Verfügbarkeit: Molecular basis of health and disease

Molecular basis of health and disease:

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	Das, Undurti N. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Dordrecht [u.a.] Springer 2011
Schlagworte:	Molekularpathologie
Online-Zugang:	Inhaltstext Inhaltsverzeichnis
Beschreibung:	XX, 583 S. Ill., graph. Darst.
ISBN:	9400704941 9789400704947

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV037189207
003	DE-604
005	20110517
007	t
008	110127s2011 gw ad\|\| \|\|\|\| 00\|\|\| eng d
015			\|a 10,N42 \|2 dnb
016	7		\|a 1007589906 \|2 DE-101
020			\|a 9400704941 \|9 94-007-0494-1
020			\|a 9789400704947 \|9 978-94-007-0494-7
024	3		\|a 9789400704947
028	5	2	\|a Best.-Nr.: 80027483
035			\|a (OCoLC)706990609
035			\|a (DE-599)DNB1007589906
040			\|a DE-604 \|b ger \|e rakddb
041	0		\|a eng
044			\|a gw \|c XA-DE-BE
049			\|a DE-355
084			\|a XG 2100 \|0 (DE-625)152788:12905 \|2 rvk
084			\|a 610 \|2 sdnb
100	1		\|a Das, Undurti N. \|e Verfasser \|0 (DE-588)140907246 \|4 aut
245	1	0	\|a Molecular basis of health and disease \|c Undurti N. Das
264		1	\|a Dordrecht [u.a.] \|b Springer \|c 2011
300			\|a XX, 583 S. \|b Ill., graph. Darst.
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
650	0	7	\|a Molekularpathologie \|0 (DE-588)4170396-0 \|2 gnd \|9 rswk-swf
689	0	0	\|a Molekularpathologie \|0 (DE-588)4170396-0 \|D s
689	0		\|5 DE-604
776	0	8	\|i Erscheint auch als \|n Online-Ausgabe \|z 978-94-007-0495-4
856	4	2	\|m X:MVB \|q text/html \|u http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm \|3 Inhaltstext
856	4	2	\|m Digitalisierung UB Regensburg \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
943	1		\|a oai:aleph.bib-bvb.de:BVB01-021103654

Datensatz im Suchindex

_version_	1805095284613578752
adam_text	Contents 1 Introduction . , . 1 Measuring Health and Disease . 2 Is There a Better Definition of Health? . 5 Determinants of Health . 6 Maintaining Health . 6 Observations of Daily Living . 6 Social Activity . 6 Hygiene . 7 Stress Management . 7 HealthCare . 7 Workplace Wellness Programs . 7 Public Health . 8 Role of Science in Health . 9 Applied Health Sciences . 9 2 Health and Disease as Two Sides of the Same Coin . U Low-Grade Systemic Inflammation Occurs in Many Diseases . 11 3 Inflammation . 15 Introduction . 15 Phases of Inflammatory Response . 16 Components of Acute Inflammation . 17 Vascular Changes . 18 Cellular Events . 23 Mediators of Inflammation . 34 Histamine . 35 Serotonin .-. 37 Effects of Food Content . 40 Location of Serotonergic Neurons . 42 5-HT Receptors .·. 42 Serotonylation . 43 Biosynthesis of Serotonin . 43 Contents Drugs Targeting the 5-НТ System . 43 Serotonin Modulates Inflammation and Immune Response . 44 Dopamine . 45 Catecholamines . 46 Acetylcholine . 48 Melanocortin . 48 Leptin . 49 NeuropeptideY . 50 Ghrelin . 51 Gut Peptides . 53 Cholecystokinin . 54 Kinins . 56 Essential Fatty Acids and Their Products . 58 Cyclo-oxygenase (COX), Lipoxygenase (LO) Pathways and Generation of Lipoxins, Resolvins, Protectins and Maresins . 59 Aspirin-triggered 15 Epimer LXs (ATLs) and Resolvins and Formation of Protectins and Maresins . 62 Platelet Activating Factor (PAF) . 63 Cytokines in Inflammation . 65 Chemokines in Inflammation . 66 Nitric Oxide (NO) . 67 NO is an Endogenous Anti-infective Molecule . 69 NO and Cellular Senescence . 70 NO and Brain-derived Neurotrophic Factor (BDNF) . 71 Leukocyte Lysosomal Enzymes . 72 Reactive Oxygen Species (ROS) . 73 Neuropeptides in Inflammation . 74 Obesity, type 2 diabetes, hypertension, hyperlipidemia, insulin resistance, Alzheimer's disease, depression, schizophrenia and cancer are low-grade systemic inflammatory conditions . 