Microbial biochemistry:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2011
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XXVIII, 557 S. graph. Darst. |
| ISBN: | 9789048194360 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV037325826 | ||
| 003 | DE-604 | ||
| 005 | 20110509 | ||
| 007 | t | ||
| 008 | 110407s2011 gw d||| |||| 00||| eng d | ||
| 015 | |a 10,N17 |2 dnb | ||
| 016 | 7 | |a 1001748387 |2 DE-101 | |
| 020 | |a 9789048194360 |c GB. : ca. EUR 160.45 (freier Pr.), ca. sfr 233.00 (freier Pr.) |9 978-90-481-9436-0 | ||
| 024 | 3 | |a 9789048194360 | |
| 028 | 5 | 2 | |a 80014546 |
| 035 | |a (OCoLC)699768508 | ||
| 035 | |a (DE-599)DNB1001748387 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BE | ||
| 049 | |a DE-355 | ||
| 084 | |a WF 1350 |0 (DE-625)148326: |2 rvk | ||
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Cohen, Georges N. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Microbial biochemistry |c G.N. Cohen |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2011 | |
| 300 | |a XXVIII, 557 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Mikroorganismus |0 (DE-588)4039226-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biochemie |0 (DE-588)4006777-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekularbiologie |0 (DE-588)4039983-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Mikroorganismus |0 (DE-588)4039226-0 |D s |
| 689 | 0 | 1 | |a Biochemie |0 (DE-588)4006777-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Mikroorganismus |0 (DE-588)4039226-0 |D s |
| 689 | 1 | 1 | |a Molekularbiologie |0 (DE-588)4039983-7 |D s |
| 689 | 1 | |8 1\p |5 DE-604 | |
| 856 | 4 | 2 | |q text/html |u http://deposit.dnb.de/cgi-bin/dokserv?id=3458487&prov=M&dok_var=1&dok_ext=htm |3 Inhaltstext |
| 856 | 4 | 2 | |m SWB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022479899&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-022479899 | |
Datensatz im Suchindex
| _version_ | 1805095781925912576 |
|---|---|
| adam_text |
CONTENTS
1 BACTERIAL GROWTH
. 1
THE LAG PHASE
. 1
THE EXPONENTIAL
PHASE. 1
LINEAR
GROWTH.
2
THE YIELD OF GROWTH
. 3
VARIATION OF THE GROWTH RATE AT LIMITING CARBON SOURCE
CONCENTRATIONS
. 4
CONTINUOUS GROWTH: THE CHEMOSTAT
. 5
ADVANTAGES OF THE CONTINUOUS EXPONENTIAL CULTURE
. 7
DIAUXIC GROWTH
. 7
SELECTED REFERENCES
. 10
2 THE OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIA
AND THE CYTOPLASMIC MEMBRANE
. 11
THE OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIA . .
. 11
THE CYTOPLASMIC
MEMBRANE. 12
ENERGY GENERATION
. 13
ATP SYNTHASE
. 13
SUBUNIT COMPOSITION OF THE ATP SYNTHASE
. 14
ATP SYNTHESIS IN ARCHAEA
. 16
SELECTED REFERENCES
. 16
3 PEPTIDOGLYCAN SYNTHESIS AND CELL DIVISION
. 17
GENERAL STRUCTURE
. 17
ASSEMBLY OF THE PEPTIDOGLYCAN UNIT
. 18
THE MEMBRANE STEPS
. 19
ASSEMBLY OF THE MUREIN SACCULUS
. 20
PENICILLIN SENSITIVITY
. 20
CELL DIVISION .
. 21
SELECTED REFERENCES
. 22
VII
4 CELLULAR PERMEABILITY
. 23
ACCUMULATION, CRYPTICITY, AND SELECTIVE PERMEABILITY
. 24
B
-GALACTOSIDE PERMEASE.
. 25
ACCUMULATION IN INDUCED CELLS: KINETICS AND SPECIFICITY
. 26
THE INDUCED SYNTHESIS OF GALACTOSIDE PERMEASE .
. 29
FUNCTIONAL SIGNIFICANCE OF GALACTOSIDE PERMEASE: SPECIFIC CRYPTICITY . .
. 30
FUNCTIONAL RELATIONSHIPS OF PERMEASE: INDUCTION
. 32
GENETIC RELATIONSHIPS OF GALACTOSIDASE AND GALACTOSIDE
PERMEASE. . .
. 32
GALACTOSIDE PERMEASE AS PROTEIN
. 33
PERIPLASMIC BINDING PROTEINS AND ATP BINDING
CASSETTES. 36
PHOSPHOTRANSFERASES: THE PTS SYSTEM
. 39
TRAP TRANSPORTERS
. 41
A FEW WELL-IDENTIFIED CASES OF SPECIFIC CELLULAR PERMEABILITY
. 42
AMINO ACID PERMEASES
. 42
PEPTIDE PERMEASES
. 43
PORINS.
