Epigenetics and human health: linking hereditary, environmental and nutritional aspects
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2010
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| Beschreibung: | Literaturangaben |
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| ISBN: | 9783527324279 9783527628384 |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
VII
CONTENTS
PREFACE XV LIST OF CONTRIBUTORS XVII
PART I GENERAL INTRODUCTION
1 THE RESEARCH PROGRAM IN EPIGENETICS: THE BIRTH OF A NEW PARADIGM 3
PAOLO VINEIS REFERENCES 5
2 INTERACTIONS BETWEEN NUTRITION AND HEALTH 7 IBRAHIM ELMADFA 2.1
INTRODUCTION 7
2.2 EPIGENETIC EFFECTS OF THE DIET 8 2.3 CURRENT NUTRITION RELATED
HEALTH PROBLEMS 8 REFERENCES 9
3 EPIGENETICS: COMMENTS FROM AN ECOLOGIST 11 FRITZ SCHIEMER REFERENCES
12
4 INTERACTION OF HEREDITARY AND EPIGENETIC MECHANISMS IN THE REGULATION
OF GENE EXPRESSION 13 THALER ROMAN, EVA AUMUELLER, CAROLIN BERNER, AND
ALEXANDER G. HASLBERGER
4.1 HEREDITARY DISPOSITIONS 13 4.2 THE EPIGENOME 14
4.3 EPIGENETIC MECHANISMS 15 4.3.1 METHYLATION J5 4.3.2 HISTONE
MODIFICATIONS 18 4.3.3 MICRO RNAS 20
4.4 ENVIRONMENTAL INFLUENCES 20 4.4.1 NUTRITIONAL AND ENVIRONMENTAL
EFFECTS IN EARLY LIFE CONDITIONS 20 4.4.2 ENVIRONMENTAL POLLUTION AND
TOXINS 22 4.5 DIETARY EFFECTS 22
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/994010788
DIGITALISIERT DURCH
IMAGE 2
VILI I CONTENTS
4.5.1 NUTRITION AND THE IMMUNE SYSTEM 26 4.5.2 NUTRITION AND AGING 26
4.6 INHERITANCE AND EVOLUTIONARY ASPECTS 28 4.7 CONCLUSION 29
REFERENCES 30
PART II HEREDITARY ASPECTS
5 METHYLENETETRAHYDROFOLATE REDUCTASE C677T AND A1298C POLYMORPHISMS AND
CANCER RISK: A REVIEW OF THE PUBLISHED META-ANALYSES 37 STEFANIA BOCCIA
5.1 KEY CONCEPTS OF POPULATION-BASED GENETIC ASSOCIATION STUDIES 37
5.1.1 DEFINITION AND GOALS OF GENETIC EPIDEMIOLOGY 37 5.1.2 STUDY
DESIGNS IN GENETIC EPIDEMIOLOGY 38 5.1.3 THE HUMAN GENOME 38
5.1.4 META-ANALYSIS IN GENETIC EPIDEMIOLOGY 39 5.1.5 HUMAN GENOME
EPIDEMIOLOGY NETWORK 40 5.1.6 MENDELIAN RANDOMIZATION 41 5.2
METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISMS
(C677T AND A1298C) AND ITS ASSOCIATION WITH CANCER RISK 41 5.2.1 GENE
AND FUNCTION 41 5.2.2 C677T AND A1298C GENE VARIANTS 43 5.2.3
GENE-ENVIRONMENT INTERACTION 43 5.3 META-ANALYSES OF
METHYLENETETRAHYDROFOLATE REDUCTASE C677T AND
A1298C POLYMORPHISMS AND CANCER 44 REFERENCES 47
6 THE ROLE OF BIOBANKS FOR THE UNDERSTANDING OF GENE-ENVIRONMENT
INTERACTIONS 51 CHRISTIAN VIERILER, MICHAELA MAYRHOFER, AND KURT
