Drug delivery systems:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla. [u.a.]
CRC Press
2011
|
| Ausgabe: | 3. ed. |
| Schriftenreihe: | Pharmacology and toxicology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 590 S. Ill., graph. Darst. |
| ISBN: | 9781439806180 |
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| 245 | 1 | 0 | |a Drug delivery systems |c Vasant V. Ranade ; John B. Cannon |
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| 300 | |a XVIII, 590 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804143830959652864 |
|---|---|
| adam_text | Titel: Drug delivery systems
Autor: Ranade, Vasant V.
Jahr: 2011
Contents
Preface to the Third Edition....................................................................................xv
Authors...................................................................................................................xvii
Chapter 1 Site-Specific Drug Delivery Using Liposomes and Emulsions
as Carriers............................................................................................1
Introduction..........................................................................................1
Liposomes in Drug Delivery................................................................2
Regional Drug Delivery..................................................................2
Chemical Characteristics of Liposomes..........................................3
Liposome-Drug Concept......................................................................5
Liposome Size.................................................................................5
Targeting Ligands............................................................................6
Problems and Advantages of Liposomal Drug Delivery.................6
Manufacturing Methods and Issues................................................8
Liposomes as Carriers of Therapeutic Agents...................................12
Application....................................................................................12
Liposomal Products and Manufacturers.......................................15
Parenteral Emulsions..........................................................................18
Recent Advances and Future Prospects.............................................20
Highlights of Current Research.....................................................20
Concluding Remarks..........................................................................32
References..........................................................................................32
Chapter 2 Site- Specific Drug Delivery Utilizing Monoclonal Antibodies.........47
Introduction........................................................................................47
Chemistry......................................................................................47
Polyclonals vs. Monoclonals..........................................................47
Conjugation of Antibodies.............................................................48
Production of Monoclonal Antibodies...............................................48
Continuously Proliferating Cell Lines...........................................49
Human-Human Hybridomas........................................................49
Large-Scale Production.................................................................50
Drug-Monoclonal Antibody Conjugates for Drug Targeting............50
Principles.......................................................................................50
Drug Antibody Bonding................................................................51
In Vitro and In Vivo Testing..........................................................51
Recent Studies with Monoclonal Antibodies.....................................54
Highlights of Current Research.....................................................54
Conclusion and Basis for Future Trends.............................................70
References..........................................................................................71
Contents
Chapter 3 Role of Polymers in Drug Delivery....................................................79
Introduction........................................................................................79
Currently Available Polymers............................................................79
Diffusion-Controlled Systems.......................................................79
Solvent-Activated Systems............................................................80
Chemically Controlled Systems....................................................80
Magnetically Controlled Systems..................................................80
Soluble Polymers as Drug Carriers....................................................81
Pinocytosis.....................................................................................81
Ideal Soluble Polymers..................................................................82
Biodegradable or Bioerodible Polymers.............................................84
Drug Release by Matrix Solubilization.........................................90
Erodible Diffusional Systems........................................................91
Monolithic Systems.......................................................................91
Mucoadhesive Polymers.....................................................................94
Polymers Containing Pendant Bioactive Substituents........................98
Matrix Systems.................................................................................101
Heparin-Releasing Polymers............................................................103
Ionic Polymers..................................................................................104
Oligomers.........................................................................................109
Miscellaneous...................................................................................109
Recent Advances.............................................................................. Ill
Conclusion........................................................................................122
References........................................................................................124
Chapter 4 Implants in Drug Delivery...............................................................137
Introduction......................................................................................137
Insulin Delivery as a Model Implant Pump System........................138
Peristaltic Pumps......................................................................... 141
Fluorocarbon Propellant-Driven Pumps.....................................143
Osmotic Pumps............................................................................144
Miniosmotic Pumps: Systemic Delivery.....................................146
Miniosmotic Pumps: Local Delivery..........................................146
Miniosmotic Pumps: Patterned Delivery....................................147
Positive-Displacement Pumps.....................................................148
Controlled-Release Micropump..................................................148
Other Devices..............................................................................150
Implants for Contraception...............................................................150
Biodegradable..............................................................................150
Nonbiodegradable........................................................................151
Delivery of Chemotherapeutic Agents Using Implants....................152
Recent Advances in Implants and Related Devices
(Excluding Inserts)...........................................................................154
Future Prospects...............................................................................161
References........................................................................................162
Chapter 5 Oral Drug Delivery..........................................................................169
Controlled-Release Formulations.....................................................169
Introduction.................................................................................169
Features of the GI Tract...............................................................171
Targeting of Drugs in the GI Tract..............................................172
Mathematical Models for Controlled-Release Kinetics..............173