45
IRON UPTAKE. . .
. 47
CONCLUSION . . .
. 48
SELECTED REFERENCES
. 48
5 ALLOSTERIC ENZYMES
. 51
ALLOSTERIC INHIBITION AND ACTIVATION
. 54
AN ALTERNATIVE
MODEL. 61
CONCLUSION . . .
. 62
SELECTED REFERENCES
. 62
6 GLYCOLYSIS, GLUCONEOGENESIS AND GLYCOGEN SYNTHESIS
. 63
GLYCOGEN DEGRADATION
. 63
GLYCOLYSIS
. 63
HEXOKINASE
. 65
GLUCOSE 6-PHOSPHATE
ISOMERASE. 65
PHOSPHOFRUCTOKINASE
. 66
FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE
. 68
TRIOSE PHOSPHATE
ISOMERASE. 68
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) . 68
PHOSPHOGLYCERATE
KINASE. 69
PHOSPHOGLYCEROMUTASE
. 69
ENOLASE
. 69
PYRUVATE KINASE
. 70
GLUCONEOGENESIS
. 70
FRUCTOSE BISPHOSPHATASE IN MICROORGANISMS
. 70
GLYCOGEN SYNTHESIS
. 71
GLYCOGEN SYNTHASE
. 71
VIII CONTENTS
CONTROL OF GLYCOGEN BIOSYNTHESIS
. 72
BRANCHING ENZYME
. 72
7 THE PENTOSE PHOSPHATE AND ENTNER*DOUDOROFF PATHWAYS
. 73
THE PENTOSE PHOSPHATE
PATHWAY. 73
THE ENZYMES OF THE OXIDATIVE
PHASE. 73
GLUCOSE 6-PHOSPHATE DEHYDROGENASE .
73
6-PHOSPHOGLUCONOLACTONASE
. 74
6-PHOSPHOGLUCONATE DEHYDROGENASE (DECARBOXYLATING) . 74
RIBOSE PHOSPHATE ISOMERASE
. 74
THE ENZYMES OF THE NON-OXIDATIVE
PHASE. 74
TRANSKETOLASE
. 75
TRANSALDOLASE
. 76
RIBULOSE-5-PHOSPHATE-3-EPIMERASE
. 76
REGULATION OF THE PENTOSE PHOSPHATE PATHWAY
. 77
THE ENTNER
*
DOUDOROFF PATHWAY . 77
8 THE TRICARBOXYLIC ACID CYCLE AND THE GLYOXYLATE BYPASS
. 79
THE ORIGIN OF ACETYL COA: THE PYRUVATE DEHYDROGENASE COMPLEX . 79
OVERVIEW OF THE TRICARBOXYLIC ACID (TCA) CYCLE .
. 81
ORIGIN OF THE OXALOACETATE
. 81
ORGANIZATION OF THE ENZYMES OF THE TRICARBOXYLIC ACID CYCLE.
96
THE TRICARBOXYLIC ACID CYCLE IS A SOURCE OF BIOSYNTHETIC
PRECURSORS . . .
. 97
THE ANAPLEROTIC GLYOXYLIC PATHWAY BYPASS
. 97
9 ATP-GENERATING PROCESSES: RESPIRATION AND FERMENTATION
. 101
RESPIRATION . .
. 101
FERMENTATION
. 104
ACETONE-BUTANOL FERMENTATION
. 104
THE STICKLAND REACTION
. 105
ORNITHINE FERMENTATION
. 105
GLYCINE AND PROLINE DEGRADATION
. 106
THREONINE
DEGRADATION. 106
GLUTAMATE DEGRADATION
. 107
LYSINE DEGRADATION
. 108
ARGININE FERMENTATION
. 109
METHIONINE DEGRADATION
. 110
D-SELENOCYSTINE AND D-CYSTEINE DEGRADATION .
110
SELECTED REFERENCES
. 111
10 BIOSYNTHESIS OF LIPIDS
. 115
BIOSYNTHESIS OF SHORT CHAIN FATTY ACIDS
. 115
BIOSYNTHESIS OF LONG-CHAIN FATTY ACIDS
. 116
SYNTHESIS OF ACETYL COA
. 116
CONTENTS IX
SYNTHESIS OF MALONYL COA .
116
FROM MALONYL COA TO PALMITATE .
117
REGULATION OF YEAST FATTY ACID SYNTHESIS AT THE GENETIC LEVEL
. 120
REGULATION OF FATTY ACID SYNTHESIS IN BACTERIA
. 122
BIOSYNTHESIS OF TRIGLYCERIDES
. 122
BIOSYNTHESIS OF PHOSPHOGLYCERIDES
. 122
CYCLOPROPANE FATTY ACID SYNTHASE (CFA SYNTHASE) .
