
8.7.2 REGULATION OF THE PENTOSE PHOSPHATE PATHWAY 202
REFERENCES 203
9 THE TRICARBOXYLIC ACID CYCLE 205
9.1 THE CONVERSION OF PYRUVATE TO ACETYL-COA 206
9.2 THE TCA CYCLE: THE FATE OF ACETYL-COA 210
9.3 ENERGETICS OF PYRUVATE OXIDATION 212
9.4 STEREOCHEMISTRY OF THE TCA CYCLE 213
9.5 TCA CYCLE ENZYMES AND THEIR MECHANISMS 214
9.5.1 CITRATE SYNTHASE 214
9.5.2 ACONITASE 215
9.5.3 ISOCITRATE DEHYDROGENASE 216
9.5.4 A-KETOGLUTARATE DEHYDROGENASE 217
9.5.5 SUCCINYL-COA SYNTHETASE 217
IMAGE 5
CONTENTS XV
9.5.6 SUCCINATE DEHYDROGENASE 218
9.5.7 FUMARASE 219
9.5.8 MALATE DEHYDROGENASE 220
9.6 REGULATION OF ACETYL-COA OXIDATION 220
9.6.1 PYRUVATE DEHYDROGENASE REGULATION 220
9.6.2 TCA CYCLE REGULATION 221
REFERENCES 222
10 ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION 223 10.1 ELECTRON
TRANSPORT 224
10.2 COMPONENTS OF THE ELECTRON TRANSPORT CHAIN 226
10.2.1 COENZYMEQ 226
10.2.2 IRON SULFUR PROTEINS 228
10.2.3 THE CYTOCHROMES 229
10.3 ELECTRON AND PROTON TRANSPORT 230
10.4 THE CHEMIOSMOTIC HYPOTHESIS 230
10.5 ATPSYNTHASE 233
10.5.1 THE BINDING CHANGE MECHANISM 233
10.5.2 CHEMICAL MECHANISM OF THE ATP SYNTHASE REACTION . 235 10.6
TRANSPORT OF NUCLEOTIDES AND P THROUGH MITOCHONDRIAL MEMBRANES 235
10.7 THE FATE OF NADH IN AEROBIC TISSUE 236
10.8 THE REGULATION OF OXIDATIVE PHOSPHORYLATION 237
10.9 INHIBITORS OF OXIDATIVE PHOSPHORYLATION 237
REFERENCES 238
11 CARBOHYDRATE METABOLISM B: DI-, OLIGO-, AND POLYSACCHARIDE SYNTHESIS
AND DEGRADATION 239
11.1 DISACCHARIDE SYNTHESIS AND DEGRADATION 239
11.1.1 SUCROSE (TABLE SUGAR) 239
11.1.2 LACTOSE 241
11.1.3 MALTOSE 244
11.2 GLYCOGENOLYSIS 245
11.2.1 GLYCOGEN PHOSPHORYLASE 245
11.2.2 GLUCAN TRANSFERASE 247
11.2.3 A( 1 - 6) GLUCOSIDASE (DEBRANCHING ENZYME) 248 11.3 GLYCOGENESIS
249
11.3.1 GLYCOGEN SYNTHASE 249
11.3.2 THE BRANCHING ENZYME (AMYLO-( 1,4- * 1,6)- TRANSGLUCOSYLASE) 250
11.3.3 GLYCOGENIN 252
11.4 REGULATION OF GLYCOGEN METABOLISM 253
11.5 REGULATION OF PHOSPHORYLASE 253
11.6 REGULATION OF GLYCOGEN SYNTHASE 254
IMAGE 6
XVI CONTENTS
11.7 SYNTHESIS AND DEGRADATION OF STARCH 255
11.8 SYNTHESIS AND DEGRADATION OF CELLULOSE 255
REFERENCES 256
12 LIPID METABOLISM 257
12.1 LIPID DIGESTION 257
12.2 DEGRADATION OF FATTY ACIDS 258
12.3 TRANSPORT OF FATTY ACIDS INTO MITOCHONDRIA 260
12.4 SS-OXIDATION OF FATTY ACIDS 261
12.5 ENERGETICS OF THE SS-OXIDATION PATHWAY 262
12.6 SS-OXIDATION OF UNSATURATED FATTY ACIDS 263
12.7 OXIDATION OF ODD NUMBERED FATTY ACIDS 263
12.8 FATTY ACID BIOSYNTHESIS 264
12.9 COMMENTS ON THE FAS SYSTEM 266
12.10 REGULATION OF FATTY ACID METABOLISM 267
12.11 TRIACYLGLYCEROL BIOSYNTHESIS 268
12.12 KETONE BODY FORMATION 269
12.13 FATTY ACID ELONGATION 271
12.14 FATTY ACID DESATURATION 271
12.15 LIPOPROTEINS AND LIPID TRANSPORT 273
12.16 CHOLESTEROL BIOSYNTHESIS 275
12.17 THE GLYOXYLATE CYCLE 276
REFERENCES 277
13 AMINO ACID METABOLISM 279
13.1 THE NITROGEN CYCLE 279
13.2 AMINO ACID METABOLISM 280
13.3 BIOSYNTHESIS OF THE NONESSENTIAL AMINO ACIDS 280
13.4 AMINO ACID DEGRADATION 284
13.5 ESSENTIAL AMINO ACIDS 285
13.6 AMINO ACIDS ARE PRECURSORS OF METABOLIC REGULATORS 286 13.6.1
GLUTATHIONE 286
13.6.2 EPINEPHRINE 287
13.6.3 HISTAMINE 287
13.6.4 SEROTONIN 287
13.6.5 THYROXINE 288
13.6.6 NITRICOXIDE 288
13.6.7 S-ADENOSYLMETHIONINE 288
13.7 THE KREBS UREA CYCLE 290
REFERENCES 292
14 NUCLEOTIDE METABOLISM 293
14. 1 DE NOVO PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS 293
14.1.1 THE SYNTHESIS OF URIDINE-5'-MONOPHOSPHATE 293
IMAGE 7
CONTENTS XVII
14.1.2 ENZYMES OF PYRIDINE NUCLEOTIDE BIOSYNTHESIS 295 14.1.3 SYNTHESIS
OF CYTIDINE NUCLEOTIDES 299
14.1.4 CONTROL OF PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS 300 14.2 PYRIMIDINE
CATABOLISM 302
14.3 DE NOVO PURINE NUCLEOTIDE BIOSYNTHESIS 302
14.3.1 THE BIOSYNTHESIS OF INOSINE-5'-MONOPHOSPHATE 303 14.3.2 AMP AND
GMP BIOSYNTHESIS 304
14.3.3 PURINE NUCLEOTIDE BIOSYNTHESIS: ENZYME MECHANISMS . 305 14.3.4
REGULATION OF PURINE NUCLEOTIDE BIOSYNTHESIS 309 14.4
