Clinical cancer prevention:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2011
|
| Schriftenreihe: | Recent results in cancer research
188 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 162 S. Ill., graph. Darst. |
| ISBN: | 9783642108563 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
1 ALLOCATING CANCER-DIRECTED EXPENDITURES: TENSIONS BETWEEN
PREVENTION, EARLY DETECTION AND TREATMENT IS UNNECESSARY 1 BRUCE E.
HILLNER AND THOMAS J. SMITH
1.1 INTRODUCTION 1
1.2 OUR LIFE EXPECTANCY AND CANCER SUCCESS STORIES 2
1.3 NO CURE IN SIGHT: COSTS OF DRUGS, GADGETS, GENOMICS AND TECHNOLOGY 2
1.4 BENDING THE CANCER COST CURVE 5
1.5 CONCLUSION 8
REFERENCES 8
2 LESSONS LEARNED FROM PREVENTION PROGRAMS: DIFFERENT ENDPOINTS SHOULD
BE USED IN SECONDARY AND TERTIARY PREVENTION 11
FRANZ PORZSOLT
2.1 INTRODUCTION 11
2.2 METHODS 12
2.3 RESULTS 13
2.3.1 TRADITIONAL OUTCOMES OF TREATMENT AND OF PREVENTION PROGRAMS 13
2.3.2 PROPOSAL FOR THE EVALUATION OF PREVENTION PROGRAMS 15
2.4 DISCUSSION 16
2.4.1 THE RISK OF INTERPRETATION IN PREVENTION PROGRAMS 16
2.4.2 THE RESULTING NEED FOR EVALUATION OF PREVENTIVE MEDICINE 17
2.4.3 RECOMMENDATIONS FOR FUTURE PREVENTIVE RESEARCH 18
REFERENCES 18
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1000034259
DIGITALISIERT DURCH
IMAGE 2
CONTENTS
BIOMARKERS FOR EARLY DETECTION AND AS SURROGATE ENDPOINTS IN CANCER
PREVENTION TRIALS: ISSUES AND OPPORTUNITIES 21
BARBARA K. DUNN, KARIN JEGALIAN, AND PETER GREENWALD
ABBREVIATIONS 21
3.1 BIOMARKERS: WHAT THEY ARE AND HOW THEY ARE APPLIED 23
3.1.1 SCREENING BIOMARKERS FOR EARLY DETECTION 23
3.1.2 BIOMARKERS AS SURROGATE ENDPOINTS IN CANCER PREVENTION TRIALS 26
3.2 BREAST PRECANCER AND CANCER PREVENTION 28
3.2.1 DUCTAL CARCINOMA IN SITU 30
3.2.2 TISSUE STROMA AND MAMMOGRAPHIC DENSITY 31
3.2.3 BIOMARKERS, ER-POSITIVE BREAST CANCER, AND BREAST CANCER
PREVENTION TRIALS 31
3.2.4 BIOMARKERS AND ESTROGEN RECEPTOR-NEGATIVE BREAST CANCERS 33
3.2.5 ACCESS TO BREAST TISSUE FOR BIOMARKER EVALUATION 33
3.2.6 BIOMARKERS IN PHASE 2 CHEMOPREVENTION TRIALS 34
3.3 PROSTATE CANCER PREVENTION 35
3.3.1 PSA SCREENING AND EARLY DETECTION OF PROSTATE CANCER 35
3.3.2 PHASE 3 PROSTATE CANCER PREVENTION TRIALS 35
3.3.3 DISCOVERY OF NEW BIOMARKERS FOR EARLY DETECTION OF PROSTATE CANCER
36
3.4 COLORECTAL CANCER PREVENTION 37
3.5 LUNG CANCER PREVENTION 38
3.5.1 MOLECULAR MARKERS FOR EARLY DETECTION AND PROGNOSIS 39
3.5.2 TREATING NICOTINE ADDICTION 40
3.5.3 FLUORESCENCE BRONCHOSCOPY 40
3.6 CONCLUSIONS 40
REFERENCES 40
TARGETING POLYAMINES AND INFLAMMATION FOR CANCER PREVENTION 49 NAVEEN
BABBAR AND EUGENE W. GERNER
4.1 INTRODUCTION 50
4.2 POLYAMINES, INFLAMMATION, AND CANCER 50
4.2.1 POLYAMINE METABOLISM 50
