Structure-based drug discovery: An overview
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2006
[distributor] RSC Distribution Services] |
| Schriftenreihe: | RSC Biomolecular sciences
|
| Schlagworte: | |
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| Beschreibung: | This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity, Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences |
| Beschreibung: | 1 Online-Ressource (278 p.) |
| ISBN: | 1847552544 9781847552549 |
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| id | DE-604.BV037195349 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:43:41Z |
| institution | BVB |
| isbn | 1847552544 9781847552549 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021109711 |
| oclc_num | 873740212 |
| open_access_boolean | |
| owner | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| owner_facet | DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-Aug4 DE-1046 DE-1047 DE-1102 DE-1050 DE-859 DE-M347 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-210 DE-2070s DE-634 DE-526 DE-860 DE-70 DE-B768 |
| physical | 1 Online-Ressource (278 p.) |
| psigel | ZDB-1-RSE |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Royal Society of Chemistry [distributor] RSC Distribution Services] |
| record_format | marc |
| series2 | RSC Biomolecular sciences |
| spellingShingle | Structure-based drug discovery An overview Drug Design Drugs Design Drugs Structure-activity relationships Models, Molecular Structure-Activity Relationship Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd Arzneimitteldesign (DE-588)4278218-1 gnd Biomolekül (DE-588)4135124-1 gnd Konfiguration Chemie (DE-588)4129572-9 gnd |
| subject_GND | (DE-588)4183784-8 (DE-588)4143176-5 (DE-588)4278218-1 (DE-588)4135124-1 (DE-588)4129572-9 |
| title | Structure-based drug discovery An overview |
| title_auth | Structure-based drug discovery An overview |
| title_exact_search | Structure-based drug discovery An overview |
| title_full | Structure-based drug discovery An overview |
| title_fullStr | Structure-based drug discovery An overview |
| title_full_unstemmed | Structure-based drug discovery An overview |
| title_short | Structure-based drug discovery |
| title_sort | structure based drug discovery an overview |
| title_sub | An overview |
| topic | Drug Design Drugs Design Drugs Structure-activity relationships Models, Molecular Structure-Activity Relationship Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd Arzneimitteldesign (DE-588)4278218-1 gnd Biomolekül (DE-588)4135124-1 gnd Konfiguration Chemie (DE-588)4129572-9 gnd |
| topic_facet | Drug Design Drugs Design Drugs Structure-activity relationships Models, Molecular Structure-Activity Relationship Struktur-Aktivitäts-Beziehung Arzneimittelentwicklung Arzneimitteldesign Biomolekül Konfiguration Chemie |
| url | http://www.rsc.org/publishing/ebooks/2006/9780854043514.asp |