Structure and function of calcium release channels:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2010
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Current topics in membranes
66 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 352 S. Ill., graph. Darst. |
| ISBN: | 9780123810373 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | CONTENTS CONTRIBUTORS XL PREFACE XV PREVIOUS VOLUMES IN SERIES XVII
SECTION 1 RYR CA 2 + RELEASE CHANNELS CHAPTER. RYRS: THELR DISPOSITION.
FREQUENCY, AND RELATIONSHIPS WITH OTHER PROTEINS OF CALCIUM RELEASE
UNITS CLARA FRANRINI-ARMSTRONG 1. OVERVIEW 3 II. INTRODUCTION 4 IH.
CARDIAC ERD S 4 IV. CRUS IN SKELETAL AND INVERTEBRATE BODY MUSCLES 8 V.
FACTORS AFFECTING CRD ASSEMBLY IN SKELETAL AND CARDIAC MUSCLES 12 VI.
ISOFORM-SPECIFIC FEATURES OF RYR DISTRIBUTION 16 VII. ARCHITECTURE OF SR
AND T TUBULE MEMBRANES IS MUSCLE- AND FIBER-TYPE SPECIFIC 17 REFERENCES
22 CHAPTER 2 ELECTRON MKROSCOPY OF RYANODINE RECEPTORS TERENCE C.
WAGENKNECHT AND ZHENG LIU I. OVERVIEW 27 11. INTRODUCTION 28 III.
CRYO-EM OF MACRORNOLECULAR COMPLEXES 28 IV. THREE-DIMENSIONAL
ARCHITECTURE OF RYR AS DETERMINED BY CRYO-EM 29 V. E-HELICES IN THE TM
REGION AND THE MECHANISM OF CALCIUM CHANNEL GATING 32 VI CONTENTS VI.
SYNERGISM OF 3D CRYO-EM AND OTHER BIOPHYSICAL/BIOCHEMICAL TECHNIQUES 34
VII. OUTLOOK AND PERSPECTIVES 40 REFERENCES 42 CHARTER 3 THE RYANODINE
RECEPTOR PORE: IS THERE A CONSENSUS VIEW? JOANNE CARNEY, SAMMY A. MASON,
CEDRIC VIERA, AND ALAN J. WILLIAMS 1. OVERVIEW 49 II. INTRODUCTION 50
IH. ION HANDLING IN RYR 51 IV. WHERE IS THE PFR IN THE RYR CHANNEL? 53
V. ATTEMPTS TO IDENTIFY THE STRUCTURE OF THE RYR PFR 58 VI. THEORETICAL
APPROACHES TO UNDERSTANDING THE MECHANISMS UNDERLYING ION TRANSLOCATION
AND DISCRIMINATION IN RYR 61 VII. TESTING PHYSICAL AND THEORETICAL
MODELS OF THE RYR PFR BY RESIDUE SUBSTITUTION 62 VIII. CONCLUDING
REMARKS 64 REFERENCES 64 CHARTER 4 REGULATION OF RYR CHANNEL GATING BY
CA Z+, M~+ AND ATP DEREK R. LAVA I. OVERVIEW 69 II. INTRODUCTION 70 IH.
RYR2 IN CARDIAC CONTRACTION AND PACEMAKING 70 IV. FOUL CA 2+ SENSING
MECHANISMS FOR RYR2 71 V. SYNERGISTIC CA 2+-ACTIVATION VIA CYTOPLASMIC
AND LUMINAL FACING BINDING SITES 74 VI. CHANNEL OPEN TIMES AND THE ROLE
OF CA 2+ FEED-THROUGH 76 VLI. THREE MECHANISMS FOR MG2+-INHIBITION OF
RYR2 77 VJIL A MODEL FUER CA 2+ AND M G2+ REGULATION OF RYR2 80 IX.
ADENINE NEUCLEOTIDES 82 CONTENTS X. REGULATION OF RYR2 IN CARDIAC E-C
COUPLING 84 XI. CONCLUDING REMARKS 86 REFERENCES 87 CHAPTER 5 REGULATION
OF RYANODINE RECEPTOR ION CHANNELS THROUGH POSTTRANSLATIONAL
MODIFICATIONS GERHARD MEISSNER I. OVERVIEW 91 IR. INTRODUCTION 92 III.