4.2.2 POLYAMINES AND CANCER 52
4.3 ROLES OF INFLAMMATION AND POLYAMINES IN PROSTATE CANCER 53
4.3.1 POLYAMINES AND PROSTATE CANCER 53
4.3.2 POLYAMINES, INFLAMMATION, AND PROSTATE CANCER 53
4.3.3 TARGETING POLYAMINES AND INFLAMMATION IN PROSTATE CANCER 54 4.4
ROLES OF INFLAMMATION AND POLYAMINES IN COLON CANCER 55
4.4.1 POLYAMINES AND COLON CANCER 55
4.4.2 POLYAMINES, INFLAMMATION, AND COLON CANCER 56
4.4.3 TARGETING POLYAMINES AND INFLAMMATION IN COLON CANCER 56
IMAGE 3
CONTENTS VII
4.5 ROLES OF INFLAMMATION AND POLYAMINES IN OTHER CANCERS 59
4.6 CONCLUSIONS 60
REFERENCES 60
5 THINKING ABOUT THE ROLE (LARGELY IGNORED) OF HEAVY METALS IN CANCER
PREVENTION: HEXAVALENT CHROMIUM AND MELANOMA AS A CASE IN POINT 65
FRANK L. MEYSKENS AND SUN YANG
5.1 BACKGROUND 65
5.1.1 THE EVOLUTION OF THE IDEA 65
5.1.2 SUBSTANCES THAT BIND MELANIN 66
5.2 MAJOR RISK FACTORS FOR CUTANEOUS MELANOMA 67
5.2.1 EPIDEMIOLOGY 67
5.3 METALS 69
5.3.1 CHEMISTRY AND GENETIC DAMAGE 69
5.3.2 CHROMIUM CHEMISTRY 69
5.3.3 UPREGULATION OF METALLOTHIONEINS (MTS) 70
5.3.4 SOME PRELIMINARY EXPERIMENTAL DATA 70
5.4 FUTURE PROSPECTS 72
REFERENCES 72
6 HEPATITIS B VIRUS AND CANCER PREVENTION 75
MEI-HWEI CHANG
6.1 INFECTION AND CANCER 75
6.2 DISEASE BURDEN OF LIVER CANCER 77
6.3 HEPATITIS B VIRUS INFECTION AND HEPATOCELLULAR CARCINOMA 77 6.4
CANCER PREVENTION AGAINST HEPATOCELLULAR CARCINOMA 78
6.5 HEPATITIS B VACCINATION PROGRAM 79
6.6 EFFECTIVE REDUCTION OF CHRONIC HBV INFECTION BY UNIVERSAL HEPATITIS
B IMMUNIZATION 79
6.7 THE EFFECT ON LIVER CANCER PREVENTION BY VACCINATION 80
6.8 PROBLEMS AND STRATEGIES OF SUCCESSFUL HCC PREVENTION BY HEPATITIS B
VACCINATION 81
6.9 IMPLICATIONS AND FUTURE PROSPECTS 81
REFERENCES 82
7 CHEMOPREVENTION OF HEPATOCELLULAR CARCINOMA IN CHRONIC HEPATITIS C 85
TIMOTHY R. MORGAN
7.1 HEPATITIS C 85
7.2 HEPATOCELLULAR CARCINOMA 86
7.3 PREVENTION OF HEPATOCELLULAR CARCINOMA 87
7.3.1 CURATIVE TREATMENT 87
IMAGE 4
CONTENTS
7.3.2 TREATMENTS THAT SUPPRESS HEPATITIS C VIRUS 88
7.3.3 NONCURATIVE CHEMOPREVENTION 88
7.3.4 PROSPECTIVE RANDOMIZED TRIALS: CAROTENOIDS AND PHYTOCHEMICALS 88
7.3.5 SECONDARY CHEMOPREVENTION OF HCC 89
7.3.6 NONRANDOMIZED, UNCONTROLLED AND/OR RETROSPECTIVE CLINICAL TRIALS
90
7.3.7 EPIDEMIOLOGIE STUDIES 91
7.3.8 DRUGS USED TO TREAT HEPATOCELLULAR CARCINOMA 92
7.3.9 PREVENTION OF HEPATOCELLULAR CARCINOMA IN CELL LINES AND ANIMAL
MODELS 92
7.3.10 PHASE II TRIAL OF S-ADENOSYLMETHIONINE IN HEPATITIS C CIRRHOSIS
94
7.4 CONCLUSIONS 97
REFERENCES 97
NUTRITIONAL ASPECTS OF PRIMARY PROSTATE CANCER PREVENTION 101 HANS-PETER
SCHMID, CLAUS FISCHER, DANIEL S. ENGELER, MARCELO L. BENDHACK, AND BERND
J. SCHMITZ-DRAGER
8.1 INTRODUCTION 101
