Membrane Biophysics:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2012
|
| Ausgabe: | 1., st Edition. |
| Schriftenreihe: | Biological and medical physics, biomedical engineering
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 179 S. Ill., graph. Darst. |
| ISBN: | 9783642161049 |
Internformat
MARC
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| 100 | 1 | |a Ashrafuzzaman, Mohammad |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Membrane Biophysics |c Mohammad Ashrafuzzaman, Jack Tuszynski |
| 250 | |a 1., st Edition. | ||
| 264 | 1 | |a Heidelberg [u.a.] |b Springer |c 2012 | |
| 300 | |a XIV, 179 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Biological and medical physics, biomedical engineering | |
| 650 | 0 | 7 | |a Biophysik |0 (DE-588)4006891-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biomembran |0 (DE-588)4006884-5 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Biophysik |0 (DE-588)4006891-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Tuszynski, Jack A. |d 1956- |e Verfasser |0 (DE-588)131905708 |4 aut | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022548139&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-022548139 | ||
Datensatz im Suchindex
| _version_ | 1804145686044737536 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1
REFERENCES 8
2 STRUCTURE O F MEMBRANES 9
2.1 THE MEMBRANE AS A BARRIER AND A TRANSPORTER 9
2.2 MEMBRANE CONSTITUENTS 11
2.3 CHARACTERISTICS OF MEMBRANES 12
2.3.1 PHYSICAL CHARACTERISTICS OF MEMBRANES 12
2.3.2 BIOCHEMICAL CHARACTERISTICS O F MEMBRANES 14
2.3.3 ELECTRICAL CHARACTERISTICS OF MEMBRANES 14
2.3.4 EXCITABILITY AND THE STATE O F THE MEMBRANE POTENTIAL . . . 21
2.3.5 THE FITZHUGH-NAGUMO MODEL 26
REFERENCES 29
3 LIPIDS IN MEMBRANES 31
3.1 GEOMETRY AND NATURE OF LIPIDS 31
3.2 VARIOUS LIPID PHASES IN MEMBRANES: LAMELLAR AND NON-LAMELLAR PHASE
PROPENSITIES 33
3.3 LIPID-SPECIFIC PHASE DIAGRAM: A THERMOTROPIC PERSPECTIVE . . . . 38
3.4 MODULATION O F THE PHASE PROPERTIES O F LIPIDS BY ANTIMICROBIAL
PEPTIDES 4 2
REFERENCES 48
4 THE MEMBRANE AS A TRANSPORTER, ION CHANNELS AND MEMBRANE PUMPS 51
4.1 PROTEIN-LINED ION CHANNELS IN LIPID MEMBRANES 54
4.1.1 GRAMICIDIN A CHANNELS 55
4.1.2 ALAMETHICIN CHANNELS 56
4.2 LIPID-LINED ION CHANNELS IN MEMBRANES 57
X I
HTTP://D-NB.INFO/1006508473
IMAGE 2
XII CONTENTS
4.3 LIPIDIC CHANNELS IN MEMBRANES 58
4.4 DEFECTS IN MEMBRANES 59
4.5 COMPARATIVE ANALYSIS O F THE ELECTRICAL CONDUCTANCE STATES THAT
DETERMINE THE MEMBRANE S TRANSPORT PROPERTIES INDUCED BY ION CHANNELS OR
OTHER CONDUCTANCE EVENTS 6 0
4.6 GENERAL MODELS FOR PEPTIDE PATHWAYS AND THE CREATION OF CHANNELS IN
MEMBRANES 62
4.6.1 THE TRANS-MEMBRANE HELICAL BUNDLE MODEL 66
4.6.2 THE WORMHOLE MODEL 67
4.6.3 THE CARPET MODEL 68
4.6.4 DETERGENT-LIKE EFFECTS 68
4.6.5 THE IN-PLANE DIFFUSION MODEL 69
4.6.6 THE LINEAR /?-HELIX 69
4.7 SODIUM-POTASSIUM PUMPS IN MEMBRANES 69
REFERENCES 71
5 LIPID BILAYER-MEMBRANE PROTEIN COUPLING 75
5.1 LIPID MEMBRANE-MEMBRANE PROTEIN COUPLING DUE TO MEMBRANE ELASTICITY
76
5.1.1 DEFINITION O F ELASTICITY 76
5.1.2 THE MEMBRANE S ELASTICITY HELPS IT TO BE FLEXIBLE: A STUDY USING
THE GRAMICIDIN A CHANNEL AS A T O O L . . . . 78
5.1.3 THE MEMBRANE S ELASTIC PROPERTY CONTRIBUTES TO THE
MEMBRANE-MEMBRANE PROTEIN COUPLING: A STUDY USING THE GRAMICIDIN A
CHANNEL AS A T O O L . . . . 81
5.2 LIPID MEMBRANE-MEMBRANE PROTEIN COUPLING DUE TO ELECTRICAL
PROPERTIES O F LIPIDS AND PROTEINS 86
5.2.1 SCREENED COULOMB POTENTIALS AND LENNARD-JONES INTERACTIONS BETWEEN
PEPTIDES ON ION CHANNELS AND LIPIDS IN THE MEMBRANE: A STUDY USING
GRAMICIDIN A CHANNEL AS A TOOL 86
5.2.2 SCREENED COULOMB INTERACTIONS AND LENNARD-JONES POTENTIALS BETWEEN
PEPTIDES ON ION CHANNELS AND LIPIDS ON THE MEMBRANE: A STUDY USING AN
ALAMETHICIN CHANNEL AS A TOOL 91
5.3 CHANNEL ENERGETICS AND RELATED PROBABILITIES IN THE CONTEXT OF
CHANNEL STABILITY IN LIPID BILAYERS 92
5.3.1 ANALYSIS OF THE ALAMETHICIN CHANNEL EXPERIMENTS 94
5.3.2 DERIVATION O F GRAMICIDIN A CHANNEL LIFETIME ( T) IN A CONTINUUM
DISTRIBUTION OF LOCAL ENERGY TRAPS . . . . 96
