Cigarette smoke toxicity: linking individual chemicals to human diseases
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2011
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| ISBN: | 9783527326815 9783527635320 |
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| 245 | 1 | 0 | |a Cigarette smoke toxicity |b linking individual chemicals to human diseases |c ed. David Bernhard |
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CONTENTS
PREFACE XV LIST OF CONTRIBUTORS XVII
1 FROM DISCARDED LEAF TO GLOBAL SCOURGE-THE EXTRAORDINARY HISTORY OF THE
ASCENT OF TOBACCO AND ITS MANY MODES OF CONSUMPTION 1 BARRY A. FINEGAN
AND GARRETT J. FINEGAN 1.1 PUBLIC HEALTH POLICY AND COMMERCIAL
INTEREST-AN UNEASY
EQUILIBRIUM 1
1.2 BLESSED OFFSPRING OF AN UNCOUTH LAND 2 1.3 A VALUABLE POISON 3
1.4 SNIFFING, CHEWING, AND SMOKING 5 1.5 THE DEVELOPMENT OF THE
CIGARETTE-A PERFECT NICOTINE DELIVERY SYSTEM 6 1.6 A CENTURY OF GROWTH 7
1.7 AN EPIDEMIC OF DISEASE 8
1.8 TOBACCO MANUFACTURED PRODUCTS-MULTIPLE ROUTES TO ADDICTION 9 1.9
HISTORY REVISITED OR LESSON LEARNED 13 REFERENCES 13
PARTI CIGARETTE SMOKING 17
2 COMPONENTS OF A CIGARETTE 19 ANDREAS ZEMANN 2.1 INTRODUCTION 19
2.2 COMPONENTS OF A CIGARETTE 20
2.2.1 TOBACCO 21
2.2.2 FILTER AND PLUGWRAP PAPER 23 2.2.3 CIGARETTE PAPER 26 2.2.4
TIPPING PAPER 27
2.3 GENERATION OF CIGARETTE SMOKE 28 2.3.1 PUFFING-FORMATION OF
MAINSTREAM SMOKE 29
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1006150161
DIGITALISIERT DURCH
IMAGE 2
VI CONTENTS
2.3.2 SMOLDERING-FORMATION OF SIDESTREAM SMOKE 30
2.3.3 INFLUENCE OF CIGARETTE COMPONENTS ON SMOKE YIELDS 30 2.4
REGULATION AND FUTURE PERSPECTIVES OF CIGARETTE SMOKING 31 2.4.1 SMOKING
REGIMES 31 2.4.2 CIGARETTES WITH REDUCED IGNITION PROPENSITY 32 2.4.3
REDUCED EXPOSURE SMOKING ARTICLES 33
REFERENCES 35
3 THE PROCESS OF CIGARETTE SMOKING 37 JIAN WANG AND XING LI WANG 3.1
INTRODUCTION 37 3.2 BIO-COMPLEXITY OF PATHOGENIC COMPONENTS OF SMOKING
38 3.3 MULTIPLICITY OF TOBACCO-INDUCED DISEASES 39 3.4 TOPOGRAPHY OF
CIGARETTE SMOKING 41 3.5 HOW TO DEFINE A HUMAN SMOKER? 42 3.6 WILL THERE
BE STANDARDIZED EXPERIMENTAL MODELS TO STUDY BIOLOGICAL
IMPACT BY SMOKING? 42 3.7 SUMMARY 43
ACKNOWLEDGMENT 44 REFERENCES 44
4 SMOKE CHEMISTRY 55
ANDREAS ZEMANN
4.1 INTRODUCTION 55
4.2 CIGARETTE SMOKE 56 4.2.1 FORMATION OF MAINSTREAM SMOKE 56 4.2.2
FORMATION OF SIDESTREAM SMOKE 58 4.2.3 CHEMICAL CONSTITUENTS IN
CIGARETTE SMOKE 59 4.2.4 ENVIRONMENTAL TOBACCO SMOKE 63 4.3 FACTORS
INFLUENCING SMOKE CHEMISTRY 63 4.3.1 TOBACCO 63 4.3.2 CIGARETTE DESIGN
64
REFERENCES 64
5 EXPOSURE TO TOBACCO SMOKE 67 ANDRE CONRAD 5.1 ACTIVE SMOKING 67 5.1.1
PREVALENCE 67 5.1.2 DETERMINANTS OF EXPOSURE 68 5.2 SECONDHAND SMOKE 69