123
SELECTED REFERENCES
. 125
11 IRON*SULFUR PROTEINS
. 127
IRON*SULFUR
CLUSTERS. 127
2FE*2S CLUSTERS
. 128
4FE*4S CLUSTERS
. 128
3FE*4S CLUSTERS
. 129
OTHER FE*S
CLUSTERS. 129
BIOSYNTHESIS OF FE*S CLUSTERS
. 129
IRON*SULFUR
PROTEINS. 130
SELECTED REFERENCES
. 132
12 THE ARCHAEA
. 133
CHEMICAL CHARACTERISTICS OF ARCHAEA
. 135
ARCHAEA: FOSSIL RECORD
. 136
ECONOMIC IMPORTANCE OF THE ARCHAEA
. 137
SELECTED REFERENCES
. 137
13 METHANOGENS AND METHYLOTROPHS
. 139
METHANOGENS AND METHANOGENESIS .
140
REDUCTION OF CO
2
. 140
FORMYLMETHANOFURAN DEHYDROGENASE .
142
FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE . 143
METHENYLTETRAHYDROMETHANOPTERIN CYCLOHYDROLASE. 144
5, 10-METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE . 144
5, 10-METHYLENETETRAHYDROMETHANOPTERIN F
420
OXIDOREDUCTASE . 145
THE METHYLREDUCTASE: METHYL COENZYME M REDUCTASE . 145
SIMPLIFICATION OF THE METHYLREDUCTASE SYSTEM . .
. 147
STRUCTURE OF THE METHYLREDUCTASE
. 148
SOURCE OF THE ENERGY NEEDED FOR THE GROWTH OF METHANOGENS . 149
BIOSYNTHESIS OF SOME COFACTORS INVOLVED IN METHANOGENESIS . 149
METHANOFURAN.
149
METHANOPTERIN
. 149
COENZYME M .
150
7-MERCAPTOHEPTANOYLTHREONINEPHOSPHATE (COENZYME B) . 151
BIOSYNTHESIS OF COENZYME F
420
. 152
BIOSYNTHESIS OF FACTOR F
430
. 152
X CONTENTS
BIOSYNTHESIS OF FACTOR III
. 153
METHYLOTROPHS
. 153
METHANOTROPHS.
153
METABOLISM OF METHYL COMPOUNDS .
154
METHANOL DEHYDROGENASE (MDH). .
155
ANAEROBIC OXIDATION OF METHANE .
155
METHYLAMINE DEHYDROGENASE .
156
CARBON ASSIMILATION BY METHYLOTROPHS.
156
CARBOXYDOTROPHS
. 158
SELECTED REFERENCES
. 160
14 ENZYME INDUCTION IN CATABOLIC SYSTEMS
. 163
THE SPECIFICITY OF INDUCTION
. 163
DE NOVO SYNTHESIS OF
B
-GALACTOSIDASE . 164
CONSTITUTIVE MUTANTS
. 166
PLEIOTROPY OF THE CONSTITUTIVE MUTANTS
. 167
THE GENETIC CONTROL AND THE CYTOPLASMIC EXPRESSION
OF INDUCIBILITY IN THE SYNTHESIS OF
B
-GALACTOSIDASE IN
E. COLI
.
THE LAC REPRESSOR
. 168
OPERATORS AND
OPERONS. 174
SELECTED REFERENCES
. 177
15 TRANSCRIPTION: RNA POLYMERASE
. 179
THE SYNTHESIS OF MESSENGER RNA: THE BACTERIAL RNA POLYMERASE . 180
TERMINATION OF TRANSCRIPTION IN PROKARYOTES
. 183
YEAST RNA POLYMERASES .
184
ARCHAEAL RNA POLYMERASES.
185
TRANSCRIPTION TERMINATION AND POLYA TAILS
. 186
SELECTED REFERENCES
. 186
16 NEGATIVE REGULATION
. 189
INDUCTION IS CORRELATED WITH THE SYNTHESIS
OF A SPECIFIC
MESSENGER. 189
ISOLATION OF THE LAC REPRESSOR
. 191
THE
LAC
OPERATOR IS A DNA SEQUENCE . 193
DIRECT OBSERVATION OF TRANSCRIPTION FACTOR DYNAMICS
IN A LIVING CELL
. 199
SELECTED REFERENCES
. 199
17 ENZYME REPRESSION IN ANABOLIC PATHWAYS
. 201
DESCRIPTION OF THE PHENOMENON
. 201
ISOLATION OF DEREPRESSED (CONSTITUTIVE) MUTANTS IN BIOSYNTHETIC
PATHWAYS. THE USE OF STRUCTURAL ANALOGUES
. 205
REPLACEMENT OF METHIONINE BY SELENOMETHIONINE IN PROTEINS.
206
SELECTED REFERENCES
. 207
CONTENTS XI
18 POSITIVE REGULATION
. 209
THE PROMOTER REGION
. 210
ROLE OF CYCLIC AMP AND OF THE CAP PROTEIN IN THE BINDING
OF RNA POLYMERASE TO THE PROMOTER REGION.
