Regenerative medicine and biomaterials for the repair of connective tissues:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press [u.a.]
2010
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| Ausgabe: | 1. publ. |
| Schriftenreihe: | Woodhead publishing in materials
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 485 S. Ill., graph. Darst. |
| ISBN: | 9781845694173 9781439801109 9781845697792 |
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Datensatz im Suchindex
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| adam_text | Titel: Regenerative medicine and biomaterials for the repair of connective tissues
Autor: Archer, Charles W.
Jahr: 2010
Contents
Contributor contact details xiii
1 The structure and regenerative capacity of synovial
joint tissues 1
A.-M. Saamanen, University of Turku, Finland,
J.P.A.Arokoski, University of Kuopio and Kuopio
University Hospital, Finland, J.S. Jurvelin, University of
Kuopio, Finland and I. Kiviranta, University of Helsinki,
Finland
1.1 Introduction 1
1.2 Structure and function of synovial joint 2
1.3 Joint tissues and their biomechanical properties 4
1.4 Resident mesenchymal progenitor cells in synovial joint tissues 16
1.5 Conclusions and future trends 26
1.6 Sources of further information and advice 28
1.7 References 29
2 The myofibroblast in connective tissue repair and
regeneration 39
B. HlNZ, University of Toronto, Canada
2.1 Introduction 39
2.2 Myofibroblasts: humble tissue construction workers 41
2.3 Know thy enemy: a quick guide to identify the myofibroblast 44
2.4 Origins of the myofibroblast 46
2.5 Mesenchymal stem cells (MSC) and the myofibroblast
phenotype: regeneration, repair or risk? 49
2.6 What drives myofibroblast differentiation? 55
2.7 Lessons to be learned from the myofibroblast for the effective
use of mesenchymal stem cells (MSC) 60
2.8 Conclusions and future trends 62
2.9 References 63
vi Contents
Part I Cartilage repair and regeneration
3 The structure of articular cartilage 83
E. B. HUNZIKER, University of Bern, Switzerland
3.1 Introduction 83
3.2 General structure and function of articular cartilage 84
3.3 Dual function of immature articular cartilage during
postnatal growth 89
3.4 Physiological mechanism underlying the evolution of a mature
from an immature articular cartilage structure 95
3.5 Inter-species differences in articular cartilage structure, and
structure-function correlations in humans 98
3.6 References 101
4 Measuring the biomechanical properties of
cartilage cells 106
D. L. B A D E R and M. M. K NIG H T, Queen Mary University
of London, UK
4.1 Introduction 106
4.2 Measurement of chondrocyte biomechanics 107
4.3 Intracellular biomechanics 116
4.4 Biomechanical conditioning of chondrocytes 117
4.5 Future trends 129
4.6 Acknowledgements 130
4.7 References 130
5 Understanding tissue response to cartilage injury 137
F. Dell accio, Baits and The London School of Medicine
and Dentistry, UK and T. L. Vincent, Kennedy Institute
of Rheumatology, UK
5.1 Introduction 13 7
5.2 Clinical in vivo cartilage injury 138
5.3 Animal models of cartilage injury 143
5.4 In vitro cartilage injury 146
5.5 Conclusions 149
5.6 References 149
6 Understanding osteoarthritis and other cartilage
diseases 155
T. AiGNER, Medical Center Coburg, Germany,
N. Schmitz, University of Leipzig, Germany and
S. So DER, University of Erlangen-Nurnberg, Germany
6.1 Introduction 155
Contents vii
6.2 The normal joint 156
6.3 Major cartilage pathology and pathobiology 157
6.4 In vivo cartilage repair 165
6.5 Grading/scoring systems for cartilage degeneration 168
6.6 Grading/scoring of cartilage repair 170
6.7 Sources of further information and advice 173
6.8 Future trends 174
6.9 References 174
7 Using animal models of cartilage repair to screen
new clinical techniques 178
C.W. MclLWRAlTH, Colorado State University, USA