5.2.1 PREVALENCE 69 5.2.2 DETERMINANTS OF EXPOSURE 71 5.3 THIRD-HAND
SMOKE 72 5.3.1 PREVALENCE 72 5.3.2 DETERMINANTS OF EXPOSURE 73
IMAGE 3
CONTENTS VII
5.4 QUANTIFYING TOBACCO SMOKE EXPOSURE 73
5.4.1 ACTIVE SMOKING 73 5.4.1.1 QUESTIONNAIRES AND INTERVIEWS 74 5.4.1.2
BIOMARKERS 74
5.4.1.3 TOBACCO SMOKE ANALYSIS 77 5.4.2 SECONDHAND SMOKE 78 5.4.2.1
QUESTIONNAIRES AND INTERVIEWS 78 5.4.2.2 INDOOR AIR MONITORING 78
5.4.2.3 BIOMARKERS 80 5.4.3 THIRD-HAND SMOKE 81 5.4.3.1 AMBIENT
MONITORING 82
5.5 POLICY MEASURES FOR REDUCING TOBACCO-RELATED EXPOSURE 82 5.5.1 PRICE
INCREASES 82 5.5.2 PROMOTING AND SUPPORTING CESSATION 82 5.5.3 BANS ON
ADVERTISING 83 5.5.4 SMOKING BANS AND RESTRICTIONS 83
REFERENCES 84
6 AN EPIDEMIOLOGICAL APPRAISAL OF SMOKING-RELATED OUTCOMES 93 ELKE
MUNTERS AND TIM S. NAWROT 6.1 INTRODUCTION 93
6.2 META-ANALYTICAL EVIDENCE ON ACTIVE SMOKING 93 6.3 CANCER 94
6.4 CARDIOVASCULAR 94
6.5 FRACTURES 98
6.6 HELICOBACTER PYLORI ERADICATION 98 6.7 FERTILITY 99
6.8 OCULAR DAMAGE 99
6.9 NEUROLOGICAL EFFECTS OF SMOKING 99 6.10 RHEUMATOID ARTHRITIS 104
6.11 PRENATAL AND POSTNATAL EFFECTS OF SMOKING IN CHILDREN 104 6.12
REVIEW OF META-ANALYSIS ON SECONDHAND SMOKE 109
6.13 MORTALITY, BIOLOGICAL AGING, AND SMOKING 115 6.14 CONCLUSION 115
REFERENCES 116
PART II LINKING CIGARETTE SMOKE CHEMICALS TO HUMAN DISEASES AND
PATHOPHYSIOLOGY 121
7 SMOKING AND CARDIOVASCULAR DISEASES 123 DAVID BERNHARD 7.1
INTRODUCTION 123
7.2 CARDIOVASCULAR DISEASES 123 7.2.1 OVERVIEW 123
IMAGE 4
VIII CONTENTS
7.2.2 PATHOPHYSIOLOGY OF CVDS 124
7.2.3 RISK FACTORS FOR CVDS 126 7.3 SMOKING AND CVDS 227
7.3.1 OVERVIEW 127 7.3.2 PATHOPHYSIOLOGY OF CVDS CAUSED BY SMOKING 227
7.3.2.1 OXIDATIVE STRESS AND LIPID OXIDATION 128 7.3.2.2 SMOKING AND
INFLAMMATION 128 7.3.2.3 ENDOTHELIAL STRESS, DYSFUNCTION, AND INJURY 129
7.3.2.4 THROMBOSIS AND FIBRINOLYSIS 130 7.3.2.5 PLAQUE FORMATION AND
PLAQUE STABILITY 131 7.3.2.6 AGING OF THE CARDIOVASCULAR SYSTEM 232
7.3.2.7 CALCIUM METABOLISM AND HORMONES 232 7.3.3 CVDS-RELEVANT
ACTIVITIES OF SELECTED CIGARETTE SMOKE CHEMICALS 133 7.3.3.1 NICOTINE
133 7.3.3.2 CARBON MONOXIDE 135 7.3.3.3 POLYCYCLIC AROMATIC HYDROCARBONS
135 7.3.3.4 INFECTIOUS AGENTS 136 7.3.3.5 IIPOPOLYSACCHARIDES 236
7.3.3.6 REACTIVE OXYGEN SPECIES (ROS), OTHER OXIDANTS, AND
RADICALS 136
7.3.3.7 METALS 237 7.4 SUMMARY 138
ACKNOWLEDGMENT 138 REFERENCES 239
8 SMOKING AND CANCER 145
PARIMAL CHOWDHURY AND STEWART MACLEOD 8.1 INTRODUCTION 145
8.2 FACTS ON SMOKING AND CANCER 146
8.3 CANCER OF THE LUNG 246
8.3.1 EFFECTS OF SMOKING ON LUNG CANCER 148 8.3.2 ROLE OF NICOTINE IN
LUNG CANCER DEVELOPMENT 150 8.4 TOBACCO USE AND PANCREATIC CANCER 151
8.4.1 NICOTINE: ACTION IN PANCREAS 154 8.5 TOBACCO SMOKE COMBUSTION
