The cell biology of stem cells:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
2010
|
| Schriftenreihe: | Advances in experimental medicine and biology
695 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XX, 229 S. Ill. |
| ISBN: | 9781441970367 |
Internformat
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Datensatz im Suchindex
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THE CELL BIOLOGY OF STEM CELLS EDITED BY ERAN MESHORER, PHD DEPARTMENT
OF GENETICS, INSTITUTE OF LIFE SCIENCES, THE HEBREW UNIVERSITY OF
JERUSALEM, JERUSALEM, ISRAEL KATHRIN PLATH, PHD UCLA SCHOOL OF MEDICINE,
DEPARTMENT OF BIOLOGICAL CHEMISTRY, LOS ANGELES, CALIFORNIA, USA
SPRINGER SCIENCE+BUSINESS MEDIA, LLC LANDES BIOSCIENCE CONTENTS 1. EARLY
EMBRYONIC CELL FATE DECISIONS IN THE MOUSE 1 YOJIRO YAMANAKA AND AMY
RALSTON ABSTRACT 1 INTRODUCTION 1 LINEAGE ESTABLISHMENT AND THE PRE-STEM
CELL PROGRAM: FORMATION OF THE BLASTOCYST 2 LINEAGE MAINTENANCE AND THE
STEM CELL PROGRAM: BEYOND THE BLASTOCYST 6 THE SECOND LINEAGE DECISION:
SUBDIVIDING THE ICM 6 CELL SIGNALING REGULATES PE/EPI SPECIFICATION 7
ESTABLISHMENT AND MODULATION OF PLURIPOTENCY IN THE EPI LINEAGE 9
CONCLUSION 10 2. NUCLEAR ARCHITECTURE IN STEM CELLS 14 KELLY J. MORRIS,
MITA CHOTALIA AND ANA POMBO ABSTRACT 14 INTRODUCTION 14 FUNCTIONAL
COMPARTMENTALIZATION OF THE ES CELL NUCLEUS 15 STEM CELL FEATURES OF
OTHER NUCLEOPLASMIC SUBCOMPARTMENTS 19 CHROMATIN FEATURES CHARACTERISTIC
OF ES CELL NUCLEI 20 CONCLUSION 22 3. EPIGENETIC REGULATION OF
PLURIPOTENCY 26 ELENI M. TOMAZOU AND ALEXANDER MEISSNER ABSTRACT 26
INTRODUCTION 26 EPIGENETIC MODIFICATIONS 28 THE EPIGENOME OF ES CELLS 31
CONCLUSION 36 XVII XVIII CONTENTS 4. AUTOSOMAL LYONIZATION OF
REPLICATION DOMAINS DURING EARLY MAMMALIAN DEVELOPMENT 41 ICHIRO
HIRATANI AND DAVID M. GILBERT ABSTRACT 41 INTRODUCTION 42 REPLICATION
TIMING PROGRAM: AN ELUSIVE MEASURE OF GENOME ORGANIZATION 42 AN
EVOLUTIONARILY CONSERVED EPIGENETIC FINGERPRINT 48 REPLICATION TIMING AS
REPLICATION TIMING REVEALS AN EPIGENETIC TRANSITION: AUTOSOMAL
LYONIZATION AT THE EPIBLAST STAGE 51 REPLICATION TIMING AND CELLULAR
REPROGRAMMING: FURTHER SUPPORT FOR AUTOSOMAL LYONIZATION 52 MAINTENANCE
AND ALTERATION OF REPLICATION TIMING PROGRAM AND ITS POTENTIAL ROLES 53
CONCLUSION 54 5. PRESERVATION OF GENOMIC INTEGRITY IN MOUSE EMBRYONIC
STEM CELLS 59 PETER J. STAMBROOK AND ELISIA D. TICHY ABSTRACT 59
INTRODUCTION AND HISTORICAL PERSPECTIVE 60 MUTATION FREQUENCIES IN
SOMATIC CELLS 62 PROTECTION OF THE MOUSE ES CELL GENOME 62 CONCLUSION 72
6. TRANSCRIPTIONAL REGULATION IN EMBRYONIC STEM CELLS 76 JIAN-CHIEN
DOMINIC HENG AND HUCK-HUI NG ABSTRACT 76 INTRODUCTION 76 EMBRYONIC STEM
CELLS AS A MODEL TO STUDY TRANSCRIPTIONAL REGULATION 77 TRANSCRIPTION
FACTORS GOVERNING ESC PLURIPOTENCY 78 TRANSCRIPTIONAL REGULATORY NETWORK
81 TECHNOLOGIES FOR DISSECTING THE TRANSCRIPTIONAL REGULATORY NETWORK 81
THE CORE TRANSCRIPTIONAL REGULATORY NETWORK: OCT4, SOX2 AND NANOG 82
EXPANDED TRANSCRIPTIONAL REGULATORY NETWORK 84 ENHANCEOSOMES:
TRANSCRIPTION FACTOR COMPLEX 86 INTEGRATION OF SIGNALING PATHWAYS TO
TRANSCRIPTIONAL NETWORK 87 INTERFACE BETWEEN TRANSCRIPTIONAL AND
EPIGENETIC REGULATION 88 CONCLUSION 89 7. ALTERNATIVE SPLICING IN STEM
CELL SELF-RENEWAL AND DIFFERENTIATION 92 DAVID A. NELLES AND GENE W. YEO
ABSTRACT 92 INTRODUCTION 92 CONTENTS XIX INTRODUCTION TO ALTERNATIVE
