Hox genes: studies from the 20th to the 21st century
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2010
|
| Schriftenreihe: | Advances in experimental medicine and biology
689 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XXIII, 165 S. zahlr. Ill. |
| ISBN: | 9781441966728 |
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Datensatz im Suchindex
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IMAGE 1
HOX GENES
STUDIES FROM THE 20TH TO THE 21ST CENTURY EDITED BY JEAN S. DEUTSCH, PHD
DEVELOPMENTAL BIOLOGY, PIERRE AND MARIE CURIE UNIVERSITY PARIS, FRANCE
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
LANDES BIOSCIENCE
IMAGE 2
CONTENTS
SECTION I. MECHANISMS OF ACTIVITY
1. REGULATION OF HOX ACTIVITY: INSIGHTS FROM PROTEIN MOTIFS 3
SAMIR MERABET, NAGRAJ SAMBRANI, JACQUES PRADEL AND YACINE GRABA *
ABSTRACT 3
INTRODUCTION 3
THE HOMEODOMAIN 4
THE HEXAPEPTIDE MOTIF. 8
ADDITIONAL HOX FUNCTIONAL MOTIFS 9
CONCLUSION 10
2. C/5-REGULATION IN THE DROSOPHILA BITHORAX COMPLEX 17
ROBERT K. MAEDA AND FRANCOIS KARCH
ABSTRACT 17
GENETICS OF THE BITHORAX COMPLEX: THE MODEL OF ED LEWIS 17
THE BX-C ENCODES ONLY THREE GENES, UBX, ABD-A AND ABD-B 19 THE
SEGMENT-SPECIFIC FUNCTIONS ACT AS SEGMENT/PARASEGMENT-SPECIFIC ENHANCERS
22 INITIATION AND MAINTENANCE PHASE IN BX-C REGULATION 23
INITIATION, MAINTENANCE AND CELL TYPE-SPECIFIC ELEMENTS WITHIN THE
C/S-REGULATORY DOMAIN 25
THE C/S-REGULATORY REGIONS ARE ORGANIZED IN SEGMENT-SPECIFIC CHROMOSOMAL
DOMAINS 26
CHROMATIN BOUNDARIES FLANK THE PARASEGMENT-SPECIFIC DOMAINS 28 ELEMENTS
MEDIATING LONG-DISTANCE CIS- AND TRANS- REGULATORY INTERACTIONS 28
TRANSVECTION STUDIES 28
PROMOTER TARGETING SEQUENCES 31
PROMOTER TETHERING ELEMENT 32
INTERGENIC TRANSCRIPTION IN THE BX-C 32
MICRORNAS IN THE BX-C 34
CONCLUSION 35
XIX
IMAGE 3
XX CONTENTS
3. M A I N T E N A N CE OF H OX G E NE E X P R E S S I ON P A T T E R NS
41
SAMANTHA BECK, FLORIA FARADJI, HUGH BROCK AND FREDERIQUE PERONNET
ABSTRACT 41
INTRODUCTION 41
GENETICS OF PCG AND TRXG GENES 42
PCG PROTEINS AND THEIR COMPLEXES 43
TRXG PROTEINS AND THEIR COMPLEXES 46
ETP PROTEINS -. 46
PCG AND TRXG RESPONSE ELEMENTS 47
RECRUITMENT OF MAINTENANCE PROTEINS TO MAINTENANCE ELEMENTS 48
ROLE OF MAINTENANCE PROTEINS IN REGULATION OF TRANSCRIPTION 50
EPIGENETIC MARKS 51
RELEASE OF PCG SILENCING 53
ROLE OF PCG PROTEINS IN CHROMATIN REPLICATION 54
ROLE OF PCG PROTEINS IN STEM CELLS 54
CONCLUSION 55
FUTURE RESEARCH IN THE FIELD 55
4. C O N T R OL OF V E R T E B R A TE H OX C L U S T E RS BY R E M O TE
AND G L O B AL CIS- ACTING R E G U L A T O RY S E Q U E N C ES 63
FRANCOIS SPITZ '
ABSTRACT 63
INTRODUCTION 63
COLINEARITY AND CLUSTERING OF THE HOMEOTIC GENES: AN OBLIGATORY