PRODUCTS: HETEROCYCLIC AMINES 154 8.5.1 TOBACCO-SPECIFIC NITROSAMINES
254 8.6 SMOKING, K-RAS MUTATIONS AND PANCREATIC ADENOCARCINOMA 155
8.7 INTERINDIVIDUAL VARIATION IN THE RISK OF PANCREATIC CANCER 255 8.8
MECHANISMS OF CARCINOGENESIS BY CIGARETTE SMOKE 257 8.9 SUMMARY 258
REFERENCES 259
9 SMOKING AND COPD AND OTHER RESPIRATORY DISEASES 167 THOMAS E. SUSSAN
AND SHYAM BISWAL 9.1 INTRODUCTION 267
9.2 PATHOGENESIS OF COPD 267
IMAGE 5
CONTENTS IX
9.3 MOLECULAR DETERMINANTS OF PROTEASE ACTIVITY IN COPD 270
9.4 MOLECULAR DETERMINANTS OF INFLAMMATION IN COPD 272 9.5 MOLECULAR
DETERMINANTS OF OXIDATIVE STRESS IN COPD 272 9.6 ACTIVATION OF NRF2 BY
CIGARETTE SMOKE 173 9.7 EXACERBATIONS OF COPD 274
9.8 EFFECTS OF CIGARETTE SMOKE ON INNATE IMMUNITY AND COPD EXACERBATIONS
275 9.9 EFFECTS OF CIGARETTE SMOKE ON ASTHMA 275 9.10 EFFECTS OF
CIGARETTE SMOKE ON OTHER RESPIRATORY DISEASES 276 9.11 OTHER MOLECULAR
EFFECTS OF CIGARETTE SMOKE EXPOSURE 277 9.12 EFFECTS OF INDIVIDUAL
COMPONENTS OF CIGARETTE SMOKE IN LUNGS 278 9.12.1 NICOTINE 278 9.12.2
TOBACCO-SPECIFIC NITROSAMINES 279 9.12.3 AROMATIC AMINES 279 9.12.4
POLYCYCLIC AROMATIC HYDROCARBONS 279 9.12.5 OXIDANTS AND FREE RADICALS
279 9.12.6 VOLATILE ORGANIC COMPOUNDS 280 9.12.7 ACROLEIN 280 9.12.8
CARBON MONOXIDE 280 9.12.9 METALS 282 9.12.10 PARTICULATE MATTER 282
9.13 CONCLUDING REMARKS 282
REFERENCES 282
10 SMOKING, INFECTIOUS DISEASES AND INNATE IMMUNE (DYS)FUNCTION 292
DAVID A. SCOTT AND JUHI BAGAITKAR 10.1 SMOKING AND SUSCEPTIBILITY TO
BACTERIAL DISEASES 292 10.2 THE NEEDLE IN THE HAYSTACK 292 10.3
RECOGNITION OF INFECTIOUS AGENTS BY THE INNATE IMMUNE
RESPONSE 293
10.3.1 TOLL-LIKE RECEPTORS 293 10.3.1.1 TLR DOWNSTREAM SIGNALING 194
10.3.2 NOD-LIKE RECEPTORS 194 10.3.3 RIG-LIKE RECEPTORS 295 10.3.4
DURATION AND INTENSITY OF THE INNATE RESPONSE 195 10.4 THE CHOLINERGIC
ANTI-INFLAMMATORY SYSTEM 196
10.5 TOBACCO SMOKING AND NEUTIOPHIL FUNCTION 200 10.6 TOBACCO SMOKING
AND BACTERIAL VIRULENCE 202 10.7 NICOTINE AND CELLS OF THE ADAPTIVE
IMMUNE SYSTEM 203
10.8 CONCLUSIONS 204 REFERENCES 204
11 SMOKING AND REPRODUCTION 217 MARTINA PRELOG 11.1 INTRODUCTION 227
11.2 SMOKING AND FEMALE FERTILITY 217
IMAGE 6
X CONTENTS
11.2.1 OVARIAN FUNCTION 228
11.2.2 OOCYTE MATURATION 220 11.2.3 SMOKING AND ASSISTED REPRODUCTION
220 11.2.4 GAMETE AND EMBRYO TRANSPORT AND UTERINE RECEPTIVENESS 222
11.2.5 SMOKING AND PREGNANCY 222 11.2.5.1 MUTAGENIC POTENTIAL 222
11.2.5.2 MALFORMATIONS AND EMBRYO DEVELOPMENT 222 11.3 REPRODUCTIVE
CONSEQUENCES OF SMOKING FOR MEN 224 11.4 CONSEQUENCES OF IN UTERO
TOBACCO EXPOSURE IN LATER LIFE OF
OFFSPRING 225 REFERENCES 227
12 SMOKING TOBACCO AND GASTROINTESTINAL PATHOPHYSIOLOGY AND DISEASES 239
HITOSHI ASAKURA 12.1 INTRODUCTION 239