74 Diagnosis of Low-grade Systemic Inflammation . 76 Hs-CRP . 76 Cytokines and Chemokines . 77 Conventional Markers of Inflammation . 78 Role of Pro-inflammatory Markers in the Pathophysiology of the Low-grade Systemic Inflammatory Conditions . 78 Essential Fatty Adds — Biochemistry, Physiology and Clinical Significance . 101 Introduction . 101 Metabolism of EFAs . 102 The n-6 Polyunsaturated Fatty Acids . 102 The n-3 Polyunsaturated Fatty Acids . 105 Dietary Sources of EFAs . 109 Contents xiii The Activities of Δ6 and Δ5 Desaturases Are Low in Humans . 110 Modulators of EFAs/PUFAs Metabolism . Ill Protein and Insulin Augment Δ6 Desaturase Activity . Ill Ageing and Season Influence Δ6 Desaturase Activity . 112 Oncogenic Viruses, Radiation, SREBP and PPARs Influence EFA Metabolism . 112 Statins Enhance EFA Metabolism . 113 Trans-fats, Saturated Fats and Cholesterol Inhibit Δ6 Desaturase . 113 Zinc Modifies EFA and PG Metabolism . 114 Magnesium is an Essential Co-factor for Normal Δ6 Desaturase . 115 Calcium Enhances PGI2 Synthesis and Interacts with PUFAs . 116 Vitamin С and Ethanol Enhance the Formation of PGEi . 117 Actions of EFAs/PUFAs and Their Metabolites . 117 Cell Membrane Fluidity . 117 EFAs/PUFAs Have Second Messenger Actions . 119 PUFAs Behave as Endogenous Anti-infective Molecules . 120 PUFAs Inhibit ACE Activity and Enhance Endothelial Nitric Oxide Generation . 122 PUFAs and Cytokines . 124 PUFAs Decrease HMG-CoA Reducíase Activity . 126 Lipoxins, Resolvins, Protectins and Maresins . 127 NO Reacts with PUFAs to Yield Nitrolipids . 129 Formation of Nitro Fatty Acids (Nitrolipids) in Tissues . 134 Actions of Nitro Fatty Acids (Nitrolipids) . 136 Interaction^) Among n-3, n-6 Fatty Acids, NO and Nitrolipids . 138 5 Cell Membrane Organization . 153 Introduction . 153 Fluid Mosaic Model of the Membrane . 153 The Phospholipid (PL) Bilayer—Its Structure, Properties and Functions . 154 Cell Membrane Properties . 158 Integral Membrane Proteins . 159 Cell Membrane-Cytoskeleton Integration . 159 Cell Membrane Lipids . 160 Plasma Membrane Carbohydrates . 161 Plasma Membrane Proteins . 161 Cell Membrane Permeability . 162 Lipid Rafts, Caveolae and Polyunsaturated Fatty Acids (PUFAs) . 166 6 Low-grade Systemic Inflammation is Present in Common Diseases/Disorders . 175 Introduction . 175 Low-grade Systemic Inflammation is Present in Chronic Diseases . 177 Contents Obesity . 181 Definition of Obesity . 182 Incidence and Prevalence of Obesity . 182 Obesity May Be Familial . 183 Fast Food Industry and Obesity . 183 Obesity Is Harmful . 184 Genetic and Non-genetic Factors Contributing to Obesity . 185 Gene Expression Profile in Obesity . 186 All Adipose Cells are Not the Same . 187 Biochemical and Functional Differences Between Adipose Cells of Different Regions . 188 Intramyocellular Lipid (IMCL) Droplets and Perilipins . 189 Perilipins and Inflammation . 189 Low Grade Systemic Inflammation Occurs in Obesity . 190 Weight Loss Ameliorates Inflammation . 192 Adipose Tissue Macrophages (ATMs) and Inflammation . 193 Macrophage Differentiation Is Dependent on Fatty Acid Synthesis . 194 Fatty Acid Metabolism Enhances Τ Cell Memory . 195 What Causes Abdominal Obesity — How and Why? . 198 Excess H/i-hydroxysteroidDehydrogenaseType 1 (11^-HSD-l) Enzyme Activity May Cause Abdominal Obesity . 198 Interaction Among llß-HSD-l, TNF -α and Insulin . 199 Glucocorticoids and Perilipins . 201 Glucocorticoids, TNF-a, and Inflammation . 202 Diet, Genetics, Inflammation and Obesity . 203 Gut and Obesity . 205 Perinatal Nutritional Environment Influences Development of Obesity . 