Design and Fabrication of Oral Delivery Systems......................174
Dissolution-Controlled Release.............................................. 174
Osmotically Controlled Release.............................................176
Diffusion-Controlled Release.................................................179
Chemically Controlled Release..............................................184
Miscellaneous Forms of Controlled Release..........................184
Survey of Oral Controlled-Release Products..............................198
Recent Advances.........................................................................198
Current Development of Oral Drug Delivery Systems...............205
Conclusion...................................................................................209
References........................................................................................210
Enhancing Oral Bioavailability........................................................215
Introduction.................................................................................215
Increasing Bioavailability of Water-Insoluble Drugs..................216
General Approaches for Water-Insoluble Drugs: Salt
Formation, Cosolvents, and Particle Size Reduction..............216
Lipid-Based and Micellar Formulations.................................217
Solid Dispersions and Related Technologies..........................231
Cyclodextrins and Complexation Techniques........................234
Increasing Bioavailability of Proteins, Peptides,
and Other Drugs with Absorption Problems...............................235
Recent Advances and Future Prospects......................................236
References........................................................................................238
Chapter 6 Transdermal Drug Delivery.............................................................243
Introduction......................................................................................243
Theoretical Aspects of Transdermal Drug Delivery........................245
Structure of Human Skin.............................................................245
Mechanisms of Penetration.........................................................246
Optimization of Percutaneous Absorption and Effects
of Penetration Enhancers.............................................................253
Development of the Transdermal Therapeutic System....................257
Types of Transdermal Patches.....................................................257
Formulation.................................................................................259
Adhesion......................................................................................260
Bioactivity and Metabolism.........................................................261
Polymers in Transdermal Delivery Systems...............................262
Examples of Transdermal Applications...........................................262
Diseases for Which TDD Is Used...............................................262
Current Transdermal Products and Devices...............................263
Minimally Invasive Technologies............................................265
Iontophoresis Systems.............................................................267
Microneedle Systems..............................................................270
Other Minimally Invasive and Combination Systems............272
Other Transdermal Controlled-Release Products and Devices...273
Recent Advances and Future Prospects...........................................274
Conclusion........................................................................................287
References........................................................................................288
Chapter 7 Transmucosal and Ocular Drug Delivery........................................305
Introduction: Transmucosal and Ocular Drug Delivery..................305
Pulmonary Drug Delivery................................................................305
Introduction.................................................................................305
Lung Physiology and Pulmonary Drug Administration.............305
Pulmonary Drug Delivery Devices.............................................306
Recent Advances.........................................................................317
Intranasal Drug Delivery.................................................................322
Introduction.................................................................................322
Nasal Physiology and Intranasal Drug Administration...............323
Nasal Drug Delivery Devices......................................................325
Examples of Intranasal Drug Delivery Systems.........................327
Recent Advances.........................................................................332
Buccal and Sublingual Drug Delivery.............................................333
Introduction.................................................................................333
Examples of Buccal and Sublingual Drug Delivery Systems.....335
Recent Advances.........................................................................335
Rectal, Vaginal, and Other Forms of Transmucosal Drug Delivery.... 337
Intravaginal Delivery...................................................................337
Rectal Delivery............................................................................341
Ocular Drug Delivery......................................•.................................347
Introduction.................................................................................347
Relevant Anatomy and Physiology of the Eye.............................348
Examples of Ocular Drug Delivery Systems..............................352
Recent Advances.........................................................................357
Conclusions and Future Outlook for Transmucosal
and Ocular Drug Delivery................................................................359
References........................................................................................361
Chapter 8 Miscellaneous Forms of Drug Delivery...........................................373
Introduction......................................................................................373
Pro-Drugs.........................................................................................373
Infusion Devices...............................................................................382
Pumps..........................................................................................382
Mechanical Pumps.................................................................382
Closed- and Open-Loop Systems...........................................382
Programmable and Manual Systems......................................383
Implantable and External Systems.........................................383
Syringe Pumps........................................................................383
Piston Pumps..........................................................................383
Peristaltic Pumps....................................................................383
Balloon Pumps........................................................................384
Gas-Pressure Pumps...............................................................384
Portable Infusion Pumps.........................................................384
Controllers..............................................................................384
Other External Infusion Systems................................................385
Percutaneous Catheters...........................................................385
Totally Implantable Pump and Reservoir Systems.................386
Totally Implantable Portal and Catheter Systems..................387
Insulin Delivery................................................................................388
Parenteral Prolonged-Action Dosage Forms....................................391
Complex Formation and Addition of Macromolecules...............392
Salts of Low Solubility and Slowly Hydrolyzable Esters............392
Aqueous Suspensions..................................................................392
Oleaginous Suspensions and Emulsions......................................393
Precipitation of Drug in Tissue...................................................393
Implants.......................................................................................393
