Transformation of scientific knowledge in biology: changes in our understanding of the living cell through microscopic imaging
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin
Max-Planck-Inst. für Wissenschaftsgeschichte
2010
|
| Schriftenreihe: | Preprint / Max-Planck-Institut für Wissenschaftsgeschichte
408 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 89 S. Ill., graph. Darst. 30 cm |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | TRANSFORMATION
OF
SCIENTIFIC KNOWLEDGE IN BIOLOGY:
CHANGES IN OUR UNDERSTANDING
OFTHE
LIVING CELL
THROUGH MICROSCOPIC IMAGING
TOBIAS
BREIDENMOSERV ,
FYNN OIE ENGLER
2
,3,
GUENTHER JIRIKOWSKIT,
MICHAEL POHL
2
AND DIETER
G
WEISS
1
,2
I
INSTITUTE
OF
BIOLOGICAL SCIENCES, DEPT.
OF
ANIMAL PHYSIOLOGY AND LIVE CELL IMAGING
CENTER, UNIVERSITY
OF
ROSTOCK, 18051 ROSTOCK, GERMANY
2CENTER FOR LOGIC, PHILOSOPHY AND HISTORY
OF
SCIENCE, UNIVERSITY
OF
ROSTOCK, 18057
ROSTOCK, GERMANY
3
INSTITUTE
OF
PHILOSOPHY, UNIVERSITY
OF
ROSTOCK, 18051 ROSTOCK, GERMANY
4
MAX PLANCK INSTITUTE FOR THE HISTORY
OF
SCIENCE, 14195 BERLIN, GERMANY
TABLE
OF
CONTENTS
1 INTRODUCTION 7
2 DEVELOPMENT OF MICROSCOPIC TECHNIQUES
AND
THEIR
INFLUENCE ON
THE
UNDERSTANDING
OF
TBE
CELL
..*.*.*.*...**...*.*.*................*.*.*..*..................*....*.*.*...*....
9
2.1 THE INVENTION
OFTHE
MICROSCOPE AND THE DISCOVERY OFMICROORGANISMS 9
2.2 CONVENTIONALLIGHT MICROSCOPY: MICROSCOPES MADE BY ARTS AND CRAFTS 9
2.3 BUILDING MICROSCOPES BASED ON SCIENTIFIC KNOWLEDGE: IMAGING PHYSICAL
ASPECTS
OFTHE
CELL. 13
2.4 ELECTRON MICROSCOPY: THE ULTRASTRUCTURE
OF
DEHYDRATED CELLS 19
2.5 LIGHT MICROSCOPY SUPPORTED BY ELECTRONIC CAMERAS AND COMPUTERS: THE
LIVING
CELL REVISITED 21
2.5.1
AN
OVERVIEW OFELECTRONIC LIGHT MICROSCOPY 21
2.5.2 ALLEN VIDEO CONTRAST ENHANCEMENT: THE CYTOSKELETON IS ALIVE .27
2.5.3 VIDEO-INTENSIFIED FLUORESCENCE MICROSCOPY: LOCALIZING MOLECULES IN
THE CELL. 30
2.5.4 CONFOCAL MICROSCOPY: THREE-DIMENSIONAL FLUORESCENCE IMAGES 32
2.5.5 CYTOMICS AND SYSTEMS BIOLOGY: CHARTING AND MODELLING THE ENTIRE
CELL. 33
3 CLASSIFICATION
AND
EVALUATION
OF
MICROSCOPIC IMAGES 35
3.1 TYPES OFMICROSCOPIC IMAGES 35
3.2 OBJECTIVITY 40
4 TRANSFORMATION
OF
OUR
KNOWLEDGE
OF
THE CELL
AND
THE
CYTOSKELETON :
FROM THE
STATIC TO A DYNAMIC CONCEPT .46
4.1 A SHORT HISTORY
OF
CELL BIOLOGY WITH SPECIAL EMPHASIS ON THE CYTOSKELETO .46
4.1.1 EARLY CELL BIOLOGY 46
4.1.2 DISCOVERY
OFTHE
CYTOSKELETON .47
4.1.3 DISCOVERY OFAXONAL TRANSPORT .48
4.1.4 THE INVOLVEMENT
OF
ELECTRON MICROSCOPY .49
4.1.5 ELECTRON MICROSCOPY AT ITS BEST.. 50
4.2 EXPLANATORY SCHEMES FOR THE MECHANISM OFAXONAL TRANSPORT 51
4.2.1 THE CONTRACTION HYPOTHESIS 54
4.2.2 THE MICROSTREAM HYPOTHESIS 56
4.2.3 THE RENAISSANCE
OF
LIGHT MICROSCOPY AND THE EVALUATION
OF
EXPLANATORY
CONCEPTS 59
4.2.4 CONFUTATION
OFTHE
CONTRACTION HYPOTHESIS 59
4.2.5 FALSIFICATION
OFTHE
MICROSTREAM HYPOTHESIS 61
5 PHILOSOPHICAL REFLECTIONS 65
5.1 NOVEL PREDICTIONS AND SCIENTIFIC TRUTH: THE CASE
OFTHE
CYTOSKELETON 65
5.2 INFERENCE TO THE BEST EXPLANATION: THE CASE OFAXONAL TRANSPORT 72
5.3 SCIENTIFIC REVOLUTION OR NORMAL SCIENCE ? 75
6 OUTLOOK.
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11I 11I 11I11I
**
79
7 ACKNOWLEDGEMENTS
11I
11I.11I
11I11I
11I.11I
11I11I
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***
11I11I11I11I
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************************
80
8 ABBREVIATIONS.
11I11I
**********************************************************************************
80
9 REFERENCES 81
|
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| bvnumber | BV037255488 |
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| dewey-ones | 571 - Physiology & related subjects |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| era | Geschichte gnd |
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| language | English |
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| spelling | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging Tobias Breidenmoser ... Berlin Max-Planck-Inst. für Wissenschaftsgeschichte 2010 89 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Preprint / Max-Planck-Institut für Wissenschaftsgeschichte 408 Literaturangaben Geschichte gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Mikroskopie (DE-588)4039238-7 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Mikroskopie (DE-588)4039238-7 s Zelle (DE-588)4067537-3 s Cytologie (DE-588)4070177-3 s Geschichte z DE-604 Breidenmoser, Tobias Sonstige oth Max-Planck-Institut für Wissenschaftsgeschichte Preprint 408 (DE-604)BV010030164 408 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021168724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging Cytologie (DE-588)4070177-3 gnd Mikroskopie (DE-588)4039238-7 gnd Zelle (DE-588)4067537-3 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4039238-7 (DE-588)4067537-3 |
| title | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging |
| title_auth | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging |
| title_exact_search | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging |
| title_full | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging Tobias Breidenmoser ... |
| title_fullStr | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging Tobias Breidenmoser ... |
| title_full_unstemmed | Transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging Tobias Breidenmoser ... |
| title_short | Transformation of scientific knowledge in biology |
| title_sort | transformation of scientific knowledge in biology changes in our understanding of the living cell through microscopic imaging |
| title_sub | changes in our understanding of the living cell through microscopic imaging |
| topic | Cytologie (DE-588)4070177-3 gnd Mikroskopie (DE-588)4039238-7 gnd Zelle (DE-588)4067537-3 gnd |
| topic_facet | Cytologie Mikroskopie Zelle |
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