206 Obesity and Type 2 Diabetes Mellitus as Disorders of the Brain . 206 Cross-Talk Between the Liver, Adipose Tissue and the Brain Through Vagus . 207 Cross-Talk Between the Liver and Pancreatic β Cells is Mediated by the Vagus . 207 The Gut-Brain-Liver Axis Circuit is Activated by Long-Chain Fatty Acids . 208 BDNF and Obesity . 211 Interaction^) Among Insulin, Melanocortin, and BDNF . 212 Ghrelin, Leptin, and BDNF . 213 Obesity and Type 2 Diabetes Mellitus Are Inflammatory Conditions . 213 BDNF and Inflammation . 214 Gut Bacteria and Obesity . 215 Gut Flora . 215 Gut Bacteria Are Different in the Lean and Obese . 216 Gut Bacteria and GPR41 . 217 Contents xv Diet, Low-Grade Systemic Inflammation, and Obesity . 219 Gastric Bypass Surgery for Obesity Alters Gut Bacteria and Hypothalamic Factors . 219 Insulin Acts Not only on Peripheral Tissues but Also in the Brain . 220 Interaction Between PUFAs and BDNF and its Relationship to Obesity . 221 Diet, Gut Peptides and Hypothalamic Neurotransmitters in Obesity . 221 8 Hypertension . 239 Introduction . 239 Nutritional Factors in the Pathobiology of HTN . 240 Interaction^) Between Minerals, Trace Elements, Vitamins and Essential Fatty Acids . 241 Salt, Calcium, NO, and Hypertension . 242 Asymmetrical Dimethylarginine and Hypertension . 243 NO, ADMA and Oxidative Stress in Preeclampsia . 243 VEGF, Endoglin, Placental Growth Factor, TGF-ß, Catechol-O-methyltransferase Activity and Preeclampsia . 246 Homocysteine and Endothelial Damage . 248 Nutritional Factors, Oxidant Stress and Endothelial Dysfunction . 249 Increased Oxidant Stress Occurs in Hypertension . 250 Superoxide Anion Production Is Increased in Hypertension: How and Why? . 251 Superoxide Anion and Hypertension . 252 NO and Hypertension . 252 Cyclosporine Increases Blood Pressure by Augmenting O¿~ · Generation . 253 Anti-hypertensive Drugs Enhance eNO Synthesis and Show Antioxidant Property . 253 Transforming Growth Factor-jS (TGF-ß) in Hypertension . 255 Essential Fatty Acids and Blood Pressure . 256 Free Radicals, NO, ACE Activity and Essential Hypertension . 257 Essential Fatty Acids and Hypertension . 259 Low-grade Systemic Inflammation Occurs in Hypertension . 262 Does Adult Hypertension have its Origins in the Perinatal Period? . 262 9 Insulin Resistance, Dyslipidemia, Type 2 Diabetes Mellitus and Metabolic Syndrome . 277 Introduction . 277 Metabolic Syndrome . 278 Metabolic Syndrome Is an Inflammatory Condition . 279 Why Abdominal Obesity Occurs? . 279 Glucose Is Pro-inflammatory in Nature . 280 Insulin Is Anti-inflammatory in Nature . 281 xvi Contents Endothelial Nitric Oxide in Metabolic Syndrome . 281 Perinatal Origins of Metabolic Syndrome . 284 Hypothalamic Neuropeptides and Food Intake . 286 Appetite Regulatory Centers Are in Place During Perinatal Period and Fine-tuned/Programmed by Maternal and Perinatal Factors . 286 Ventromedial Hypothalamus may have a Role in the Development of Type 2 Diabetes Mellitus . 288 Insulin Receptors in the Brain and the Metabolic Syndrome . 290 Mechanism of Action of Insulin Receptors in the Brain and Elsewhere . 291 Insulin, GLUT-4 and Glucose Transport . 297 Muscle-specific GLUM Knockout Mice (MG4KO) . 297 Fat-specific GLUT-4 Knockout Mice . 299 PUFAs, Expression of Insulin Receptors and GLUTs and Diabetes Mellitus . 300 Polygenic Knockout Models . 302 Triple Heterozygous Knockouts (IR/IRS-1/P85) . 302 Weight Loss After Gastric Bypass and Changes in Hypothalamic Neuropeptides and Monoamines . 304 Monoaminergic Amines and Hypothalamic and Gut Peptides and Inflammation . 305 Dopamine . 305 Serotonin (5-hydroxytryptamine) . 306 Neuropeptide Y. 307 Ghrelin . 308 Melanocortin . 310 Acetylcholine . 