Bacterial pathogenesis: a molecular approach
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, DC
ASM Press
2011
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Bis 2. Aufl. u.d.T.: Bacterial pathogenesis / Salyers, Abigail A. |
| Beschreibung: | XIV, 526 S. Ill., graph. Darst. |
| ISBN: | 9781555814182 |
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Datensatz im Suchindex
| _version_ | 1804143386535395328 |
|---|---|
| adam_text | Titel: Bacterial pathogenesis
Autor: Wilson, Brenda A
Jahr: 2011
Contents
Preface xiii
Chapter 1
The Power of Bacteria 1
Why Are Bacteria Once Again in the Public Health
Spotlight? 1
Bacteria, an Ancient Life Form 2
Pressing Current Infectious Disease Issues 4
Emerging and Reemerging Infectious Diseases 4
Food-Borne and Water-Borne Infections 4
Modern Medicine as a Source of New Diseases 6
Postsurgical and Other Wound Infections 6
Bioterrorism 8
A New Respect for Prevention 8
Surveillance: an Early-Warning System 9
Making Hospitals Safe for Patients 9
And Now for Some Really Good News: You ve Got a Bacterial
Infection! 10
The H. pylori Revolution 10
The Aftermath 11
Microbiota Shift Diseases 11
Genomics 12
Modeling the Host-Pathogen Interaction in Experimental Animals 13
Correlation Studies 13
A Brave New World of Pathogenesis Research 13
SELECTED READINGS 14
QUESTIONS 15
viii Contents
Chapter 2
Skin and Mucosa: the First Lines of
Defense against Bacterial Infections 16
Barriers: Skin and Mucosal Membranes 16
Defenses of the Skin 18
Epidermis 18
Normal Microbiota 19
Defenses of the Dermis 20
Defenses of Mucosal Surfaces 21
Special Defenses of the Gastrointestinal Tract 23
Models for Studying Breaches of Barrier
Defenses 26
SELECTED READINGS 26
QUESTIONS 27
Chapter 3
The Innate Immune System: Always on
Guard 28
Triggering Innate Immune Defenses 28
Phagocytes: Powerful Defenders of Blood and Tissue 28
Inflammation and Collateral Damage 36
NK Cells 37
The Complement Cascade 38
Characteristics and Roles of Complement Proteins and the
Complement Cascade 38
Roles of Cytokines and Chemokines in Directing the
Phagocyte Response 42
Other Activities of Cytokines 46
The Dark Side of the Innate Defenses: Septic Shock 47
SELECTED READINGS 50
QUESTIONS 50
Chapter 4
The Second Line of Defense: Antibodies
and Cytotoxic T Cells 51
Antibodies 52
Characteristics of Antibodies and Their Diverse Roles in
Preventing Infection 52
Serum Antibodies 54
Secretory Antibodies—Antibodies That Protect Mucosal
Surfaces 56
Affinity and Avidity 57
CTLs 57
Production of Antibodies and Activated CTLs 58
Processing of Protein Antigens by DCs 58
Interaction between APCs and T Cells: the
T-Cell-Dependent Response 61
The Thl/Th2 View of the Adaptive Immune System 62
Production of Antibodies by B Cells 64
Links between the Innate and Adaptive Defense
Systems 65
T-Cell-Independent Antibody Responses 65
Mucosal Immunity 66
Development of the Adaptive Response System
from Infancy to Adulthood 69
Adaptive Defense Systems in Nonmammals 70
The Dark Side of the Adaptive Defenses—
Autoimmune Disease 70
SELECTED READINGS 71
QUESTIONS 71
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 72
Chapter 5_
The Normal Human Microbiota 73
Importance of the Normal Microbial Populations
(Microbiota) of the Human Body 73
Nucleic Acid-Based Approaches to Characterization
of the Microbiota 74
Taking a Microbial Census by Using Microbial rRNA
Sequence Analysis 74
Beyond the Metagenome 90
Overview of the Human Microbiota 90
Skin Microbiota 90
Oropharyngeal Microbiota 90