7.1 Introduction 178
7.2 Review of models in non-equine species 179
7.3 Early equine models of cartilage repair 181
7.4 Current models of cartilage repair in the equine femoropatellar
and femorotibial joints 185
7.5 Current status of animal models of cartilage repair 194
7.6 References and further reading 196
8 Cartilage tissue repair: autologous osteochondral
mosaicplasty 201
L. Hangody, Uzsoki Hospital, Hungary, G. Kish, Saint
George Medical, USA, T. Koreny, Pecs Medical School,
Hungary, L.R. Hangody, Semmelweis Medical School,
Hungary and L. MODIS, Debrecen Medical School, Hungary 201
8.1 Introduction 201
8.2 The development of the mosaicplasty resurfacing technique:
animal and other studies 202
8.3 Surgical technique: pre-operative planning 204
8.4 Surgical instruments and choice of surgical technique 204
8.5 Arthroscopic mosaicplasty 206
8.6 Conclusions 219
8.7 References 220
9 Cartilage tissue repair: autologous chondrocyte
implantation 227
M. Brittberg, University of Gothenburg, Sweden
9.1 Introduction 227
9.2 Chondrogeneic cell implantation 228
9.3 Articular or other types of chondrocytes, allogeneic or
autologous chondrocytes? 228
viii Contents
9.4 Autologous chondrocytes 230
9.5 Human clinical use and studies with autologous chondrocyte
implantation 233
9.6 Other joints besides the knee joint 239
9.7 Clinical follow-up results 239
9.8 Imaging evaluation of the cartilage repair 242
9.9 Randomised controlled studies 243
9.10 Chondrocyte implantation and osteoarthritis (OA) 244
9.11 Conclusions and future trends 245
9.12 Sources of further information and advice 246
9.13 References 246
10 Cell sheet technologies for cartilage repair 251
M. Sato, Tokai University School of Medicine, Japan
10.1 Introduction 251
10.2 Overview of present clinical applications 252
10.3 Challenge for cartilage repair 253
10.4 Properties of chondrocyte sheets 258
10.5 Future trends in cartilage repair 262
10.6 Regulations regarding regenerative medicine in Japan 262
10.7 References 263
11 Cell therapies for articular cartilage repair:
chondrocytes and mesenchymal stem cells 266
R. ANDRIAMANALIJAONA, University of Caen, France
11.1 Introduction 266
11.2 The chondrocyte: a unique cell 267
11.3 The macromolecular network and biomechanical properties of
cartilage 271
11.4 Phenotypic changes 273
11.5 Cell therapy for articular cartilage repair: chondrocytes
and mesenchymal stem cells (MSCs) 273
11.6 The use of chemical compounds to enhance matrix production 277
11.7 Strategies to maintain the chondrogenic phenotype: the use
of three-dimensional systems 279
11.8 Use of exogenous growth factors to promote chondrogenic
phenotype 281
11.9 Use of gene therapy to deliver chondrogenic factors 283
11.10 Control of chondrocyte phenotype and chondrogenesis by
hydrostatic pressure 284
11.11 Use of low oxygen tension in cartilage repair 285
11.12 Conclusions 289
11.13 Acknowledgements 291
Contents ix
11.14 References and further reading 292
12 Scaffolds for musculoskeletal tissue engineering 301
H. Li and J.H. Elisseeff, Johns Hopkins University, USA
12.1 Introduction 301
12.2 Cell types utilized for tissue regeneration 302
12.3 Scaffolds for engineering musculoskeletal tissue 306
12.4 Tissue remodeling 310
12.5 Matrix stimulation and cell-cell communications in tissue
regeneration 314
12.6 Future trends and perspectives 318
12.7 References 319
13 Outcome measures of articular cartilage repair 330
M. E. Trice, Johns Hopkins University School of Medicine,
USA
13.1 Introduction 330
13.2 Patient-based (subjective) outcome measures 333
13.3 Process-centered (objective) outcome measures 338
13.4 Conclusions 344
13.5 References 344
Part II Repair of tendons and ligaments
14 The structure of tendons and ligaments 351
M. Benjamin, Cardiff University, UK
14.1 Introduction 351
14.2 Basic aspects of cell and extracellular matrix (ECM) structure 354
