Regulation of microRNAs:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media [u.a.]
2010
|
| Schriftenreihe: | Advances in experimental medicine and biology
700 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 161 S. zahlr. Ill. |
| ISBN: | 9781441978226 1441978224 |
Internformat
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| 245 | 1 | 0 | |a Regulation of microRNAs |c ed. by Helge Großhans. [Participants: Paola Briata ...] |
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| 650 | 2 | |a MicroRNAs |a genetics | |
| 650 | 2 | |a Gene Expression Regulation |a genetics | |
| 700 | 1 | |a Großhans, Helge |e Sonstige |4 oth | |
| 700 | 1 | |a Briata, Paola |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804143884867993600 |
|---|---|
| adam_text | IMAGE 1
REGULATION OF MICRORNAS
EDITED BY HELGE GROBHANS FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL
RESEARCH, BASEL, SWITZERLAND
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
LANDES BIOSCIENCE
IMAGE 2
CONTENTS
1. MICRORNA BIOGENESIS AND FUNCTION: AN OVERVIEW 1
RENE F. KETTING
ABSTRACT 1
INTRODUCTION: PTGS IN PLANTS AND SMALL RNAS 1
RNAI 2
DICER 2
ARGONAUTE 4
THE FIRST MICRORNAS AND LINKS TO RNAI 4
MIRNAS: ANCIENT MEDIATORS OF GENE REGULATION 5
PRIMARY MIRNA PROCESSING BY DROSHA 6
SMALL RNA SELECTIVITY OF ARGONAUTE PROTEINS 7
TARGET RECOGNITION 7
MECHANISMS OF MIRNA-MEDIATED SILENCING 8
REGULATING MIRNAS 10
CONCLUSION 10
2. REGULATION OF PRI-MIRNA PROCESSING THROUGH SMADS 15
AKIKO HATA AND BRANDI N. DAVIS
ABSTRACT 15
INTRODUCTION: BASIC TGFP SIGNALING 15
MIRNA BIOGENESIS 17
THE FIRST PROCESSING STEP BY DROSHA 19
R-SMADS REGULATE MIRNA MATURATION 20
MECHANISM OF REGULATION OF SPECIFIC PRI-MIRNAS BY SMAD 22
TRANSCRIPTIONAL REGULATION OF MIRNA GENES BY SMADS 24
CONCLUSION AND FUTURE PROSPECTS 24
XIII
IMAGE 3
XIV CONTENTS
3. STIMULATION OF PRI-MIR-18A P R O C E S S I NG BY H N R N P AL 28
GRACJAN MICHLEWSKI, SONIA GUIL AND JAVIER F. CACERES
ABSTRACT 28
INTRODUCTION 28
HNRNPAL BINDS TO THE PRI-MIR-18A STEM-LOOP STRUCTURE 29
HNRNPAL PROMOTES THE DROSHA-MEDIATED PROCESSING OF PRI-MIR-18A 30 ROLE
OF THE TERMINAL LOOPS IN MIRNA PROCESSING 31
CONCLUSION AND FUTURE PROSPECTS 33
4. KSRP P R O M O T ES T HE MATURATION OF A G R O UP OF MIRNA P R E C U
R S O RS 36
MICHELE TRABUCCHI, PAOLA BRIATA, WITOLD FILIPOWICZ, ANDRES RAMOS,
ROBERTO GHERZI AND MICHAEL G. ROSENFELD
ABSTRACT 36
INTRODUCTION 36
CO-ACTIVATORS AND CO-REPRESSORS OF MIRNA PRECURSOR MATURATION 37
IMPACT OF KSRP AND OTHER CO-ACTIVATORS AND CO-REPRESSORS OF MIRNA
PRECURSOR MATURATION ON CELL PROLIFERATION, DIFFERENTIATION AND CANCER
39 CONCLUSION 41
5. H O R M O N AL R E P R E S S I ON OF MIRNA BIOSYNTHESIS T H R O U GH
A N U C L E AR S T E R O ID H O R M O NE R E C E P T OR 43
SALLY FUJIYAMA-NAKAMURA, KAORU YAMAGATA AND SHIGEAKI KATO
ABSTRACT 43
INTRODUCTION 43
P68/P72 DEAD-BOX RNA HELICASES SERVE AS RNA-BINDING COMPONENTS IN THE
DROSHA COMPLEX 44
GENE REGULATION BY NUCLEAR ESTROGEN RECEPTORS 46
ESTROGEN-INDUCED NIRNA STABILITY IS MEDIATED THROUGH HORMONALLY
REGULATED MIRNA BIOSYNTHESIS 49
CONCLUSION 52
6. AUTOREGULATORY M E C H A N I S MS C O N T R O L L I NG T HE M I C R O
P R O C E S S OR 56
ROBINSON TRIBOULET AND RICHARD I. GREGORY
ABSTRACT 56
INTRODUCTION 56
POSTTRANSCRIPTIONAL REGULATION OF DGCR8 BY THE MICROPROCESSOR 59
STABILIZATION OF DROSHA PROTEIN BY DGCR8 61
CONCLUSION 61
IMAGE 4
CONTENTS XV
7. REGULATION OFPRE-MIRNA PROCESSING 67
NICOLAS J. LEHRBACH AND ERIC A. MISKA
ABSTRACT 67
INTRODUCTION 67
MIRNAS AND DEVELOPMENTAL TIMING IN C. ELEGANS 68
THE HETEROCHRONIC GENE LIN-28 ENCODES A REGULATOR OILET-7 MICRORNA
PROCESSING 69 LIN28/LIN-28 PROMOTES URIDYLATION AND DEGRADATION OF
PRE-LET-7 71 HETEROCHRONIC GENE ORTHOLOGUES: ANCIENT STEM CELL
REGULATORS? 71 CONCLUSION 73
8. THE EFFECT OF RNA EDITING AND ADARS ON MIRNA BIOGENESIS AND FUNCTION
76
BRET S.E. HEALE, LIAM P. KEEGARI AND MARY A. O CONNELL
ABSTRACT 76
INTRODUCTION 76
PREVALENCE OF EDITED MIRNAS 78
