High-temperature liquid chromatography: a user's guide for method development
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
RSC Publ.
2010
|
| Schriftenreihe: | RSC chromatography monographs
13 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 210 S. Ill., graph. Darst. |
| ISBN: | 9781849730136 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804143387270447104 |
|---|---|
| adam_text | Titel: High-temperature liquid chromatography
Autor: Teutenberg, Thorsten
Jahr: 2010
Contents
Chapter 1 A Brief Definition of High-Temperature Liquid
Chromatograph} 1
1.1 What is High-Temperature Liquid
Chromatography? 1
1.2 What is a Suitable Temperature Range for
High-Temperature Liquid Chromatography? 4
1.3 Why should High Temperatures be used in
Liquid Chromatography? 5
1.4 What are the Principal Requirements of
High-Temperature Liquid Chromatography? 8
Chapter 2 System Set-up for High-Temperature Liquid
Chromatography 15
2.1 The Heating System 15
2.2 The Column 20
2.3 The Detector 21
2.4 The Back-Pressure Regulator 22
Chapter 3 The Heating System 24
3.1 Preheating of the Mobile Phase 25
3.1.1 Thermal Mismatch Broadening 25
3.1.2 Viscous Heat Dissipation 31
RSC Chromatography Monographs No. 13
High-Temperature Liquid Chromatography: A User s Guide for Method Development
By Thorsten Teutenberg
© Thorsten Teutenberg 2010
Published by the Royal Society of Chemistry, www.rsc.org
viii Contents
3.1.3 Technical Implementation of Eluent
Preheating 35
3.1.4 Experimental Verification of Eluent Preheating
Efficiency 37
3.2 Column Heating 40
3.2.1 Air-Bath Ovens 40
3.2.2 Water-Jacket Ovens 40
3.2.3 Block-Heating Ovens 41
3.3 Post-Column Cooling of the Mobile Phase 42
3.4 Temperature Programming 43
3.5 A Critical Comparison between Different Ovens 46
3.5.1 Air-Bath Ovens 46
3.5.2 Water-Jacket Ovens 48
3.5.3 Block-Heating Ovens 48
3.5.4 Summary 49
Chapter 4 Mobile Phase Considerations 52
4.1 Infiuence of Temperature on Vapour Pressure 52
4.1.1 Prevention of a Phase Transition using a
Back-Pressure Regulator 56
4.1.2 Prevention of a Phase Transition using a
Restriction Capillary 61
4.2 Infiuence of Temperature on Viscosity 64
4.2.1 Practical Implications - The Restriction
Capillary 67
4.2.2 Practical Implications - Kinetic Aspects and
Column Pressure 69
4.3 Infiuence of Temperature on Static Permittivity 75
4.4 The Water-THF System 81
4.5 The Dortmund Data Bank 83
Chapter 5 Suitable Stationary Phases 87
5.1 Column Bleed 89
5.2 Investigation of Column Degradation at High
Temperatures 91
5.3 Silica-Based Stationary Phases 93
5.4 Zirconium Dioxide Stationary Phases 97
5.5 Titanium Dioxide Stationary Phases 101
5.6 Polymerie Stationary Phases 104
5.7 Other Materials 105
5.7.1 Graphitized Carbon Column 105
5.7.2 Thermo-Responsive Stationary Phases 107
5.8 General Conclusions 109
Contents ix
Chapter 6 Method Development using Temperature as an Active
Variable 114
6.1 Special Requirements of the Heating System 114
6.2 Special Requirements of the Column
Hardware 115
6.3 Mobile Phase Considerations 116
6.4 Infiuence of Temperature on Resolution 118
6.4.1 Infiuence of Temperature on
Retention 119
6.4.2 Infiuence of Temperature on
Selectivity 125
6.4.3 Infiuence of Temperature on Efficiency 128
6.5 Method Development 131
6.5.1 Isothermal and Isocratic Separations 131
6.5.2 Temperature Gradient and Isocratic
Separation 135
6.5.3 Simultaneous Temperature and Solvent
Gradient Separation 140
6.5.4 Detector Optimization 143
Chapter 7 Analyte Stability 149
7.1 Evaluation of Analyte Stability using UV
Detection 150
7.2 Infiuence of the Stationary Phase on Analyte
Stability 152
7.3 Definition of Critical Criteria for Analyte
Stability 154
Chapter 8 Special Hyphenation Techniques 158
8.1 Flame Ionization Detection 159
8.2 LC-NMR 164
8.3 Isotope Ratio Mass Spectrometry 168
8.4 LC Taste* 174
8.5 Drug Screening 177
Chapter 9 Critical Outlook and Future Prospects 182
9.1 Pellicular Particles 182
9.2 Capillary and Nano HPLC 184
9.3 Comprehensive Two-Dimensional Liquid
Chromatography 189
x Contents
Appendix A Vapour Pressure Data 193
Appendix B Viscosity Data 197
Appendix C Stade Permittivity Data 201
Subject Index 205
|
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| id | DE-604.BV036733164 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:46:51Z |
| institution | BVB |
| isbn | 9781849730136 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020650791 |
| oclc_num | 699735318 |
| open_access_boolean | |
| owner | DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-11 DE-19 DE-BY-UBM |
| physical | X, 210 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | RSC Publ. |
| record_format | marc |
| series | RSC chromatography monographs |
| series2 | RSC chromatography monographs |
| spelling | Teutenberg, Thorsten 1973- Verfasser (DE-588)12928839X aut High-temperature liquid chromatography a user's guide for method development Thorsten Teutenberg Cambridge RSC Publ. 2010 X, 210 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier RSC chromatography monographs 13 Hochtemperatur (DE-588)4282597-0 gnd rswk-swf HPLC (DE-588)4072641-1 gnd rswk-swf HPLC (DE-588)4072641-1 s Hochtemperatur (DE-588)4282597-0 s DE-604 RSC chromatography monographs 13 (DE-604)BV041129265 13 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650791&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Teutenberg, Thorsten 1973- High-temperature liquid chromatography a user's guide for method development RSC chromatography monographs Hochtemperatur (DE-588)4282597-0 gnd HPLC (DE-588)4072641-1 gnd |
| subject_GND | (DE-588)4282597-0 (DE-588)4072641-1 |
| title | High-temperature liquid chromatography a user's guide for method development |
| title_auth | High-temperature liquid chromatography a user's guide for method development |
| title_exact_search | High-temperature liquid chromatography a user's guide for method development |
| title_full | High-temperature liquid chromatography a user's guide for method development Thorsten Teutenberg |
| title_fullStr | High-temperature liquid chromatography a user's guide for method development Thorsten Teutenberg |
| title_full_unstemmed | High-temperature liquid chromatography a user's guide for method development Thorsten Teutenberg |
| title_short | High-temperature liquid chromatography |
| title_sort | high temperature liquid chromatography a user s guide for method development |
| title_sub | a user's guide for method development |
| topic | Hochtemperatur (DE-588)4282597-0 gnd HPLC (DE-588)4072641-1 gnd |
| topic_facet | Hochtemperatur HPLC |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650791&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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