FUNCTIONAL LINK?. 64 VERTEBRATE HOX CLUSTERS ARE MORE CLUSTERED THAN
OTHERS 65
GLOBAL REGULATION OF THE COMPLEX THROUGH SHARED MECHANISMS: THE RETINOIC
ACID CONNECTION 66
HIGH-ORDER STRUCTURES OVER THE COMPLEX AND COLINEARITY 66
CONTROL OF VERTEBRATE HOX GENES BY SHARED INTERNAL ENHANCERS 67 THE INS
AND OUTS OF HOXDGENT REGULATION 67
THE ROLE OF THE FLANKING REGIONS IN THE CONTROL OF VERTEBRATE HOX GENES
68 CONTROL OF THE HOXD CLUSTER THROUGH REMOTE ENHANCERS 69
REGULATION OF THE HOXD CLUSTER AND MORE: GLOBAL CONTROL REGIONS AND
REGULATORY LANDSCAPES 70
REMOTE ENHANCERS FOR THE OTHER VERTEBRATE HOX CLUSTERS? 71
AN EVOLUTIONARY SUCCESS STORY AND AN INCREASING NEED FOR A GLOBAL
REGULATION 73 CONCLUSION AND OUTLOOK FOR HOX GENE REGULATION IN THE 21ST
CENTURY 74
SECTION II. EVOLUTION OF HOX GENES
AND COMPLEXES
5. THE EARLY EVOLUTION OF HOX GENES: A BATTLE OF BELIEF? 81
BERND SCHIERWATER AND KAI KAMM
ABSTRACT 81
THE HOX SYSTEM 81
IMAGE 4
CONTENTS XXI
PHYLOGENETIC EVIDENCE 82
OPPOSING VIEWS 84
CONCLUSION 87
6. EVOLUTION OF H OX C O M P L E X ES 91
DAVID E.K. FERRIER
ABSTRACT 91
INTRODUCTION .". 91
ORIGIN OF THE PROTOHOX GENE 91
ORIGIN OF THE HOX CLUSTER FROM A PROTOHOX CLUSTER, OR NOT? 92
EXPANSION AND CONTRACTION OF THE NUMBER OF HOX GENES IN EVOLUTION 96
CONCLUSION 98
7. THE NEMATODE STORY: H OX G E NE LOSS AND R A P ID E V O L U T I ON
101
AZIZ ABOOBAK'ER ARID MARK BLAXTER
ABSTRACT . 101
INTRODUCTION: HOX GENE LOSS, THE THIRD WAY 101
THE CAENORHABDITIS ELEGANS HOX CLUSTER, AN EXTREME CASE OF GENE LOSS 102
TRACING HOX GENE LOSS THROUGH THE NEMATODE PHYLUM: MODE AND TEMPO 104
SEA SQUIRTS AND NEMATODES: WHY DO BOTH GROUPS LOSE HOX GENES 105 HOX
GENE LOSS IN FLAGRANTE 106
NEMATODE HOX GENE FUNCTION: A STORY OF NOVELTY, CONSERVATION AND
REDEPLOYMENT 106
CONCLUSION 108
8. ARE THE D E U T E R O S T O ME P O S T E R I OR H OX G E N ES A
FAST-EVOLVING CLASS? I LL
ROBERT LANFEAR
ABSTRACT I LL
THE DISTRIBUTION OF THE POSTERIOR HOX GENES IN THE METAZOA I LL
EARLY DUPLICATIONS OF THE POSTERIOR HOX GENES 113
THE 'DEUTEROSTOME POSTERIOR FLEXIBILITY' HYPOTHESIS 114
THE MECHANISTIC BASIS OF DEUTEROSTOME POSTERIOR FLEXIBILITY 116
CONCLUSION AND FUTURE DIRECTIONS 118
SECTION III. BIOLOGICAL FUNCTION
9. HOX GENES AND THE BODY PLANS OF CHELICERATES AND PYCNOGONIDS 125
WIM G.M. DAMEN
ABSTRACT 125
ARTHROPODS, MANDIBULATES VS CHELICERATES 125
IMAGE 5
XXII CONTENTS
CHELICERATE HOX GENES '. 126
CHELICERATE HOX GENES AND THE CHELICERATE VS MANDIBULATE BODY PLAN 127
HOX GENES AND THE ENIGMATIC SEA SPIDER BODY PLAN 130
CONCLUSION 131
10. HOX3/ZEN AND THE EVOLUTION OF EXTRAEMBRYONIC EPITHELIA IN INSECTS
133
URS SCHMIDT-OTT, AB. MATTEEN RAFIQI AND STEFFEN LEMKE * ABSTRACT 133