311 Adrenaline and Noradrenaline . 311 Gut Peptides . 312 Leptin . 313 Cholecystokinin . 314 Neurotransmitters and Gut Peptides as Modulators of Inflammation and Immune Response . 315 10 Atherosclerosis . 333 Introduction . 333 Atherosclerosis Is a Low-grade Systemic Inflammatory Condition . 334 Mediators of Inflammation in Atherosclerosis . 335 Cross Talk Among Platelets, Leukocytes and Endothelial Cells . 337 Lipoxins in Rheumatoid Arthritis . 338 Leukocytes and Atherosclerosis . 340 Uncoupling Protein- 1, Essential Fatty Acids, and Atherosclerosis . 341 Contents xvii PUFAs of ω -З and ω-6 Series, Trans-fats, Saturated Fats, Cholesterol and Their Role in Atherosclerosis . 342 Atheroprotective Actions of ω -Ъ and ω -б Fatty Acids . 343 Effects on Endothelial Function . 344 PUFAs Inhibit Angiotensin-converting Enzyme (ACE) Activity and Augment Endothelial Nitric Oxide Generation . 345 PUFAs Suppress the Production of Pro-inflammatory Cytokines . 346 Effects on HMG-CoA Reducíase Enzyme . 346 11 Osteoporosis . 359 Introduction . 359 Dietary Protein and Osteoporosis . 359 Magnesium and Osteoporosis . 361 Osteoporosis Is a Low-grade Systemic Inflammatory Condition . 361 Nitric Oxide in Osteoporosis . 364 Post-menopausal Osteoporosis, Cytokines and NO . 366 Dose Dependent Action of NO on Bone . 366 Anti-diabetic Drag Metformin, NO and Osteoporosis . 368 Polyunsaturated Fatty Acids and Osteoporosis . 369 12 Alzheimer's Disease, Schizophrenia and Depression . 377 Introduction . 377 Pathobiology of Alzheimer's Disease . 377 Amyloid β in AD . 379 Oxidative Stress Causes Neuronal Death . 379 Alzheimer's is an Inflammatory Condition . 380 Cholinergic System in Alzheimer's Disease . 381 Neurotrophic Factors and AD . 382 PUFAs in Alzheimer's Disease . 384 PUFAs and Neurogenesis and Neurite Outgrowth . 385 Interaction^)BetweenPUFAsandBDNF . 387 Schizophrenia . 390 Prenatal and Perinatal Factors on Psychopathology . 390 Early Fetal Environment and Development and Schizophrenia . 391 Maternal Infections and Schizophrenia . 392 Is Schizophrenia an Inflammatory Condition? . 393 PUFAs and Their Metabolites and Schizophrenia . 393 Depression . 395 Depression May Be Associated with Low BDNF Levels . 396 BDNF and Serotonin Interact with Each Other . 397 BDNF and Inflammation . 398 Serotonin and Catecholamines Modulate Inflammation . 399 Depression is an Inflammatory Condition . 399 Depression and PUFAs . 400 xv¡jj Contents 13 Rheumatological Conditions . 417 Introduction . 417 Autoimmunity . 418 Self and Non-self and Immunological Tolerance . 418 Genetic Factors . 419 Gender . 420 Environmental Factors . 422 Pathogenesis of Autoimmunity . 423 Systemic Lupus Erythematosus . 427 Pathobiology of Inflammation with Emphasis on Chronic Inflammation . 428 Components and Mediators of the Inflammatory Response . 429 Cytokines in Inflammation . 431 Inflammatory and Anti-inflammatory Molecules and Antioxidants in Lupus . 432 TGF-ß in Scleroderma and Lupus . 434 Immune Dysfunction in Lupus . 434 Loss of Self-tolerance in Lupus . 435 UV Radiation, Immune Response, Mast Cells and its Role in Lupus . 438 Mast Cells in Rheumatological Conditions . 439 PLA2, TNF-a, MIF and Pro- and Anti-inflammatory Lipids . 440 Glucocorticoids, COX Enzymes, LTs, Cytokines, NO, LXs, and Inflammation . 444 Cell Membrane Fatty Acid Content Could Modulate Inflammation and Repair . 448 Nitric Oxide, Lipid Peroxides, and Antioxidant Status in Lupus . 449 Oxidant Stress, Anti-oxidants, NO and PUFAs in Lupus . 450 1,25-dihydroxy vitamin D3 Suppresses Autoimmunity . 451 ADMA is Useful in Lupus and Other Rheumatological Conditions . 452 14 Cancer . 465 Tobacco and Cancer . 