Verfügbarkeit: Handbook of cell signaling

Handbook of cell signaling: 1

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Bibliographische Detailangaben
1. Verfasser:	Bradshaw, Ralph A. 1941- (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam [u.a.] Elsevier, Acad. Press 2010
Ausgabe:	2. ed.
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XLVI, 384 S. Ill., graph. Darst.
ISBN:	9780123741462

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MARC


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245	1	0	\|a Handbook of cell signaling \|n 1 \|c ed.-in-chief Ralph A. Bradshaw ; Edward A. Dennis
250			\|a 2. ed.
264		1	\|a Amsterdam [u.a.] \|b Elsevier, Acad. Press \|c 2010
300			\|a XLVI, 384 S. \|b Ill., graph. Darst.
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700	1		\|a Dennis, Edward A. \|e Sonstige \|4 oth
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Datensatz im Suchindex

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adam_text	Contents VOLUME 1 Contributors xxi Preface to the Second Edition xliii Preface to the First Edition xlv 1. Cell Signaling: Yesterday, Today, and Tomorrow 1 Ralph A. Bradshaw and Edward A. Dennis Parti Initiation: Extracellular and Membrane Events 5 James A. Wells Section A - Molecular Recognition 9 Ian Wilson 2. Structural and Energetic Basis of Molecular Recognition 11 EmilAlexov and Barry Honig 3. Free Energy Landscapes in Protein- Protein Interactions 15 Jacob Piehler and Gideon Schreiber 4. Molecular Sociology 23 Irene M. A. Nooren and Janet M. Thornton 5. Antibody-Antigen Recognition and Conformational Changes 29 Robyn L Stanfìeld, and Ian A. Wilson 6. Binding Energetics in Antigen-Antibody interfaces 37 Roy A. Mariuzza 7. Immunoglobulin-Fc Receptor Interactions 41 Jenny M. Woof 8. Ig-Superfold and its Variable Uses in Molecular Recognition 49 Nathan R. Zaccai and E. Yvonne Jones 9. T Cell Receptor/pMHC Complexes 55 Markus G. Rudolph, Robyn L Stanfield, and Ian A. Wilson 10. Mechanistic Features of Cell-Surface Adhesion Receptors 63 Steven C. Almo, Anne R. Bresnick, and Xuewu Zhang 11. The Immunological Synapse 71 Michael L. Dustin 12. NK Receptors 77 Roland К. Strong 13. Carbohydrate Recognition and Signaling 85 James M. Rini and Hakon Leffler 14. Rhinovirus-Receptor Interactions 93 Elizabeth A. Hewat 15. HIV-i-Receptor Interactions 97 Peter D. Kwong 16. Influenza Virus Neuraminidase Inhibitors 103 Garry Taylor and Rupert Russell 17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin 111 Russell F. Doolittle 18. Structural Basis of Integrin Signaling 115 Robert C. Liddington 19. Structures of Heterotrimeric G Proteins and their Complexes 119 Stephen R. Sprang 20. G Protein-Coupled Receptor Structures 129 Veli-Pekkajaakola and Raymond C. Stevens Contents 21. Toll-Like Receptors-Structure and Signaling 139 Istvan Botos and David R. Davies 22. Variable Lymphocyte Receptors Brantley R. Herrín and Max D. Cooper 145 Section В - Multi-pass Receptors James A. Wells 149 23. Structure and Function of G-Protein- Coupled Receptors: Lessons from Recent Crystal Structures 151 Thomas P. Sakmar 24. Chemokines and Chemokine Receptors: Structure and Function 157 Carol J. Raport and Patrick W. Gray 25. The ß2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation by Diffusible Hormones 163 Daniel M. Rosenbaum, Spren G. F. Rasmussen and Brian K. Kobilka 26. Protease-Activated Receptors 171 Shaun R. Coughlin 27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors 177 Michael Tanowitz and Mark von Zastrow 28. Functional Role(s) of Dimeric Complexes Formed from G -Protein Coupled-Receptors 185 Raphael Rozenfeldand LakshmiA Devi 