Oral bioavailability: basic principles, advanced concepts, and applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J
Wiley
2011
|
| Schriftenreihe: | Wiley series in drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references |
| Beschreibung: | XVII, 540 S. Ill., graph. Darst. |
| ISBN: | 9780470260999 |
Internformat
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| 245 | 1 | 0 | |a Oral bioavailability |b basic principles, advanced concepts, and applications |c ed. by Ming Hu, Xiaoling Li |
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| 500 | |a Includes bibliographical references | ||
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| 650 | 4 | |a Drug development | |
| 650 | 4 | |a Intestinal absorption | |
| 650 | 4 | |a Biological Availability | |
| 650 | 4 | |a Drug Delivery Systems | |
| 650 | 4 | |a Intestinal Absorption | |
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Datensatz im Suchindex
| _version_ | 1804145658100187136 |
|---|---|
| adam_text | Titel: Oral bioavailability
Autor: Hu, Ming
Jahr: 2011
CONTENTS
Foreword xi
Preface xiii
Contributors xv
1 Barriers to Oral Bioavailability-An Overview 1
Ming Hu and Xiaoling Li
2 Physicochemical Characterization of Pharmaceutical Solids 7
Smita Debnath
3 Solubility of Pharmaceutical Solids 21
Lauren Wiser, Xiaoling Gao, Bhaskara Jasti, and Xiaoling Li
4 In Vitro Dissolution of Pharmaceutical Solids 39
Josephine L. P. Soh and Paul W. S. Heng
5 Biological and Physiological Features of the Gastrointestinal
Tract Relevant to Oral Drug Absorption 51
Paul C. Ho
6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated
Pathways 63
Miki Susanto Park and Jae H. Chang
1 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms 77
Deliang Zhou and Yihong Qiu
8 Drug Metabolism in Gastrointestinal Tract 91
Rashim Singh and Ming Hu
9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 111
Jae H. Chang, James A. Uchizono, and Miki Susanto Park
10 Liver Drug Metabolism 127
Leslie M. Tompkins and Hongbing Wang
viii CONTENTS
11 Protein Binding of Drugs 145
Antonia Kotsiou and Christine Tesseromatis
12 Urinary Excretion of Drugs and Drug Reabsorption 167
Pankaj Gupta, Bo Feng, and Jack Cook
13 Pharmacokinetic Behaviors of Orally Administered Drugs 183
Jaime A. Yáñez, Dion R. Brocks, Laird M. Forrest, and Neat M. Davies
14 Effects of Food on Drug Absorption 221
Venugopal P. Marasanapalle, Xiaoling Li, and Bhaskara R. Jasti
15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions 233
Ge Lin, Zhong Zuo, Na Li, and Li Zhang
16 Anatomical and Physiological Factors Affecting Oral Drug
Bioavailability in Rats, Dogs, and Humans 253
Ayman El-Kattan, Susan Hurst, Joanne Brodfuehrer, and Cho-Ming Loi
17 Amino Acid Drug Transporters 267
Zhong Qiu Liu and Ming Hu
18 Drug Transporters and Their Role in Absorption and Disposition
of Peptides and Peptide-Based Pharmaceuticals 291
David J. Lindley, Stephen M. Carl, Dea Herrera-Ruiz, Li F. Pan, Lori B. Karpes,
Jonathan M. E. Goole, Olafur S. Gudmundsson, and Gregory T. Knipp
19 Organic Anion and Cation Drug Transporters 309
Takashi Sekine and Hiroyuki Kusuhara
20 Gastric Retentive Drug Delivery Systems 329
John R. Cardinal and Avinash Nangia
21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems 343
Sravan Penchala, Anh-Nhan Pham, Ying Huang, and Jeffrey Wang
22 Prodrug Strategies to Enhance Oral Drug Absorption 355
Sai H. S. Boddu, Deep Kwatra, and Ashim K. Mitra
23 Oral Delivery of Protein/Peptide Therapeutics 371
Puchun Liu and Steven Dinh
2A ABC Transporters in Intestinal and Liver Efflux 381
Marilyn E. Morris and Yash A. Gandhi
25 Interplay Between Efflux Transporters and Metabolic Enzymes 401
Stephen Wang
26 Regulatory Considerations in Metabolism- and Transporter-Based Drug
Interactions 413
