Fundamentals of heterocyclic chemistry: importance in nature and in the synthesis of pharmaceuticals
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hobooken, NJ
Wiley
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Formerly CIP Uk |
| Beschreibung: | XV, 327 S. Ill., graph. Darst. |
| ISBN: | 9780470566695 0470566698 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804143496410431489 |
|---|---|
| adam_text | Titel: Fundamentals of heterocyclic chemistry
Autor: Quin, Louis D.
Jahr: 2010
CONTENTS
PREFACE xiii
ACKNOWLEDGMENT xv
Chapter 1 THE SCOPE OF THE FIELD OF HETEROCYCLIC
CHEMISTRY 1
References / 5
Appendix / 6
Chapter 2 COMMON RING SYSTEMS AND THE NAMING
OF HETEROCYCLIC COMPOUNDS 8
2.1. General / 8
2.2. Naming Simple Monocyclic Compounds / 11
2.3. Handling the Extra Hydrogen / 13
2.4. Substituted Monocyclic Compounds / 14
2.5. Rings With More Than One Heteroatom / 15
2.6. Bicyclic Compounds / 17
2.7. Multicyclic Systems / 19
2.8. The Replacement Nomenclature System / 21
2.9. Saturated Bridged Ring Systems / 22
VII
Vill
CONTENTS
Chapter 3
Chapter 4
Chapter 5
References / 23
Review Exercises / 23
NATURE AS A SOURCE OF HETEROCYCLIC
COMPOUNDS 29
3.1. General / 29
3.2. Naturally Occurring Nitrogen Heterocyclic
Compounds / 30
3.3. Oxygen Compounds / 51
3.4. Sulfur and Phosphorus Heterocyclic Compounds
in Nature / 55
References / 57
PRINCIPLES OF SYNTHESIS OF AROMATIC
HETEROCYCLES BY INTRAMOLECULAR
CYCLIZATION 58
4.1. General / 58
4.2. Some of the Classic Synthetic Methods / 60
4.3. Cyclizations Involving Metallic Complexes as
Catalysts / 78
4.4. Cyclizations with Radical Intermediates / 82
4.5. Cyclizations by Intramolecular Wittig
Reactions / 84
4.6. Synthesis of Heterocycles by the Alkene
Metathesis Reaction / 89
References / 91
Review Exercises / 92
SYNTHESIS OF HETEROCYCLIC SYSTEMS
BY CYCLOADDITION REACTIONS
5.1. The Diels-Alder Reaction / 98
5.2. Dipolar Cycloadditions / 112
5.3. [2 + 2] Cycloadditions / 122
References / 125
Review Exercises / 126
98
CONTENTS
ix
Chapter 6 AROMATICITY AND OTHER SPECIAL
PROPERTIES OF HETEROCYCLES:
PI-DEFICIENT RING SYSTEMS 131
6.1. General / 131
6.2. Review of the Aromaticity of Benzene / 132
6.3. Pi-Deficient Aromatic Heterocycles / 138
References / 165
Review Exercises / 166
Chapter 7 AROMATICITY AND OTHER SPECIAL
PROPERTIES OF HETEROCYCLES:
PI-EXCESSIVE RING SYSTEMS AND
MESOIONIC RING SYSTEMS 170
7.1. Pi-Excessive Aromatic Heterocycles / 170
7.2. Mesoionic Heterocycles / 189
References / 191
Review Exercises / 192
Chapter 8 THE IMPORTANCE OF HETEROCYCLES
IN MEDICINE 196
8.1. General / 196
8.2. Historical / 197
8.3. Pyridines / 204
8.4. índoles / 207
8.5. Quinolines / 209
8.6. Azepines / 211
8.7. Pyrimidines / 213
8.8. Concluding Remarks / 217
References / 219
Chapter 9 SYNTHETIC METHODS FOR SOME PROMINENT
HETEROCYCLIC FAMILIES: EXAMPLES
OF PHARMACEUTICALS SYNTHESIS 221
9.1. Scope of the Chapter / 221
9.2. Pyrroles / 222
X CONTENTS
9.3. Furans / 225
9.4. Thiophenes / 227
9.5. 1,3-Thiazoles / 228
9.6. 1,3-Oxazoles / 233
9.7. Imidazoles / 235
9.8. Pyrazoles / 239
9.9. 1,2,4-Triazoles / 239
9.10. Tetrazoles / 240
9.11. 1,3,4-Thiadiazoles and other 5-Membered
Systems / 241
9.12. índole / 242
9.13. Pyridines / 246
9.14. Quinolines and Isoquinolines / 250
9.15. Benzodiazepines / 254
9.16. Pyrimidines / 256
9.17. Fused Pyrimidines: Purines and
Pteridines / 265
9.18. 1,3,5-Triazines / 267
9.19. Multicyclic Compounds / 270
References / 272
Review Exercises / 273
Chapter 10 GEOMETRIC AND STEREOCHEMICAL
ASPECTS OF NONAROMATIC
HETEROCYCLES 280
10.1. General / 280
10.2. Special Properties of Three-Membered
Rings / 282
10.3. Closing Heterocyclic Rings: Baldwin s
Rules / 287
10.4. Conformations of Heterocyclic Rings / 290
10.5. Chirality Effects on Biological Properties of
Heterocycles / 298
References / 302
Review Exercises / 303
CONTENTS X¡
Chapter 11 SYNTHETIC HETEROCYCLIC COMPOUNDS
IN AGRICULTURAL AND OTHER
APPLICATIONS 306
11.1. Heterocyclic Agrochemicals / 306
11.2. Applications of Heterocyclic Compounds in
Commercial Fields / 316
References / 319
Appendix UNIFIED AROMATICITY INDICES (IA)
OF BIRD 321
INDEX 323
|
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| indexdate | 2024-07-09T22:48:35Z |
| institution | BVB |
| isbn | 9780470566695 0470566698 |
| language | English |
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| physical | XV, 327 S. Ill., graph. Darst. |
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| spelling | Quin, Louis D. 1928- Verfasser (DE-588)103174987X aut Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals Louis D. Quin ; John A. Tyrell Hobooken, NJ Wiley 2010 XV, 327 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Formerly CIP Uk Heterocyclische Verbindungen (DE-588)4159726-6 gnd rswk-swf Heterocyclic chemistry Heterocyclic compounds / Synthesis Heterocyclische Verbindungen (DE-588)4159726-6 s DE-604 Tyrell, John A. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020719521&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Quin, Louis D. 1928- Tyrell, John A. Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals Heterocyclische Verbindungen (DE-588)4159726-6 gnd |
| subject_GND | (DE-588)4159726-6 |
| title | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals |
| title_auth | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals |
| title_exact_search | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals |
| title_full | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals Louis D. Quin ; John A. Tyrell |
| title_fullStr | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals Louis D. Quin ; John A. Tyrell |
| title_full_unstemmed | Fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals Louis D. Quin ; John A. Tyrell |
| title_short | Fundamentals of heterocyclic chemistry |
| title_sort | fundamentals of heterocyclic chemistry importance in nature and in the synthesis of pharmaceuticals |
| title_sub | importance in nature and in the synthesis of pharmaceuticals |
| topic | Heterocyclische Verbindungen (DE-588)4159726-6 gnd |
| topic_facet | Heterocyclische Verbindungen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020719521&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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