Microbiota of the Small Intestine and Colon 91
Microbiota of the Vaginal Tract 94
The Forgotten Eukaryotes 94
SELECTED READINGS 95
QUESTIONS 95
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 96
Chapter 6
Microbes and Disease: Establishing a
Connection 98
History and Relevance of Koch s Postulates 98
The First Postulate: Association of the Microbe with
Lesions of the Disease 99
The Second Postulate: Isolating the Bacterium in Pure
Culture 100
The Third Postulate: Showing that the Isolated Bacterium
Causes Disease in Humans or Animals 101
The Fourth Postulate: Reisolating the Bacterium from the
Intentionally Infected Animal 102
Modern Alternatives To Satisfy Koch s Postulates 102
Is a Fifth Postulate Needed? 103
The Microbiota Shift Disease Problem 106
Concepts of Disease 106
Contents ||| ix
Varieties of Human-Microbe Interactions 106
Views of the Microbe-Human Interaction 106
Molecular Koch s Postulates 107
Virulence as a Complex Phenomenon 107
SELECTED READINGS 108
QUESTIONS 108
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 109
Chapter 7
Mechanisms of Genetic Modification
and Exchange: Role in Pathogen
Evolution 111
Adapt or Perish 111
Acquiring New Virulence Traits by HGT 111
Mechanisms of Genetic Change and
Diversification 112
Point Mutations, Gene Deletions or Duplications, and
Chromosomal Rearrangements 112
Phase Variation 112
Antigenic Variation 115
HGT: Mobile Genetic Elements 116
Natural Transformation 116
Conjugation: Plasmids and Transposons 117
Phage Transduction 119
PAIs and Pathogen Evolution 121
Properties of PAIs 121
Pathogen Evolution in Quantum Leaps 123
SELECTED READINGS 126
QUESTIONS 127
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 128
Chapter 8
Identification of Virulence Factors:
Measuring Infectivity and Virulence 130
Animal Models of Infection 131
Human Volunteers 131
Nonhuman Animal Models 132
Measuring Bacterial Infection in Animal
Models 135
Ethical Considerations 135
LDso and IDS0 Values 137
Competition Assays 138
Tissue Culture and Organ Culture Models 139
Tissue Culture Models 139
Gentamicin Protection Assay 141
Plaque Assay for Cell-to-Cell Spread 143
Fluorescence Microscopy Techniques for Assessing Effects
of Pathogens on Host Cells 143
Organ Culture Models 144
The Continuing Need for Reliable and Plentiful
Information about Disease Pathology 145
SELECTED READINGS 145
QUESTIONS 146
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 146
Chapter 9
Identification of Virulence Factors:
Molecular Approaches for Bacterial
Factors 149
Traditional Biochemical and Genetic
Approaches 151
Traditional Biochemical Approaches 151
Molecular Genetic Approaches 152
Transposon Mutagenesis 152
Measuring Virulence Gene Regulation: Gene Fusions 154
Finding Genes That Are Expressed In Vivo 156
Signature-Tagged Mutagenesis 156
IVET 159
Genomic Methods for Identifying Virulence
Genes 165
GSH 165
IVIAT 167
Microarrays 169
Comparative Genomics for Vaccines and Therapeutics 171
The Importance of Bacterial Physiology 171
SELECTED READINGS 174
QUESTIONS 175
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 176
Chapter 10
Identification of Virulence Factors:
Molecular Approaches for Host
Factors 178
Approaches to Identifying Host Factors Required
for Infection 178
Transgenic Animal Models 178
Comparative Genomics of the Host Response 180
Transcriptional and Proteomic Profiling To Identify Host
Factors Required for Infection 180
Using Genome-Wide RNAi Screening To Identify Host
Factors Required for Infection 184
Using the Host s Immune Response To Find Bacterial