8.2 DIETARY/NUTRITIONAL FACTORS 102
8.2.1 DIETARY FAT 102
8.2.2 OBESITY 102
8.2.3 MICRONUTRIENTS 102
8.2.4 VITAMINS 103
8.2.5 MINERALS 103
8.2.6 PHYTOESTROGENS 104
8.2.7 DIABETES MELLITUS 104
8.3 AMERICAN CANCER SOCIETY (ACS) GUIDELINE 105
8.3.1 A: TRY TO MAINTAIN A HEALTHY WEIGHT 105
8.3.2 B: TAKE REGULAR PHYSICAL EXERCISE 105
8.3.3 C: MAINTAIN A HEALTHY DIET WITH A FOCUS ON FRUIT AND VEGETABLES
105
8.3.4 D: REDUCE ALCOHOL INTAKE 105
8.4 CONCLUSIONS 106
REFERENCES 106
PROSTATE CANCER PREVENTION WITH 5 ALPHA-REDUCTASE INHIBITORS 109 DIPEN
J. PAREKH
9.1 RATIONALE FOR THE CHEMOPREVENTION OF PROSTATE CANCER 109
9.2 THE PROSTATE CANCER PREVENTION TRIAL 110
9.3 PATHOLOGIE CHARACTERISTICS OF THE CANCERS IN THE PROSTATE CANCER
PREVENTION TRIAL 110
IMAGE 5
CONTENTS
9.4 FINASTERIDE INCREASES SENSITIVITY OF
PROSTATE-SPECIFIC ANTIGEN, DIGITAL RECTAL EXAMINATION AND BIOPSY
DETECTION FOR PROSTATE CANCER 111 9.4.1 DECREASED PROSTATE VOLUME WITH
FINASTERIDE INCREASES CANCER DETECTION 112
9.5 SIDE EFFECTS OF FINASTERIDE 113
9.6 CONCLUSION 113
REFERENCES 113
10 HORMONC REPLACEMENT THERAPY AND BREAST CANCER 115
ANTHONY HOWELL AND GARETH D. EVANS
10.1 BACKGROUND 115
10.2 HRT USE IN WOMEN DIAGNOSED WITH BREAST CANCER 116
10.2.1 OBSERVATIONAL STUDIES 116
10.2.2 RANDOMISED TRIALS 117
10.2.3 EFFECTS OF WITHDRAWAL OF HRT IN WOMEN WITH BREAST CANCER 117 10.3
HRT AND RISK OF BREAST CANCER 118
10.3.1 OBSERVATIONAL STUDIES 118
10.3.2 RANDOMISED STUDIES 118
10.3.3 WITHDRAWAL OFHRT IN WOMEN WITHOUT BREAST CANCER 119 10.3.4
SUMMARY 119
10.4 HRT AFTER OOPHORECTOMY IN WOMEN LESS THAN 50 YEARS OF AGE 119
10.4.1 OBSERVATIONAL STUDIES 120
10.5 CORONARY HEART DISEASE 120
10.6 POTENTIAL BIOLOGICAL EXPLANATIONS 121
10.7 CONCLUSIONS 122
REFERENCES 122
11 PHYSICAL ACTIVITY AND BREAST CANCER: REVIEW OF THE EPIDEMIOLOGIE
EVIDENCE AND BIOLOGIE MECHANISMS 125 CHRISTINE M. FRIEDENREICH
11.1 EPIDEMIOLOGIE EVIDENCE 126
11.1.1 BACKGROUND 126
11.1.2 METHODOLOGIE ISSUES IN STUDIES OF PHYSICAL ACTIVITY AND CANCER
126
11.1.3 OVERALL ASSOCIATIONS BETWEEN PHYSICAL ACTIVITY AND BREAST CANCER
RISK 126
11.1.4 TYPE, DOSE, AND TIMING OF ACTIVITY 126
11.1.5 POPULATION SUBGROUPS 128
11.1.6 SUMMARY OF EPIDEMIOLOGIE FINDINGS 131
11.2 BIOLOGIE MECHANISMS 132
11.2.1 ADIPOSITY 132
11.2.2 SEX HORMONES 132
IMAGE 6
CONTENTS
11.2.3 INSULIN-RELATED FACTORS 134
11.2.4 ADIPOKINES AND INFLAMMATION 134
11.2.5 OTHER MECHANISMS 135
11.3 CONCLUSION 135
REFERENCES 136
12 PREVENTION OF BREAST CANCER BY NEWER SERMS IN THE FUTURE 141 TREVOR
POWLES
12.1 INTRODUCTION 141
12.2 ARZOXIFENE 142
12.3 LASOFOXIFENE 142
12.4 DISCUSSION 143
12.5 CONCLUSIONS 144
REFERENCES 144
13 CHEMOPREVENTION OF HORMONE RECEPTOR-NEGATIVE BREAST CANCER: NEW