RYRL AND RYR2 PHOSPHORYLATION 93 IV. RYR MODULATION BY REACTIVE OXYGEN
AND NITROGEN SPECIES 99 V. CONC1USIONS 104 REFERENCES 105 CHAPTER 6
CROSSTALK VIA THE SARCOPLASMIC GAP: THE DHPR-RYR INTERACTION MAN/RED
GRABNER AND ANTIMIKA DAYAL 1. OVERVIEW 115 11. DHPR AND RYR ARRANGEMENT
IN SKELETAL AND CARDIAC MUSCLE MEMBRANES-BASIS FOR DIFFERENCES IN THE EC
COUPLING MECHANISM 116 IRR. STRUCTURAL DOMAINS LNVOLVED IN SKDHPR-RYRL
INTERACTION 11.9 IV. THE ROLE OF INTRACELLULAR MOLECULAR REGIONS BESIDES
THE O:]S II-IH LOOP IN SKDHPR-RYRL INTERACTION 126 V. INTRACELLULAR
MOLECULAR REGIONS OF O:]S INVOLVED IN TETRAD FORMATION 128 VI. THE ROLE
OF THE ACCESSORY SKDHPR SUBUNITS IN INTERACTION WITH RYRL 128 VII.
CONCLUSION 131 REFERENCES ] 33 CHAPTER 7 RYANODINOPATHIES: RYR-LINKED
MUSCLE DLSEASES LAN WEI AND ROBEN T. DIRKSEN 1. OVERVIEW 139 H.
INTRODUCTION 140 IH. RYRI-LINKED DISEASES 142 VII VIII CONTENTS IV.
RYR2-LINKED DISEASES 153 V. CONCLUSIONS AND PERSPECTIVES 158 REFERENCES
160 SECTION 2 1P3R CA 2 + RELEASE CHANNELS CHAPTER 8 3D STRUCTURE OF ]P
3 RECEPTOR LRINA I. SERYSHEVA AND STEVEN I. LUDTKE I. OVERVIEW 171 11.
INTRODUCTION 172 IN. PREDICTED TOPOLOGY OF IP3R MOLEEULE 173 IV.
ARRANGEMENT OF IP3R IN THE NATIVE MEMBRANE 175 V. 3D STRUCTURE OF 1P3R
BY ELECTRON MICROSCOPY 176 V]. CRYSTAL STRUCTURES OF ISOLATED DOMAINS
182 VII. CONFORRNATIONAL TRANSITIONS IN IP3R CHANNEL 183 VIII. FUTURE
OUTLOOK 185 REFERENCES 186 CHAPTER 9 MOLECULAR ARCHITECTURE OF THE
INOSITOLL ,4,5-TRISPHOSPHATE RECEPTOR PORE DARREN F. BOEHNING I.
OVERVIEW 191 II. INTRODUCTION 192 III. THE TRANSMEMBRANE DOMAINS 194 IV.
THE ION CONDUCTION PORE: ELECTROPHYSIOLOGIC STUDIES 197 V. THE ION
CONDUCTION PORE: MODELING STUDIES 202 REFERENCES 204 CHARTER T 0
ADENOPHOSTINS: HIGH-AFFINITY AGONISTS OF 1P3 RECEPTORS ANA M. ROSSI,
ANDREW M. RIFEY, BARRY V. L. POTTER, AND COLIN W. TAYLOR I. OVERVIEW 209
TI. DISCOVERY AND INITIAL CHARACTERIZATION OF ADENOPHOSTINS 210 IN.
STRUCTURE AND SYNTHESIS OF ADENOPHOSTIN 212 IV. ACTIVATION OF IP3R BY
ADENOPHOSTIN 216 CONTENTS V. WHY DOES ADENOPHOSTIN BIND TO 1P3R WITH
HIGH-AFFINITY? 220 VI. IS ADENOPHOSTIN MORE THAN A STABLE, HIGH-AFFINITY
AGONIST OF 1P3R? 225 REFERENCES 228 CHAPTER 11 REGULATION OF 1P3R
CHANNEL GATING BY CA 2 + AND CA 2 + BINDING PROTEINS J. KEVIN FOSKETT
AND DON-ON DANIEL MAK L OVERVIEW 235 II. INTRODUCTION 236 BI.