Origins of Disease 186
The Promise and the Caution 187
SELECTED READINGS 187
QUESTIONS 188
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 188
X El Contents
Chapter 11
Bacterial Strategies for Evading or
Surviving Host Defense Systems 193
Overview of Bacterial Defense Strategies 193
Preinfection 196
Survival in the External Environment 196
Biofilms 196
Motility and Chemotaxis 197
Colonization of Host Surfaces 199
Penetrating Intact Skin 199
Penetrating the Mucin Layer 199
Secretory IgA Proteases 200
Resistance to Antibacterial Peptides 200
Iron Acquisition Mechanisms 201
Adherence 203
Evading the Host Immune Response 210
Avoiding Complement and Phagocytosis 210
Invasion and Uptake by Host Cells 213
Surviving Phagocytosis 215
Evading the Host s Antibody Response 219
Cell-to-Cell Spread 220
Tissue Penetration and Dissemination 220
Beyond Virulence Factors 221
SELECTED READINGS 222
QUESTIONS 223
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 224
Chapter 12
Toxins and Other Toxic Virulence
Factors 225
Bacterial Toxins 225
Transparent Mechanisms, Mysterious Purposes 225
Characteristics and Nomenclature 230
Nonprotein Toxins 231
Protein Exotoxins 233
Protein Exoenzymes/ Effectors 239
Examples of Diseases Mediated by Toxins 239
DT 239
Botulism and Tetanus 246
Immunotoxins: Toxin-Based Therapeutics and
Research Tools 251
SELECTED READINGS 252
QUESTIONS 252
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 253
Chapter 13
Delivery of Virulence Factors 256
Bacterial Secretion Systems and Virulence 256
Common Secretory Systems 257
Secretion Systems Specific to Gram-Negative
Bacteria 259
Sec-Dependent Secretion Systems 259
Sec-Independent Secretion Systems 260
Secretion Systems Specific to Gram-Positive
Bacteria 267
CMT and ExPortal 267
T7SS 268
Secretion Systems as Vaccine and Therapeutic
Targets 269
SELECTED READINGS 269
QUESTIONS 270
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 270
Chapter 14
Virulence Regulation 275
Mechanisms of Virulence Gene Regulation 275
Types of Regulation 276
Gene Rearrangements 276
Transcriptional Regulation 277
cis-Acting RNA Thermosensors 287
Translational Regulation 289
Quorum Sensing 292
Quorum Sensing in Gram-Negative Bacteria 297
Quorum Sensing in Gram-Positive Bacteria 299
New Theory: Antibiotics and Quorum Sensing 299
SELECTED READINGS 307
QUESTIONS 307
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 309
SPECIAL GLOBAL-PERSPECTIVE PROBLEMS:
INTEGRATING CONCEPTS IN PATHOGENESIS 313
Chapter 15
Antimicrobial Compounds 317
Antimicrobial Compounds: the Safety Net of
Modern Medicine 317
Importance of Antimicrobial Compounds 317
Killing versus Inhibiting Growth 318
Antiseptics and Disinfectants 319
Mechanisms of Action 319
Resistance to Antiseptics and Disinfectants 321
Antibiotics 321
Characteristics of Antibiotics 321
Tests Used To Assess Antibiotics 323
The Process of Antibiotic Discovery 324
Finding New Targets by Exploiting Genomics 327
The Economics of Antibiotic Discovery 328
Mechanisms of Antibiotic Action 330
Targets of Antibiotic Action 330
Contents
xi
Cell Wall Synthesis Inhibitors 331
Protein Synthesis Inhibitors 334
Antibiotics That Target DNA Synthesis 337
Antibiotics That Inhibit RNA Synthesis 340
Inhibitors of Tetrahydrofolate Biosynthesis 340
The Newest Antibiotics 340
The Newest Antibiotic Targets 342
Strategies for Enhancing Antibiotic Efficacy 343
The Continuing Challenge 343
SELECTED READINGS 344
QUESTIONS 345
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 346
Chapter 16
How Bacteria Become Resistant to
