Clinical pharmacokinetics and pharmacodynamics: concepts and applications
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa.
Kluwer [u.a.]
2011
|
| Ausgabe: | 4. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Rev. ed. of: Clinical pharmacokinetics. 1995 |
| Beschreibung: | XXII, 839 S. graph. Darst. |
| ISBN: | 9780781750097 0781750091 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Clinical pharmacokinetics and pharmacodynamics
Autor: Rowland, Malcolm
Jahr: 2011
*m
mmmmm
TABLE OF CONTENTS
Preface ix
Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii
Definition of Symbols xix
SECTION I BASIC CONSIDERATIONS_____________________________
1 Therapeutic Relevance.........................................,3
2 Fundamental Concepts and Terminology.........................17
SECTION II EXPOSURE AND RESPONSE AFTER A SINGLE DOSE
3 Kinetics Following an Intravenous Bolus Dose
4 Membranes and Distribution..............
5 Elimination............................
6 Kinetics Following an Extravascular Dose ....
7 Absorption.............................
8 Response Following a Single Dose..........
......49
......73
.....Ill
.....159
.....183
.....217
SECTION III THERAPEUTIC REGIMENS
9 Therapeutic Window ...
10 Constant-Rate Input
11 Multiple-Dose Regimens
.245
259
293
SECTION IV INDIVIDUALIZATION
12 Variability...................
13 Genetics.....................
14 Age, Weight, and Gender.......
15 Disease.......................
IS Nonlinearities................
17 Drug Interactions.............
18 Initiating and Managing Therapy
333
357
.373
403
445
483
,527
TABLE OF CONTENTS
SECTION V SUPPLEMENTAL TOPICS
19 Distribution Kinetics..........................................561
20 Metabolites and Drug Response................................603
21 Protein Drugs ...............................................633
22 Prediction and Refinement of Human Kinetics from In Vitro,
Preclinical, and Early Clinical Data..............................663
APPENDICES________________________________________________________
A. Assessment of AUG............................................687
B. Ionization and the pH Partition Hypothesis.......................691
C Distribution of Drugs Extensively Bound to Plasma Proteins..........695
D. Plasma-to-Blood Concentration Ratio ............................703
E. Well-stirred Model of Hepatic Clearance..........................705
F. Absorption Kinetics...........................................709
G. Wagner-Nelson Method.......................................713
H. Mean Residence Time.........................................717
I. Amount of Drug in Body on Accumulation to Plateau...............723
J. Answers to Study Problems.....................................727
Index 819
|
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| discipline | Chemie / Pharmazie Chemie Chemie-Ingenieurwesen Medizin |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:46:09Z |
| institution | BVB |
| isbn | 9780781750097 0781750091 |
| language | English |
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| physical | XXII, 839 S. graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
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| publisher | Kluwer [u.a.] |
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| spelling | Rowland, Malcolm Verfasser aut Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer 4. ed. Philadelphia, Pa. Kluwer [u.a.] 2011 XXII, 839 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Rev. ed. of: Clinical pharmacokinetics. 1995 Pharmakodynamik (DE-588)4174134-1 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s Pharmakodynamik (DE-588)4174134-1 s DE-604 Tozer, Thomas N. Verfasser aut DE-601 pdf/application http://www.gbv.de/dms/bs/toc/605529191.pdf kostenfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020621353&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rowland, Malcolm Tozer, Thomas N. Clinical pharmacokinetics and pharmacodynamics concepts and applications Pharmakodynamik (DE-588)4174134-1 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4174134-1 (DE-588)4115557-9 |
| title | Clinical pharmacokinetics and pharmacodynamics concepts and applications |
| title_auth | Clinical pharmacokinetics and pharmacodynamics concepts and applications |
| title_exact_search | Clinical pharmacokinetics and pharmacodynamics concepts and applications |
| title_full | Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer |
| title_fullStr | Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer |
| title_full_unstemmed | Clinical pharmacokinetics and pharmacodynamics concepts and applications Malcolm Rowland ; Thomas N. Tozer |
| title_short | Clinical pharmacokinetics and pharmacodynamics |
| title_sort | clinical pharmacokinetics and pharmacodynamics concepts and applications |
| title_sub | concepts and applications |
| topic | Pharmakodynamik (DE-588)4174134-1 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Pharmakodynamik Pharmakokinetik |
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