ZATLOUKAL 6.1 BACKGROUND 5]
6.1.1 WHAT PURPOSE DO DIFFERENT BIOBANK FORMATS SERVE? 52 6.1.2 WHY DO
WE NEED NETWORKS OF BIOBANKS? 53 6.2 THE INVESTIGATION OF
GENE-ENVIRONMENT INTERACTIONS AS A CHALLENGE FOR BIOBANKS 55
6.2.1 HOW TO EVALUATE RISK FACTORS FOR METABOLIC SYNDROME AND
STEATOHEPATITIS? 58 6.2.2 WHY ARE BIOBANKS NEEDED IN THIS CONTEXT AND
WHAT CHALLENGES DO THEY HAVE TO FACE? 58
REFERENCES 60
7 CASE STUDIES ON EPIGENETIC INHERITANCE 63 CUNNAR KAATI 7.1
INTRODUCTION 64
7.2 METHODOLOGY 65
IMAGE 3
CONTENTS IX
7.2.1 ON THE STUDY OF EPIGENETIC INHERITANCE 65
7.2.2 THE IDEAL STUDY DESIGN 66 7.2.3 THE OEVERKALIX COHORTS OF 1890,
1905 AND 1920 67 7.2.4 THE ALS PAC DATA SET 68 7.2.5 THE PROBAND S
CHILDHOOD 68
7.2.6 FOOD AVAILABILITY 69 7.2.7 ANCESTORS EXPERIENCE OF CRISES 69
7.2.8 GROWTH VELOCITY 69 7.3 PATTERNS OF TRANSGENERATIONAL RESPONSES 70
7.3.1 THE SOCIAL CONTEXT 70 7.3.2 THE ANCESTORS NUTRITION 71 7.3.3
LONGEVITY AND PATERNAL ANCESTORS NUTRITION 71 7.3.4 THE INFLUENCE OF
NUTRITION DURING THE SLOW GROWTH PERIOD ON
CARDIOVASCULAR AND DIABETES MORTALITY 72 7.3.5 IS HUMAN EPIGENETIC
INHERITANCE MEDIATED BY THE SEX CHROMOSOMES? 73 7.3.5.1 PATERNAL
INITIATION OF SMOKING AND PREGNANCY OUTCOME 75 7.3.6 EPIGENETIC
INHERITANCE, EARLY LIFE CIRCUMSTANCES AND LONGEVITY 75 7.3.7 HOW TO
EXPLAIN THE EFFECTS OF FOOD AVAILABILITY DURING SGP ON
HUMAN HEALTH? 76 7.3.7.1 GENETIC SELECTION THROUGH DIFFERENTIAL SURVIVAL
OR FERTILITY? 76 73.7.2 CHROMOSOMAL TRANSMISSION OF NUTRITIONALLY
INDUCED EPIGENETIC
MODIFICATIONS 76 7.4 EPIGENETIC INHERITANCE 77 7.4.1 FETAL PROGRAMMING
AND EPIGENETIC INHERITANCE 78 7.5 FUTURE DIRECTIONS 80
7.6 CONCLUSIONS 81
REFERENCES 83
PART III ENVIRONMENTAL AND TOXICOLOGICAL ASPECTS
8 GENOTOXIC, NON-CENOTOXIC AND EPIGENETIC MECHANISMS IN CHEMICAL
HEPATOCARCINOGENESIS: IMPLICATIONS FOR SAFETY EVALUATION 89 WILFRIED
BURSCH 8.1 INTRODUCTION 90
8.2 GENOTOXIC AND NON-GENOTOXIC CHEMICALS IN RELATION TO THE MULTISTAGE
MODEL OF CANCER DEVELOPMENT 91 8.2.1 TUMOR INITIATION 91 8.2.2 TUMOR
PROMOTION 92
8.2.3 TUMOR PROGRESSION 93 8.2.4 CELLULAR AND MOLECULAR MECHANISMS OF
TUMOR INITIATION AND PROMOTION 93 8.2.5 EPIGENETIC EFFECTS OF GENOTOXIC
AND NON-GENOTOXIC
HEPATOCARCINOGENS 96
IMAGE 4
X CONTENTS
8.2.6 HOW CARCINOGENS ALTER THE MICROENVIRONMENT - CRUCIAL ROLES
OF INFLAMMATION 97 8.3 CONCLUDING REMARKS 97
REFERENCES 99
9 CARCINOGENS IN FOODS: OCCURRENCE, MODES OF ACTION AND MODULATION OF
HUMAN RISKS BY GENETIC FACTORS AND DIETARY CONSTITUENTS 105 M. MISIK, A.
