Mass spectrometry: principles and applications
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2009
|
| Ausgabe: | 3. ed., repr. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XII, 489 S. Ill., graph. Darst. |
| ISBN: | 9780470033111 9780470033104 |
Internformat
MARC
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| 240 | 1 | 0 | |a Spectrométrie de masse |
| 245 | 1 | 0 | |a Mass spectrometry |b principles and applications |c Edmond de Hoffmann ; Vincent Stroobant |
| 250 | |a 3. ed., repr. | ||
| 264 | 1 | |a Chichester |b Wiley |c 2009 | |
| 300 | |a XII, 489 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804143448702320640 |
|---|---|
| adam_text | Contents
Preface
xi
Introduction
1
Principles
1
Diagram of a Mass Spectrometer
4
History
5
Ion Free Path
10
1
Ion
Sources
15
1.1
Electron Ionization
15
1.2
Chemical Ionization
17
1.2.1
Proton transfer
19
1.2.2
Adduct formation
21
1.2.3
Charge-transfer chemical ionization
21
1.2.4
Reagent gas
22
1.2.5
Negative ion formation
25
1.2.6
Desorption chemical ionization
27
1.3
Field Ionization
28
1.4
Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry
29
1.5
Field Desorption
31
1.6
Plasma Desorption
32
1.7
Laser Desorption
33
1.8
Matrix-Assisted Laser Desorption Ionization
33
1.8.1
Principle of
MALDÏ
33
1.8.2
Practical considerations
36
1.8.3
Fragmentations
39
1.8.4
Atmospheric pressure matrix-assisted laser desorption ionization
39
1.9
Thermospray
41
1.10
Atmospheric Pressure Ionization
42
1.11
Electrospray
43
1.11.1
Multiply charged ions
46
1.11.2
Electrochemistry and electric field as origins of multiply charged ions
48
1.11.3
Sensitivity to concentration
50
1.11.4
Limitation of ion current from the source by the electrochemical process
51
1.11.5
Practical considerations
54
1.12
Atmospheric Pressure Chemical Ionization
55
1.13
Atmospheric Pressure Photoionization
56
CONTENTS
1.14
Atmospheric Pressure Secondary Ion Mass Spectrometry
61
1.14.1
Desorption electrospray ionization
01
1.14.2
Direct analysis in real time 6~
1.15
Inorganic Ionization Sources ^
1.15.1
Thermal ionization source ^o
1.15.2
Spark source ^
1.15.3
Glow discharge source °°
1.15.4
Inductively coupled plasma source
69
1.15.5
Practical considerations
*
1.16
Gas-Phase Ion-Molecule Reactions
72
1.17
Formation and Fragmentation of Ions: Basic Rules
76
1.17.1
Electron ionization and photoionization under vacuum
77
1.17.2
Ionization at low pressure or at atmospheric pressure
7
1.17.3
Proton transfer
77
1.17.4
Adduct formation
78
1.17.5
Formation of aggregates or clusters
79
1.17.6
Reactions at the interface between source and analyser
79
Mass Analysers
85
DO
2.1
Quadrupole Analysers °*o
2.1.1
Description 88
2.1.2
Equations of motion
1
2.1.3
Ion guide and collision cell
-*
2.1.4
Spectrometers with several quadrupoles in tandem o
2.2
Ion Trap Analysers
100
2.2.1
The
3D
ion trap
100
2.2.2
The 2D ion trap
117
2.3
The Electrostatic Trap or Orbitrap
122
2.4
Time-of-Flight Analysers
126
2.4.1
Linear time-of-flight mass spectrometer
126
2.4.2
Delayed pulsed extraction
129
2.4.3
Reflectrons
131
2.4.4
Tandem mass spectrometry with time-of-flight analyser
134
2.4.5
Orthogonal acceleration time-of-flight instruments
139
2.5
Magnetic and Electromagnetic Analysers
143
2.5.1
Action of the magnetic field
143
2.5.2
Electrostatic field
144
2.5.3
Dispersion and resolution
145
2.5.4
Practical considerations
146
2.5.5
Tandem mass spectrometry in electromagnetic analysers
149
2.6
Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry
157
2.6.1
General principle
157
2.6.2
Ion cyclotron resonance
159
2.6.3
Fourier transform mass spectrometry
159
2.6.4
MS in ICR/FTMS instruments
164
2.7
Hybrid Instruments
164
2.7.1
Electromagnetic analysers coupled to quadrupoles or ion trap
165
2.7.2
Ion trap analyser combined with time-of-flight or ion cyclotron
resonance 66
2.7.3
Hybrids including time-of-flight with orthogonal acceleration
167
CONTENTS
3
Detectors and Computers
3.1
Detectors
3.1.1
Photographic plate
3.1.2
Faraday cup
3.1.3
Electron multipliers
3.1.4
Electro-optical ion detectors
3.2
Computers
3.2.1
Functions
3.2.2
Instrumentation
