Structure-related anti-inflammatory mechanisms of probiotic bacteria:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Logos-Verl.
2010
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 106 S. Ill., graph. Darst. |
| ISBN: | 9783832525811 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS PUBLICATIONS AND PRESENTATIONS 1 ZUSAMMENFASSUNG 5
ABSTRACT 6 TABLE OF CONTENTS 7 1 INTRODUCTION 9 1.1 MICROBIOTA-HOST
INTERACTIONS IN HEALTH AND DISEASE 10 1.1.1 DEVELOPMENT AND COMPLEXITY
OF THE MICROBIAL ECOSYSTEM IN THE GASTROINTESTINAL TRACT 10 1.1.2 IMPACT
OF THE INTESTINAL MICROBIOTA ON THE INTESTINAL IMMUNE SYSTEM 12 1.1.3
DISTURBED MICROBIOTA-HOST INTERACTIONS IN IBD 13 1.2 IBD ARE
CHARACTERIZED BY DISTURBED IEC FUNCTIONS AND DYSREGULATED IMMUNE CELL
ACTIVITIES 15 1.2.1 IMPAIRED INTESTINAL EPITHELIAL BARRIER FUNCTIONS IN
IBD 15 1.2.2 LOSS OF IEC HOMEOSTASIS IN IBD 18 1.2.3 DYSREGULATED
ACTIVITIES OF THE INTESTINAL IMMUNE SYSTEM IN RESPONSE TO THE NORMAL
INTESTINAL MICROBIOTA IN IBD 22 1.3 PROBIOTICS: CLINICAL RELEVANCE AND
MOLECULAR MECHANISMS 25 1.3.1 HISTORY AND DEFINITION OF PROBIOTICS 25
1.3.2 CLINICAL RELEVANCE OF PROBIOTICS IN THE CONTEXT OF IBD 26 1.3.3
PROBIOTIC TREATMENT RESULTS IN INCREASED IEC BARRIER FUNCTIONS AND
NORMALISATION OF THE INTESTINAL IMMUNE RESPONSE 28 2 AIMS OF THE WORK 35
3 MATERIAL AND METHODS 37 4 RESULTS 47 4.1 L. EASEL (VSL#3) MEDIATES
FUNCTIONALLY RELEVANT SELECTIVE INHIBITION OF IP-10 SECRETION IN IEC 47
4.1.1 L. CASEI (VSL#3) SELECTIVELY INHIBITS IP-10 EXPRESSION IN IEC 47
4.1.2 BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1006687971
DIGITALISIERT DURCH TABLE OF CONTENTS 4. 1 .6 L. CASEI (VSL#3) INDUCES
AN IP-10 SPECIFIC SECRETIONAL BLOCKADE RESULTING IN DEGRADATION OF THE
CHEMOKINE IN IEC 56 4.2 LACTOCEPIN, A SURFACE-ASSOCIATED AND SECRETED
BACTERIAL SERIN PROTEASE IS RESPONSIBLE FOR THE OBSERVED LOSS OF IP-10
61 4.2.1 SECRETED COMPOUNDS OF L. CASEI (VSL#3) INDUCE LOSS OF IP-10
PROTEIN IN IEC ANALOGOUS TO BACTERIAL SURFACE PROTEINS 61 4.2.2 THE
ACTIVE BACTERIAL COMPONENT SECRETED BY L. CASEI (VSL#3) IS A BACTERIAL
PROTEASE 63 4.2.3 THE ACTIVE BACTERIAL PROTEASE DOES NOT REDUCE TEER 67
4.2.4 LACTOCEPIN IS THE ACTIVE BACTERIAL PROTEASE OF L. CASEI (VSL#3) 68
4.3 VSL#3 AND L. CASEI (VSL#3) ARE NOT EFFECTIVE IN THE PREVENTION OR
TREATMENT OF ILEITIS IN TNF^*^ MICE 71 4.3.1 POST-WEANING FEEDING OF
VSL#3 OR L. CASEI (VSL#3) DOES NOT REDUCE LEITIS IN TNF AARE/+ MICE 71
4.3.2 COMBINED PRE-WEANING AND POST-BIRTH VSL#3-FEEDING DOES NOT PREVENT
ILEITIS IN AARE/T 4.4 PROTECTIVE EFFECTS OF VSL#3 ON COLITIS IN ILIO-/-
MICE ARE SEGMENT-SPECIFIC AND CORRELATE WITH IP-10 EXPRESSION IN IEC 75
4.4.1 VSL#3 IS PROTECTIVE ON CECAL INFLAMMATION IN ILIO-/- MICE WHEREAS
COLONIE INFLAMMATION IS UNAFFECTED BY PROBIOTIC TREATMENT 75 4.4.
|
| any_adam_object | 1 |
| author | Hörmannsperger, Gabriele 1982- |
| author_GND | (DE-588)142294039 |
| author_facet | Hörmannsperger, Gabriele 1982- |
| author_role | aut |
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| dewey-full | 616.344061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.344061 |
| dewey-search | 616.344061 |
| dewey-sort | 3616.344061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin Ökotrophologie |
| format | Thesis Book |
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| id | DE-604.BV036694435 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:45:57Z |
| institution | BVB |
| isbn | 9783832525811 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020613009 |
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| physical | 106 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
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| publisher | Logos-Verl. |
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| spelling | Hörmannsperger, Gabriele 1982- Verfasser (DE-588)142294039 aut Structure-related anti-inflammatory mechanisms of probiotic bacteria Gabriele Hörmannsperger Berlin Logos-Verl. 2010 106 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: München, Techn. Univ., Diss., 2010 Antiphlogistikum (DE-588)4123144-2 gnd rswk-swf Chronische Darmentzündung (DE-588)4273697-3 gnd rswk-swf Probiotikum (DE-588)4338112-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chronische Darmentzündung (DE-588)4273697-3 s Probiotikum (DE-588)4338112-1 s Antiphlogistikum (DE-588)4123144-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020613009&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hörmannsperger, Gabriele 1982- Structure-related anti-inflammatory mechanisms of probiotic bacteria Antiphlogistikum (DE-588)4123144-2 gnd Chronische Darmentzündung (DE-588)4273697-3 gnd Probiotikum (DE-588)4338112-1 gnd |
| subject_GND | (DE-588)4123144-2 (DE-588)4273697-3 (DE-588)4338112-1 (DE-588)4113937-9 |
| title | Structure-related anti-inflammatory mechanisms of probiotic bacteria |
| title_auth | Structure-related anti-inflammatory mechanisms of probiotic bacteria |
| title_exact_search | Structure-related anti-inflammatory mechanisms of probiotic bacteria |
| title_full | Structure-related anti-inflammatory mechanisms of probiotic bacteria Gabriele Hörmannsperger |
| title_fullStr | Structure-related anti-inflammatory mechanisms of probiotic bacteria Gabriele Hörmannsperger |
| title_full_unstemmed | Structure-related anti-inflammatory mechanisms of probiotic bacteria Gabriele Hörmannsperger |
| title_short | Structure-related anti-inflammatory mechanisms of probiotic bacteria |
| title_sort | structure related anti inflammatory mechanisms of probiotic bacteria |
| topic | Antiphlogistikum (DE-588)4123144-2 gnd Chronische Darmentzündung (DE-588)4273697-3 gnd Probiotikum (DE-588)4338112-1 gnd |
| topic_facet | Antiphlogistikum Chronische Darmentzündung Probiotikum Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020613009&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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