SC Drug Delivery Systems..........................................................394
Intravenous Delivery...............................................................395
Magnetically Modulated Systems...............................................397
Intrauterine Delivery...................................................................399
Microspheres...............................................................................403
Hydrogels.....................................................................................406
Microcapsules and Microencapsulation......................................411
Microparticles-Nanoparticles...................................................414
Colloids and Microemulsions......................................................417
Hollow Fibers..............................................................................421
Ultrasonically Controlled............................................................422
Liquid-Crystalline Phases...........................................................423
Time-Controlled Explosion Systems .......................................423
Mammalian Cells........................................................................423
Sutures.........................................................................................424
Microsealed Drug Delivery.........................................................425
Recent Advances..............................................................................426
Summary..........................................................................................436
References........................................................................................436
Chapter 9 Nanoscience and Nanotechnology for Drug Delivery.....................451
Introduction......................................................................................451
Nanotechnologies.............................................................................451
Fundamentals..............................................................................453
Biopharmaceutical, Physiological, and Clinical
Considerations.............................................................................453
Delivery of Small Molecules, Proteins, and Nucleic Acids........463
Nanoethics, Safety, and Risk Assessment...................................467
Nanomaterial Characterization...................................................467
FDA Regulations and Manufacturers..........................................468
Building Business and Trends.....................................................470
Miscellaneous Applications of Nanomaterials................................471
Nano-oncology............................................................................471
Nanoneurology and Nanoneurosurgery.......................................478
Nanodermatology, Nanopulmonology, Nanogeriatrics,
Nanoimmunology, and Nanodentistry.........................................479
Nano-orthopedics........................................................................480
Nanomicrobiology.......................................................................480
Nanodevices for Medicine and Surgery..........;...........................480
Nanocardiology...........................................................................481
Nano-ophthalmology...................................................................481
Nanobiotechnology for Regenerative Medicine and Tissue
Engineering.................................................................................482
Nanomolecular Diagnostics.........................................................482
Nanotechnology for Gene and Vaccine Delivery........................484
Nanoparticles and Nanostructures...................................................485
Nanoparticles...............................................................................487
Nanocomposites...........................................................................493
Nanotubes, Nanorods, Nanofibers, and Nanohorns....................493
Nanocarriers...........................................................................499
Nanochips...............................................................................500
Nanosized Colloids.................................................................500
Nanoemulsions........................................................................501
Nanocrystals...........................................................................501
Nanostructures........................................................................501
Nanomaterials.........................................................................502
Nanomedicine and Nanopharmaceuticals........................................507
Worldwide Development.............................................................507
Future Prospects..........................................................................511
References........................................................................................513
Chapter 10 Regulatory Considerations for Drug Delivery Systems...................525
Introduction......................................................................................525
Current Status of Drug Delivery Technology..................................528
Regulatory Requirements............................................................528
Bioavailability Data.....................................................................532
The Reference Standard..............................................................533
Requirements to Demonstrate Drug Controlled-Release............533
In Vitro Drug Release Data....................................................533
In Vivo Bioavailability Data...................................................533
Bioequivalence............................................................................540
Stability Testing...........................................................................542
Submission of Documents for Manufacture and Quality.................546
Control of Drug Products............................................................546
Drug Product (NDAs and ANDAs)........................................546
Regulatory Specifications and Methods for Drug Products.....548
Methods of Manufacturing and Packaging............................550
Current FDA Draft Guidelines and Regulations....................551
Implants..................................................................................555
Monoclonal Antibodies..........................................................556
Computer Access and Security Requirements.......................558
References........................................................................................559
Chapter 11 Drug Delivery Industry and the Global Outlook.............................563
Basis for the Recent Trend...............................................................569
References........................................................................................572
Index......................................................................................................................575
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| isbn | 9781439806180 |
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| spelling | Ranade, Vasant V. Verfasser aut Drug delivery systems Vasant V. Ranade ; John B. Cannon 3. ed. Boca Raton, Fla. [u.a.] CRC Press 2011 XVIII, 590 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmacology and toxicology Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 s DE-604 Cannon, John B. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021141062&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ranade, Vasant V. Cannon, John B. Drug delivery systems Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd |
| subject_GND | (DE-588)4165181-9 (DE-588)4143413-4 |
| title | Drug delivery systems |
| title_auth | Drug delivery systems |
| title_exact_search | Drug delivery systems |
| title_full | Drug delivery systems Vasant V. Ranade ; John B. Cannon |
| title_fullStr | Drug delivery systems Vasant V. Ranade ; John B. Cannon |
| title_full_unstemmed | Drug delivery systems Vasant V. Ranade ; John B. Cannon |
| title_short | Drug delivery systems |
| title_sort | drug delivery systems |
| topic | Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd |
| topic_facet | Kontrollierte Wirkstofffreisetzung Aufsatzsammlung |
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