29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation and Receptor Clustering 195 Weiru Wang and Sung-Hou Kim 30. An Overview of Ion Channel Structure 201 Daniel L Minor 31. Molecular Mechanism of Store- Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai 209 Aubin Penna, Shenyuan L Zhang, Andy V. Yeromin, and Michael D. Cabalan 32. Ion Permeation: Mechanisms of Ion Selectivity and Block 217 Bertil Hille 33. Nicotinic Acetylcholine Receptors 221 Arthur Karlin 34. Ion Channels Regulated by Direct Binding of Cyclic Nucleotides 225 Edgar С Young Section С - Horizontal Receptors Robert M. Stroud 233 35. Overview of Cytokine Receptors 235 Robert M. Stroud 36. Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation 237 Anthony A. Kossiakoffand Charles V. Clevenger 37. Erythropoietin Receptor as a Paradigm for Cytokine Signaling 245 Deborah J. Stauber, Minmin Yu, and Ian A. Wilson 38. The Fibroblast Growth Factor (FGF) Signaling Complex 253 Wallace L. McKeehan, Fen Wang and Yongde Luo 39. Structure of IFN-f and its Receptors 261 Mark R. Walter 40. Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface 265 Hao Wu and Sarah G. Hymowitz Contents 41. The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes 277 /. Fernando Bazan and Christian Wiesmann 42. The Mechanism of VEG FR Activation byVEGF 287 Christian Wiesmann 43. Receptor-Ligand Recognition in the TGFß Superfamily as Suggested by Crystal Structures of their Ectodomain Complexes 293 Matthias K. Dreyer 44. Insulin Receptor Complex and Signaling by Insulin 301 Lindsay G. Sparrow and S. Lance Macaulay 45. Structure and Mechanism of the Insulin Receptor Tyrosine Kinase 307 Stevan R. Hubbard 46. IL-21 Increased Potency Design 315 Kent Bondensgaard, Lishan Kang, and Siv A. Hjorth 47. Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State? 323 Thomas Weidemann, Siegfried Höfinger, and Manfred Auer 48. Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling 329 Andrew H.A. Clayton Section D - Membrane Proximal Events James A. Wells 337 49. Tumor Necrosis Factor Receptor- Associated Factors in Immune Receptor Signal Transduction 339 Qian Yin, Su-Chang Lin, Yu-Chih Lo, Steven M. Damo and Hao Wu 50. Assembly of Signaling Complexes for TNF Receptor Family Molecules 347 Gail A. Bishop and Bruce S. Hostager 51. Mechanisms of CD40 Signaling the Immune System 353 Randolph Noëlle, Victor C. de Vries and Raul Elgueta 52. Role of Lipid Domains in EGF Receptor Signaling 359 Linda J. Pike 53. Lipid-Mediated Localization of Signaling Proteins 365 Maurine E. Linder 54. Organization of Photoreceptor Signaling Complexes 373 Susan Tsunoda 55. Transmembrane Receptor Oligomerization 379 Darren R. Tyson and Ralph A. Bradshaw ________ VOLUME 2________ Contributors xxi Preface to the Second Edition xliii Preface to the First Edition xlv Partii Transmission: Effectors and Cytosolic Events 385 Tony Hunter Section A - Protein Phosphory lation 391 Tony Pawson 56. Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases 393 Gerard Manning and Tony Hunter 57. Modular Protein Interaction Domains in Cellular Communication 399 Tony Pawson and Piers Nash 58. Structures of Serine/Threonine and Tyrosine Kinases 413 Stevan R. Hubbard 59. Protein Tyrosine Kinase Receptor Signaling Overview 419 Carl-Henrik Heldin VIII Contents 60. Signaling by the Platelet-Derived Growth Factor Receptor Family 427 Lars Rönnstrand 61. The Epidermal Growth Factor Receptor Family 435 Wolfgang]. Kostier and Yosef Yardén 62. Mechanisms and Functions of Eph Receptor Signaling 443 Martin Lackmann 63. Cytokine Receptor Signaling 451 Mojib Javadi Javed, Terri D. Richmond and Dwayne L. Barber 64. The Negative Regulation of JAK/STAT signaling 467 James M. Murphy, Gillian M. Tannahill, Douglas]. Hilton and Christopher J. Greenhalgh 65. Protein Kinase Inhibitors 481 Alexander Levitzki 66. Integrin Signaling: Cell Migration, Proliferation, and Survival 491 J. Thomas Parsons, ¡ill K. Slack-Davis, Robert W. Tilghman, Marcin Iwanicki and Karen H. Martin 67. Downstream Signaling Pathways: Modular Interactions 501 Bruce J. Mayer 68. Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function 507 Susan E. Levin and Arthur Weiss 69. Receptor Tyrosine Kinase Signaling and Ubiquitination 517 Daniela Hoeller and Ivan Dikic 70. TGFß Signal Transduction 521 Cristoforo Silvestri, Rohit Bose, Liliana Attisano and Jeffrey L. Wrana 71. Mitogen-Activated Protein Kinases 533 Eric Ho and Jim Woodgett 72. Recognition of Phospho-Serine/ Threonine Phosphorylated Proteins by Phospho-Serine/Threonine-Binding Domains 539 Stephen J. Smerdon and Michael B. Yaffe 73. AMP-Activated Protein Kinase 551 D. Grahame Hardie 74. Principles of Kinase Regulation 559 Bostjan Kobe and Bruce E. Kemp 75. Calcium/Calmodulin-Dependent Protein Kinase II 565 Mary B. Kennedy 76. Glycogen Synthase Kinase 3 569 Philip Cohen and Sheelagh Frame 77. The PIKK Family of Protein Kinases 575 Graeme C. M. Smith and Stephen P.Jackson 78. Histidine Kinases in Two-Component Signaling Pathways 581 A Ila O. Kaserer and Ann H. West 79. The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases 587 Shari L. Wiseman, Fan-Yan Wei, and Angus C. Nairn 80. The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana - a Paradigm for Plant LRR Receptors 601 John C. Walker and Kevin A. Lease 81. Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors 609 Chao Zhang and Kevan M. Shokat 82. Clinical Applications of Kinase Inhibitors in Solid Tumors 615 William Pao and Nicolas Girard 83. Ubiquitin-mediated Regulation of Protein Kinases in NFk,B Signaling 633 Ming Xu and Zhijian J. Chen 84. Global Analysis of Phosphoregulatory Networks 645 Janine Mok and Michael Snyder Contents Section В - Protein Dephosphory lation 657 Nick Tonks 85. Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins Patricia T.W. Cohen 659 86. The Structure and Topology of Protein Serine/Threonine Phosphatases 677 David Barford 87. Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases 683 Carol MacKintosh and Julie Diplexcito 88. Protein Phosphatase 1 Binding Proteins 689 Anna A. DePaoli-Roach 89. Protein Serine/Threonine Phosphatase Inhibitors and Human Disease 699 Shirish Shenolikar and Matthew H. Brush 90. Calcineurin 705 Claude B. Klee and Seun-Ah Yang 91. Protein Serine/Threonine-Phosphatase 2C (PP2C) 711 Hisashi Tatebe and Kazuhiro Shiozaki 92. Approaches to the Identification of Protein Tyrosine Phosphatase Substrates 717 Anton M. Bennett and Tony Tiganis 93. Inhibitors of Protein Tyrosine Phosphatases 727 Zhong-Yin Zhang 94. Regulating Receptor PTP Activity 737 Aurnab Chose and David Van Vactor 95. CD45 743 Michelle L Hermiston, Vikas Gupta and Arthur Weiss 96. Cell-Cycle Functions and Regulation of Cdc14 Phosphatases 749 Harry Charbonneau 97. MAP Kinase Phosphatases 755 Stephen M. Keyse 98. SH2 Domain-Containing Protein- Tyrosine Phosphatases 771 Benjamin G. Neel, Gordon Chan, and Salim Dhanji 99. Insulin Receptor PTP: PTP1B 811 Sofi G. Julien and Michel L Tremblay 100. STYX/Dead Phosphatases 817 Matthew J. Wishart 101. Zebrafish and Phosphatase Function 827 Jemen den Hertog and Mark van Eekelen 102. Eyes Absent Protein Tyrosine Phosphatases: A New Eukàryotic Branch of the Haloacid Dehalogenase Superfamily 835 Carolyn N. Wróbel and Ilaria Rebay 103. PHLPP: PH Domain Leucine-Rich