DEOXYRIBONUCLEOTIDE SYNTHESIS AND REGULATION 310 14.5 THYMIDYLATE
SYNTHASE 312
14.6 DEGRADATION OF PURINES 313
14.7 PURINE AND PYRIMIDINE NUCLEOTIDE SALVAGE PATHWAYS 314 REFERENCES
314
15 PHOTOSYNTHESIS 317
15.1 THE CHLOROPLAST 317
15.2 LIGHT AND ITS PROPERTIES 318
15.3 PHOTOSYNTHESIS PIGMENTS 319
15.4 THE PHOTOSYSTEMS 320
15.4.1 PSII 321
15.4.2 PSI 323
15.5 ATPSYNTHESIS 324
15.6 THE LIGHT INDEPENDENT REACTIONS 324
15.7 THE CALVIN CYCLE 325
15.7.1 THE MECHANISM OF THE RUBISCO REACTION 327
15.7.2 STARCH AND SUCROSE CAN BE USED TO SYNTHESIZE D-GLUCOSE 327
15.7.3 REGULATION OF THE CALVIN CYCLE 328
15.7.4 COMMENTS ON THE CALVIN CYCLE 328
REFERENCES 329
16 DNA, RNA, AND PROTEIN METABOLISM 331
16.1 DNA 331
16.1.1 STRUCTURE 331
16.1.2 DNA REPLICATION 334
16.1.3 REPAIROFDNA 337
16.1.4 DEGRADATION OF CELLULAR DNA 338
16.2 RNA 338
16.2.1 THE CENTRAL DOGMA HYPOTHESIS 339
16.2.2 POSTTRANSLATIONAL MODIFICATION OF TRNA, RRNA,ANDMRNA 341
16.2.3 RIBOZYMES 343
16.2.4 DEGRADATION OF RNA 344
IMAGE 8
XVUEI CONTENTS
16.3 PROTEIN METABOLISM 344
16.3.1 PROTEIN SYNTHESIS 344
16.3.2 INTRACELLULAR PROTEIN CATABOLISM 351
REFERENCES 351
INDEX 353 |
| any_adam_object | 1 |
| author | Fromm, Herbert J. Hargrove, Mark S. |
| author_facet | Fromm, Herbert J. Hargrove, Mark S. |
| author_role | aut aut |
| author_sort | Fromm, Herbert J. |
| author_variant | h j f hj hjf m s h ms msh |
| building | Verbundindex |
| bvnumber | BV037400959 |
| classification_rvk | WD 4010 WD 5000 |
| classification_tum | CHE 800f |
| ctrlnum | (OCoLC)707189515 (DE-599)DNB1009990160 |
| dewey-full | 572 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572 |
| dewey-search | 572 |
| dewey-sort | 3572 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
| format | Book |
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| genre_facet | Lehrbuch |
| id | DE-604.BV037400959 |
| illustrated | Illustrated |
| indexdate | 2024-09-06T00:18:48Z |
| institution | BVB |
| isbn | 3642196233 9783642196232 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022553646 |
| oclc_num | 707189515 |
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| owner_facet | DE-11 DE-91G DE-BY-TUM DE-703 DE-355 DE-BY-UBR DE-29T DE-19 DE-BY-UBM |
| physical | XVIII, 364 S. Ill., graph. Darst. 235 mm x 155 mm |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer |
| record_format | marc |
| spelling | Fromm, Herbert J. Verfasser aut Essentials of biochemistry Herbert J. Fromm ; Mark S. Hargrove Berlin [u.a.] Springer 2012 XVIII, 364 S. Ill., graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Biochemie (DE-588)4006777-4 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Biochemie (DE-588)4006777-4 s DE-604 Hargrove, Mark S. Verfasser aut Erscheint auch als Online-Ausgabe 978-3-642-19624-9 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3669412&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022553646&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fromm, Herbert J. Hargrove, Mark S. Essentials of biochemistry Biochemie (DE-588)4006777-4 gnd |
| subject_GND | (DE-588)4006777-4 (DE-588)4123623-3 |
| title | Essentials of biochemistry |
| title_auth | Essentials of biochemistry |
| title_exact_search | Essentials of biochemistry |
| title_full | Essentials of biochemistry Herbert J. Fromm ; Mark S. Hargrove |
| title_fullStr | Essentials of biochemistry Herbert J. Fromm ; Mark S. Hargrove |
| title_full_unstemmed | Essentials of biochemistry Herbert J. Fromm ; Mark S. Hargrove |
| title_short | Essentials of biochemistry |
| title_sort | essentials of biochemistry |
| topic | Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Biochemie Lehrbuch |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3669412&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022553646&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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