NERSESYAN, W. PARZEFALL, AND S. KNASMUELLER 9.1 INTRODUCTION 105
9.2 GENOTOXIC CARCINOGENS IN HUMAN FOODS 106 9.2.1 POLYCYCLIC AROMATIC
HYDROCARBONS 107 9.2.2 NITROSAMINES 107 9.2.3 HETEROCYCLIC AROMATIC
AMINES (HAAS) AND OTHER THERMAL
DEGRADATION PRODUCTS 108 9.2.4 MYCOTOXINS 109 9.2.5 FOOD ADDITIVES AND
CARCINOGENS IN PLANT-DERIVED FOODS 109 9.2.6 ALCOHOL 111
9.3 CONTRIBUTION OF GENOTOXIC DIETARY CARCINOGENS TO HUMAN CANCER RISKS
111 9.4 PROTECTIVE EFFECTS OF DIETARY COMPONENTS TOWARDS DNA-REACTIVE
CARCINOGENS 112 9.5 GENE POLYMORPHISMS AFFECTING THE METABOLISM OF
GENOTOXIC
CARCINOGENS 1 14 9.6 CONCLUDING REMARKS, EPIGENETICS AND OUTLOOK 118
REFERENCES 118
PART IV NUTRITIONAL ASPECTS
10 FROM MOLECULAR NUTRITION TO NUTRITIONAL SYSTEMS BIOLOGY 127 CUY
VERGERES 10.1 IMPACT OF LIFE SCIENCES ON MOLECULAR NUTRITION RESEARCH
127 10.2 NUTRIGENOMICS 129 10.2.1 GENOMICS AND NUTRITION RESEARCH 129
10.2.2 TRANSCRIPTOMICS AND NUTRITION RESEARCH 130 10.2.3 PROTEOMICS AND
NUTRITION RESEARCH 131 10.2.4 METABOLOMICS AND NUTRITION RESEARCH 132
10.3 NUTRIGENETICS 133 10.4 NUTRI-EPIGENETICS 135 10.5 NUTRITIONAL
SYSTEMS BIOLOGY 137 10.6 ETHICS AND SOCIO-ECONOMICS OF MODERN NUTRITION
RESEARCH 137
REFERENCES 139
IMAGE 5
CONTENTS XI
11 EFFECTS OF DIETARY NATURAL COMPOUNDS ON DNA METHYLATION RELATED TO
CANCER CHEMOPREVENTION AND ANTICANCER EPIGENETIC THERAPY 141 BARBARA
MARIA STEFANSKA AND KRYSTYNA FABIANOWSKA-MAJEWSKA 11.1 INTRODUCTION 141
11.2 DNA METHYLATION REACTION 142 11.3 IMPLICATION OF THE SELECTED
NATURAL COMPOUNDS IN DNA METHYLATION
REGULATION 144
11.3.1 ATRA, VITAMIN D 3 , RESVERATROL, AND GENISTEIN 144 11.3.1.1
INVOLVEMENT OF P21 WAF1/CIP1 AND RB/E2F PATHWAY IN REGULATION OF DNMT1
147 11.3.1.2 INVOLVEMENT OF THE AP-1 TRANSCRIPTIONAL COMPLEX IN
REGULATION
OF DNMT1 148
11.3.2 POLYPHENOLS WITH A CATECHOL GROUP 149 11.4 CONCLUSIONS AND FUTURE
PERSPECTIVES 151 REFERENCES 152
12 HEALTH DETERMINANTS THROUGHOUT THE LIFE CYCLE 157 PETRA RUST 12.1
INTRODUCTION 157 12.2 PRE- AND POSTNATAL DETERMINANTS 159 12.3
DETERMINANTS DURING INFANCY AND ADULTHOOD 160 12.4 DETERMINANTS IN
ADULTS AND OLDER PEOPLE 160 12.5 INTERACTIONS THROUGHOUT THE IIFECYCLE
161 12.6 INTERGENERATIONAL EFFECTS 161
REFERENCES 162
PART V CASE STUDIES
13 VIRAL INFECTIONS AND EPIGENETIC CONTROL MECHANISMS 167 KLAUS R. HUBER
13.1 THE EVOLUTIONARY NEED FOR CONTROL MECHANISMS 167 13.2 CONTROL BY
RNA SILENCING 168 13.3 VIRAL INFECTIONS AND EPIGENETIC CONTROL
MECHANISMS 169 13.3.1 RNA SILENCING IN PLANTS 169 13.3.2 RNA SILENCING
IN FUNGI 170 13.3.3 RNA SILENCING IN MAMMALS 170
13.4 EPIGENETICS AND ADAPTIVE IMMUNE RESPONSES 171 REFERENCES 171
14 EPIGENETICS ASPECTS IN GYNEACOLOGY AND REPRODUCTIVE MEDICINE 173
ALEXANDER JUST AND JOHANNES HUBER REFERENCES 178
IMAGE 6
XII CONTENTS
15 EPIGENETICS AND TUMORIGENESIS 179
HEIDRUN KARLIC AND FRANZ VARGA 15.1 INTRODUCTION 179 15.2 ROLE OF
METABOLISM WITHIN THE EPIGENETIC NETWORK 181 15.3 EPIGENETIC
MODIFICATION BY DNA METHYLATION DURING LIFETIME 183
15.4 INTERACTION OF GENETIC AND EPIGENETIC MECHANISMS IN CANCER 184 15.5
DNA METHYLATION IN NORMAL AND CANCER CELLS 185 15.6 PROMOTER
HYPERMETHYLATION IN HEMATOPOIETIC MALIGNANCIES 186 15.7 HYPERMETHYLATED