APPROACHES NEEDED 147
IVAN P. URAY AND POWEL H. BROWN
13.1 INTRODUCTION 148
13.2 ENDOCRINE PREVENTIVE AGENTS 148
13.3 SELECTIVE ESTROGEN RECEPTOR MODULATORS 148
13.4 AROMATASE INHIBITORS 151
13.5 NEW STRATEGIES TO PREVENT HORMONE-INDEPENDENT BREAST CANCER 152
13.5.1 PARP INHIBITORS 152
13.6 CELL GROWTH INHIBITORS 153
13.6.1 STATINS 153
13.6.2 METFORMIN 153
13.6.3 RETINOIDS 154
13.6.4 PPAR AGONISTS 156
13.6.5 COX-2 INHIBITORS 156
13.6.6 TYROSINE KINASE INHIBITORS 157
13.6.7 THE IGF SYSTEM 158
13.6.8 CONCLUSIONS AND FUTURE DIRECTIONS 158
REFERENCES 159
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| id | DE-604.BV036789417 |
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| indexdate | 2024-07-09T22:48:08Z |
| institution | BVB |
| isbn | 9783642108563 |
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| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020705858 |
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| publishDate | 2011 |
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| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Clinical cancer prevention Hans-Jörg Senn ... (ed.) Berlin [u.a.] Springer 2011 X, 162 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 188 Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Prävention (DE-588)4076308-0 gnd rswk-swf Sankt Gallen (DE-588)4051594-1 gnd rswk-swf Cancer / Prevention / Congresses (DE-588)1071861417 Konferenzschrift gnd-content Krebs Medizin (DE-588)4073781-0 s Prävention (DE-588)4076308-0 s Sankt Gallen (DE-588)4051594-1 g DE-604 Senn, Hansjörg 1934- (DE-588)120310740 edt Erscheint auch als Online-Ausgabe 978-3-642-10858-7 Recent results in cancer research 188 (DE-604)BV000000043 188 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020705858&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Clinical cancer prevention Recent results in cancer research Krebs Medizin (DE-588)4073781-0 gnd Prävention (DE-588)4076308-0 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4076308-0 (DE-588)4051594-1 (DE-588)1071861417 |
| title | Clinical cancer prevention |
| title_auth | Clinical cancer prevention |
| title_exact_search | Clinical cancer prevention |
| title_full | Clinical cancer prevention Hans-Jörg Senn ... (ed.) |
| title_fullStr | Clinical cancer prevention Hans-Jörg Senn ... (ed.) |
| title_full_unstemmed | Clinical cancer prevention Hans-Jörg Senn ... (ed.) |
| title_short | Clinical cancer prevention |
| title_sort | clinical cancer prevention |
| topic | Krebs Medizin (DE-588)4073781-0 gnd Prävention (DE-588)4076308-0 gnd |
| topic_facet | Krebs Medizin Prävention Sankt Gallen Konferenzschrift |
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