Epilepsy: mechanisms, models, and translational perspectives
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla. [u.a.]
CRC Press
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XXII, 646 S. Ill., graph. Darst. |
| ISBN: | 9781420085594 142008559X |
Internformat
MARC
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| 245 | 1 | 0 | |a Epilepsy |b mechanisms, models, and translational perspectives |c ed. by Jong M. Rho ... |
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| 300 | |a XXII, 646 S. |b Ill., graph. Darst. | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-021094759 | ||
Datensatz im Suchindex
| _version_ | 1804143761017536513 |
|---|---|
| adam_text | Contents
Preface
...............................................................................................................................................xi
Editors............................................................................................................................................xiii
Contributors
.....................................................................................................................................xv
Introduction
.....................................................................................................................................xxi
SECTION I Scientific Foundations
Chapter
1
Pathophysiological Mechanisms of Seizures and Epilepsy: A Primer
........................3
Carl E. Stafstrom
Chapter
2
Blood-Brain Barrier, Blood Flow, Neoplasms,
and Epilepsy: The Role of Astrocytes
........................................................................21
Luca Cuculio,
Nicola
Marchi,
Vincent Fazio,
Minh-Tri Nguxen, and Damir Janigro
Chapter
3
Metabolic Regulation of Seizures and Epileptogenesis
.............................................35
Μα η
is
ha Patel
Chapter
4
Brain Inflammation and Epilepsy
..............................................................................45
Teresa Ravizza, Silvia Balosso,
Eleonora
Aronica, and
Annamaria
Vezzani
Chapter
5
Drug Resistance in Epilepsy and Status Epilepticus
..................................................61
Jaideep Kapur and Edward H. Bertram
Chapter
6
Epilepsy with Complex Genetics: Looking Beyond the Channelopathies
.................83
Asuri
N.
Prasad
and Chitra
Prasad
Chapter
7
Pathophysiology of Developmental Epilepsies
.........................................................103
Judith L.Z.
Weisenberg
and Michael Wong
SECTION II Antiepileptic Drugs
Chapter
8
Mechanisms of Antiepileptic Drug Action
..............................................................123
Timothx
A. Simeoné
Chapter
9
Epilepsy and Disease Modification:
Animal Models for Novel Drug Discovery
..............................................................143
H. Steve White
vii
viii Contents
Chapter
10
Pharmacogenetics of
AED
Development
.................................................................159
Russell
J
Buono,
Thomas
N.
Ferrare,
Dennis
J.
Dlugos, and Karen S. Wilcox
Chapter
11
Neuroprotective Strategies Using Antiepileptic Drugs
............................................173
Patrick G. Sullivan and Ryan D. Readnower
Chapter
12
Posttraumatic Seizures and Epileptogenesis: Good and Bad Plasticity
...................181
Christopher C.
Giza
Chapter
13
Possible Roles of Nonsynaptic Mechanisms in Synchronization
of Epileptic Seizures: Potential Antiepileptic Targets?
............................................209
F. Edward
Dudek,
Li-Rong Shao, and John E. Rash
Chapter
14
A Mechanistic Approach to Antiepileptic Drug Interactions
..................................229
Gail D. Anderson
SECTION III Epilepsy Surgery
Chapter
15
Advances in Structural and Functional Neuroimaging:
How Are These Guiding Epilepsy Surgery?
............................................................257
Hyunmi Kim, A. LeBron Paige, and Robert C. Knowlton
Chapter
16
Magnetoencephalography in Clinical Epilepsy:
A Translational Viewpoint
.......................................................................................283
Jerry J. Shih and Michael P.
Weisend
Chapter
17
What Have We Learned from Resective Surgery
in
Pediatrie
Patients with Cortical Dysplasia?
.........................................................301
Carlos
Cepeda
and Gary W.
Mathern
Chapter
18
Nonsurgical Ablation for Epilepsy
...........................................................................319
Erich O.
Richter,
Marina V. Abramova, William A. Friedman, and Steven
N.
Roper
Chapter
19
Deep Brain Stimulation for Epilepsy
.......................................................................345
Francisco Velasco,
Ana Luisa Velasco, Luisa Rocha,
Marcos Velasco,
Jose D. Carrillo-Ruiz, Manoela Cuellar,
Guillermo
Castro,
Fiacro Jimenez, and David Trejo
Chapter
20
Optical Imaging Techniques in
Pediatrie Neocortical
Epilepsy
..............................361
Daryl W. Hochman and Michael M.
Haglund
Chapter
21
High-Frequency Oscillations in Epileptic Brain
......................................................367
S. Matt Stead, Mark Bower, and Greg Worrell
Contents ix
SECTION
IV
Alternative
Therapies
Chapter
22
Special Treatments in Epilepsy
................................................................................381
Kevin Chapman and James W. Wheless
Chapter
23
Herbs and Botanicals
...............................................................................................407
Steven C.