12.2 THE ESOPHAGUS 239
12.2.1 GASTROESOPHAGEAL REFLUX DISEASE 240 12.2.2 ESOPHAGEAL CANCER 240
12.3 STOMACH 242
12.3.1 GASTRIC SECRETION AND PEPTIC ULCER DISEASES 242 12.3.1.1 GASTRIC
ACIDS 242 12.3.1.2 REGULATING SUBSTANCES 243 12.3.1.3 GASTRIC MUCOSAL
BLOOD FLOW 243
12.3.2 GASTRIC CANCER 244 12.3.2.1 SMOKING 244 12.3.2.2 ANTIOXIDANTS 245
12.3.2.3 SALTS 246 12.4 INTESTINE 246
12.4.1 PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE 246 12.4.2 ULCERATIVE
COLITIS 247 12.4.3 CROHN S DISEASE 248 12.4.4 MECHANISMS 249 12.4.5
CANCER 249 12.4.5.1 SMOKING 249 12.4.5.2 OTHER FACTORS 252 12.4.5.3
GENES 252
12.5 LIVER AND PANCREAS 252 12.6 SUMMARY 253
REFERENCES 253
13 SMOKING AND ORAL HEALTH 257 EMAN ALLAM, WEIPING ZHANG, CUNGE ZHENG,
RICHARD L. GREGORY, AND L.JACK WINDSOR
13.1 PERIODONTAL DISEASE 258 13.2 DENTAL CARIES 265
IMAGE 7
CONTENTS XI
13.3 ORAL CANCER 267
13.4 OTHER ORAL CONDITIONS 269 13.4.1 SMOKER S MELANOSIS 269 13.4.2
STOMATITIS NICOTINA 270 13.4.3 HAIRY TONGUE 270 13.4.4 HALITOSIS 270
13.4.5 ORAL CANDIDIASIS 272 13.4.6 DRY SOCKET 272 13.5 OTHER DENTAL
CONDITIONS 272 13.6 CONCLUSION 272
REFERENCES 273
14 SMOKING AND EYE DISEASES 282 MARIA E. MARIN-CASTANO AND MARIANNE PONS
14.1 INTRODUCTION 282 14.2 SMOKING AND CATARACT 283 14.3 SMOKING AND
GLAUCOMA 285 14.4 AGE-RELATED MACULAR DEGENERATION 287 14.5 ASSOCIATION
BETWEEN SMOKING AND AGE-RELATED MACULAR
DEGENERATION 290 14.6 SMOKING AND UVEITIS 293 14.7 OCULAR ISCHEMIA 294
14.8 SMOKING AND DIABETIC RETINOPATHY 296 14.9 OTHER OCULAR DISEASES 297
14.9.1 LEBER S HEREDITARY OPTIC NEUROPATHY 297 14.9.2 MISCELLANEOUS 297
14.10 CONCLUSIONS 298 14.11 ACKNOWLEDGMENTS 298
REFERENCES 298
PART III PREVENTION AND TREATMENT OF SMOKING-LNDUCED DISEASES 322
15 SMOKING: PREVENTION AND CESSATION 323 ADAM CSORDAS 15.1 STRATEGIES
FOR SMOKING PREVENTION AND CESSATION 323 15.1.1 SMOKING PREVENTION 323
15.1.2 SMOKING CESSATION 326 15.1.2.1 NICOTINE REPLACEMENT THERAPY 316
15.1.2.2 ANTIDEPRESSANTS 327 15.1.2.3 ANTICANNABINOID 328
15.1.2.4 SMOKELESS TOBACCO 328 15.1.2.5 EFFICACY OF PHARMACOLOGICAL
THERAPIES 319 15.2 CESSATION AND RISK REVERSAL: HEALTH BENEFITS FROM
GIVING UP SMOKING 329
15.2.1 CESSATION AND NEOPLASTIC DISEASES 320
IMAGE 8
XII I CONTENTS
15.2.2 NON-NEOPLASTIC CONDITIONS 320
15.2.3 SMOKING-RELATED CORONARY HEART DISEASE 322 15.2.4 SMOKING
CESSATION AND REPRODUCTION 322 15.2.5 SURVIVAL BENEFITS OF CESSATION
(AFTER OVERT DISEASE IS DIAGNOSED) 322
15.3 SMOKING CESSATION AND GENDER 323 15.4 SMOKING CESSATION AND
GENETICS 324 REFERENCES 324
16 INTERFERING WITH SMOKING-LNDUCED PATHOPHYSIOLOGY 329 ADAM CSORDAS
16.1 INTRODUCTION 329 16.2 CELLULAR REDOX MECHANISMS AFFECTED BY
CIGARETTE SMOKE 329 16.2.1 NADPH OXIDASE AS A MAJOR PLAYER IN CIGARETTE
