The cancer degradome: proteases and cancer biology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2008
|
| Schlagworte: | |
| Online-Zugang: | Publisher description Table of contents only Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXIII, 926 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9780387690568 0387690565 |
Internformat
MARC
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| 020 | |a 9780387690568 |c hbk. : alk. paper |9 978-0-387-69056-8 | ||
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| 245 | 1 | 0 | |a The cancer degradome |b proteases and cancer biology |c Dylan Edwards ... ed. |
| 246 | 1 | 3 | |a Proteases and cancer biology |
| 264 | 1 | |a New York, NY |b Springer |c 2008 | |
| 300 | |a XXIII, 926 S. |b Ill., graph. Darst. |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Proteolytic enzymes | |
| 650 | 4 | |a Cancer |x Molecular aspects | |
| 650 | 4 | |a Peptide Hydrolases | |
| 650 | 4 | |a Neoplasm Invasiveness |x enzymology | |
| 700 | 1 | |a Edwards, Dylan |e Sonstige |0 (DE-588)13787586X |4 oth | |
| 856 | 4 | |u http://www.loc.gov/catdir/enhancements/fy0907/2008928134-d.html |3 Publisher description | |
| 856 | 4 | |u http://www.loc.gov/catdir/enhancements/fy0907/2008928134-t.html |3 Table of contents only | |
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Datensatz im Suchindex
| _version_ | 1804143562027171840 |
|---|---|
| adam_text | Titel: The cancer degradome
Autor: Edwards, Dylan
Jahr: 2008
Contents
Section I: The Degradome and Its Analysis
1 Protease Genomics and the Cancer Degradome 3
Xose S. Puente, Gonzalo R. Ordonez, and Carlos Lopez-Otin
2 The CLIP-CHIP™: A Focused Oligonucleotide Microarray
Platform for Transcriptome Analysis of the Complete
Human and Murine Cancer Degradomes 17
Reinhild Kappelhoff, Claire H. Wilson, and Christopher M. Overall
3 The Hu/Mu Protln Chip: A Custom Dual-Species
Oligonucleotide Microarray for Profiling Degradome
Gene Expression in Tumors and Their Microenvironment 37
Donald R. Schwartz, Kamiar Moin, Ekkehard Weber, and Bonnie F. Sloane
4 Quantitative Real-Time PCR Analysis of Degradome Gene Expression 49
Caroline J. Pennington, Robert K. Nuttall, Clara Sampieri-Ramirez,
Matthew Wallard, Simon Pilgrim, and Dylan R. Edwards
5 Identification of Protease Substrates by Mass
Spectrometry Approaches-1 67
Mari Enoksson, Wenhong Zhu, and Guy S. Salvesen
6 Identification of Protease Substrates
by Mass Spectrometry Approaches-2 83
Anna Prudova, Ulrich auf dem Keller, and Christopher M. Overall
7 Activity-Based Imaging and Biochemical Profiling Tools
for Analysis of the Cancer Degradome 101
Vincent Dive, Margot G. Paulick, J. Oliver Mclntyre,
Lynn M. Matrisian, and Matthew Bogyo
vii
v;jj Contents
8 Images of Cleavage: Tumor Proteases in Action 137
Kamiar Moin, Mansoureh Sameni, Christopher Jedeszko,
Quanwen Li, Mary B. Olive, Raymond R. Mattingly, and Bonnie F. Sloane
Section II: Insights into Protease Function
9 Proteolytic Pathways: Intersecting Cascades
in Cancer Development 157
Nesrine I. Affara and Lisa M. Coussens
10 Physiological Functions of Plasminogen Activation:
Effects of Gene Deficiencies in Humans and Mice 183
Thomas H. Bugge
11 The Plasminogen Activation System in Tissue
Remodeling and Cancer Invasion 203
Kasper Almholt, Anna Juncker-Jensen, Kirsty Anne Green,
Helene Solberg, Leif R0ge Lund, and John R0mer
12 The Urokinase Plasminogen Activator Receptor
as a Target for Cancer Therapy 223
Silvia D Alessio and Francesco Blasi
13 The Endocytic Collagen Receptor, uPARAP/Endol80,
in Cancer Invasion and Tissue Remodeling 245
Thore Hillig, Lars H. Engelholm, and Niels Behrendt
14 Physiological and Pathological Functions of Type II
Transmembrane Serine Proteases: Lessons from
Transgenic Mouse Models and Human Disease-Associated
Mutations 259
Karin List and Thomas H. Bugge
15 Roles of Cysteine Proteases in Tumor Progression:
Analysis of Cysteine Cathepsin Knockout Mice
in Cancer Models 281
Thomas Reinheckel, Vasilena Gocheva, Christoph Peters,
and Johanna A. Joyce
16 In Vitro and In Vivo Models of Angiogenesis
to Dissect MMP Functions 305
Sarah Berndt, Francoise Bruyere, Maud Jost, and Agnes Noel
Contents ix
17 The Surface Transplantation Model to Study
the Tumor-Host Interface 327
Maud Jost, Silvia Vosseler, Silvia Blacher, Norbert E. Fusenig,
Margareta M. Mueller, and Agnes Noel
18 Unravelling the Roles of Proteinases in Cell Migration
In Vitro and In Vivo 343
Jelena Gavrilovic and Xanthe Scott
19 New Insights into MMP Function in Adipogenesis 361
Kumari L. Andarawewa and Marie-Christine Rio
20 TIMPs: Extracellular Modifiers in Cancer Development 373
Aditya Murthy, William Cruz-Munoz, and Rama Khokha
Section III: The Interface Between Proteolysis and Cell Signalling