Schachter
Chapter
24
The Ketogenic Diet: Scientific Principles Underlying Its Use
.................................417
Kristopher J. Bough and Carl E. Stafstrom
Chapter
25
Vagus Nerve Stimulation
..........................................................................................441
Matthew M. Troester and Dean K. Naritoku
Chapter
26
Antiinflammatory Treatments for Seizure Syndromes and Epilepsy
......................459
Stephane
Auvin and Raman Sankar
SECTION V Other Modulators of the Epileptic State
Chapter
27
Impact of
Neuroendocrine
Factors on Seizure Genesis and Treatment
...................475
Pavel Klein and
Jaromír Janoušek
Chapter
28
Neurosteroid Replacement Therapy for Catamenial Epilepsy
.................................501
Doodipala S. Reddy and Michael A.
Rogowski
Chapter
29
Chronobiology and Sleep: Implications for Seizure Propensity
..............................515
Mark Quigg
Chapter
30
Pediatrie
Epilepsy: A Developmental
Neuropsychiatrie
Disorder
...........................535
Rochelle Caplan
SECTION VI The Future of Epilepsy Therapy
Chapter
31
Novel Mechanisms of Drug Delivery
.......................................................................551
Vijay
haturi
and James Cloxd
Chapter
32
Early Seizure Detection: Considerations and Applications
.....................................573
Christophe
С.
Jouny,
Piotr
J.
Franaszczuk, and Gregory
К.
Bergey
x
Contents
Chapter
33
Gene and Stem Cell Therapies for Treating Epilepsy
..............................................589
Janice R. Naegele andXu Maisano
Chapter
34
Arresting Epileptogenesis: The Current Challenge
.................................................609
Philip A. Schwartzkroin
Index
..............................................................................................................................................627
Neuroscience
EPILEPSY
Mechanisms, Models, and
Translational Perspectives
Edited by Jong M. Rho
Raman Sankar
·
Carl E. Stafstrom
Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century,
that significant progress has been made in our basic understanding of the epileptic brain. Pivotal
advances in drug development and surgical techniques, as well as the emergence of innovative
approaches such as electrical stimulation of the nervous system, have led to a substantial reduction
in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments
in
neuroscience
have enhanced our understanding of brain structure and function.
Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational
advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It
brings togetherthe work of more than
70
of the field s most respected and cutting-edge researchers
and clinicians. In
24
chapters, this extraordinarily comprehensive and current work
—
•
Offers an overview of the basic anatomic and functional substrates of seizure genesis and
considers novel pathogenic concepts that have both emerged and been validated experimentally
•
Examines antiepileptic drug therapy, including the latest on molecular targets
•
Looks at the state of surgical treatments for epilepsy and discusses advances in the fields
of structural and functional neuroimaging
•
Reviews the variety of
nontraditional
therapeutic options, such as the ketogenic diet, the
vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
•
Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure
susceptibility
—
information that can be incorporated into the design of treatment algorithms
on an individualized basis
•
Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms
of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods,
to the ultimate goal of disease prevention.
The idea for this book was inspired by the editors collective desire to promote bridging of the
so-called translational divide
—
that is, covering innovative treatment strategies based on scientific
principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners
with new and promising approaches toward epilepsy therapeutics.
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| spelling | Epilepsy mechanisms, models, and translational perspectives ed. by Jong M. Rho ... Boca Raton, Fla. [u.a.] CRC Press 2010 XXII, 646 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Epilepsie (DE-588)4015035-5 gnd rswk-swf Epilepsie (DE-588)4015035-5 s DE-604 Rho, Jong M. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021094759&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021094759&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Epilepsy mechanisms, models, and translational perspectives Epilepsie (DE-588)4015035-5 gnd |
| subject_GND | (DE-588)4015035-5 |
| title | Epilepsy mechanisms, models, and translational perspectives |
| title_auth | Epilepsy mechanisms, models, and translational perspectives |
| title_exact_search | Epilepsy mechanisms, models, and translational perspectives |
| title_full | Epilepsy mechanisms, models, and translational perspectives ed. by Jong M. Rho ... |
| title_fullStr | Epilepsy mechanisms, models, and translational perspectives ed. by Jong M. Rho ... |
| title_full_unstemmed | Epilepsy mechanisms, models, and translational perspectives ed. by Jong M. Rho ... |
| title_short | Epilepsy |
| title_sort | epilepsy mechanisms models and translational perspectives |
| title_sub | mechanisms, models, and translational perspectives |
| topic | Epilepsie (DE-588)4015035-5 gnd |
| topic_facet | Epilepsie |
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