SMOKE-INDUCED
OXIDATIVE STRESS 330 16.2.2 ACTIONS OF NITRIC OXIDE AS AFFECTED BY
CIGARETTE SMOKE 331 16.2.3 CIGARETTE SMOKE-INDUCED LOSS OF SULFHYDRYL
REDUCING POWER 332 16.2.3.1 GLUTATHIONE 332 16.2.3.2 THIOREDOXIN 332
16.2.3.3 PEROXIREDOXINS AND SULFIREDOXIN 333
16.2.4 REDOX BALANCE AS AFFECTED BY METALS IN CIGARETTE SMOKE 334 16.3
PERSPECTIVES FOR PREVENTION AND TREATMENT OF CIGARETTE SMOKE-INDUCED
PATHOPHYSIOLOGY IN DIFFERENT TISSUES 334 16.3.1 ANTIOXIDANT
SUPPLEMENTATION FOR ATTENUATION OF CIGARETTE SMOKE-
INDUCED OXIDATIVE STRESS AND DAMAGE 334 16.3.2 AMELIORATING CIGARETTE
SMOKE-INDUCED INFLAMMATION 336 16.3.2.1 SYNERGY OF ROS AND TNF-A ON IL-8
INDUCTION IN MACROPHAGES AS TARGET OF TREATMENT 336 16.3.2.2 PARADOXICAL
INCREASE OF INFLAMMATORY RESPONSE TO CIGARETTE
SMOKE IN NADPH OXIDASE-DEFICIENT (P47 PHLW - AND GPVV* 1 *- -) MICE 337
16.3.2.3 SIDENAFIL SUPPRESSES CSE-INDUCED OVEREXPRESSION OF
ANGIOPOIETIN-2 IN HPAECS 337
16.3.2.4 CIGARETTE SMOKE-INDUCED CHEMOKINE RELEASE IN DENDRITIC CELLS
REVERSED BY NAC 338 16.3.2.5 STATINS AGAINST CIGARETTE SMOKE-INDUCED
INFLAMMATION AND ATHEROSCLEROSIS 338 16.3.3 NAC SUPPRESSES CIGARETTE
SMOKE-INDUCED PTEN PHOSPHORYLATION AND
DISRUPTION OF ADHERENS JUNCTIONS 340 16.3.4 TREATMENT OF CIGARETTE
SMOKE-INDUCED OSTEOPOROSIS 340 16.3.5 CIGARETTE SMOKE AND CANCER-RELATED
OBSERVATIONS 341 16.3.5.1 NAC INHIBITS CSE-INDUCED PROLIFERATION AND
PROMOTES TERMINAL
DIFFERENTIATION 342 16.3.6 DRUGS AGAINST CIGARETTE SMOKE-INDUCED
DEGENERATIVE DISEASES OF THE EYE 342
IMAGE 9
CONTENTS XIII
16.3.6.1 BENZO(E)PYRENE-INDUCED CELL DEATH IN ARPE-19 RETINAL PIGMENTED
EPITHELIAL CELLS, AND INHIBITORY ACTIONS OF DRUGS AND ANTIOXIDANTS 342
16.3.6.2 HIGH-DOSE ANTIOXIDANT VITAMIN THERAPY REDUCES THE ADVANCEMENT
OF INTERMEDIATE NON-NEOVASCULAR AGE-RELATED MACULAR
DEGENERATION 343 16.4 DIETARY AND LIFESTYLE CONSIDERATIONS AS RELATED TO
PATHOPHYSIOLOGY IN SMOKERS 343 16.4.1 NUTRITIONAL STATUS OF SMOKERS 343
16.4.2 CHEMOPREVENTION OF CIGARETTE SMOKE-INDUCED LUNG TUMORS 343 16.4.3
ANTIOXIDANT RESCUE OF ISCHEMIA-INDUCED NEOVASCULARIZATION 344 16.4.4
DIET AND SUPPLEMENTS RECOMMENDED FOR SMOKERS 345 16.4.4.1 POSITIVE
EFFECT OF DIETARY INTERVENTIONS ON CIGARETTE SMOKE-INDUCED
PATHOPHYSIOLOGY 345 16.4.4.2 DIETARY INTERVENTIONS WITH MIXED EFFECTS ON
CIGARETTE SMOKE-INDUCED PATHOPHYSIOLOGY 347 16.5 CONCLUDING REMARKS 348
REFERENCES 349
PART IV SUMMARY 355
17 SUMMARY 357
DAVID BERNHARD
17.1 CIGARETTE SMOKING AND HUMAN DISEASES-A CRITICAL CONCLUDING COMMENT
357 17.2 CONCLUDING REMARKS TO THIS BOOK 358
INDEX 362
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| edition | 1. ed. |