211
THE SYNTHESIS AND DEGRADATION OF CYCLIC AMP.
213
HOW DOES GLUCOSE EXERT ITS INHIBITORY EFFECT ON
E. COLI
B
-GALACTOSIDASE SYNTHESIS?
. 214
SELECTED REFERENCES
. 214
19 THE RIBOSOMES
. 217
THE COMPONENTS OF
E. COLI
RIBOSOMES. 218
THE RIBOSOMES OF EUKARYOTES AND OF ARCHAEA.
219
MECHANISTIC ASPECTS OF TRANSLATION OF MESSENGER RNA
TO PROTEIN BY RIBOSOMES
. 220
SELECTED REFERENCES
. 221
20 THE GENETIC CODE, THE TRANSFER RNAS AND THE AMINOACYL-TRNA-
SYNTHETASES
. 223
THE GENETIC CODE
. 223
THE TRANSFER RNAS
. 226
SELECTED REFERENCES
. 231
21 ATTENUATION
. 233
REGULATION OF THE TRP OPERON IN
BACILLUS SUBTILIS
. 237
GENERAL REMARKS ON REGULATORY MECHANISMS .
237
SELECTED REFERENCES
. 238
22 RIBOSWITCHES
. 241
MECHANISMS OF RIBOSWITCHES
. 243
SELECTED REFERENCES
. 244
23 THE BIOLOGICAL FIXATION OF NITROGEN
. 245
CONTROL OF NITROGENASE SYNTHESIS AND
ACTIVITY. 248
SELECTED REFERENCES
. 250
24 HOW BIOSYNTHETIC PATHWAYS HAVE BEEN ESTABLISHED
. 251
USE OF ISOTOPES
. 251
USE OF AUXOTROPHIC
MUTANTS. 254
ENZYMATIC ANALYSIS
. 256
SELECTED REFERENCES
. 256
25 THE ASPARTIC ACID FAMILY OF AMINO ACIDS: BIOSYNTHESIS
. 257
THE BIOSYNTHESIS OF ASPARTIC ACID AND ASPARAGINE.
257
BIOSYNTHESIS OF LYSINE FROM ASPARTATE SEMIALDEHYDE IN BACTERIA. .
260
XII CONTENTS
THE SYNTHESIS OF DIPICOLINIC ACID, A SUBSTANCE PRESENT
IN THE SPORES OF GRAM-POSITIVE BACILLI
. 262
THE REDUCTION OF ASPARTATE SEMIALDEHYDE TO HOMOSERINE,
THE COMMON PRECURSOR OF METHIONINE AND THREONINE .
263
BIOSYNTHESIS OF METHIONINE FROM HOMOSERINE .
263
S-ADENOSYLMETHIONINE (SAM) BIOSYNTHESIS .
268
BIOSYNTHESIS OF THREONINE FROM HOMOSERINE .
269
BIOSYNTHETIC THREONINE DEHYDRATASE
. 270
ISOLEUCINE BIOSYNTHESIS
. 271
SUMMARY OF THE BIOSYNTHETIC PATHWAY OF THE ASPARTATE
FAMILY OF AMINO ACIDS
. 272
ECTOINE BIOSYNTHESIS
. 273
SELECTED REFERENCES
. 273
26 REGULATION OF THE BIOSYNTHESIS OF THE AMINO ACIDS
OF THE ASPARTIC ACID FAMILY IN
ENTEROBACTERIACEAE
. 275
A PARADIGM OF ISOFUNCTIONAL AND MULTIFUNCTIONAL ENZYMES
AND OF THE ALLOSTERIC
EQUILIBRIUM. 275
TWO ASPARTOKINASES IN
E. COLI
. 276
THE THREONINE-SENSITIVE HOMOSERINE DEHYDROGENASE
OF
E. COLI
. 278
ISOLATION OF A MUTANT LACKING THE LYSINE-SENSITIVE ASPARTOKINASE
AND OF REVERTANTS
THEREOF. 278
EVIDENCE THAT THE THREONINE-SENSITIVE ASPARTOKINASE
AND HOMOSERINE DEHYDROGENASE OF
E. COLI
ARE CARRIED
BY THE SAME BIFUNCTIONAL PROTEIN
. 281
THE BINDING OF THREONINE TO ASPARTOKINASE I-HOMOSERINE
DEHYDROGENASE
I. 281
THE BINDING OF PYRIDINE NUCLEOTIDES TO ASPARTOKINASE
I-HOMOSERINE DEHYDROGENASE I .
283
THE EFFECTS OF THREONINE ON ASPARTOKINASE I-HOMOSERINE
DEHYDROGENASE I ARE NOT ONLY DUE TO DIRECT INTERACTIONS .
284
THE ALLOSTERIC TRANSITION OF ASPARTOKINASE
I-DEHYDROGENASE I
. 286
ASPARTOKINASE II-HOMOSERINE DEHYDROGENASE II .