SPLICING 93 ALTERNATIVE SPLICING OF GENES IMPLICATED IN STERNNESS AND
DIFFERENTIATION 93 GENOME-WIDE METHODS TO IDENTIFY AND DETECT
ALTERNATIVE SPLICING EVENTS 98 REGULATION OF ALTERNATIVE SPLICING BY RNA
BINDING PROTEINS 98 CONCLUSION AND PERSPECTIVES 101 8. MICRORNA
REGULATION OF EMBRYONIC STEM CELL SELF-RENEWAL AND DIFFERENTIATION 105
COLLIN MELTON AND ROBERT BLELLOCH ABSTRACT 104 INTRODUCTION: THE
SELF-RENEWAL PROGRAM 105 EMBRYONIC STEM CELLS 106 MIRNA BIOGENESIS AND
FUNCTION 106 ESCC MIRNAS PROMOTE SELF-RENEWAL 108 MIRNAS INDUCED DURING
ESC DIFFERENTIATION SUPPRESS THE SELF-RENEWAL PROGRAM 110 REGULATORY
NETWORKS CONTROLLING MIRNA EXPRESSION 112 MIRNAS CAN PROMOTE OR INHIBIT
DEDIFFERENTIATION TO IPS CELLS 113 MIRNAS IN SOMATIC STEM CELLS 113
MIRNAS IN CANCER CELLS 114 CONCLUSION 114 9. TELOMERES AND TELOMERASE IN
ADULT STEM CELLS AND PLURIPOTENT EMBRYONIC STEM CELLS 118 ROSA M. MARION
AND MARIA A. BLASCO ABSTRACT .' 118 INTRODUCTION 119 REGULATION OF
TELOMERES AND TELOMERASE 120 ROLE OF TELOMERES AND TELOMERASE IN ADULT
SC COMPARTMENTS 121 TELOMERES AND TELOMERASE REGULATION DURING
REPROGRAMMING BY SCNT 124 TELOMERES AND TELOMERASE REGULATION DURING IPS
CELL GENERATION 125 TELOMERASE ACTIVATION IS ESSENTIAL FOR THE "GOOD"
QUALITY OF THE RESULTING IPS CELLS 126 REGULATION OF TELOMERE
REPROGRAMMING 126 CONCLUSION 127 10. X CHROMOSOME INACTIVATION AND
EMBRYONIC STEM CELLS 132 TAHSIN STEFAN BARAKAT AND JOOST GRIBNAU
ABSTRACT 132 INTRODUCTION 132 CIS ACTING FACTORS IN XCI 134 TRANS ACTING
FACTORS IN XCI 136 COUNTING AND CHOICE 136 SILENCING AND MAINTENANCE OF
SILENCING 141 XCI AND HUMAN ES CELLS 144 CONCLUSION 146 XX CONTENTS 11.
ADULT STEM CELLS AND THEIR NICHES 155 FRANCESCA FERRARO, CRISTINA LO
CELSO AND DAVID SCADDEN ABSTRACT 155 THE NICHE CONCEPT, DEFINITION AND
HISTORICAL BACKGROUND 155 STEM CELL NICHE COMPONENTS 157 MOLECULAR
PATHWAYS ASSOCIATED WITH NICHE FUNCTION 159 EXTRACELLULAR MATRIX AND
CELL-CELL INTERACTIONS 160 STEM CELL NICHE DYNAMISM 161 STEM CELL NICHE
AGING 162 MALIGNANT STEM CELL NICHES 163 CONCLUSION 164 12. ADULT STEM
CELL DIFFERENTIATION AND TRAFFICKING AND THEIR IMPLICATIONS IN DISEASE
169 YING ZHUGE, ZHAO-JUN LIU AND OMAIDA C. VELAZQUEZ ABSTRACT 169
DIFFERENTIATION 170 TRAFFICKING '. 174 CONCLUSION 179 13. VERTEBRATES
THAT REGENERATE AS MODELS FOR GUIDING STEM CELLS 184 CHRISTOPHER L.
ANTOS AND ELLY M. TANAKA ABSTRACT 184 VERTEBRATE MODELS OF REGENERATION:
THEIR ATTRIBUTES 184 REGENERATION MECHANISMS OF MATURE TISSUES 186
CONCLUSION 206 14. REPROGRAMMING OF SOMATIC CELLS TO
PLURIPOTENCY.215 MASATO NAKAGAWA AND SHINYA YAMANAKA ABSTRACT
215 INTRODUCTION 215 SOMATIC NUCLEAR REPROGRAMMING IN FROG 216 BIRTH OF
A CLONED ANIMAL, DOLLY 216 CHANGING CELL FATE BY DEFINED FACTORS, MYOD
216 REPROGRAMMING OF SOMATIC CELLS BY CELL FUSION 217 GENERATION OF
INDUCED PLURIPOTENT STEM CELLS BY SOX2, OCT3/4, KLF4 AND C-MYC 217
METHODS FOR IPS CELL INDUCTION 219 MOLECULAR MECHANISM FOR IPS CELL
GENERATION 220 DIRECTED CELL REPROGRAMMING: P-CELLS FROM PANCREATIC
CELLS 220 DIRECTED CELL REPROGRAMMING: NEURONAL CELLS FROM FIBROBLASTS
220 DISEASE IPS CELLS FOR CLINICAL APPLICATIONS 221 CONCLUSION 222 INDEX
225 |
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| title | The cell biology of stem cells |
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