3.2.3
Data acquisition
3.2.4
Data conversion
3.2.5
Data reduction
3.2.6
Library search
175
175
176
176
177
181
182
183
183
183
186
186
186
4
Tandem Mass Spectrometry
189
4.1
Tandem Mass Spectrometry in Space or in Time
189
4.2
Tandem Mass Spectrometry Scan Modes
192
4.3
Collision-Activated Decomposition or Collision-Induced Dissociation
195
4.3.1
Collision energy conversion to internal energy
196
4.3.2
High-energy collision (keV)
198
4.3.3
Low-energy collision (between
1
and
100
eV)
199
4.4
Other Methods of Ion Activation
199
4.5
Reactions Studied in MS/MS
202
4.6
Tandem Mass Spectrometry Applications
204
4.6.1
Structure elucidation
205
4.6.2
Selective detection of target compound class
207
4.6.3
Ion-molecule reaction
210
4.6.4
The kinetic method
211
5
Mass Spectrometry/Chromatography Coupling
217
5.1
Elution Chromatography Coupling Techniques
218
5.1.1
Gas chromatography/mass spectrometry
219
5.1.2
Liquid chromatography/mass spectrometry
221
5.1.3
Capillary electrophoresis/mass spectrometry
228
5.2
Chromatography Data Acquisition Modes
228
5.3
Data Recording and Treatment
230
5.3.1
Data recording
230
5.3.2
Instrument control and treatment of results
232
6
Analytical Information
243
6.1
Mass Spectrometry Spectral Collections
243
6.2
High Resolution
245
6.2.1
Information at different resolving powers
249
6.2.2
Determination of the elemental composition
251
6.3
Isotopie
Abundances
251
6.4
Low-mass Fragments and Lost Neutrals
257
6.5
Number of Rings or Unsaturations
258
6.6
Mass and Electron Parities, Closed-shell Ions and Open-shell Ions
259
6.6.1
Electron parity
259
6.6.2
Mass parity
259
6.6.3
Relationship between mass and electron parity
260
CONTENTS
6.7 Quantitative Data 260
6.7.1
Specificity
260
6.7.2
Sensitivity and detection limit
262
6.7.3
External standard method
264
6.7.4
Sources of error
265
6.7.5
Internal standard method
266
6.7.6
Isotopie
dilution method
268
Fragmentation Reactions
273
7.1
Electron Ionization and Fragmentation Rates
273
7.2
Quasi-Equilibrium and RRKM Theory
275
7.3
Ionization and Appearance Energies
279
7.4
Fragmentation Reactions of Positive Ions
280
7.4.1
Fragmentation of odd-electron cations or radical cations (OE* *
) 280
7.4.2
Fragmentation of cations with an even number of electrons
(ЕЕ 1 )
286
7.4.3
Fragmentations obeying the parity rule
288
7.4.4
Fragmentations not obeying the parity rule
291
7.5
Fragmentation Reactions of Negative Ions
291
7.5.1
Fragmentation mechanisms of even electron anions
(ЕЕ )
292
7.5.2
Fragmentation mechanisms of radical anions (OE*
) 293
7.6
Charge Remote Fragmentation
293
7.7
Spectrum Interpretation
294
7.7.1
Typical ions
296
7.7.2
Presence of the molecular ion
296
7.7.3
Typical neutrals
296
7.7.4
A few examples of the interpretation of mass spectra
298
Analysis of Biomolecules
305
8.1
Biomolecules and Mass Spectrometry
305
8.2
Proteins and Peptides
306
8.2.1
ESIandMALDI
307
8.2.2
Structure and sequence determination using fragmentation
309
8.2.3
Applications
324
8.3
Oligonucleotides
342
8.3.1
Mass spectra of oligonucleotides
343
8.3.2
Applications of mass spectrometry to oligonucleotides
346
8.3.3
Fragmentation of oligonucleotides
351
8.3.4
Characterization of modified oligonucleotides
355
8.4
Oligosaccharides
357
8.4.1
Mass spectra of oligosaccharides
358
8.4.2
Fragmentation of oligosaccharides
360
8.4.3
Degradation of oligosaccharides coupled with mass spectrometry
367
8.5
Lipids
371
8.5.1
Fatty acids
373
8.5.2
Acylglycerols
376
8.5.3
Bile acids
382
8.6
Metabolomics
386
8.6.1
Mass spectrometry in metabolomics
387
8.6.2
Applications
388
CONTENTS
ix
9
Exercises
403
Questions
403
Answers
415
Appendices
437
1
Nomenclature
437
1.1
Units
437
1.2
Definitions
437
1.3
Analysers
438
1.4
Detection
439
1.5
Ionization
440
1.6
Ion types
441
1.7
Ion-molecule reaction
442
1.8
Fragmentation
442
2
Acronyms and abbreviations
442
3
Fundamental Physical Constants
446
4A Table of Isotopes in Ascending Mass Order
447
4B Table of Isotopes in Alphabetical Order
452
5
Isotopie
Abundances (in
%)
for Various Elemental Compositions CHON
457
6
Gas-Phase Ion Thermochemical Data of Molecules
467