289
ASPARTOKINASE III
. 291
REGULATIONS AT THE GENETIC LEVEL
. 294
THE THREONINE OPERON .
294
REGULATION OF THE LYSINE REGULON AT THE GENETIC LEVEL.
296
REGULATION OF METHIONINE BIOSYNTHESIS AT THE
GENETIC
LEVEL. 296
THE METHIONINE REPRESSOR .
298
THE METR GENE AND ITS PRODUCT.
302
THE REGULATION OF ISOLEUCINE SYNTHESIS AT THE GENETIC LEVEL .
304
CONTENTS XIII
APPENDIX: MORE ON REGULONS .
304
SELECTED REFERENCES
. 305
27 OTHER PATTERNS OF REGULATION OF THE SYNTHESIS OF AMINO ACIDS
OF THE ASPARTATE FAMILY
. 307
CONCERTED FEEDBACK INHIBITION OF ASPARTOKINASE ACTIVITY
IN
RHODOBACTER CAPSULATUS
(FORMERLY
RHODOPSEUDOMONAS
CAPSULATA
) .
307
PSEUDOMONADS
. 308
SPECIFIC REVERSAL OF A PARTICULAR FEEDBACK INHIBITION BY
OTHER ESSENTIAL METABOLITES. THE CASE OF
RHODOSPIRILLUM RUBRUM
. 310
THE PARTICULAR CASE OF SPORE-FORMING
BACILLI
. 311
SOME OTHER
CASES. 314
CONCLUSION . .
. 314
SELECTED REFERENCES
. 314
28 BIOSYNTHESIS OF THE AMINO ACIDS OF THE GLUTAMIC ACID FAMILY
AND ITS REGULATION
. 317
THE BIOSYNTHESIS OF GLUTAMINE
. 317
BIOSYNTHESIS OF GLUTAMINE: CUMULATIVE FEEDBACK
INHIBITION .
. 317
BIOSYNTHESIS OF GLUTAMINE: THE COVALENT MODIFICATION
OF GLUTAMINE SYNTHETASE
. 319
GLUTAMINE SYNTHETASE STRUCTURE.
320
REVERSIBLE ADENYLYLATION OF THE GLUTAMINE SYNTHETASE .
323
REGULATION OF GLUTAMINE SYNTHETASE ACTIVITY BY
COVALENT ADENYLYLATION
. 324
THE REGULATION OF THE SYNTHESIS OF GLUTAMINE
SYNTHETASE ALSO INVOLVES THE TWO FORMS OF PII
AND UTASE/UR
. 325
GLUTAMINE SYNTHETASE IN OTHER MICROORGANISMS .
327
THE BIOSYNTHESIS OF GLUTAMATE
. 329
GLUTAMATE DEHYDROGENASE .
329
GLUTAMATE SYNTHASE
. 329
BIOSYNTHESIS OF PROLINE
. 330
UTILIZATION OF PROLINE
. 332
THE BIOSYNTHESIS OF ARGININE AND POLYAMINES
. 333
BIOSYNTHESIS OF ARGININE
. 333
REGULATION OF ARGININE BIOSYNTHESIS AT THE
TRANSCRIPTIONAL LEVEL
. 336
THE ARGININE REPRESSOR
. 336
POLYAMINE BIOSYNTHESIS
. 337
UTILIZATION OF ARGININE AS SOLE NITROGEN SOURCE
BY
B. SUBTILIS
. 340
XIV CONTENTS
NITRIC OXIDE SYNTHASE IN BACTERIA
. 341
THE BIOSYNTHESIS OF LYSINE IN YEASTS AND MOLDS . .
. 341
THE AMINOADIPIC ACID PATHWAY .
342
SELECTED REFERENCES
. 345
29 BIOSYNTHESIS OF AMINO ACIDS DERIVED FROM PHOSPHOGLYCERIC
ACID AND PYRUVIC ACID
. 347
BIOSYNTHESIS OF GLYCINE AND SERINE
. 347
REGULATION OF SERINE HYDROXYMETHYLTRANSFERASE
AT THE TRANSCRIPTIONAL LEVEL
. 349
BIOSYNTHESIS OF CYSTEINE
. 350
O-ACETYLATION OF SERINE
. 352
CYSTEINE SYNTHESIS IN METHANOGENS.
352
ALLOSTERIC REGULATION OF CYSTEINE SYNTHESIS.
353
REGULATION OF CYSTEINE SYNTHESIS AT THE GENETIC LEVEL .
353
BIOSYNTHESIS OF
ALANINE. 354
BIOSYNTHESIS OF VALINE
. 355
BIOSYNTHESIS OF
LEUCINE. 357
ISOLEUCINE SYNTHESIS FROM PYRUVATE
. 359
REGULATION OF VALINE, ISOLEUCINE AND LEUCINE BIOSYNTHESIS
. 359
SELECTED REFERENCES
. 360
30 SELENOCYSTEINE AND SELENOPROTEINS
. 363
OUTLOOK.