CYTOPLASMIC CA 2 + REGULATION OF IP 3R CHANNEL GATING 237 IV. CA 2 +
BINDING PROTEIN REGULATION OF IP3R CHANNEL GATING 263 REFERENCES 267
CHAPTER 12 REGULATION OF LNOSITOL ] ,4,5-TRISPHOSPHATE RECEPTORS BY
PHOSPHORYLATION AND ADENINE NUCLEOTIDES MATTHEW J. BETZENHAUSER AND
DAVID 1. YULE I. OVERVIEW 273 II. REGULATION OF IP3R BY PHOSPHORYLATION
274 IN. REGULATION OF 1P3R BY ADENINE NUCLEOTIDES 283 REFERENCES 292
CHAPTER 13 ROLE OF THIOLS IN THE STRUCTURE AND FUNCTION OF LNOSLTOL
TRISPHOSPHATE RECEPTORS SURESH K. JOSEPH I. OVERVIEW 299 11.
INTRODUCTION 300 III. REGULATION OF IP3R FUNCTION BY CHANGES IN THIOL
REDOX STATE 300 IV. COMPARISON OF THIOL REGULATION OF 1P3RS AND RYRS 308
V. CYSTEINE RESIDUES AS PROBES OF IP3R STRUCTURE 310 VI. FUTURE
DIRECTIONS 314 REFERENCES 315 IX X CONTENTS CHARTER .4 INOSITOL
1,4,S-TRIPSHOSPHATE RECEPTOR, CALCIUM SIGNALING, ARID POLYGLUTAMINE
EXPANSION DISORDERS LLYA BEZPROZVANNY I. OVERVIEW 323 II. HUNTINGTON S
DISEASE, SPINOCEREBELLAR ATAXIA TYPE 2, AND SPINOCEREBELLAR ATAXIA TYPE
3 324 IN. MUTANT HUNTINGTIN SPECIFICAUY SENSITIZES 1P3R1 TO IP 3 325 IV.
MUTANT HUNTINGTIN ACTIVATES NR2B-CONTAINING NMDA RECEOTOXS 326 V.
DERANGED CA 2 + SIGNALING AND APOPTOSIS OF HD MSN 329 VI. 1P3R AND
ABNORMAL CA 2 + SIGNALING IN SCA2 NEURONS 330 VII. IP3R AND ABNORMAL CA
2 + SIGNALING IN SCA3 NEURONS 332 VIII. CA 2 + BLOCKERS AND PERSPECTIVES
FOR CLINICAL INTERVENTION IN HD AND SCA PATIENTS 333 REFERENCES 335
INDEX 343
|
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| isbn | 9780123810373 |
| language | English |
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| spelling | Structure and function of calcium release channels ed. by Irina I. Serysheva 1. ed. Amsterdam [u.a.] Elsevier 2010 XX, 352 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 66 Ryanodin-Rezeptor (DE-588)4418984-9 gnd rswk-swf Membranproteine (DE-588)4130026-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Ryanodin-Rezeptor (DE-588)4418984-9 s Membranproteine (DE-588)4130026-9 s b DE-604 Serysheva, Irina I. Sonstige (DE-588)142502928 oth Current topics in membranes 66 (DE-604)BV036839511 66 OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020604071&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Structure and function of calcium release channels Current topics in membranes Ryanodin-Rezeptor (DE-588)4418984-9 gnd Membranproteine (DE-588)4130026-9 gnd |
| subject_GND | (DE-588)4418984-9 (DE-588)4130026-9 (DE-588)4143413-4 |
| title | Structure and function of calcium release channels |
| title_auth | Structure and function of calcium release channels |
| title_exact_search | Structure and function of calcium release channels |
| title_full | Structure and function of calcium release channels ed. by Irina I. Serysheva |
| title_fullStr | Structure and function of calcium release channels ed. by Irina I. Serysheva |
| title_full_unstemmed | Structure and function of calcium release channels ed. by Irina I. Serysheva |
| title_short | Structure and function of calcium release channels |
| title_sort | structure and function of calcium release channels |
| topic | Ryanodin-Rezeptor (DE-588)4418984-9 gnd Membranproteine (DE-588)4130026-9 gnd |
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