7
Gas-Phase Ion Thermochemical Data of Radicals
469
8
Literature on Mass Spectrometry
470
9
Mass Spectrometry on Internet
476
Index
479
Mass Spectrometry
Principles and Applications
Third Edition
Edmond de
Hoffmann,
Université Catholique de Louvain,
Belgium
Vincent Stroobant,
Ludwig Institute
for Cancer Research,
Brussels Branch, Belgium
Mass Spectrometry, Third Edition, provides students with a complete overview
of the principles, theories and key applications of modern mass spectrometry.
Extensively revised and updated, the third edition of this successful textbook
focuses on recent developments in techniques and applications. All instrumental
aspects of mass spectrometry are clearly and concisely described. Emphasis is
placed throughout the text on practical application examples. As with previous
editions, it contains numerous tables of useful data, references and a series of
exercises of increasing difficulty to encourage student understanding.
■
Provides a complete overview of the principles, theories and
applications of modern mass spectrometry
Ш
An extensive revision and update including: increased coverage of
MALDI and ESI, resolution and mass accuracy and activation of ions
■
New material about instruments such as linear traps, Orbitrap,
ГОРДОЕ
hybrid instruments, and about new atmospheric
ionisation
techniques such as
APPI,
DESI
and DART. The range of applications has
been expanded and newer methods such as metabolomics are included
■
Contains numerous examples and exercises to encourage student
understanding
Mass Spectrometry: Principles and Applications, Third Edition, will prove
invaluable to undergraduates and postgraduates using MS in departments of
chemistry, biochemistry, medicine, pharmacology, agriculture, materials science
and food science. It will also appeal to researchers looking for an overview of
the latest techniques and developments.
|
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| id | DE-604.BV036775761 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:47:50Z |
| institution | BVB |
| isbn | 9780470033111 9780470033104 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020692523 |
| oclc_num | 554064172 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XII, 489 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Wiley |
| record_format | marc |
| spelling | De Hoffmann, Edmond Verfasser (DE-588)137318790 aut Spectrométrie de masse Mass spectrometry principles and applications Edmond de Hoffmann ; Vincent Stroobant 3. ed., repr. Chichester Wiley 2009 XII, 489 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Massenspektrometrie (DE-588)4037882-2 gnd rswk-swf Massenspektrometrie (DE-588)4037882-2 s DE-604 Stroobant, Vincent Verfasser (DE-588)137318294 aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020692523&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020692523&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | De Hoffmann, Edmond Stroobant, Vincent Mass spectrometry principles and applications Massenspektrometrie (DE-588)4037882-2 gnd |
| subject_GND | (DE-588)4037882-2 |
| title | Mass spectrometry principles and applications |
| title_alt | Spectrométrie de masse |
| title_auth | Mass spectrometry principles and applications |
| title_exact_search | Mass spectrometry principles and applications |
| title_full | Mass spectrometry principles and applications Edmond de Hoffmann ; Vincent Stroobant |
| title_fullStr | Mass spectrometry principles and applications Edmond de Hoffmann ; Vincent Stroobant |
| title_full_unstemmed | Mass spectrometry principles and applications Edmond de Hoffmann ; Vincent Stroobant |
| title_short | Mass spectrometry |
| title_sort | mass spectrometry principles and applications |
| title_sub | principles and applications |
| topic | Massenspektrometrie (DE-588)4037882-2 gnd |
| topic_facet | Massenspektrometrie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020692523&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020692523&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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