Verfügbarkeit: Molecular imaging in oncology

Molecular imaging in oncology:

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Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin [u.a.] Springer 2013
Schriftenreihe:	Recent results in cancer research 187
Schlagworte:	Cancer / Imaging Cancer / Diagnosis / Equipment and supplies Molekulare Bildgebung Krebs > Medizin
Online-Zugang:	Inhaltsverzeichnis Klappentext
Beschreibung:	XV, 415 S. Ill., graph. Darst.
ISBN:	3642108520 9783642108525

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Datensatz im Suchindex

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adam_text	Contents Part I Technology and Probe Design Computed Tomography and Magnetic Resonance Imaging ......... 3 1 Imaging Targets in Cancer .............................. 4 1.1 Introduction .................................... 4 1.2 Physiological Imaging Targets ....................... 5 1.3 Molecular Targets ................................ 7 1.4 Cellular Targets ................................. 8 1.5 Image-Guided Drug Delivery ........................ 8 2 Recent Technological Developments in X-ray Computed Tomography of Cancer ................................. 9 2.1 Basics of Multi-Slice Spiral Computed Tomography ........ 9 2.2 Multi-Energy Computed Tomography .................. 13 2.3 Preclinical Computed Tomography .................... 14 2.4 Dedicated Imaging Systems and New Developments ....... 15 2.5 Multimodality Imaging ............................ 16 3 Recent Technological Developments in Magnetic Resonance Imaging of Cancer .................................... 16 3.1 Magnetic Resonance Imaging: Introduction .............. 16 3.2 MRI Signal Formation and Contrast ................... 17 3.3 Magnetic Field Strength and Signal Sensitivity ........... 21 3.4 Imaging Gradients, Signal Encoding, and Signal Reception Chain ................................. 21 3.5 MRI Pulse Sequences, Parametric Mapping .............. 23 3.6 Contrast-Enhanced MRI ........................... 24 4 Imaging Biomarkers in Cancer ........................... 25 4.1 Imaging Biomarkers: X-ray Computed Tomography ........ 25 4.2 Imaging Biomarkers: Magnetic Resonance Imaging ........ 26 5 Magnetic Resonance Imaging Probes in Cancer ................ 33 5.1 Introduction .................................... 33 5.2 Non-Targeted Probes ............................. 33 5.3 Targeted Probes ................................. 43 5.4 Responsive Probes ............................... 43 5.5 Reporter Genes ................................. 45 χ Contents 6 Future Perspectives ................................... 53 References ............................................. 53 Single Photon Emission Computed Tomography Tracer ........... 65 1 Introduction ......................................... 66 2 General Aspects for the Design of SPECT Tracers ............. 69 3 Peptide-Receptor Radionuclide Imaging ..................... 73 3.1 Somatostatin Analogs ............................. 74 3.2 Bombesin Analogs ............................... 76 3.3 Neurotensin Analogs .............................. 79 3.4 Other Peptides-Based Radiotracers.................... 81 4 Antibodies and Antibody Fragments ........................ 82 4.1 Targeting Fibronectin Extra-Domain B: Antiangiogenic Antibody Fragment L19 ........................... 84 5 Vitamin-Based Radiotracers............................. 85 5.1 Folie Acid Conjugates ............................. 85 5.2 Vitamin B12 Conjugates ........................... 87 5.3 Other Vitamin Targeting Agents ...................... 89 6 Intracellular Targets ................................... 90 6.1 Tc-Carbohydrate Complexes ...................... 90 6.2 Radiolabeled Nucleoside Analogs for Targeting Human Thymidine Kinase .......................... 91 6.3 Radioiodinated Meta-Iodobenzylguanidine ............... 93 7 Optimization of SPECT Tracer Design and Potential Reasons for Failure ................................... 95 8 Summary and Conclusion ............................... 96 References ............................................. 97 Non-peptidyl F-Labelled PET Tracers as Radioindicators for the Noninvasive Detection of Cancer ...................... 107 1 Introduction ......................................... 108 2 [ FJFDG for Imaging Glucose Metabolism .................. 109 3 ^-Labelled Amino Acids (AAs) for Imaging AA Transport and Protein Synthesis .................................. Ill 3.1 O-(2-[18F]Fluoroethyl)-l-tyrosine ([18F]FET) ............. Ill 3.2 6-[18F]Fluoro-3,4-dihydroxy-l-phenylalanine ([18F]FDOPA). . . 113 4 ^-Labelled Choline Derivatives for Imaging Membrane Lipid Synthesis ...................................... 115 4.1 [ FJFluorocholine (Dimethyl-t 8F]fluoromethyl-2- hydroxyethylammonium, [ FJFCH) ................... 