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RNA exosome:

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Format:	Buch
Sprache:	English
Veröffentlicht:	New York, NY Springer Science+Business Media [u.a.] 2010
Schriftenreihe:	Advances in experimental medicine and biology 702
Online-Zugang:	Inhaltstext Inhaltsverzeichnis
Beschreibung:	XVI, 146 S. Ill., graph. Darst.
ISBN:	9781441978400

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MARC


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adam_text	IMAGE 1 RNA EXOSOME EDITED BY TORBEN HEICK JENSEN, PHD CENTRE FOR MRNP BIOGENESIS AND METABOLISM, DEPARTMENT OF MOLECULAR BIOLOGY, AARHUS UNIVERSITY, AARHUS, DENMARK SPRINGER SCIENCE+BUSINESS MEDIA, LLC LANDES BIOSCIENCE IMAGE 2 CONTENTS 1. FINDING THE EXOSOME 1 PHIL MITCHELL AND DAVID TOLLERVEY ABSTRACT 1 INTRODUCTION 1 FROM NORTHERNS TO NUCLEASES 2 A GLIMPSE OF THE EXOSOME 3 THE COMPLETE COMPLEX 5 A BROADER PERSPECTIVE 6 CONCLUSION 6 2. STRUCTURAL COMPONENTS AND ARCHITECTURES OF RNA EXOSOMES 9 KURT JANUSZYK AND CHRISTOPHER D. LIMA ABSTRACT. 9 INTRODUCTION 9 GLOBAL STRUCTURE OF THE EXOSOME 11 RNASE PH-LIKE DOMAINS IN BACTERIAL, ARCHAEAL AND EUKARYOTIC CORE EXOSOMES 15 SI AND KH CONTAINING DOMAINS IN BACTERIAL, ARCHAEAL AND EUKARYOTIC CORE EXOSOMES 16 MECHANISM OF PHOSPHOROLYTIC ACTIVITY IN BACTERIAL PNPASE AND ARCHAEAL EXOSOMES 17 RRP44, A EUKARYOTIC EXOSOME SUBUNIT WITH HYDROLYTIC ENDORIBONUCLEASE AND PROCESSIVE EXORIBONUCLEASE ACTIVITIES 19 RRP44 PIN DOMAIN 19 RRP44 RNB DOMAIN 21 RRP44 AND THE 10-COMPONENT EXOSOME 22 RRP6, A EUKARYOTIC EXOSOME SUBUNIT WITH DISTRIBUTIVE HYDROLYTIC ACTIVITIES 23 RRP6 INTERACTIONS WITH THE EXOSOME CORE 25 CONCLUSION 25 IMAGE 3 XIV CONTENTS 3. THE ARCHAEAL EXOSOME 29 ELENA EVGUENIEVA-HACKENBERG ABSTRACT 29 INTRODUCTION 29 CORE SUBUNITS OF THE ARCHAEAL EXOSOME 30 STRUCTURE AND MECHANISM 31 PHYSIOLOGICAL FUNCTIONS 35 CONCLUSION 36 4. THE EXOSOMES OF TRYPANOSOMES AND OTHER PROTISTS 39 CHRISTINE CLAYTON AND ANTONIO ESTEVEZ ABSTRACT 39 INTRODUCTION: WHY STUDY THE EXOSOMES OF ORGANISMS OTHER THAN YEAST AND ANIMALS? 39 TRYPANOSOMES AS A MODEL SYSTEM FOR RNA PROCESSING AND TURNOVER 40 THE STRUCTURE OF THE TRYPANOSOME EXOSOME 41 THE POSITION OF RRP6 RELATIVE TO THE EXOSOME CORE 41 FUNCTIONS OF THE TRYPANOSOME EXOSOME IN THE NUCLEUS 43 FUNCTIONS OF THE TRYPANOSOME EXOSOME IN THE CYTOPLASM 44 CONSERVATION OF THE EXOSOME IN EUKARYOTIC EVOLUTION 46 CONCLUSION 47 5. THE EXOSOME AND 3-5' RNA DEGRADATION IN PLANTS 50 HEIKE LANGE AND DOMINIQUE GAGLIARDI ABSTRACT 50 INTRODUCTION 50 COMPOSITION OF PLANT EXOSOME CORE COMPLEXES 51 FUNCTIONAL SPECIALISATION OF INDIVIDUAL SUBUNITS? 53 EXOSOME COFACTORS AND AUXILIARY PROTEINS IN PLANTS 55 RNA SUBSTRATES OF THE PLANT EXOSOME COMPLEX 56 IMPACT OF 3'-5' RNA DECAY ON PLANT GENOME EXPRESSION 57 IMPACT OF 3'-5' DEGRADATION IN ORGANELLES 58 CONCLUSION 59 6. CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME 63 ALEKSANDER CHLEBOWSKI, RAFAI TOMECKI, MARIA EUGENIA GAS LOPEZ, BERTRAND SERAPHIN, AND ANDRZEJ DZIEMBOWSKI ABSTRACT 63 INTRODUCTION 63 EXOSOME COMPOSITION 64 DIS3 66 RRP6 71 HOLOENZYME ACTIVITIES 71 NONCATALYTIC ACTIVITIES OF THE EXOSOME RING 74 CONCLUSION 76 IMAGE 4 CONTENTS XV 7. FUNCTIONS OF THE CYTOPLASMIC EXOSOME 79 DANEEN SCHAEFFER, AMANDA CLARK, A. ALEJANDRA KLAUER, BORISLAVA TSANOVA, AND AMBRO VAN HOOF ABSTRACT 79 INTRODUCTION 79 THE CYTOPLASMIC EXOSOME REQUIRES FOUR COFACTORS 80 THE EXOSOME FUNCTIONS IN ONE OF TWO GENERAL PATHWAYS FOR CYTOPLASMIC MRNA DEGRADATION 82 THE CYTOPLASMIC EXOSOME FUNCTIONS IN MRNA