Fat cells control low-grade inflammation in obesity by the production of adipokines:
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| Format: | Thesis Book |
| Language: | English |
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2010
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| Online Access: | Inhaltsverzeichnis |
| Item Description: | Enth. Zeitschriftenaufsätze |
| Physical Description: | 121 Bl. Ill., graph. Darst. |
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| adam_text | IMAGE 1
AUS DEM ELSE KROENER-FRESENIUS-ZENTRUM FUER ERNAEHRUNGSMEDIZIN
LEHRSTUHL FUER ERNAEHRUNGSMEDIZIN
TECHNISCHE UNIVERSITAET MUENCHEN
FAT CELLS CONTROL LOW-GRADE INFLAMMATION IN OBESITY
BY THE PRODUCTION OF ADIPOKINES
HABILITATIONSSCHRIFT
VORGELEGT DER
FAKULTAET FUER MEDIZIN
TECHNISCHE UNIVERSITAET MUENCHEN
VON DR. MED. THOMAS SKURK
MUENCHEN / WEIHENSTEPHAN MAI 2010
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/100846015X
DIGITALISIERT DURCH
IMAGE 2
CONTENTS
1. INTRODUCTION 6
DEVELOPMENT OF ADIPOSE TISSUE 6
DETERMINANTS OF ADIPOGENESIS 7
ADIPOSE TISSUE: A SPECIALIZED FORM OF CONNECTIVE TISSUE 8
METABOLIC FUNCTION OF ADIPOSE TISSUE 8
DIFFERENCES BETWEEN WHITE AND BROWN ADIPOSE TISSUE 10
ANATOMICAL DIFFERENCES BETWEEN ADIPOSE TISSUE DEPOTS 10
2. CELL CULTURE MODELS FOR THE STUDY OF ADIPOSE TISSUE FUNCTION 12
ISOLATION AND CULTURE OF HUMAN ADIPOSE PRECURSOR CELLS 13 PROPAGATION OF
HUMAN ADIPOSE PRECURSOR CELLS 13
(ORIGINAL PAPER) PROPAGATION OF HUMAN ADIPOSE PRECURSOR CELLS 15
3. THE SECRETORY FUNCTION OF ADIPOSE TISSUE 22
ADIPOSE TISSUE IS AN ENDOCRINE ORGAN 22
(ORIGINAL PAPER) ANG II PROMOTES LEPTIN PRODUCTION IN ADIPOCYTES 24
(ORIGINAL PAPER) ANG II STIMULATES IL-6/IL-8 IN AN ERK-DEPENDENT PATHWAY
29 (ORIGINAL PAPER) ANG II STIMULATES PAI-1 FROM CULTURED HUMAN FAT
CELLS 34 OBESITY AND INFLAMMATION 39
INFLAMMATION IN OBESITY AND ASSOCIATED COMPLICATIONS 39
PRO-INFLAMMATORY PRODUCTS OF ADIPOSE TISSUE 39
CHEMOTACTIC SIGNALS FROM ADIPOCYTES 42
(ORIGINAL PAPER) PRODUCTION AND RELEASE OF IL-18 44
(ORIGINAL PAPER) PRODUCTION AND RELEASE OF MIF. 50
(ORIGINAL PAPER) PRODUCTION AND RELEASE OFLP-10 63
(ORIGINAL PAPER) SDF-1 SECRETION AND LEUKOCYTE INFILTRATION 70 INFLUENCE
OF FAT CELL SIZE ON FAT CELL FUNCTION 78
(ORIGINAL PAPER) ADIPOCYTE HYPERTROPHY AND CHRONIC INFLAMMATION 81
4. CONCLUSIONS AND OUTLOOK 92
PERSPECTIVES FOR THE TREATMENT OF OBESITY AND ITS RELATED METABOLIC
COMPLICATIONS 92
FAT CELL SIZE AND MACROPHAGE INFILTRATION 94
ER-STRESS AND INFLAMMATION 96
ABBREVIATIONS 99
REFERENCES 100
LIST OF PUBLICATIONS (SELECTION) 114
ORAL PRESENTATIONS (SELECTION) 118
CURRICULUM VITAE 119
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| spelling | Skurk, Thomas 1970- Verfasser (DE-588)121238636 aut Fat cells control low-grade inflammation in obesity by the production of adipokines von Thomas Skurk 2010 121 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Enth. Zeitschriftenaufsätze München, Techn. Univ., Habil.-Schr., 2010 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020700740&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Skurk, Thomas 1970- Fat cells control low-grade inflammation in obesity by the production of adipokines |
| subject_GND | (DE-588)4113937-9 |
| title | Fat cells control low-grade inflammation in obesity by the production of adipokines |
| title_auth | Fat cells control low-grade inflammation in obesity by the production of adipokines |
| title_exact_search | Fat cells control low-grade inflammation in obesity by the production of adipokines |
| title_full | Fat cells control low-grade inflammation in obesity by the production of adipokines von Thomas Skurk |
| title_fullStr | Fat cells control low-grade inflammation in obesity by the production of adipokines von Thomas Skurk |
| title_full_unstemmed | Fat cells control low-grade inflammation in obesity by the production of adipokines von Thomas Skurk |
| title_short | Fat cells control low-grade inflammation in obesity by the production of adipokines |
| title_sort | fat cells control low grade inflammation in obesity by the production of adipokines |
| topic_facet | Hochschulschrift |
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