GENE PROMOTERS IN SOLID CANCERS 187 15.8 INTERACTION DNA METHYLATION AND
CHROMATIN 188
REFERENCES 190
16 EPIGENETIC APPROACHES IN ONCOLOGY 195 SABINE ZOECHBAUER-MUELLER AND
ROBERT A/I. MADER 16.1 INTRODUCTION 195 16.2 DNA METHYLATION, CHROMATIN
AND TRANSCRIPTION 196
16.3 METHODS FOR DETECTING METHYLATION 197 16.4 THE PARADIGM OF LUNG
CANCER 198 16.4.1 FREQUENTLY METHYLATED TUMOR SUPPRESSOR GENES AND OTHER
CANCER-RELATED GENES IN LUNG CARCINOMAS 199
16.4.2 MONITORING OF DNA METHYLATION IN BLOOD SAMPLES 200 16.5
EPIGENETICS AND THERAPY 200 16.6 EPIGENETIC ALTERATIONS UNDER CYTOTOXIC
STRESS 201 16.7 THERAPEUTIC APPLICATIONS OF INHIBITORS OF DNA
METHYLATION 202 16.8 HOW MAY METHYLATION BECOME RELEVANT TO CLINICAL
APPLICATIONS? 203 16.9 CONCLUSIONS 204 REFERENCES 205
17 EPIGENETIC DYSREGULATION IN AGING AND CANCER 209 DESPINA KOMNINOU AND
JOHN P. RICHIE 17 A INTRODUCTION 210
17.2 THE CANCER-PRONE METABOLIC PHENOTYPE OF AGING 210 17.3 AGE-RELATED
EPIGENETIC SILENCING VIA DNA METHYLATION 212 17.4 INFLAMMATORY CONTROL
OF AGE-RELATED EPIGENETIC REGULATORS 214 17.5 LESSONS FROM ANTI-AGING
MODALITIES 215 17.6 CONCLUSIONS 217
REFERENCES 218
18 THE IMPACT OF GENETIC AND ENVIRONMENTAL FACTORS IN NEURODEGENERATION:
EMERGING ROLE OF EPIGENETICS 225 LUCIA MIGLIORE AND FABIO COPPEDE
18.1 NEURODEGENERATIVE DISEASES 225 18.2 THE ROLE OF CAUSATIVE AND
SUSCEPTIBILITY GENES IN NEURODEGENERATIVE DISEASES 226
IMAGE 7
CONTENTS XIII
18.3 THE CONTRIBUTION OF ENVIRONMENTAL FACTORS TO NEURODEGENERATIVE
DISEASES 231
18.4 EPIGENETICS, ENVIRONMENT AND SUSCEPTIBILITY TO HUMAN DISEASES 233
18.5 EPIGENETICS AND NEURODEGENERATIVE DISEASES 234 18.6 THE EPIGENETIC
ROLE OF THE DIET IN NEURODEGENERATIVE DISEASES 237 18.7 CONCLUDING
REMARKS 238
REFERENCES 239
19 EPIGENETIC BIOMARKERS IN NEURODEGENERATIVE DISORDERS 245 BORUT
PETERLIN 19.1 INTRODUCTION 245 19.2 EPIGENETIC MARKS IN INHERITED
NEUROLOGICAL AND NEURODEGENERATIVE
DISORDERS 246
19.3 EPIGENETIC DYSREGULATION IN NEURODEGENERATIVE DISORDERS 247 19.4
GENE CANDIDATES FOR EPIGENETIC BIOMARKERS 248 19.5 CONCLUSIONS 249
REFERENCES 250
20 EPIGENETIC MECHANISMS IN ASTHMA 253 RACHEL L MILLER AND JULIE
HERBSTMAN 20.1 INTRODUCTION 253 20.2 EPIGENETIC MECHANISMS 255 20.3
FETAL BASIS OF ADULT DISEASE 255 20.4 FETAL BASIS OF ASTHMA 256 20.5
EXPERIMENTAL EVIDENCE 257 20.6 EPIGENETIC MECHANISMS IN ASTHMA 257 20.7
CELL-SPECIFIC RESPONSES 259 20.8 CONCLUSION 259
REFERENCES 260
PART VI WAYS TO TRANSLATE THE CONCEPT
21 PUBLIC HEALTH GENOMICS - INTEGRATING GENOMICS AND EPIGENETICS INTO
NATIONAL AND EUROPEAN HEALTH STRATEGIES AND POLICIES 267 TOBIAS SCHULTE
IN DEN BAEUMEN AND ANGELA BRAND 21.1 PUBLIC HEALTH AND GENOMICS 267 21.2
THE BELLAGIO MODEL OF PUBLIC HEALTH GENOMICS 268 21.3 THE PUBLIC HEALTH
GENOMICS EUROPEAN NETWORK 271 21.4 FROM PUBLIC HEALTH GENOMICS TO PUBLIC
HEALTH AND EPIGENETICS/
EPIGENOMICS 272 21.5 HEALTH IN ALL POLICIES-TRANSLATING
EPIGENETICS/EPIGENOMICS INTO POLICIES AND PRACTICE 272 21.6 HEALTH IN
ALL POLICIES AS A GUIDING CONCEPT FOR EUROPEAN
POLICIES 273
21.7 RELATIVE RISK AND RISK REGULATION - A MODEL FOR THE REGULATION OF
EPIGENETIC RISKS? 274
IMAGE 8
XIV CONTENTS
21.8 ATTRIBUTABLE RISKS AND RISK REGULATION 275