21 Invadopodia: Interface for Invasion 403
Susette C. Mueller, Vira V. Artym, and Thomas Kelly
22 uPAR and Proteases in Mobilization
of Hematopoietic Stem Cells 433
Pia Ragno and Francesco Blasi
23 The Urokinase Receptor and Integrins Constitute
a Cell Migration Signalosome 451
Bernard Degryse
24 Measuring uPAR Dynamics in Live Cells 475
Moreno Zamai, Gabriele Malengo, and Valeria R. Caiolfa
25 Janus-Faced Effects of Broad-Spectrum and Specific
MMP Inhibition on Metastasis 495
Charlotte Kopitz and Achim Kriiger
26 Cytokine Substrates: MMP Regulation of Inflammatory
Signaling Molecules 519
Jennifer H. Cox and Christopher M. Overall
27 Matrix Metalloproteinases as Key Regulators
of Tumor-Bone Interaction 541
Conor C. Lynch and Lynn M. Matrisian
x Contents
Section IV: The Degradome as Source of Cancer Diagnostic
and Prognostic Markers
28 The Plasminogen Activation System as a Source
of Prognostic Markers in Cancer 569
Ib Jarle Christensen, Helle Pappot, and Gunilla H0yer-Hansen
29 Cysteine Cathepsins and Cystatins as Cancer Biomarkers 587
Tamara T. Lah, Natasa Obermajer, Maria Beatriz Duran Alonso,
and Janko Kos
30 Novel Degradome Markers in Breast Cancer 627
Caroline J. Pennington, Simon Pilgrim, Paul N. Span,
Fred C. Sweep, and Dylan R. Edwards
31 Meta-Analysis of Gene Expression Microarray Data:
Degradome Genes in Healthy and Cancer Tissues 645
Kristiina Iljin, Sami Kilpinen, Johanna Ivaska, and Olli Kallioniemi
32 Degradome Gene Polymorphisms 663
Ross Laxton and Shu Ye
33 TIMP-1 as a Prognostic Marker in Colorectal Cancer 679
Camilla Frederiksen, Anne Fog Lomholt, Hans J0rgen Nielsen,
and Nils Briinner
Section V: Novel Therapeutic Strategies
34 Structure and Inhibition of the Urokinase-Type
Plasminogen Activator Receptor 699
Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gardsvoll,
and Michael Ploug
35 Engineered Antagonists of uPA and PAI-1 721
M. Patrizia Stoppelli, Lisbeth M. Andersen, Giuseppina Votta,
and Peter A. Andreasen
36 MMP Inhibitor Clinical Trials - The Past, Present, and Future .... 759
Barbara Fingleton
37 Tailoring TIMPs for Selective Metalloproteinase Inhibition 787
Hideaki Nagase and Gillian Murphy
Contents xi
38 Third-Generation MMP Inhibitors: Recent Advances
in the Development of Highly Selective Inhibitors 811
Athanasios Yiotakis and Vincent Dive
39 Protease-Activated Delivery and Imaging Systems 827
Gregg B. Fields
40 Development of Tumour-Selective and
Endoprotease-Activated Anticancer Therapeutics 853
Jason H. Gill and Paul M. Loadman
41 Targeting Degradome Genes via Engineered
Viral Vectors 877
Risto Ala-aho, Andrew H. Baker, and Veli-Matti Kahari
Appendix 895
Index 899
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:49:38Z |
| institution | BVB |
| isbn | 9780387690568 0387690565 |
| language | English |
| lccn | 2008928134 |
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| physical | XXIII, 926 S. Ill., graph. Darst. 25 cm |
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| spelling | The cancer degradome proteases and cancer biology Dylan Edwards ... ed. Proteases and cancer biology New York, NY Springer 2008 XXIII, 926 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Proteolytic enzymes Cancer Molecular aspects Peptide Hydrolases Neoplasm Invasiveness enzymology Edwards, Dylan Sonstige (DE-588)13787586X oth http://www.loc.gov/catdir/enhancements/fy0907/2008928134-d.html Publisher description http://www.loc.gov/catdir/enhancements/fy0907/2008928134-t.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020777632&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The cancer degradome proteases and cancer biology Proteolytic enzymes Cancer Molecular aspects Peptide Hydrolases Neoplasm Invasiveness enzymology |
| title | The cancer degradome proteases and cancer biology |
| title_alt | Proteases and cancer biology |
| title_auth | The cancer degradome proteases and cancer biology |
| title_exact_search | The cancer degradome proteases and cancer biology |
| title_full | The cancer degradome proteases and cancer biology Dylan Edwards ... ed. |
| title_fullStr | The cancer degradome proteases and cancer biology Dylan Edwards ... ed. |
| title_full_unstemmed | The cancer degradome proteases and cancer biology Dylan Edwards ... ed. |
| title_short | The cancer degradome |
| title_sort | the cancer degradome proteases and cancer biology |
| title_sub | proteases and cancer biology |
| topic | Proteolytic enzymes Cancer Molecular aspects Peptide Hydrolases Neoplasm Invasiveness enzymology |
| topic_facet | Proteolytic enzymes Cancer Molecular aspects Peptide Hydrolases Neoplasm Invasiveness enzymology |
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