466 Infection and Cancer . 466 Tobacco and Inflammation . 467 Inflammation of Chronic Infections and Cancer are due to TNF-a andIL-1 . 468 Glucose Sensing by Neuronal and Tumor Cells and Its Relationship to ATP-Sensitive K+ Channels and ROS . 470 Eicosanoids, Free Radicals and Inflammation in Cancer . 473 PUFAs, Pro- and Anti-inflammatory Metabolites of PUFAs and Lipid Peroxidation and Cancer . 474 Free Radicals Have both Beneficial and Harmful Actions . 475 Lipid Peroxidation in Tumor Cells . 476 Contents xix PUFA Deficiency Exists in Tumor Cells . 476 Superoxide Dismutase and Free Radicals in Tumor Cells . 477 Free Radicals Induce Translocation of p53 . 478 Oxidant Stress and Telomere . 479 Bcl-2 Opposes the Action of p53 . 479 Polyunsaturated Fatty Acids Inhibit Cell Proliferation by Augmenting Free Radical Generation and Lipid Peroxidation. 480 Normal and Tumor Cells May Process PUFAs Differentially . 481 15 Aging . 491 Introduction . 491 Telomere and Aging . 492 Theories of Aging . 492 Telomere and Aging . 493 Telomere in Type 2 Diabetes Mellitus . 495 Telomere and Hypertension . 497 Endothelial Dysfunction, Insulin Resistance, Obesity, Hypertension, Type 2 Diabetes, Inflammation and Telomere . 498 PUFAs and Their Anti-inflammatory Products and Telomere . 499 P53, Telomere, Aging, Type 2 Diabetes Mellitus, Cancer . 500 Other Theories of Aging . 504 Aging is a Low-grade Systemic Inflammatory Condition . 504 Exercise is Anti-inflammatory in Nature . 506 16 Adult Diseases and Low-Grade Systemic Inflammation Have Their Origins in the Perinatal Period . 513 Introduction . 513 When and How the Inflammatory Process is Initiated? . 515 Perinatal Programming of Adult Diseases . 515 Factors Influencing the Metabolism of EFAs . 516 PUFAs Modulate Glucose and Glutaminę Uptake and Their Metabolism . 517 PUFAs, Insulin, and Acetylcholine Function as Endogenous Cyto- and Neuroprotectors . 519 PUFAs in Brain Growth and Development . 521 Syntaxin, SNARE Complex andPUFAs . 521 PUFAs Modulate RAR-RXR and Other Nuclear Receptors and are Essential for Brain Growth and Development . 522 PUFAs Modulate Gene Expression and Interact with Cytokine TNF-a and Insulin to Influence Neuronal Growth and Synapse Formation . 525 Neurogenesis and Neuronal Movement During the Growth and Development of Brain and PUFAs _. 527 Insulin, PUFAs and Neuronal Proliferation . 528 xx Contents Catenin, wnt and Hedgehog Signaling Pathway in Brain Growth and Development and PUFAs . 529 PUFAs Modulate NMDA, y-Aminobutyric Acid (GABA), Serotonin and Dopamine in the Brain . 532 Maternal Diet Influences EFA Metabolism and Leptin Levels . 536 Perinatal PUFA Deficiency May Initiate Low-Grade Systemic Inflammation and Adult Diseases . 537 17 Clinical Implications . 551 Introduction . 551 Glucose-Insulin-Potassium Regimen . 552 Ethyl Pyravate . 555 Lipid-enriched Albumin . 556 Vagai Nerve Stimulation (VNS) Suppresses Inflammation . 558 VNS for Obesity, Hypertension, Type 2 Diabetes Mellitus and Metabolic Syndrome . 559 Lipoxins, Resolvins, Protectins or Their Synthetic Analogues . 562 Ghrelin . 563 PUFAs as Potential Anti-cancer Drugs . 563 PUFAs, Especially GLA, for Glioma . 565 Modified GLA (and Other PUFAs) for Cancer . 566 PUFAs+Growth Factors for Cancer . 567 PUFAs for Rheumatological Conditions . 568 Index . 575
any_adam_object	1
author	Das, Undurti N.
author_GND	(DE-588)140907246
author_facet	Das, Undurti N.
author_role	aut
author_sort	Das, Undurti N.
author_variant	u n d un und
building	Verbundindex
bvnumber	BV037189207
classification_rvk	XG 2100
ctrlnum	(OCoLC)706990609 (DE-599)DNB1007589906
discipline	Medizin