21.9 TRANSLATING ATTRIBUTABLE RISKS INTO POLICIES 275 21.10 LIMITS TO
THE CONCEPT OF HEALTH IN ALL POLICIES IN GENOMICS AND EPIGENETICS 277
21.11 CONCLUSION 278
REFERENCES 278
22 TAKING A FIRST STEP: EPIGENETIC HEALTH AND RESPONSIBILITY 281 ASTRID
H. CESCHE 22.1 INTRODUCTION 281
22.2 RESPONDING TO EPIGENETIC CHALLENGES 282 22.3 RESPONSIBILITY AND
PUBLIC HEALTH CARE POLICY 283 22.4 CONCLUSION 284
REFERENCES 285
INDEX 287
|
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| author2 | Haslberger, Alexander G. |
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| format | Electronic eBook |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036851524 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T22:49:23Z |
| institution | BVB |
| isbn | 9783527324279 9783527628384 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020767480 |
| oclc_num | 551898155 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-861 |
| owner_facet | DE-355 DE-BY-UBR DE-861 |
| physical | 1 Online-Ressource |
| psigel | ZDB-35-WIC ebook FHR_PDA_WIC UBG_PDA_WIC ZDB-35-WIC FRO_PDA_WIC |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Epigenetics and human health linking hereditary, environmental and nutritional aspects ed. by Alexander G. Haslberger Weinheim Wiley-VCH 2010 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Literaturangaben Epigenetik (DE-588)7566079-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Epigenetik (DE-588)7566079-9 s DE-604 Haslberger, Alexander G. (DE-588)13982295X edt https://onlinelibrary.wiley.com/doi/book/10.1002/9783527628384 Verlag Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020767480&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Epigenetics and human health linking hereditary, environmental and nutritional aspects Epigenetik (DE-588)7566079-9 gnd |
| subject_GND | (DE-588)7566079-9 (DE-588)4143413-4 |
| title | Epigenetics and human health linking hereditary, environmental and nutritional aspects |
| title_auth | Epigenetics and human health linking hereditary, environmental and nutritional aspects |
| title_exact_search | Epigenetics and human health linking hereditary, environmental and nutritional aspects |
| title_full | Epigenetics and human health linking hereditary, environmental and nutritional aspects ed. by Alexander G. Haslberger |
| title_fullStr | Epigenetics and human health linking hereditary, environmental and nutritional aspects ed. by Alexander G. Haslberger |
| title_full_unstemmed | Epigenetics and human health linking hereditary, environmental and nutritional aspects ed. by Alexander G. Haslberger |
| title_short | Epigenetics and human health |
| title_sort | epigenetics and human health linking hereditary environmental and nutritional aspects |
| title_sub | linking hereditary, environmental and nutritional aspects |
| topic | Epigenetik (DE-588)7566079-9 gnd |
| topic_facet | Epigenetik Aufsatzsammlung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527628384 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020767480&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT haslbergeralexanderg epigeneticsandhumanhealthlinkinghereditaryenvironmentalandnutritionalaspects |