EFFECTS OF EDITING OF PRI-MIRNAS AND PRE-MIRNAS ON BIOGENESIS 80 THE
EFFECT OF EDITING ON MIRNA FUNCTION 81
ADARS AS COMPETING DSRNA-BINDING PROTEINS 82
EDITING OF SEED TARGET SEQUENCES WITHIN 3 UTRS 82
CONCLUSION 83
9. MIRNAS NEED A TRIM: REGULATION OF MIRNA ACTIVITY BY TRIM-NHL PROTEINS
85
F. GREGORY WULCZYN, ELISA CUEVAS, ELEONORA FRANZONI AND AGNIESZKA RYBAK
ABSTRACT 85
INTRODUCTION 86
THE TRIM-NHL FAMILY OF DEVELOPMENTAL REGULATORS 87
THE TRIM DOMAIN AS E3 UBIQUITIN LIGASE 89
FUNCTIONAL ANALYSIS OF INDIVIDUAL TRIM-NHL FAMILY MEMBERS 90 TRIM-NHL
PROTEINS AS REGULATORS OF THE MIRNA PATHWAY 95
CONCLUSION 99
10. PROPERTIES OF THE REGULATORY RNA-BINDING PROTEIN HUR AND ITS ROLE IN
CONTROLLING MIRNA REPRESSION 106
NICOLE-CLAUDIA MEISNER AND WITOLD FILIPOWICZ
ABSTRACT 106
INTRODUCTION TO HUR AND ARE ELEMENTS 106
REGULATION OF THE REGULATOR 108
MOLECULAR MECHANISMS OF POSTTRANSCRIPTIONAL CONTROL BY HUR 112 FUNCTION
OF HUR IN THE RELIEF OF MIRNA-MEDIATED REPRESSION 114 SYNERGISM BETWEEN
HUR AND LET-7 IN TRANSLATIONAL REPRESSION OF C-MYC MRNA 117 CONCLUSION
118
IMAGE 5
XVI CONTENTS
11. TURNOVER OF MATURE MIRNAS AND SIRNAS IN PLANTS
AND ALGAE 124
HERIBERTO CERUTTI AND FADIA IBRAHIM
ABTRACT 124
INTRODUCTION 125
SMALL RNA PROCESSING 126
SMALL RNA MODIFICATION BY 2 -0-METHYLATION 126
SMALL RNA LOADING AND ACTIVATION OF THE RNA-INDUCED SILENCING COMPLEX
128 MATURE SMALL RNA DEGRADATION BY RIBONUCLEASES 130
QUALITY CONTROL OF MATURE SMALL RNAS 133
CONCLUSION 134
12. MICRORNASES AND THE REGULATED DEGRADATION OF MATURE ANIMAL MIRNAS
140
HELGE GROBHANS AND SAIBAL CHATTERJEE
ABSTRACT 140
INTRODUCTION 140
MICRORNA BIOGENESIS AND FUNCTION 141
XRN-2, A MULTIFUNCTIONAL EXORIBONUCLEASE 143
DEGRADATION OF C. ELEGANS MIRNAS BY XRN-2 144
IS MIRNA TURNOVER A SUBSTRATE-SPECIFIC EVENT? 148
A FUNCTION OF XRN-2 IN MIRNA TURNOVER BEYOND C. ELEGANS? 148
HALF-LIVES OF MIRNAS-NOT ALL MIRNAS ARE EQUAL 149
TARGET AVAILABILITY AFFECTS RELEASE OF MIRNAS FROM AGO AND THEIR
SUBSEQUENT DEGRADATION 151
CONCLUSION 152
INDEX 157
|
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| id | DE-604.BV037264342 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:54:46Z |
| institution | BVB |
| isbn | 9781441978226 1441978224 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021177409 |
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| physical | XVI, 161 S. zahlr. Ill. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Springer Science + Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Regulation of microRNAs ed. by Helge Großhans. [Participants: Paola Briata ...] New York, NY Springer Science + Business Media [u.a.] 2010 XVI, 161 S. zahlr. Ill. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 700 MicroRNAs genetics Gene Expression Regulation genetics Großhans, Helge Sonstige oth Briata, Paola Sonstige oth Advances in experimental medicine and biology 700 (DE-604)BV000003102 700 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021177409&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Regulation of microRNAs Advances in experimental medicine and biology MicroRNAs genetics Gene Expression Regulation genetics |
| title | Regulation of microRNAs |
| title_auth | Regulation of microRNAs |
| title_exact_search | Regulation of microRNAs |
| title_full | Regulation of microRNAs ed. by Helge Großhans. [Participants: Paola Briata ...] |
| title_fullStr | Regulation of microRNAs ed. by Helge Großhans. [Participants: Paola Briata ...] |
| title_full_unstemmed | Regulation of microRNAs ed. by Helge Großhans. [Participants: Paola Briata ...] |
| title_short | Regulation of microRNAs |
| title_sort | regulation of micrornas |
| topic | MicroRNAs genetics Gene Expression Regulation genetics |
| topic_facet | MicroRNAs genetics Gene Expression Regulation genetics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021177409&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
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