14.3 Specialised regions of tendons and ligaments 362
14.4 Conclusions 368
14.5 References 369
15 Tendon biomechanics 375
M. Kj^r, Bispebjerg Hospital and University of Copenhagen,
Denmark, S.P. Magnusson, University of Copenhagen,
Denmark and A. Mac key, Bispebjerg Hospital, Denmark
15.1 Introduction 375
15.2 Biochemical adaptation of tendon to loading 376
15.3 Biomechanics of human tendon 382
15.4 References and further reading 388
x Contents
16 Tendon injury and repair mechanisms 394
N. Maffijlli, Barts and The London School of Medicine
and Dentistry, UK, and U.G. LONGO, P. Sharma and
V. Denaro, Campus Biomedico University, Italy
16.1 Introduction: tendon injury 394
16.2 Tendinopathy 394
16.3 Genetics 398
16.4 Tendon rupture 400
16.5 Pain in tendinopathy 406
16.6 Tendon healing following acute injuries 407
16.7 Conclusions 410
16.8 References 410
17 Tissue engineering for ligament and tendon repair 419
M. LEE and B. M. Wu, University of California, Los
Angeles, USA
17.1 Introduction 419
17.2 Tissue engineering approaches for ligament and tendon repair 420
17.3 Reconstruction of ligaments and tendons 427
17.4 Future trends 428
17.5 Sources of further information and advice 430
17.6 References 430
18 Cell-based therapies for the repair and
regeneration of tendons and ligaments 436
R.K.W. Smith, The Royal Veterinary College, UK
18.1 Introduction 436
18.2 The rationale behind the use of cells to treat tendon and
ligament injuries 437
18.3 Cell choice for tendon and ligament treatment 438
18.4 Mixed cell populations 441
18.5 Allogenic versus autologous sources 442
18.6 Proposed beneficial actions of stem cells on tendon healing 442
18.7 Stem cell-induced tenogenesis in vitro 442
18.8 Stem cell-induced tenogenesis in vivo 443
18.9 Conclusions 447
18.10 Sources of further information and advice 447
18.11 References 447
Contents xi
19 Scaffolds for tendon and ligament tissue
engineering 452
J.C.H. Goh and S. Sahoo, National University of
Singapore, Singapore
19.1 Criteria and requirements for tendon/ligament tissue
engineering scaffolds 452
19.2 Biomaterials for tendon and ligament tissue engineering 453
19.3 Scaffold architecture 455
19.4 Functional scaffolds 460
19.5 Future trends 462
19.6 References 463
Index 469
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| spelling | Regenerative medicine and biomaterials for the repair of connective tissues ed. by Charles Archer ... 1. publ. Boca Raton [u.a.] CRC Press [u.a.] 2010 XVII, 485 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Woodhead publishing in materials Biomaterial (DE-588)4267769-5 gnd rswk-swf Bindegewebe (DE-588)4006725-7 gnd rswk-swf Regenerative Medizin (DE-588)7652075-4 gnd rswk-swf Bindegewebe (DE-588)4006725-7 s Regenerative Medizin (DE-588)7652075-4 s Biomaterial (DE-588)4267769-5 s DE-604 Archer, Charles W. edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020778802&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Regenerative medicine and biomaterials for the repair of connective tissues |
| title_auth | Regenerative medicine and biomaterials for the repair of connective tissues |
| title_exact_search | Regenerative medicine and biomaterials for the repair of connective tissues |
| title_full | Regenerative medicine and biomaterials for the repair of connective tissues ed. by Charles Archer ... |
| title_fullStr | Regenerative medicine and biomaterials for the repair of connective tissues ed. by Charles Archer ... |
| title_full_unstemmed | Regenerative medicine and biomaterials for the repair of connective tissues ed. by Charles Archer ... |
| title_short | Regenerative medicine and biomaterials for the repair of connective tissues |
| title_sort | regenerative medicine and biomaterials for the repair of connective tissues |
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