| format | Electronic eBook |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV037294672 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T22:55:29Z |
| institution | BVB |
| isbn | 9783527326815 9783527635320 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021207181 |
| oclc_num | 1039149993 |
| open_access_boolean | |
| owner | DE-11 DE-355 DE-BY-UBR DE-861 |
| owner_facet | DE-11 DE-355 DE-BY-UBR DE-861 |
| physical | 1 Online-Ressource |
| psigel | ZDB-35-WIC ebook FHR_PDA_WIC UBG_PDA_WIC ZDB-35-WIC FRO_PDA_WIC |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Cigarette smoke toxicity linking individual chemicals to human diseases ed. David Bernhard 1. ed. Weinheim Wiley-VCH 2011 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier 367 S. Zigarettenrauch (DE-588)4190814-4 gnd rswk-swf Rauchen (DE-588)4048539-0 gnd rswk-swf Gesundheitsgefährdung (DE-588)4071808-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Rauchen (DE-588)4048539-0 s Zigarettenrauch (DE-588)4190814-4 s Gesundheitsgefährdung (DE-588)4071808-6 s DE-604 Bernhard, David edt https://onlinelibrary.wiley.com/doi/book/10.1002/9783527635320 Verlag Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021207181&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cigarette smoke toxicity linking individual chemicals to human diseases Zigarettenrauch (DE-588)4190814-4 gnd Rauchen (DE-588)4048539-0 gnd Gesundheitsgefährdung (DE-588)4071808-6 gnd |
| subject_GND | (DE-588)4190814-4 (DE-588)4048539-0 (DE-588)4071808-6 (DE-588)4143413-4 |
| title | Cigarette smoke toxicity linking individual chemicals to human diseases |
| title_auth | Cigarette smoke toxicity linking individual chemicals to human diseases |
| title_exact_search | Cigarette smoke toxicity linking individual chemicals to human diseases |
| title_full | Cigarette smoke toxicity linking individual chemicals to human diseases ed. David Bernhard |
| title_fullStr | Cigarette smoke toxicity linking individual chemicals to human diseases ed. David Bernhard |
| title_full_unstemmed | Cigarette smoke toxicity linking individual chemicals to human diseases ed. David Bernhard |
| title_short | Cigarette smoke toxicity |
| title_sort | cigarette smoke toxicity linking individual chemicals to human diseases |
| title_sub | linking individual chemicals to human diseases |
| topic | Zigarettenrauch (DE-588)4190814-4 gnd Rauchen (DE-588)4048539-0 gnd Gesundheitsgefährdung (DE-588)4071808-6 gnd |
| topic_facet | Zigarettenrauch Rauchen Gesundheitsgefährdung Aufsatzsammlung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527635320 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021207181&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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