115 4.2 [ 8F]Huoroethylcholine (Dimethyl-2-t 8F]fluoroethyl-2- hydroxyethylammonium, [ TYFECH) .................. 117 5 p-Labelled Nucleoside Derivatives for Imaging Cell Proliferation ..................................... 118 Contents xi 5.1 3 -Deoxy-3418F]fluoro-l-thymidine ([18F]FLT) ........... 118 5.2 l-(2 -Deoxy-2 -[18F]fluoro-/î-d-arabinofuranosyl)-5- methyluracil ([^FJFMAU) .......................... 119 6 ^-Labelled Nitroimidazole Derivatives for Imaging Tumour Hypoxia ..................................... 120 6.1 [ FlFluoromisonidazole ([ FJFMISO) ................. 120 6.2 1 -(S-Deoxy-o-t 8F]Fluoro-a-d-arabinofuranosyl)-2- nitroimidazole ([^FJFAZA) ......................... 122 7 [^FjFES for Imaging Estrogen Receptor Status ................ 122 8 [^FjFluoride for Imaging Bone Metabolism .................. 124 9 Perspectives ........................................ 124 References ............................................. 125 Optical and Opto-Acoustic Imaging .......................... 133 1 Introduction ......................................... 134 2 Multi-Spectral Optoacoustic Tomography .................... 135 2.1 Sensitivity of Biomarker Detection .................... 139 2.2 Other Applications of Optoacoustic Imaging ............. 142 3 FMT-XCT .......................................... 142 4 Overview of Performance Characteristics .................... 145 5 Quantification ....................................... 146 6 Optical Imaging Applications in Oncology ................... 148 References ............................................. 149 Multifunctional Magnetic Resonance Imaging Probes ............. 151 1 The Need for Imaging and Contrast Agents in Oncology ......... 152 2 Imaging Techniques and Contrast Agents .................... 155 2.1 Magnetic Resonance Imaging of Cancer ................ 155 2.2 Multifunctional Imaging Probes ...................... 159 3 Probing the Tumor Vasculature ........................... 161 3.1 Dynamic Contrast-Enhanced MRI .................... 162 3.2 Macromolecular Dynamic Contrast-Enhanced MRI ......... 164 4 Molecular Imaging .................................... 167 5 Combined Imaging and Therapy .......................... 175 6 Translations and Future Outlook .......................... 181 References ............................................. 183 Part Π PrecUnical Studies Preclinical SPECT and SPECT/CT .......................... 193 1 Introduction ......................................... I94 хи __________________________________________________________________ Contents 2 Part I: Considerations when Evaluating the Potential Role of SPECT/CT Imaging in a Preclinical Oncology Research Application .................................. 195 2.1 Choice and Implications of Various Small Animal Models of Cancer ................................ 195 2.2 Framing the Research Question in Imaging Terms ......... 198 2.3 Available in vivo Imaging Modalities and Characteristics of Preclinical Oncology Applications Amenable to SPECT ... 198 2.4 SPECT Versus SPECT/CT .......................... 199 3 Part II: Technical Considerations when Implementing SPECT/CT in Preclinical Oncology Research ................. 200 3.1 Anesthesia and Animal Handling ..................... 200 3.2 Availability of Radiopharmaceuticals and Evaluation of Their Biodistribution Characteristics ................. 201 3.3 Injection of the Radiopharmaceutical .................. 203 3.4 Injection of CT Contrast Agent ...................... 203 3.5 Radiation Exposure ............................... 203 4 Part III: State-of-the-Art Preclinical SPECT/CT Systems ......... 205 4.1 SPECT/CT System Design ......................... 205 4.2 A Sampling of Available Small-Animal SPECT- and SPECT/CT Systems ........................... 207 4.3 Image Reconstruction Techniques and the Quest for Quantitative SPECT ............................ 208 5 Part IV: Recent Examples of SPECT/CT as Applied in the Preclinical Oncology Setting ........................ 210 5.1 Characterizing Tumor Perfusion or Other Inherent Characteristics .................................. 210 5.2 Imaging the Targeting Abilities of Molecules in the Development of Potential Therapeutics and Molecular Imaging Agents ................................. 210 5.3 Imaging Cell Trafficking ........................... 213 5.4 Imaging Gene Transfer and Expression ................. 213 5.5 Imaging Biodistributions and Evaluating Dosimetry — Chemotherapeutics and Combined Therapeutic/Imaging Agents ........................ 215 5.6 Imaging Other Pathologic Processes Associated with Cancer or Cancer Therapies ..................... 216 6 Conclusion ......................................... 216 References ............................................. 216 Optical Imaging ........................................ 