SURVEILLANCE 83 THE ANTIVIRAL FUNCTION OF THE CYTOPLASMIC EXOSOME 85 CONCLUSION AND FUTURE PERSPECTIVES 86 8. RRP6, RRP477 AND COFACTORS OF THE NUCLEAR EXOSOME 91 J. SCOTT BUTLER AND PHIL MITCHELL ABSTRACT 91 INTRODUCTION 91 STRUCTURE AND ACTIVITY OF RRP6 92 THE ROLE OF RRP6 IN THE MATURATION OF NONCODING RNAS 93 THE ROLE OF RRP6 IN MRNA SURVEILLANCE 94 THE ROLE OF RRP6 IN THE REGULATION OF MRNA LEVELS 94 RRP6 AND THE TRAMP COMPLEX 95 THE EXOSOME COFACTOR RRP47 96 STRUCTURE OF RRP47 96 BIOCHEMICAL ACTIVITIES OF RRP47 97 THE ROLE OF RRP47 IN RNA PROCESSING AND DEGRADATION 97 THE EXOSOME COFACTOR MPP6 99 CONCLUSION 100 9. THE EXOSOME AND HETEROCHROMATIN: MULTILEVEL REGULATION OF GENE SILENCING 105 SARAH COY AND LIDIA VASILJEVA ABSTRACT 105 INTRODUCTION 105 HETEROCHROMATIN 106 GENE SILENCING PATHWAYS: RNAI AND THE EXOSOME 108 MULTILEVEL REGULATION OF GENE EXPRESSION 112 REGULATING THE REGULATORS: HOW THE STABILITY OF NCRNAS DETERMINES THEIR FUNCTION IN HETEROCHROMATIN FORMATION 114 CONCLUSION 117 10. CONTROL OF CRYPTIC TRANSCRIPTION IN EUKARYOTES 122 MATHIEU ROUGEMAILLE AND DOMENICO LIBRI ABSTRACT 122 INTRODUCTION: NEW PERSPECTIVES ON THE SHAPE OF THE TRANSCRIPTOME 122 A DEDICATED PATHWAY OF NUCLEAR RNA DEGRADATION 123 WIDESPREAD TRANSCRIPTION IN EUKARYOTIC GENOMES 124 IMAGE 5 XVI CONTENTS TRANSCRIPTION TERMINATION AND THE HALLMARK OF CUTS INSTABILITY 125 AN RNAPII "CTD CODE" FOR THE FATE OF NASCENT TRANSCRIPTS 126 REGULATORY ROLES OF CRYPTIC TRANSCRIPTION 128 CONCLUSION 129 11. THE HUMAN EXOSOME AND DISEASE 132 RAYMOND H.J. STAALS AND GER J.M. PRUIJN ABSTRACT 132 INTRODUCTION 132 IDENTIFICATION OF THE PM/SD COMPLEX 133 AUTOANTIBODIES TO THE EXOSOME / PM/SCL-ANTIGEN 134 INITIATION OF THE ANTI-EXOSOME / PM/SCL AUTOIMMUNE RESPONSE 137 THE HUMAN EXOSOME AND CANCER 138 CONCLUSION 139 INDEX 143
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indexdate	2024-07-20T10:54:40Z
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isbn	9781441978400
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publisher	Springer Science+Business Media [u.a.]
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series	Advances in experimental medicine and biology
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spelling	RNA exosome ed. by Torben Heick Jensen. [Participants: J. Scott Butler ...] New York, NY Springer Science+Business Media [u.a.] 2010 XVI, 146 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 702 Jensen, Torben Heick Sonstige oth Butler, J. Scott Sonstige oth Advances in experimental medicine and biology 702 (DE-604)BV000003102 702 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3534099&prov=M&dok_var=1&dok_ext=htm Inhaltstext HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020803733&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	RNA exosome Advances in experimental medicine and biology
title	RNA exosome
title_auth	RNA exosome
title_exact_search	RNA exosome
title_full	RNA exosome ed. by Torben Heick Jensen. [Participants: J. Scott Butler ...]
title_fullStr	RNA exosome ed. by Torben Heick Jensen. [Participants: J. Scott Butler ...]
title_full_unstemmed	RNA exosome ed. by Torben Heick Jensen. [Participants: J. Scott Butler ...]
title_short	RNA exosome
title_sort	rna exosome
url	http://deposit.dnb.de/cgi-bin/dokserv?id=3534099&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020803733&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV000003102
work_keys_str_mv	AT jensentorbenheick rnaexosome AT butlerjscott rnaexosome

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