format	Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV037189207</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20110517</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">110127s2011 gw ad\|\| \|\|\|\| 00\|\|\| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">10,N42</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1007589906</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9400704941</subfield><subfield code="9">94-007-0494-1</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789400704947</subfield><subfield code="9">978-94-007-0494-7</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9789400704947</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">Best.-Nr.: 80027483</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)706990609</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1007589906</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XG 2100</subfield><subfield code="0">(DE-625)152788:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Das, Undurti N.</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)140907246</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular basis of health and disease</subfield><subfield code="c">Undurti N. Das</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Dordrecht [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XX, 583 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekularpathologie</subfield><subfield code="0">(DE-588)4170396-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Molekularpathologie</subfield><subfield code="0">(DE-588)4170396-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="z">978-94-007-0495-4</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">X:MVB</subfield><subfield code="q">text/html</subfield><subfield code="u">http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm</subfield><subfield code="3">Inhaltstext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-021103654</subfield></datafield></record></collection>
id	DE-604.BV037189207
illustrated	Illustrated
indexdate	2024-07-20T10:56:50Z
institution	BVB
isbn	9400704941 9789400704947
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-021103654
oclc_num	706990609
open_access_boolean
owner	DE-355 DE-BY-UBR
owner_facet	DE-355 DE-BY-UBR
physical	XX, 583 S. Ill., graph. Darst.
publishDate	2011
publishDateSearch	2011
publishDateSort	2011
publisher	Springer
record_format	marc
spelling	Das, Undurti N. Verfasser (DE-588)140907246 aut Molecular basis of health and disease Undurti N. Das Dordrecht [u.a.] Springer 2011 XX, 583 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 s DE-604 Erscheint auch als Online-Ausgabe 978-94-007-0495-4 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Das, Undurti N. Molecular basis of health and disease Molekularpathologie (DE-588)4170396-0 gnd
subject_GND	(DE-588)4170396-0
title	Molecular basis of health and disease
title_auth	Molecular basis of health and disease
title_exact_search	Molecular basis of health and disease
title_full	Molecular basis of health and disease Undurti N. Das
title_fullStr	Molecular basis of health and disease Undurti N. Das
title_full_unstemmed	Molecular basis of health and disease Undurti N. Das
title_short	Molecular basis of health and disease
title_sort	molecular basis of health and disease
topic	Molekularpathologie (DE-588)4170396-0 gnd
topic_facet	Molekularpathologie
url	http://deposit.dnb.de/cgi-bin/dokserv?id=3549204&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021103654&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT dasundurtin molecularbasisofhealthanddisease

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Beschreibung

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge