Molecular basis of health and disease:
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Dordrecht [u.a.]
Springer
2011
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XX, 583 S. Ill., graph. Darst. |
| ISBN: | 9400704941 9789400704947 |
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| 100 | 1 | |a Das, Undurti N. |e Verfasser |0 (DE-588)140907246 |4 aut | |
| 245 | 1 | 0 | |a Molecular basis of health and disease |c Undurti N. Das |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2011 | |
| 300 | |a XX, 583 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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Contents
1 Introduction
.
,
. 1
Measuring Health and Disease
. 2
Is There a Better Definition of Health?
. 5
Determinants of Health
. 6
Maintaining Health
. 6
Observations of Daily Living
. 6
Social Activity
. 6
Hygiene
. 7
Stress Management
. 7
HealthCare
. 7
Workplace
Wellness
Programs
. 7
Public Health
. 8
Role of Science in Health
. 9
Applied Health Sciences
. 9
2
Health and Disease as Two Sides of the Same Coin
.
U
Low-Grade Systemic Inflammation Occurs in Many Diseases
. 11
3
Inflammation
. 15
Introduction
. 15
Phases of Inflammatory Response
. 16
Components of Acute Inflammation
. 17
Vascular Changes
. 18
Cellular Events
. 23
Mediators of Inflammation
. 34
Histamine
. 35
Serotonin
.-. 37
Effects of Food Content
. 40
Location of Serotonergic Neurons
. 42
5-HT Receptors
.·. 42
Serotonylation
. 43
Biosynthesis of Serotonin
. 43
Contents
Drugs
Targeting
the
5-НТ
System
. 43
Serotonin Modulates Inflammation and Immune Response
. 44
Dopamine
. 45
Catecholamines
. 46
Acetylcholine
. 48
Melanocortin
. 48
Leptin
. 49
NeuropeptideY
. 50
Ghrelin
. 51
Gut Peptides
. 53
Cholecystokinin
. 54
Kinins
. 56
Essential Fatty Acids and Their Products
. 58
Cyclo-oxygenase (COX), Lipoxygenase
(LO)
Pathways and Generation
of Lipoxins, Resolvins, Protectins and Maresins
. 59
Aspirin-triggered
15
Epimer LXs (ATLs) and Resolvins
and Formation of Protectins and Maresins
. 62
Platelet Activating Factor
(PAF)
. 63
Cytokines in Inflammation
. 65
Chemokines in Inflammation
. 66
Nitric Oxide (NO)
. 67
NO is an Endogenous Anti-infective Molecule
. 69
NO and Cellular Senescence
. 70
NO and Brain-derived Neurotrophic Factor (BDNF)
. 71
Leukocyte Lysosomal Enzymes
. 72
Reactive Oxygen Species
(ROS)
. 73
Neuropeptides in Inflammation
. 74
Obesity, type
2
diabetes, hypertension, hyperlipidemia, insulin
resistance, Alzheimer's disease, depression, schizophrenia
and cancer are low-grade systemic inflammatory
conditions
. 74
Diagnosis of Low-grade Systemic Inflammation
. 76
Hs-CRP
. 76
Cytokines and Chemokines
. 77
Conventional Markers of Inflammation
. 78
Role of Pro-inflammatory Markers in the Pathophysiology
of the Low-grade Systemic Inflammatory Conditions
. 78
Essential Fatty Adds
—
Biochemistry, Physiology and Clinical
Significance
. 101
Introduction
. 101
Metabolism of EFAs
. 102
The n-6 Polyunsaturated Fatty Acids
. 102
The n-3 Polyunsaturated Fatty Acids
. 105
Dietary Sources of EFAs
. 109
Contents xiii
The Activities of
Δ6
and
Δ5
Desaturases
Are Low in Humans
. 110
Modulators of EFAs/PUFAs Metabolism
.
Ill
Protein and Insulin Augment
Δ6
Desaturase
Activity
.
Ill
Ageing and Season Influence
Δ6
Desaturase
Activity
. 112
Oncogenic Viruses, Radiation, SREBP and PPARs Influence
EFA Metabolism
. 112
Statins Enhance EFA Metabolism
. 113
Trans-fats, Saturated Fats and Cholesterol Inhibit
Δ6
Desaturase
. 113
Zinc Modifies EFA and PG Metabolism
. 114
Magnesium is an Essential Co-factor for Normal
Δ6
Desaturase
. 115
Calcium Enhances PGI2 Synthesis and Interacts with PUFAs
. 116
Vitamin
С
and
Ethanol
Enhance the Formation of PGEi
. 117
Actions of EFAs/PUFAs and Their Metabolites
. 117
Cell Membrane Fluidity
. 117
EFAs/PUFAs Have Second Messenger Actions
. 119
PUFAs Behave as Endogenous Anti-infective Molecules
. 120
PUFAs Inhibit ACE Activity and Enhance Endothelial
Nitric Oxide Generation
. 122
PUFAs and Cytokines
. 124
PUFAs Decrease HMG-CoA
Reducíase
Activity
. 126
Lipoxins, Resolvins, Protectins and Maresins
. 127
NO Reacts with PUFAs to Yield Nitrolipids
. 129
Formation of
Nitro
Fatty Acids (Nitrolipids) in Tissues
. 134
Actions of
Nitro
Fatty Acids (Nitrolipids)
. 136
Interaction^) Among n-3, n-6 Fatty Acids, NO and Nitrolipids
. 138
5
Cell Membrane Organization
. 153
Introduction
. 153
Fluid Mosaic Model of the Membrane
. 153
The Phospholipid (PL) Bilayer—Its Structure, Properties
and Functions
. 154
Cell Membrane Properties
. 158
Integral Membrane Proteins
. 159
Cell Membrane-Cytoskeleton Integration
. 159
Cell Membrane Lipids
. 160
Plasma Membrane Carbohydrates
. 161
Plasma Membrane Proteins
. 161
Cell Membrane Permeability
. 162
Lipid
Rafts, Caveolae and Polyunsaturated Fatty Acids (PUFAs)
. 166
6
Low-grade Systemic Inflammation is Present in Common
Diseases/Disorders
. 175
Introduction
. 175
Low-grade Systemic Inflammation is Present in Chronic
Diseases
. 177
Contents
Obesity
. 181
Definition
of Obesity
. 182
Incidence and Prevalence of Obesity
. 182
Obesity May Be Familial
. 183
Fast Food Industry and Obesity
. 183
Obesity Is Harmful
. 184
Genetic and Non-genetic Factors Contributing to Obesity
. 185
Gene Expression Profile in Obesity
. 186
All Adipose Cells are Not the Same
. 187
Biochemical and Functional Differences Between Adipose Cells
of Different Regions
. 188
Intramyocellular
Lipid (IMCL)
Droplets and Perilipins
. 189
Perilipins and Inflammation
. 189
Low Grade Systemic Inflammation Occurs in Obesity
. 190
Weight Loss Ameliorates Inflammation
. 192
Adipose Tissue
Macrophages
(ATMs) and Inflammation
. 193
Macrophage
Differentiation Is Dependent on Fatty
Acid Synthesis
. 194
Fatty Acid Metabolism Enhances
Τ
Cell Memory
. 195
What Causes Abdominal Obesity
—
How and Why?
. 198
Excess H/i-hydroxysteroidDehydrogenaseType
1
(11^-HSD-l)
Enzyme Activity May Cause Abdominal Obesity
. 198
Interaction Among
llß-HSD-l,
TNF
-α
and Insulin
. 199
Glucocorticoids and Perilipins
. 201
Glucocorticoids, TNF-a, and Inflammation
. 202
Diet, Genetics, Inflammation and Obesity
. 203
Gut and Obesity
. 205
Perinatal Nutritional Environment Influences Development
of Obesity
. 206
Obesity and Type
2
Diabetes Mellitus as Disorders of the Brain
. 206
Cross-Talk Between the Liver, Adipose Tissue and the Brain
Through Vagus
. 207
Cross-Talk Between the Liver and Pancreatic
β
Cells
is Mediated by the Vagus
. 207
The Gut-Brain-Liver Axis Circuit is Activated by Long-Chain
Fatty Acids
. 208
BDNF and Obesity
. 211
Interaction^) Among Insulin, Melanocortin, and BDNF
. 212
Ghrelin, Leptin, and BDNF
. 213
Obesity and Type
2
Diabetes Mellitus Are Inflammatory Conditions
. 213
BDNF and Inflammation
. 214
Gut Bacteria and Obesity
. 215
Gut Flora
. 215
Gut Bacteria Are Different in the Lean and Obese
. 216
Gut Bacteria and GPR41
. 217
Contents xv
Diet, Low-Grade Systemic Inflammation, and Obesity
. 219
Gastric Bypass Surgery for Obesity Alters Gut Bacteria
and Hypothalamic Factors
. 219
Insulin Acts Not only on Peripheral Tissues but Also in the Brain
. 220
Interaction Between PUFAs and BDNF and its Relationship to Obesity
. 221
Diet, Gut Peptides and Hypothalamic
Neurotransmitters
in Obesity
. 221
8
Hypertension
. 239
Introduction
. 239
Nutritional Factors in the Pathobiology of HTN
. 240
Interaction^) Between Minerals, Trace Elements, Vitamins
and Essential Fatty Acids
. 241
Salt, Calcium, NO, and Hypertension
. 242
Asymmetrical Dimethylarginine and Hypertension
. 243
NO, ADMA and Oxidative Stress in
Preeclampsia
. 243
VEGF, Endoglin, Placental Growth Factor,
TGF-ß,
Catechol-O-methyltransferase Activity and
Preeclampsia
. 246
Homocysteine and Endothelial Damage
. 248
Nutritional Factors,
Oxidant
Stress and Endothelial
Dysfunction
. 249
Increased
Oxidant
Stress Occurs in Hypertension
. 250
Superoxide
Anion
Production Is Increased in Hypertension:
How and Why?
. 251
Superoxide
Anion
and Hypertension
. 252
NO and Hypertension
. 252
Cyclosporine Increases Blood Pressure by Augmenting
O¿~
·
Generation
. 253
Anti-hypertensive Drugs Enhance eNO Synthesis and Show
Antioxidant
Property
. 253
Transforming Growth Factor-jS
(TGF-ß)
in Hypertension
. 255
Essential Fatty Acids and Blood Pressure
. 256
Free Radicals, NO, ACE Activity and Essential Hypertension
. 257
Essential Fatty Acids and Hypertension
. 259
Low-grade Systemic Inflammation Occurs in Hypertension
. 262
Does Adult Hypertension have its Origins
in the Perinatal Period?
. 262
9
Insulin Resistance, Dyslipidemia, Type
2
Diabetes
Mellitus
and Metabolic Syndrome
. 277
Introduction
. 277
Metabolic Syndrome
. 278
Metabolic Syndrome Is an Inflammatory Condition
. 279
Why Abdominal Obesity Occurs?
. 279
Glucose Is Pro-inflammatory in Nature
. 280
Insulin Is Anti-inflammatory in Nature
. 281
xvi
Contents
Endothelial Nitric Oxide in Metabolic Syndrome
. 281
Perinatal Origins of Metabolic Syndrome
. 284
Hypothalamic Neuropeptides and Food Intake
. 286
Appetite Regulatory Centers Are in Place During Perinatal Period
and Fine-tuned/Programmed by Maternal
and Perinatal Factors
. 286
Ventromedial
Hypothalamus
may have a Role in the Development
of Type
2
Diabetes Mellitus
. 288
Insulin Receptors in the Brain and the Metabolic Syndrome
. 290
Mechanism of Action of Insulin Receptors in the Brain
and Elsewhere
. 291
Insulin, GLUT-4 and Glucose Transport
. 297
Muscle-specific GLUM Knockout Mice (MG4KO)
. 297
Fat-specific
GLUT-4
Knockout Mice
. 299
PUFAs, Expression of Insulin Receptors and GLUTs
and Diabetes Mellitus
. 300
Polygenic Knockout Models
. 302
Triple Heterozygous Knockouts (IR/IRS-1/P85)
. 302
Weight Loss After Gastric Bypass and Changes in Hypothalamic
Neuropeptides and Monoamines
. 304
Monoaminergic Amines and Hypothalamic and Gut Peptides
and Inflammation
. 305
Dopamine
. 305
Serotonin (5-hydroxytryptamine)
. 306
Neuropeptide
Y.
307
Ghrelin
. 308
Melanocortin
. 310
Acetylcholine
. 311
Adrenaline and
Noradrenaline
. 311
Gut Peptides
. 312
Leptin
. 313
Cholecystokinin
. 314
Neurotransmitters
and Gut Peptides as Modulators
of Inflammation and Immune Response
. 315
10
Atherosclerosis
. 333
Introduction
. 333
Atherosclerosis Is a Low-grade Systemic
Inflammatory Condition
. 334
Mediators of Inflammation in Atherosclerosis
. 335
Cross Talk Among Platelets, Leukocytes and Endothelial Cells
. 337
Lipoxins in Rheumatoid Arthritis
. 338
Leukocytes and Atherosclerosis
. 340
Uncoupling Protein-
1,
Essential Fatty Acids, and Atherosclerosis
. 341
Contents xvii
PUFAs of
ω
-З
and
ω-6
Series, Trans-fats, Saturated Fats, Cholesterol
and Their Role in Atherosclerosis
. 342
Atheroprotective Actions of
ω
-Ъ
and
ω
-б
Fatty Acids
. 343
Effects on Endothelial Function
. 344
PUFAs Inhibit Angiotensin-converting Enzyme (ACE) Activity
and Augment Endothelial Nitric Oxide Generation
. 345
PUFAs Suppress the Production of Pro-inflammatory
Cytokines
. 346
Effects on HMG-CoA
Reducíase
Enzyme
. 346
11
Osteoporosis
. 359
Introduction
. 359
Dietary Protein and Osteoporosis
. 359
Magnesium and Osteoporosis
. 361
Osteoporosis Is a Low-grade Systemic Inflammatory Condition
. 361
Nitric Oxide in Osteoporosis
. 364
Post-menopausal Osteoporosis, Cytokines and NO
. 366
Dose Dependent Action of NO on Bone
. 366
Anti-diabetic Drag Metformin, NO and Osteoporosis
. 368
Polyunsaturated Fatty Acids and Osteoporosis
. 369
12
Alzheimer's Disease, Schizophrenia and Depression
. 377
Introduction
. 377
Pathobiology of Alzheimer's Disease
. 377
Amyloid
β
in AD
. 379
Oxidative Stress Causes
Neuronal
Death
. 379
Alzheimer's is an Inflammatory Condition
. 380
Cholinergic System in Alzheimer's Disease
. 381
Neurotrophic Factors and AD
. 382
PUFAs in Alzheimer's Disease
. 384
PUFAs and Neurogenesis and Neurite Outgrowth
. 385
Interaction^)BetweenPUFAsandBDNF
. 387
Schizophrenia
. 390
Prenatal and Perinatal Factors on Psychopathology
. 390
Early Fetal Environment and Development and Schizophrenia
. 391
Maternal Infections and Schizophrenia
. 392
Is Schizophrenia an Inflammatory Condition?
. 393
PUFAs and Their Metabolites and Schizophrenia
. 393
Depression
. 395
Depression May Be Associated with Low BDNF Levels
. 396
BDNF and Serotonin Interact with Each Other
. 397
BDNF and Inflammation
. 398
Serotonin and Catecholamines Modulate Inflammation
. 399
Depression is an Inflammatory Condition
. 399
Depression and PUFAs
. 400
xv¡jj
Contents
13
Rheumatological Conditions
. 417
Introduction
. 417
Autoimmunity
. 418
Self and Non-self and Immunological Tolerance
. 418
Genetic Factors
. 419
Gender
. 420
Environmental Factors
. 422
Pathogenesis of Autoimmunity
. 423
Systemic Lupus Erythematosus
. 427
Pathobiology of Inflammation with Emphasis
on Chronic Inflammation
. 428
Components and Mediators of the Inflammatory Response
. 429
Cytokines in Inflammation
. 431
Inflammatory and Anti-inflammatory Molecules
and Antioxidants in Lupus
. 432
TGF-ß in
Scleroderma
and Lupus
. 434
Immune Dysfunction in Lupus
. 434
Loss of Self-tolerance in Lupus
. 435
UV Radiation, Immune Response, Mast Cells and its Role
in Lupus
. 438
Mast Cells in Rheumatological Conditions
. 439
PLA2, TNF-a, MIF and Pro- and Anti-inflammatory Lipids
. 440
Glucocorticoids, COX Enzymes, LTs, Cytokines, NO, LXs,
and Inflammation
. 444
Cell Membrane Fatty Acid Content Could Modulate Inflammation
and Repair
. 448
Nitric Oxide,
Lipid
Peroxides, and
Antioxidant
Status
in Lupus
. 449
Oxidant
Stress, Anti-oxidants, NO and PUFAs in Lupus
. 450
1,25-dihydroxy vitamin D3 Suppresses Autoimmunity
. 451
ADMA is Useful in Lupus and Other Rheumatological Conditions
. 452
14
Cancer
. 465
Tobacco and Cancer
. 466
Infection and Cancer
. 466
Tobacco and Inflammation
. 467
Inflammation of Chronic Infections and Cancer are due
to TNF-a andIL-1
. 468
Glucose Sensing by
Neuronal
and Tumor Cells and Its Relationship
to ATP-Sensitive K+ Channels and
ROS
. 470
Eicosanoids, Free Radicals and Inflammation in Cancer
. 473
PUFAs, Pro- and Anti-inflammatory Metabolites of PUFAs
and
Lipid
Peroxidation
and Cancer
. 474
Free Radicals Have both Beneficial and Harmful Actions
. 475
Lipid
Peroxidation
in Tumor Cells
. 476
Contents xix
PUFA
Deficiency Exists
in Tumor
Cells .
476
Superoxide Dismutase
and Free Radicals in
Tumor
Cells
. 477
Free Radicals Induce
Translocation
of p53
. 478
Oxidant
Stress and Telomere
. 479
Bcl-2 Opposes the Action of p53
. 479
Polyunsaturated Fatty Acids Inhibit Cell Proliferation by Augmenting
Free Radical Generation and
Lipid
Peroxidation.
480
Normal and Tumor Cells May Process PUFAs Differentially
. 481
15
Aging
. 491
Introduction
. 491
Telomere and Aging
. 492
Theories of Aging
. 492
Telomere and Aging
. 493
Telomere in Type
2
Diabetes Mellitus
. 495
Telomere and Hypertension
. 497
Endothelial Dysfunction, Insulin Resistance, Obesity, Hypertension,
Type
2
Diabetes, Inflammation and Telomere
. 498
PUFAs and Their Anti-inflammatory Products and Telomere
. 499
P53, Telomere, Aging, Type
2
Diabetes Mellitus, Cancer
. 500
Other Theories of Aging
. 504
Aging is a Low-grade Systemic Inflammatory Condition
. 504
Exercise is Anti-inflammatory in Nature
. 506
16
Adult Diseases and Low-Grade Systemic Inflammation Have Their
Origins in the Perinatal Period
. 513
Introduction
. 513
When and How the Inflammatory Process is Initiated?
. 515
Perinatal Programming of Adult Diseases
. 515
Factors Influencing the Metabolism of EFAs
. 516
PUFAs Modulate Glucose and
Glutaminę
Uptake
and Their Metabolism
. 517
PUFAs, Insulin, and Acetylcholine Function as Endogenous
Cyto- and Neuroprotectors
. 519
PUFAs in Brain Growth and Development
. 521
Syntaxin, SNARE Complex andPUFAs
. 521
PUFAs Modulate RAR-RXR and Other Nuclear Receptors
and are Essential for Brain Growth and Development
. 522
PUFAs Modulate Gene Expression and Interact with Cytokine TNF-a
and Insulin to Influence
Neuronal
Growth and Synapse
Formation
. 525
Neurogenesis and
Neuronal
Movement During the Growth
and Development of Brain and PUFAs
_. 527
Insulin, PUFAs and
Neuronal
Proliferation
. 528
xx Contents
Catenin, wnt
and Hedgehog Signaling Pathway in Brain Growth and
Development and PUFAs
. 529
PUFAs Modulate NMDA, y-Aminobutyric Acid
(GABA),
Serotonin
and Dopamine in the Brain
. 532
Maternal Diet Influences EFA Metabolism and Leptin Levels
. 536
Perinatal PUFA Deficiency May Initiate Low-Grade Systemic
Inflammation and Adult Diseases
. 537
17
Clinical Implications
. 551
Introduction
. 551
Glucose-Insulin-Potassium Regimen
. 552
Ethyl Pyravate
. 555
Lipid-enriched Albumin
. 556
Vagai
Nerve Stimulation (VNS) Suppresses Inflammation
. 558
VNS for Obesity, Hypertension, Type
2
Diabetes Mellitus
and Metabolic Syndrome
. 559
Lipoxins, Resolvins, Protectins or Their Synthetic Analogues
. 562
Ghrelin
. 563
PUFAs as Potential Anti-cancer Drugs
. 563
PUFAs, Especially GLA, for
Glioma
. 565
Modified GLA (and Other PUFAs) for Cancer
. 566
PUFAs+Growth Factors for Cancer
. 567
PUFAs for Rheumatological Conditions
. 568
Index
. 575 |
| any_adam_object | 1 |
| author | Das, Undurti N. |
| author_GND | (DE-588)140907246 |
| author_facet | Das, Undurti N. |
| author_role | aut |
| author_sort | Das, Undurti N. |
| author_variant | u n d un und |
| building | Verbundindex |
| bvnumber | BV037189207 |
| classification_rvk | XG 2100 |
| ctrlnum | (OCoLC)706990609 (DE-599)DNB1007589906 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV037189207 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T10:56:50Z |
| institution | BVB |
| isbn | 9400704941 9789400704947 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021103654 |
| oclc_num | 706990609 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XX, 583 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer |
| record_format | marc |
| spelling | Das, Undurti N. Verfasser (DE-588)140907246 aut Molecular basis of health and disease Undurti N. Das Dordrecht [u.a.] Springer 2011 XX, 583 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 s DE-604 Erscheint auch als Online-Ausgabe 978-94-007-0495-4 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Das, Undurti N. Molecular basis of health and disease Molekularpathologie (DE-588)4170396-0 gnd |
| subject_GND | (DE-588)4170396-0 |
| title | Molecular basis of health and disease |
| title_auth | Molecular basis of health and disease |
| title_exact_search | Molecular basis of health and disease |
| title_full | Molecular basis of health and disease Undurti N. Das |
| title_fullStr | Molecular basis of health and disease Undurti N. Das |
| title_full_unstemmed | Molecular basis of health and disease Undurti N. Das |
| title_short | Molecular basis of health and disease |
| title_sort | molecular basis of health and disease |
| topic | Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | Molekularpathologie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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