5.4 EXPERIMENTAL STUDIES OF THE FUNCTIONS O F GRAMICIDIN A AND
ALAMETHICIN CHANNELS IN LIPID MEMBRANES 97
5.4.1 MATERIALS AND METHODS 97
5.4.2 RESULTS 99
IMAGE 3
CONTENTS
XM
5.5 THEORETICAL RESULTS/NUMERICAL RESULTS REGARDING THE FUNCTIONS OF
GRAMICIDIN A AND ALAMETHICIN CHANNELS DUE TO THEIR COUPLING WITH LIPID
MEMBRANES 102
5.6 FITTING THEORETICAL PREDICTIONS TO EXPERIMENTAL RESULTS 109
5.7 EVIDENCE O F PHYSICAL INTERACTIONS BETWEEN LIPIDS AND
CHANNEL-FORMING PEPTIDES OR OTHER DRUGS: A CASE STUDY USING MOLECULAR
DYNAMICS SIMULATIONS 114
5.7.1 MD TECHNIQUES 115
5.7.2 MD RESULTS AND DISCUSSION 115
5.8 DISCUSSION AND CONCLUSIONS 116
REFERENCES 121
6 MEMBRANE-BASED NANOTECHNOLOGY AND DRUG DELIVERY 1 27
6.1 INTRODUCTION 127
6.2 THE MEMBRANE S SELECTIVE TRANSPORT AND GENERAL BARRIER PROPERTIES
128
6.3 THE MEMBRANE AS A TRANSPORTER O F NANOPARTICLES: A
NANOPARTICLE-MEMBRANE INTERACTION PERSPECTIVE 129
6.3.1 CERTAIN NANOPARTICLES DISRUPT MEMBRANES 131
6.3.2 MEMBRANE DISRUPTION DEPENDS ON SIZE AND STRUCTURE OF NANOPARTICLES
132
6.3.3 CERTAIN NANOPARTICLES AVOID MEMBRANE INTERACTIONS . . . . 136 6.4
NOVEL NANOTECHNOLOGY: MEMBRANE TRANSPORT OF NANOPARTICLES THROUGH ION
PORES/CHANNELS 138
6.4.1 MEMBRANE TRANSPORT OF NANOPARTICLES THROUGH LIPID-LINED ION PORES
139
6.4.2 MEMBRANE TRANSPORT OF NANOPARTICLES THROUGH NON-LIPID-LINED ION
PORES 144
6.4.3 THEORETICAL UNDERSTANDING O F THE NANOPARTICLE DIFFUSION THROUGH
ION PORES/CHANNELS IN M E M B R A N E S . . . 145 REFERENCES 148
7 MEMBRANE-RELATED DISEASES 151
7.1 LIPIDS AS MARKERS IN ANTI-CANCER TREATMENT: LIPID MEMBRANE BINDING
OF APTAMERS 155
7.2 LIPID MEMBRANE BINDING O F PRION PROTEINS 157
7.3 MEMBRANE TOPOLOGY AND ALZHEIMER S DISEASE 161
7.4 ALCOHOL-RELATED DISEASES, THEIR EFFECTS ON LIPID MEMBRANES AND
POSSIBLE TREATMENTS, FOCUSING ON MEMBRANE EFFECTS 161
7.5 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 162
REFERENCES 168
IMAGE 4
XIV
EPILOGUE
INDEX . .
CONTENTS
171
. 173
|
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
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| id | DE-604.BV037395309 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:23:23Z |
| institution | BVB |
| isbn | 9783642161049 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022548139 |
| oclc_num | 816306779 |
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| owner | DE-11 |
| owner_facet | DE-11 |
| physical | XIV, 179 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer |
| record_format | marc |
| series2 | Biological and medical physics, biomedical engineering |
| spelling | Ashrafuzzaman, Mohammad Verfasser aut Membrane Biophysics Mohammad Ashrafuzzaman, Jack Tuszynski 1., st Edition. Heidelberg [u.a.] Springer 2012 XIV, 179 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biological and medical physics, biomedical engineering Biophysik (DE-588)4006891-2 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf Biomembran (DE-588)4006884-5 s Biophysik (DE-588)4006891-2 s DE-604 Tuszynski, Jack A. 1956- Verfasser (DE-588)131905708 aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022548139&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ashrafuzzaman, Mohammad Tuszynski, Jack A. 1956- Membrane Biophysics Biophysik (DE-588)4006891-2 gnd Biomembran (DE-588)4006884-5 gnd |
| subject_GND | (DE-588)4006891-2 (DE-588)4006884-5 |
| title | Membrane Biophysics |
| title_auth | Membrane Biophysics |
| title_exact_search | Membrane Biophysics |
| title_full | Membrane Biophysics Mohammad Ashrafuzzaman, Jack Tuszynski |
| title_fullStr | Membrane Biophysics Mohammad Ashrafuzzaman, Jack Tuszynski |
| title_full_unstemmed | Membrane Biophysics Mohammad Ashrafuzzaman, Jack Tuszynski |
| title_short | Membrane Biophysics |
| title_sort | membrane biophysics |
| topic | Biophysik (DE-588)4006891-2 gnd Biomembran (DE-588)4006884-5 gnd |
| topic_facet | Biophysik Biomembran |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022548139&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ashrafuzzamanmohammad membranebiophysics AT tuszynskijacka membranebiophysics |