363
ENZYMES CONTAINING SELENOCYSTEINE
. 364
FORMATE DEHYDROGENASES.
364
THE GLYCINE REDUCTASE COMPLEX .
364
THE NICOTINIC ACID HYDROXYLASE OF
CLOSTRIDIUM BARKERI
. 365
HYDROGENASES.
366
XANTHINE DEHYDROGENASE.
366
ACETOACETYL COA THIOLASE .
367
GENE PRODUCTS INVOLVED IN SELENOCYSTEINE BIOSYNTHESIS
AND
INCORPORATION.
367
SELENOCYSTEINE SYNTHASE
. 368
SELENOPHOSPHATE SYNTHETASE .
368
SELENOCYSTEINE
LYASE. 368
SELENOCYSTEYL TRNA
. 368
INSERTION SEQUENCES (SECIS ELEMENTS) .
370
SELENOCYSTEINE AND ARCHAEA.
. 370
BIOCHEMICAL FUNCTION OF THE SELENOCYSTEINE RESIDUE IN CATALYSIS .
371
SELECTED REFERENCES
. 371
31 BIOSYNTHESIS OF AROMATIC AMINO ACIDS AND ITS REGULATION
. 373
THE COMMON PATHWAY (SHIKIMIC PATHWAY).
373
CONTENTS XV
FORMATION OF SHIKIMIC ACID .
373
FORMATION OF CHORISMIC ACID .
377
PHYSIOLOGICAL ASPECTS OF THE REGULATION OF THE COMMON
PATHWAY. . .
. 378
CHARACTERISTICS OF THE COMMON PATHWAY IN SEVERAL ORGANISMS . 379
BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE FROM CHORISMIC ACID .
380
THE TYRR REGULON
. 381
REGULATION OF THE
PHEA
GENE BY ATTENUATION. 382
OTHER ORGANISMS: THE AROGENATE PATHWAY OF PHENYLALANINE
AND TYROSINE BIOSYNTHESIS
. 382
ASPARTATE AS A PRESURSOR OF AROMATIC AMINO ACIDS .
383
THE BIOSYNTHESIS OF TRYPTOPHAN FROM CHORISMIC ACID .
384
ANTHRANILATE SYNTHASE-ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE .
385
PHOSPHORIBOSYLANTHRANILATE ISOMERASE-INDOLEGLYCEROPHOSPHATE
SYNTHASE . .
. 386
TRYPTOPHAN SYNTHASE
. 387
REGULATION OF TRYPTOPHAN BIOSYNTHESIS AT THE GENETIC LEVEL: THE
TRYPTOPHAN REPRESSOR
. 391
A UNITARY MODEL FOR INDUCTION AND REPRESSION . .
393
ISOLATION OF THE TRP REPRESSOR
. 393
ENTEROCHELIN (ENTEROBACTIN) BIOSYNTHESIS
. 395
THE SYNTHESIS OF 2,3-DIHYDROXYBENZOIC ACID . . .
. 395
SELECTED REFERENCES
. 397
32 THE BIOSYNTHESIS OF HISTIDINE AND ITS REGULATION
. 399
REGULATION OF HISTIDINE BIOSYNTHESIS AT THE GENETIC LEVEL
. 402
SYNTHESIS OF DIPHTHAMIDE, A MODIFIED HISTIDINE, BY ARCHAEA .
407
SELECTED REFERENCES
. 408
33 THE BIOSYNTHESIS OF NUCLEOTIDES
. 409
THE BIOSYNTHESIS OF PYRIMIDINE NUCLEOTIDES
. 409
SYNTHESIS OF 5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) . 409
SYNTHESIS OF CARBAMYLPHOSPHATE.
410
THE SYNTHESIS OF CYTIDINE AND URIDINE TRIPHOSPHATES .
412
DIRECT UTILIZATION OF PYRIMIDINES AND OF THEIR DERIVATIVES .
414
ASPARTATE TRANSCARBAMYLASE OF
E. COLI
. 414
THE ASPARTATE TRANSCARBAMYLASE OF OTHER ORGANISMS . 420
REGULATION OF PYRIMIDINE NUCLEOTIDE SYNTHESIS AT THE
GENETIC
LEVEL. 421
THE BIOSYNTHESIS OF PURINE
NUCLEOTIDES. 422
BIOSYNTHESIS OF 5-AMINO-4-IMIDAZOLE CARBOXAMIDE
RIBONUCLEOTIDE
. 422
SYNTHESIS OF INOSINIC ACID
. 425
THE SYNTHESIS OF GUANYLIC AND ADENYLIC ACIDS . .
426
REMARKS ON THE CONTROL OF PURINE NUCLEOTIDE BIOSYNTHESIS .
427
XVI CONTENTS
FROM NUCLEOSIDE MONOPHOSPHATES TO NUCLEOSIDE DIPHOSPHATES
AND TRIPHOSPHATES
. 429
SELECTED REFERENCES
. 429
34 THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES
. 431
THE FORMATION OF DEOXYRIBONUCLEOSIDE DIPHOSPHATES FROM RIBOSE
NUCLEOSIDE DIPHOSPHATES
. 431
THE RIBOSENUCLEOSIDE DIPHOSPHATE (NDP) REDUCTASE SYSTEM
OF
E. COLI
. 431
THIOREDOXIN AND THIOREDOXIN REDUCTASE .
431
RIBONUCLEOSIDE REDUCTASE .
434
REGULATION OF THE ACTIVITY OF RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE .
436
DCMP DEAMINASE AND THYMIDYLATE SYNTHASE .
437
DUTPASE.
439
THE RIBONUCLEOSIDE PHOSPHATE REDUCTASE OF OTHER ORGANISMS .
439
A RIBONUCLEOTIDE TRIPHOSPHATE REDUCTASE REACTION IN
E. COLI
GROWN UNDER ANAEROBIC CONDITIONS .
440
THE SYNTHESIS OF DEOXYRIBONUCLEOSIDE TRIPHOSPHATES FROM THE
DIPHOSPHATES
. 441
ORGANIZATION OF DNA PRECURSOR SYNTHESIS IN EUKARYOTIC CELLS.
441
SELECTED REFERENCES
. 442
35 BIOSYNTHESIS OF SOME WATER-SOLUBLE VITAMINS AND OF THEIR
COENZYME FORMS
. 443
BIOSYNTHESIS OF THIAMIN AND COCARBOXYLASE
. 443
CONTROL OF THIAMIN BIOSYNTHESIS
. 445
BIOSYNTHESIS OF RIBOFLAVIN
. 447
BIOSYNTHESIS OF NICOTINAMIDE, NAD
+
AND NADP
+
. 449
REGULATION OF THE BIOSYNTHESIS OF NICOTINAMIDE AND ITS DERIVATIVES
. 452
NAD
+
AND THE ADP-RIBOSYLATION OF PROTEINS . 453
BIOSYNTHESIS OF PARA-AMINOBENZOIC ACID, OF FOLIC ACID
AND ITS DERIVATIVES
. 454
BIOSYNTHESIS OF VITAMIN B6 PYRIDOXINE, AND OF ITS DERIVATIVES,
PYRIDOXAL, PYRIDOXAMINE AND PYRIDOXAL PHOSPHATE .
457
BIOSYNTHESIS OF BIOTIN, BIOTIN CO
2
, AND BIOCYTIN. . . 459
THE BIOTIN OPERON AND ITS
REPRESSOR. 462
BIOSYNTHESIS OF LIPOIC ACID
. 463
BIOSYNTHESIS OF PANTOTHENATE AND COENZYME A .
464
THE SYNTHESIS OF PANTOTHENIC ACID.
464
THE SYNTHESIS OF COENZYME A FROM PANTOTHENIC ACID . 466
THE ACYL CARRIER PROTEIN
. 467
THE BIOSYNTHESIS OF INOSITOL
. 467
BIOSYNTHESIS OF PYRROLOQUINOLINE QUINONE
. 467
SELECTED REFERENCES
. 470
CONTENTS XVII
36 BIOSYNTHESIS OF CAROTENE, VITAMIN A, STEROLS, UBIQUINONES AND
MENAQUINONES
. 471
SYNTHESIS OF THE COMMON
PRECURSOR. 471
THE NON-MEVALONATE PATHWAY OF ISOPRENOID PRECURSOR
(DIMETHYLALLYL PYROPHOSPHATE) BIOSYNTHESIS
. 473
SYNTHESIS OF
B
-CAROTENE, CAROTENOIDS AND VITAMIN A . 475
SYNTHESIS OF THE CAROTENOIDS
. 475
REGULATION OF CAROTENOID SYNTHESIS.
478
SYNTHESIS OF VITAMIN A
. 479
SYNTHESIS OF STEROLS
. 479
THE BIOSYNTHESIS OF UBIQUINONES AND MENAQUINONES.
481
SELECTED REFERENCES
. 484
37 BIOSYNTHESIS OF THE TETRAPYRROLE RING SYSTEM
. 487
SYNTHESIS OF PROTOPORPHYRIN
. 487
SYNTHESIS OF HEME FROM PROTOPORPHYRIN
. 492
HEME BIOSYNTHESIS IN ARCHAEA
. 493
SYNTHESIS OF CHLOROPHYLL FROM
PROTOPORPHYRIN. 493
BIOSYNTHESIS OF THE PHYCOBILIN CHROMOPHORES. CHROMATIC
ADAPTATION. . .