Antibiotics 347
The Dawning of Awareness 347
How Did We Get to Where We Are? 349
Mechanisms of Antibiotic Resistance 350
Overview of Resistance Mechanisms 350
Limiting Access of the Antibiotic 350
Enzymatic Inactivation of the Antibiotic 351
Modification or Protection of the Antibiotic Target 354
Failure To Activate an Antibiotic 357
Regulation of Resistance Genes 357
Multiple Resistance and Genetic Linkage 361
Antibiotic Tolerance 362
Horizontal Gene Transfer of Resistance Genes 362
Propagating and Maintaining Antibiotic Resistance
through Selective Pressure and Changes in
Fitness 365
Will We Return to the Preantibiotic Era? 366
SELECTED READINGS 368
QUESTIONS 368
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 369
SPECIAL GLOBAL-PERSPECTIVE PROBLEM: INTEGRATING
CONCEPTS IN PATHOGENESIS 370
Chapter 17
Vaccination—an Underappreciated
Component of the Modern Medical
Armamentarium 373
Vaccines: a Major Health Care Bargain 373
The Antivaccination Movement 374
The Success Stories 376
Subunit Vaccines 376
Conjugate Vaccines 379
The Less-than-Success Stories 379
What Makes an Ideal Vaccine? 383
Approaches to Enhancing Immunogenicity 384
Eliciting the Correct Type of Immune Response 384
Adjuvants 384
New Strategies 386
Programming Adaptive Immunity 386
Targeting Mucosal Immunity 388
DNA Vaccine Technology 392
Storage of Vaccines 392
Immunization Programs 392
Passive Immunization 393
SELECTED READINGS 393
QUESTIONS 394
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 395
SPECIAL GLOBAL-PERSPECTIVE PROBLEM: INTEGRATING
CONCEPTS IN PATHOGENESIS 397
Chapter 18_
The Gram-Positive Opportunistic
Pathogens 399
What Is an Opportunist? 399
Shared Characteristics 400
Why Commensal Bacteria Act as Pathogens 400
Examples of Notable Gram-Positive
Opportunists 401
S. aureus: a Toxically Loaded Commensal 401
S. epidermidis: an Accidental Pathogen 411
S. pneumoniae: a Commensal Nicknamed the Captain of
All the Men of Death 414
C. difficile ( C. diff. ): a True Opportunist 423
That s Not All, Folks 431
SELECTED READINGS 432
QUESTIONS 433
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 433
Chapter 19_
The Gram-Negative Opportunistic
Pathogens 437
Jumping Over the (Cell) Wall: Gram-Negative
Bacteria Can Be Opportunistic Pathogens Too 437
The Dark Side of Some Normal Inhabitants of the
Human Body 438
The Ever-Changing Face of E. coli 438
B. fragilis Internal Abscesses 441
P. gingivalis and Periodontal Disease 442
Normal Soil Inhabitants Weigh In as
Opportunists 443
P. aeruginosa Infections 443
B. cenocepacia—P. aeruginosa s Evil Twin 446
xii ITj Contents
A. baumannii—an Emerging Threat from the Iraq War 446
Don t Forget the Arthropods 447
Ehrlichia spp. 447
The Broader View 448
SELECTED READINGS 449
QUESTIONS 449
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 450
SPECIAL GLOBAL-PERSPECTIVE PROBLEM: INTEGRATING
CONCEPTS IN PATHOGENESIS 452
Chapter 20
Biosecurity: the Changing Roles of
Microbiologists in an Age of Bioterrorism
and Emerging Diseases 457
When Microbiologists Are Called to the Front
Line 457
Tracking Down a Bioterrorist 458
Unintentional or Deliberate? 459
Timing 462
Tracing the Source 462
Lessons Learned 462
The Top Four Bioterror Agents 465
B. anthracis Spores 465
Smallpox 466
V. pestis 467
Botulinum Neurotoxin 468
What If Bioterrorists Came Up with Something
Completely New? 468
Biosecurity in an Ever-Changing World 469
Food Safety and Biosecurity 470
The Case for Food Irradiation 470
The Future of Biosecurity 472
SELECTED READINGS 473
QUESTIONS 473