221 1 Non-Invasive Optical Imaging Techniques ................... 222 2 Imaging Agents for Fluorescence Imaging ................... 223 3 Reporter Systems for Bioluminescence Imaging ............... 224 Contents xiii 4 Biological Processes ................................... 224 4.1 Activity of Matrix Degrading Enzymes ................. 224 4.2 Glucose Metabolism .............................. 225 4.3 Hypoxia ...................................... 228 4.4 Proliferation .................................... 230 4.5 Angiogenesis ................................... 231 4.6 Cell Death ..................................... 233 4.7 Blood Flow .................................... 235 5 Clinical Perspective ................................... 237 6 Outlook/A Critical View ................................ 240 References ............................................. 241 Applications of Small Animal PET ........................... 247 1 Introduction ......................................... 248 2 Small Animal PET .................................... 249 2.1 General Aspects ................................. 249 2.2 Small Animal PET ............................... 251 2.3 Small Animal CT and Small Animal PET ............... 252 3 Conclusion ......................................... 254 References ............................................. 254 Preclinical Molecular Imaging Using PET and MRI .............. 257 1 Introduction ......................................... 258 2 Experimental Models of Cancer ........................... 259 3 Small Animal Molecular Imaging ......................... 261 4 Positron Emission Tomography ........................... 262 5 Magnetic Resonance Imaging and Spectroscopy ............... 264 5.1 Contrast Agents ................................. 266 5.2 Dynamic Contrast-Enhanced MRI .................... 268 5.3 Steady-State Susceptibility-Contrast MRI ............... 269 5.4 Diffusion-Weighted MRI ........................... 270 5.5 Arterial Spin Labeling ............................. 274 5.6 Blood Oxygen Level Dependent MRI .................. 274 6 Multimodality Imaging ................................. 275 7 Applications ........................................ 276 7.1 Metabolism .................................... 276 7.2 Hypoxia ...................................... 279 7.3 Reporter Gene .................................. 283 7.4 Angiogenesis ................................... 285 7.5 Apoptosis ..................................... 288 7.6 Cellular Imaging ................................. 289 8 Animal Welfare and its Impact on Imaging ................... 293 9 Summary and Outlook ................................. 296 References ............................................. 297 xiv Contents Part Ш Clinical Applications Quantitative SPECT/CT .................................. 313 1 Introduction ......................................... 314 2 Technical Aspects .................................... 314 2.1 SPECT/CT Instrumentation ......................... 314 2.2 Registration of Multimodal Images .................... 315 2.3 Attenuation Correction of SPECT ..................... 316 2.4 Quantitatively Accurate SPECT/CT ................... 318 3 Clinical Aspects ...................................... 326 4 Summary and Outlook ................................. 327 References ............................................. 327 Optical Imaging of Breast Tumors and of Gastrointestinal Cancer by Laser-Induced Fluorescence ............................. 331 1 Introduction ......................................... 332 2 Fluorescence Imaging of Breast Cancer ..................... 333 2.1 The PTB Fluorescence Mammograph .................. 334 2.2 Examination Protocol ............................. 336 2.3 Results on Malignant and Benign Tumors ............... 337 2.4 Advances of Permeability Sensitive Fluorescence Imaging with ICG ...................................... 340 3 Cancer and Early Malignancies of the GI .................... 343 3.1 Protoporphyrin IX as Tumor Marker ................... 343 3.2 Time-Gated Fluorescence Imaging .................... 343 3.3 Clinical Studies ................................. 346 4 Outlook ........................................... 347 References ............................................. 348 FDG PET and PET/CT ................................... 351 1 Introduction ......................................... 352 2 Clinical Applications of FDG PET and PET/CT in Oncology ...... 353 2.1 Non-Small Cell Lung Cancer ........................ 353 2.2 Oesophageal Cancer .............................. 355 2.3 Gastric Cancer .................................. 355 2.4 Colorectal Cancer ................................ 356 2.5 Gastrointestinal Stromal Tumors ...................... 