. 496
A TYPE OF CHROMATIC ADAPTATION UNDER CONDITIONS
OF SULFUR STARVATION
. 499
SELECTED REFERENCES
. 500
38 BIOSYNTHESIS OF COBALAMINS INCLUDING VITAMIN B
12
. 503
COBINAMIDE BIOSYNTHESIS
. 507
FROM GDP-COBINAMIDE TO COBALAMIN .
509
SELECTED REFERENCES
. 510
39 INTERACTIONS BETWEEN PROTEINS AND DNA
. 513
DNA-BINDING
PROTEINS. 513
STUDY OF THE PROTEIN*DNA COMPLEXES .
515
SOME OTHER TYPES OF DNA-BINDING PROTEINS .
521
SELECTED REFERENCES
. 524
40 EVOLUTION OF BIOSYNTHETIC PATHWAYS
. 525
PRINCIPLES OF PROTEIN EVOLUTION
. 525
TWO THEORIES FOR THE EVOLUTION OF BIOSYNTHETIC PATHWAYS .
525
THE METHIONINE AND CYSTEINE BIOSYNTHETIC PATHWAYS .
526
THE THREONINE, ISOLEUCINE, CYSTEINE AND TRYPTOPHAN BIOSYNTHETIC
PATHWAYS
. 529
THE EVOLUTIONARY PATHWAY LEADING TO THE THREE ISOFUNCTIONAL
ASPARTOKINASES IN
ESCHERICHIA COLI
. 535
XVIII CONTENTS
TRANSMEMBRANE FACILITATORS
. 542
DNA-BINDING REGULATOR PROTEINS
. 543
SELECTED REFERENCES
. 543
INDEX
.
545
CONTENTS XIX |
| any_adam_object | 1 |
| author | Cohen, Georges N. |
| author_facet | Cohen, Georges N. |
| author_role | aut |
| author_sort | Cohen, Georges N. |
| author_variant | g n c gn gnc |
| building | Verbundindex |
| bvnumber | BV037325826 |
| classification_rvk | WF 1350 |
| ctrlnum | (OCoLC)699768508 (DE-599)DNB1001748387 |
| discipline | Biologie Medizin |
| edition | 2. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV037325826</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20110509</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">110407s2011 gw d||| |||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">10,N17</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1001748387</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789048194360</subfield><subfield code="c">GB. : ca. EUR 160.45 (freier Pr.), ca. sfr 233.00 (freier Pr.)</subfield><subfield code="9">978-90-481-9436-0</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9789048194360</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">80014546</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)699768508</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1001748387</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WF 1350</subfield><subfield code="0">(DE-625)148326:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Cohen, Georges N.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Microbial biochemistry</subfield><subfield code="c">G.N. Cohen</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">2. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Dordrecht [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXVIII, 557 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Mikroorganismus</subfield><subfield code="0">(DE-588)4039226-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biochemie</subfield><subfield code="0">(DE-588)4006777-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Mikroorganismus</subfield><subfield code="0">(DE-588)4039226-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Biochemie</subfield><subfield code="0">(DE-588)4006777-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Mikroorganismus</subfield><subfield code="0">(DE-588)4039226-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Molekularbiologie</subfield><subfield code="0">(DE-588)4039983-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="q">text/html</subfield><subfield code="u">http://deposit.dnb.de/cgi-bin/dokserv?id=3458487&prov=M&dok_var=1&dok_ext=htm</subfield><subfield code="3">Inhaltstext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">SWB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022479899&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-022479899</subfield></datafield></record></collection> |
| id | DE-604.BV037325826 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T11:04:45Z |
| institution | BVB |
| isbn | 9789048194360 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022479899 |
| oclc_num | 699768508 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXVIII, 557 S. graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer |
| record_format | marc |
| spelling | Cohen, Georges N. Verfasser aut Microbial biochemistry G.N. Cohen 2. ed. Dordrecht [u.a.] Springer 2011 XXVIII, 557 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Mikroorganismus (DE-588)4039226-0 s Biochemie (DE-588)4006777-4 s DE-604 Molekularbiologie (DE-588)4039983-7 s 1\p DE-604 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3458487&prov=M&dok_var=1&dok_ext=htm Inhaltstext SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022479899&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cohen, Georges N. Microbial biochemistry Mikroorganismus (DE-588)4039226-0 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4039226-0 (DE-588)4006777-4 (DE-588)4039983-7 |
| title | Microbial biochemistry |
| title_auth | Microbial biochemistry |
| title_exact_search | Microbial biochemistry |
| title_full | Microbial biochemistry G.N. Cohen |
| title_fullStr | Microbial biochemistry G.N. Cohen |
| title_full_unstemmed | Microbial biochemistry G.N. Cohen |
| title_short | Microbial biochemistry |
| title_sort | microbial biochemistry |
| topic | Mikroorganismus (DE-588)4039226-0 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Mikroorganismus Biochemie Molekularbiologie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3458487&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022479899&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT cohengeorgesn microbialbiochemistry |