The comet assay in toxicology:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2009
|
| Schriftenreihe: | Issues in toxicology
v. 5 |
| Schlagworte: | |
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| Beschreibung: | The first book of its kind, devoted exclusively to the assessment of DNA damage by the Comet assay in modern toxicology, The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is currently in progress. This book documents the latest research and showcases the versatile, state-of-the-art technique - the Comet assay - in the field of modern toxicology. The assay is a simple, sensitive rapid and visual technique for the quantitative and qualitative assessment of DNA damage in single cells. The Comet Assay in Toxicology is the first book of its kind to be devoted exclusively to the Comet assay and its applications as an important tool in modern toxicology. This multi-author book will serve as both a reference and a guide to investigations in the biomedical, biochemical and pharmaceutical sciences. Written by investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand knowledge from their chosen sub-specialities and are active contributors to the peer-reviewed scientific literature. The book is divided into five major sections, reflecting the range of interest in the exploitation of this assay. The book's scope begins with an introduction section reviewing its genesis for those new to the technique and the current knowledge of the various fields in which it finds wide acceptance. This section sets the scene by explaining why the assay has become the most sensitive and sought after assay in modern toxicology. Next is a whole section that considers various procedures being followed to assess different types of DNA damage in various cell t++ ypes and is contributed by experts in the respective fields. The third section puts together the specific applications of the assay in the diverse fields ranging from genetic toxicity testing to human monitoring, and environmental toxicology. The fourth section consists of the guidelines and recommendations for the conduct of the assay in in vitro and in vivo systems, based on the recommendations of the International Workgroups on genotoxicity test procedures. Finally, the book draws to a close with an assessment of the statistics used for the understanding of the data generated by the assay. This is a unique reference book as it provides the scientific community with the advances in Comet assay as well as its applications. It also incorporates a detailed section with instant and comprehensive information on the procedure of the assay and the latest protocols being used worldwide as well as statistical analyses to be followed. The book is aimed at students as well as scientists in the area of molecular epidemiology and genetic toxicology |
| Beschreibung: | 1 Online-Ressource (374 p.) 43 b&w, ill |
| ISBN: | 1847559743 9781847559746 |
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| id | DE-604.BV037195527 |
| illustrated | Not Illustrated |
| indexdate | 2025-02-20T06:47:18Z |
| institution | BVB |
| isbn | 1847559743 9781847559746 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021109889 |
| oclc_num | 873742125 |
| open_access_boolean | |
| owner | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| owner_facet | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| physical | 1 Online-Ressource (374 p.) 43 b&w, ill |
| psigel | ZDB-1-RSE |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | Issues in toxicology |
| spellingShingle | The comet assay in toxicology Comet Assay Laboratory Manuals DNA Damage drug effects Laboratory Manuals DNA damage Testing Gel electrophoresis |
| title | The comet assay in toxicology |
| title_auth | The comet assay in toxicology |
| title_exact_search | The comet assay in toxicology |
| title_full | The comet assay in toxicology Edited by Alok Dhawan, Diana Anderson ; Series edited by Michael D. Waters, Timothy C. Marrs ; Contributions by Andreas Hartmann [et al.] |
| title_fullStr | The comet assay in toxicology Edited by Alok Dhawan, Diana Anderson ; Series edited by Michael D. Waters, Timothy C. Marrs ; Contributions by Andreas Hartmann [et al.] |
| title_full_unstemmed | The comet assay in toxicology Edited by Alok Dhawan, Diana Anderson ; Series edited by Michael D. Waters, Timothy C. Marrs ; Contributions by Andreas Hartmann [et al.] |
| title_short | The comet assay in toxicology |
| title_sort | the comet assay in toxicology |
| topic | Comet Assay Laboratory Manuals DNA Damage drug effects Laboratory Manuals DNA damage Testing Gel electrophoresis |
| topic_facet | Comet Assay Laboratory Manuals DNA Damage drug effects Laboratory Manuals DNA damage Testing Gel electrophoresis |
| url | http://www.rsc.org/Publishing/eBooks/2009/9780854041992.asp |
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