356 2.6 Head and Neck Cancer ............................ 357 2.7 Melanoma ..................................... 357 2.8 Lymphoma .................................... 358 2.9 Breast Cancer ................................... 359 2.10 Ovarian Cancer ................................. 360 2.11 Sarcomas ...................................... 361 2.12 Pancreatic Cancer ................................ 362 Contents________________________________________________________________xv 2.13 Thyroid Cancer ................................. 363 2.14 Cancer of Unknown Primary ........................ 364 2.15 Testicular Cancer ................................ 365 2.16 Prostate Cancer ................................. 366 3 Therapy Response Assessment with FDG PET and PET/CT ....... 366 References ............................................. 367 Molecular Imaging in Oncology ............................. 371 1 Introduction to Non-FDG PET Tracers ...................... 372 2 Clinical Applications of C-Choline ....................... 373 3 Clinical Applications of 18F-DOPA ........................ 375 4 Clinical Applications of C-Methionine ..................... 379 5 C-Acetate ......................................... 382 6 Clinical Applications of 18F-FLT .......................... 384 7 F-FET ........................................... 385 8 18F-Fluoride ........................................ 386 9 Clinical Applications of PET Tracers for Hypoxia .............. 387 10 Clinical Applications of PET Tracers for Angiogenesis .......... 388 References ............................................. 389 Part IV Future Challenges Future Challenges of Multimodality Imaging ................... 403 1 Introduction ......................................... 404 2 Technology and Probe Design ............................ 404 2.1 SPECT/CT ..................................... 405 2.2 PET/CT ....................................... 405 2.3 SPECT/MRI and PET/MRI ......................... 406 3 Tracers ............................................ 407 4 Optical Imaging ...................................... 411 5 Future and Conclusions ................................ 412 References ............................................. 413 Ota» Sdrfjer · Buifchaid Riemann fifcs Meteoifar Imaging in Oncology The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing significantly. The process of molecular imaging includes bey biotarget identification, design of specific molecular imaging probes, and their preclioical evaluation, e-g., va vivo using small animal studies, A multitude of such innovative molecular imaging probes have already entered clinical diagnostics in oncoiogy. There is no doubt that in future the emphasis will be on muttimodality imaging in which morphological,, functional, and molecular imaging techniques are combined in a single clinical investigation that will optimize diagnostic processes. This handbook addresses all aspects of molecular imaging in oncology, ranging from basic research to clinical applications in the era of evidence-based medicine. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodaiity probes. Preclimcal studies are then discussed in detail, with particular attention to multimodaiity imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
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spelling	Molecular imaging in oncology Otmar Schober ... ed. Berlin [u.a.] Springer 2013 XV, 415 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 187 Cancer / Imaging Cancer / Diagnosis / Equipment and supplies Molekulare Bildgebung (DE-588)7629820-6 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Molekulare Bildgebung (DE-588)7629820-6 s 1\p DE-604 Schober, Otmar 1948- Sonstige (DE-588)108236315 oth Erscheint auch als Online-Ausgabe 978-3-642-10853-2 Recent results in cancer research 187 (DE-604)BV000000043 187 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020705911&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020705911&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
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title	Molecular imaging in oncology
title_auth	Molecular imaging in oncology
title_exact_search	Molecular imaging in oncology
title_full	Molecular imaging in oncology Otmar Schober ... ed.
title_fullStr	Molecular imaging in oncology Otmar Schober ... ed.
title_full_unstemmed	Molecular imaging in oncology Otmar Schober ... ed.
title_short	Molecular imaging in oncology
title_sort	molecular imaging in oncology
topic	Cancer / Imaging Cancer / Diagnosis / Equipment and supplies Molekulare Bildgebung (DE-588)7629820-6 gnd Krebs Medizin (DE-588)4073781-0 gnd
topic_facet	Cancer / Imaging Cancer / Diagnosis / Equipment and supplies Molekulare Bildgebung Krebs Medizin
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