Holdings: Clinical pharmacokinetics and pharmacodynamics

Clinical pharmacokinetics and pharmacodynamics: concepts and applications

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Bibliographic Details
Main Authors:	Rowland, Malcolm (Author), Tozer, Thomas N. (Author)
Format:	Book
Language:	English
Published:	Philadelphia, Pa. Kluwer [u.a.] 2011
Edition:	4. ed.
Subjects:	Pharmakodynamik Pharmakokinetik
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Item Description:	Rev. ed. of: Clinical pharmacokinetics. 1995
Physical Description:	XXII, 839 S. graph. Darst.
ISBN:	9780781750097 0781750091

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MARC


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adam_text	Titel: Clinical pharmacokinetics and pharmacodynamics Autor: Rowland, Malcolm Jahr: 2011 *m mmmmm TABLE OF CONTENTS Preface ix Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii Definition of Symbols xix SECTION I BASIC CONSIDERATIONS_____________________________ 1 Therapeutic Relevance.........................................,3 2 Fundamental Concepts and Terminology.........................17 SECTION II EXPOSURE AND RESPONSE AFTER A SINGLE DOSE 3 Kinetics Following an Intravenous Bolus Dose 4 Membranes and Distribution.............. 5 Elimination............................ 6 Kinetics Following an Extravascular Dose .... 7 Absorption............................. 8 Response Following a Single Dose.......... ......49 ......73 .....Ill .....159 .....183 .....217 SECTION III THERAPEUTIC REGIMENS 9 Therapeutic Window ... 10 Constant-Rate Input 11 Multiple-Dose Regimens .245 259 293 SECTION IV INDIVIDUALIZATION 12 Variability................... 13 Genetics..................... 14 Age, Weight, and Gender....... 15 Disease....................... IS Nonlinearities................ 17 Drug Interactions............. 18 Initiating and Managing Therapy 333 357 .373 403 445 483 ,527 TABLE OF CONTENTS SECTION V SUPPLEMENTAL TOPICS 19 Distribution Kinetics..........................................561 20 Metabolites and Drug Response................................603 21 Protein Drugs ...............................................633 22 Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data..............................663 APPENDICES________________________________________________________ A. Assessment of AUG............................................687 B. Ionization and the pH Partition Hypothesis.......................691 C Distribution of Drugs Extensively Bound to Plasma Proteins..........695 D. Plasma-to-Blood Concentration Ratio ............................703 E. Well-stirred Model of Hepatic Clearance..........................705 F. Absorption Kinetics...........................................709 G. Wagner-Nelson Method.......................................713 H. Mean Residence Time.........................................717 I. Amount of Drug in Body on Accumulation to Plateau...............723 J. Answers to Study Problems.....................................727 Index 819
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indexdate	2024-07-09T22:46:09Z
institution	BVB
isbn	9780781750097 0781750091
language	English
lccn	2009028928
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physical	XXII, 839 S. graph. Darst.
publishDate	2011
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publisher	Kluwer [u.a.]
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spelling	Rowland, Malcolm Verfasser aut Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer 4. ed. Philadelphia, Pa. Kluwer [u.a.] 2011 XXII, 839 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Rev. ed. of: Clinical pharmacokinetics. 1995 Pharmakodynamik (DE-588)4174134-1 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s Pharmakodynamik (DE-588)4174134-1 s DE-604 Tozer, Thomas N. Verfasser aut DE-601 pdf/application http://www.gbv.de/dms/bs/toc/605529191.pdf kostenfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020621353&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Rowland, Malcolm Tozer, Thomas N. Clinical pharmacokinetics and pharmacodynamics concepts and applications Pharmakodynamik (DE-588)4174134-1 gnd Pharmakokinetik (DE-588)4115557-9 gnd
subject_GND	(DE-588)4174134-1 (DE-588)4115557-9
title	Clinical pharmacokinetics and pharmacodynamics concepts and applications
title_auth	Clinical pharmacokinetics and pharmacodynamics concepts and applications
title_exact_search	Clinical pharmacokinetics and pharmacodynamics concepts and applications
title_full	Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer
title_fullStr	Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer
title_full_unstemmed	Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer
title_short	Clinical pharmacokinetics and pharmacodynamics
title_sort	clinical pharmacokinetics and pharmacodynamics concepts and applications
title_sub	concepts and applications
topic	Pharmakodynamik (DE-588)4174134-1 gnd Pharmakokinetik (DE-588)4115557-9 gnd
topic_facet	Pharmakodynamik Pharmakokinetik
url	http://www.gbv.de/dms/bs/toc/605529191.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020621353&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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