SOLVING PROBLEMS IN BACTERIAL PATHOGENESIS 474
Glossary 477
Index 509
|
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| discipline | Biologie Medizin |
| edition | 3. ed. |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036732687 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:46:50Z |
| institution | BVB |
| isbn | 9781555814182 |
| language | English |
| lccn | 2010029309 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020650321 |
| oclc_num | 705918656 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 DE-19 DE-BY-UBM DE-20 DE-M49 DE-BY-TUM DE-29T |
| owner_facet | DE-355 DE-BY-UBR DE-188 DE-19 DE-BY-UBM DE-20 DE-M49 DE-BY-TUM DE-29T |
| physical | XIV, 526 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | ASM Press |
| record_format | marc |
| spelling | Bacterial pathogenesis a molecular approach Brenda A. Wilson ... 3. ed. Washington, DC ASM Press 2011 XIV, 526 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bis 2. Aufl. u.d.T.: Bacterial pathogenesis / Salyers, Abigail A. bacteria cabt pathogenesis cabt Pathogenese (DE-588)4115512-9 gnd rswk-swf Bakterien (DE-588)4004296-0 gnd rswk-swf Bakterielle Infektion (DE-588)4004301-0 gnd rswk-swf Virulenz (DE-588)4129834-2 gnd rswk-swf Pathogene Bakterien (DE-588)4173543-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Pathogenität (DE-588)4205990-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bakterien (DE-588)4004296-0 s Pathogenität (DE-588)4205990-2 s DE-604 Virulenz (DE-588)4129834-2 s Molekularbiologie (DE-588)4039983-7 s Bakterielle Infektion (DE-588)4004301-0 s Pathogenese (DE-588)4115512-9 s 1\p DE-604 2\p DE-604 Pathogene Bakterien (DE-588)4173543-2 s 3\p DE-604 Wilson, Brenda A. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650321&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Bacterial pathogenesis a molecular approach bacteria cabt pathogenesis cabt Pathogenese (DE-588)4115512-9 gnd Bakterien (DE-588)4004296-0 gnd Bakterielle Infektion (DE-588)4004301-0 gnd Virulenz (DE-588)4129834-2 gnd Pathogene Bakterien (DE-588)4173543-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Pathogenität (DE-588)4205990-2 gnd |
| subject_GND | (DE-588)4115512-9 (DE-588)4004296-0 (DE-588)4004301-0 (DE-588)4129834-2 (DE-588)4173543-2 (DE-588)4039983-7 (DE-588)4205990-2 (DE-588)4143413-4 |
| title | Bacterial pathogenesis a molecular approach |
| title_auth | Bacterial pathogenesis a molecular approach |
| title_exact_search | Bacterial pathogenesis a molecular approach |
| title_full | Bacterial pathogenesis a molecular approach Brenda A. Wilson ... |
| title_fullStr | Bacterial pathogenesis a molecular approach Brenda A. Wilson ... |
| title_full_unstemmed | Bacterial pathogenesis a molecular approach Brenda A. Wilson ... |
| title_short | Bacterial pathogenesis |
| title_sort | bacterial pathogenesis a molecular approach |
| title_sub | a molecular approach |
| topic | bacteria cabt pathogenesis cabt Pathogenese (DE-588)4115512-9 gnd Bakterien (DE-588)4004296-0 gnd Bakterielle Infektion (DE-588)4004301-0 gnd Virulenz (DE-588)4129834-2 gnd Pathogene Bakterien (DE-588)4173543-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Pathogenität (DE-588)4205990-2 gnd |
| topic_facet | bacteria pathogenesis Pathogenese Bakterien Bakterielle Infektion Virulenz Pathogene Bakterien Molekularbiologie Pathogenität Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020650321&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wilsonbrendaa bacterialpathogenesisamolecularapproach |