INTRODUCTION 133
SETTING THE STAGE: MORPHOLOGICAL EVOLUTION OF EXTRAEMBRYONIC DEVELOPMENT
134 VARIANTS OF ZEN EXPRESSION AND FUNCTION IN INSECTS AND POSSIBLE
MORPHOLOGICAL CORRELATES 135
THE AMNIOSEROSA GENE-NETWORK IN EVOLUTIONARY PERSPECTIVE 140 CONCLUSION
141
11. HOX GENES AND BRAIN DEVELOPMENT IN DROSOPHILA 145
HEINRICH REICHERT AND BRUNO BELLO
ABSTRACT 145
INTRODUCTION 145
EXPRESSION AND FUNCTION OF HOX GENES IN EMBRYONIC BRAIN DEVELOPMENT 146
GENETIC INTERACTIONS BETWEEN HOX GENES IN EMBRYONIC BRAIN DEVELOPMENT
148 HOX GENES IN POSTEMBRYONIC BRAIN DEVELOPMENT 149
EVOLUTIONARY CONSERVATION OF HOX GENE ACTION IN BRAIN DEVELOPMENT 151
CONCLUSION 152
12. HOMEOSIS AND BEYOND. WHAT IS THE FUNCTION OF THE HOX GENES? 155
JEAN S. DEUTSCH
ABSTRACT 155
WHAT ARE THE HOX GENES? 155
THE HOX GENES' EXPLOSION 156
WHAT IS THE FUNCTION OF A GENE? 156
HOX GENES' FUNCTION AT THE MOLECULAR AND CELLULAR LEVELS 157
HOX GENES AND HOMEOSIS 157
HOMEOSIS AS A DIFFERENTIAL FUNCTION 157
HOX GENES AS 'META-SELECTOR' GENES 158
THE HOX SPECIFICITY PARADOX 158
POSTERIOR PREVALENCE 159
AN EVOLUTIONARY PARADOX: MORPHOLOGICAL DIFFERENTIATION AND THE HOX
REPERTOIRE 159
HOX AND NEURONAL HOMEOSIS 159
MORPHOLOGICAL HOMEOSIS AS A DERIVED PROPERTY 160
WHY DOES THE 'HOX SYSTEM' MAKE SENSE? 160
CONCLUSION 161
INDEX 167 |
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| spellingShingle | Hox genes studies from the 20th to the 21st century Advances in experimental medicine and biology Genes, Homeobox Gene Expression Regulation Evolution, Molecular Homöotisches Gen (DE-588)4340715-8 gnd |
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| title | Hox genes studies from the 20th to the 21st century |
| title_auth | Hox genes studies from the 20th to the 21st century |
| title_exact_search | Hox genes studies from the 20th to the 21st century |
| title_full | Hox genes studies from the 20th to the 21st century ed. by Jean S. Deutsch. [Participants: Aziz Aboobaker ...] |
| title_fullStr | Hox genes studies from the 20th to the 21st century ed. by Jean S. Deutsch. [Participants: Aziz Aboobaker ...] |
| title_full_unstemmed | Hox genes studies from the 20th to the 21st century ed. by Jean S. Deutsch. [Participants: Aziz Aboobaker ...] |
| title_short | Hox genes |
| title_sort | hox genes studies from the 20th to the 21st century |
| title_sub | studies from the 20th to the 21st century |
| topic | Genes, Homeobox Gene Expression Regulation Evolution, Molecular Homöotisches Gen (DE-588)4340715-8 gnd |
| topic_facet | Genes, Homeobox Gene Expression Regulation Evolution, Molecular Homöotisches Gen Aufsatzsammlung |
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