Yuanchao {Derek) Zhang, Lei Zhang, John M. Strong, and Shiew-Mei Huang
27 Caco-2 Cell Culture Model for Oral Drug Absorption 431
Kaustubh Kulkami and Ming Hu
28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption 443
Deep Kwatra, Sai H. S. Boddu, and Ashim K. Mitra
29 Intestinal Perfusion Methods for Oral Drug Absorptions 461
Wei Zhu and Eun Ju Jeong
30 Liver Perfusion and Primary Hepatocytes for Studying
Drug Metabolism and Metabolite Excretion 475
Cindy Q. Xia, Chuang Lu, and Suresh K. Balani
31 In vivo Methods for Oral Bioavailability Studies 493
Ana Ruiz-Garcia and Marival Bermejo
32 Determination of Regulation of Drug-Metabolizing Enzymes and
Transporters 505
Bin Zhang and Wen Xie
33 Computational and Pharmacoinformatic Approaches to Oral
Bioavailability Prediction 519
Miguel Ángel Cabrera-Pérez and Isabel Gonzalez-Alvarez
Index 535
|
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| discipline | Chemie / Pharmazie Chemie Medizin |
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| isbn | 9780470260999 |
| language | English |
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| spelling | Oral bioavailability basic principles, advanced concepts, and applications ed. by Ming Hu, Xiaoling Li Hoboken, N.J Wiley 2011 XVII, 540 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley series in drug discovery and development Includes bibliographical references DrugsxBioavailability Drug development Intestinal absorption Biological Availability Drug Delivery Systems Intestinal Absorption Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Bioverfügbarkeit (DE-588)4145660-9 gnd rswk-swf Orales Arzneimittel (DE-588)4274444-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bioverfügbarkeit (DE-588)4145660-9 s Orales Arzneimittel (DE-588)4274444-1 s Arzneimittelentwicklung (DE-588)4143176-5 s DE-604 Hu, Ming Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022528402&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Oral bioavailability basic principles, advanced concepts, and applications DrugsxBioavailability Drug development Intestinal absorption Biological Availability Drug Delivery Systems Intestinal Absorption Arzneimittelentwicklung (DE-588)4143176-5 gnd Bioverfügbarkeit (DE-588)4145660-9 gnd Orales Arzneimittel (DE-588)4274444-1 gnd |
| subject_GND | (DE-588)4143176-5 (DE-588)4145660-9 (DE-588)4274444-1 (DE-588)4143413-4 |
| title | Oral bioavailability basic principles, advanced concepts, and applications |
| title_auth | Oral bioavailability basic principles, advanced concepts, and applications |
| title_exact_search | Oral bioavailability basic principles, advanced concepts, and applications |
| title_full | Oral bioavailability basic principles, advanced concepts, and applications ed. by Ming Hu, Xiaoling Li |
| title_fullStr | Oral bioavailability basic principles, advanced concepts, and applications ed. by Ming Hu, Xiaoling Li |
| title_full_unstemmed | Oral bioavailability basic principles, advanced concepts, and applications ed. by Ming Hu, Xiaoling Li |
| title_short | Oral bioavailability |
| title_sort | oral bioavailability basic principles advanced concepts and applications |
| title_sub | basic principles, advanced concepts, and applications |
| topic | DrugsxBioavailability Drug development Intestinal absorption Biological Availability Drug Delivery Systems Intestinal Absorption Arzneimittelentwicklung (DE-588)4143176-5 gnd Bioverfügbarkeit (DE-588)4145660-9 gnd Orales Arzneimittel (DE-588)4274444-1 gnd |
| topic_facet | DrugsxBioavailability Drug development Intestinal absorption Biological Availability Drug Delivery Systems Intestinal Absorption Arzneimittelentwicklung Bioverfügbarkeit Orales Arzneimittel Aufsatzsammlung |
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