Repeat Protein Phosphatase 843 Alexandra С Newton 104. PTEN 849 Lloyd С Trotman 105. PTP Oxidation 855 Ming-Fo Hsu, Yi-Wei Lou, Yi-Yun Chen and Tzu-Ching Meng 106. Chronophin and Slingshot Cofilin Phosphatases in Cytoskeletal Regulation 863 Céline DerMardirossian, Timothy Y. Huang and Gary M. Bokoch 107. Large Scale Structural Analysis of Protein Tyrosine Phosphatases 871 AlastairJ. Barr and Stefan Knapp 108. Protein Phosphatases and Circadian Clocks 877 Yanshan Fang andAmita Sehgal Contents Section С - Calcium Signal Transduction 883 Martin D. Bootman 109. Calcium Signalling; Messengers, Transport Pathways, Sensors, and Physiological Outcomes 885 Martin D. Bootman and H. Llewelyn Roderick 110. Phospholipase С 887 Hong-Jun Liao and Graham Carpenter 111. Cyclic ADP-ribose and NAADP 893 Antony Galione and Grant С Churchill 112. Voltage-Gated Calcium Channels 897 William A. Catterai! 113. Store-Operated Calcium Channels 911 James W. Putney 114. Arachidonic Acid-Regulated Ca2+ Channel 915 Trevor J. Shuttleworth 115. IP3 Receptors 921 Colin W. Taylor and Zhao Ding 116. Ryanodine Receptors 927 David H. MacLennan and S. R. Wayne Chen 117. Intracellular Calcium Signaling 937 Dagmar Harzheim, H. Llewelyn Roderick and Martin D. Bootman 118. Calcium Pumps 943 Ernesto Carafoli, Laura Fedrizzi, Teuta Domi, Francesca Di Leva and Marisa Brini 119. Sodium/Calcium Exchange 949 Mordecai P. Blaustein 120. Ca2 1 Buffers 955 Beat Schwaller 121. Mitochondria as Organizers of the Cellular Ca2+ Signaling Network 963 György Szabadkai and Michael R. Duchen 122. EF-Hand Proteins and Calcium Sensing: The Neuronal Calcium Sensor Proteins 973 ¿ее P. Haynes and Robert D. Burgoyne 123. Calmodulin-Mediated Signaling 979 Anthony R. Means 124. The Family of S100 Cell Signaling Proteins 983 Claus W. Heizmann and Günter Fritz 125. Annexins and Calcium Signaling 995 Stephen E. Moss 126. Calpain 999 Alan Wells and Ludovic Leloup 127. Calcium Signaling in Smooth Muscle 1009 Susan Wray 128. Calcium Signaling in Cardiac Muscle 1027 K.M. Dibb, A.W. Trafford and D.A. Eisner Section D - Lipid-Derived Second Messengers 1031 Lewis Cantley 129. Historical Overview: Protein Kinase C, Phorbol Ester and Lipid Mediators 1033 Yasutomi Nishizuka and Ushio Kikkawa 130. Type I Phosphatidylinositol 4-Phosphate 5-Kinases (P14P 5-kinases) 1037 K. A. Hinchliffe and R. F. Irvine 131. Type II P^-kinases 1043 Lucia Rameh 132. Phosphoinositide 3-Kinases 1049 David A. Fruman 133. PTEN/MTM Phosphatidylinositol Phosphatases 1061 Knut Martin Torgersen, Soo-A Kim and Jack E. Dixon Contents 134. The Src Homology 2 Containing Inositol 5 Phosphatases 1065 f rann Antignano, Jens Ruschmann, Melisa Hamilton, Victor Ho, Vivian Lam, Etsushi Kuroda, Laura M. Sly and Gerald Krystal 135. Structural Principles of Lipid Second Messenger Recognition 1085 Roger L. Williams 136. Pleckstrin Homology (PH) Domains 1093 Mark A. Lemmon 137. PX Domains 1103 Christian D. Ellson and Michael B. Yaffe 138. FYVE Domains in Membrane Trafficking and Cell Signaling 1111 Christopher Stefan, Anjon Audhya and Scott D. Emr 139. Protein Kinase C: Relaying Signals from Lipid Hydrolysis to Protein Phosphorylation 1123 Alexandra C. Newton 140. Modulation of Monomeric G Proteins by Phosphoinositides 1131 Sonja Vermeren, Len Stephens and Phillip T. Hawkins 141. Phosphoinositides and Actin Cytoskeletal Rearrangement 1141 Paul A. Janmey, Robert Bucki and Helen L. Yin 142. Phosphatidylinositol Transfer Proteins 1151 Shamshad Cockcroft 143. Inositol Pentakisphosphate: A Signal Transduction Hub 1159 Stephen B. Shears 144. Phospholipase D 1167 Wenjuan Su and Michael A. Frohman 145. Diacylglycerol Kinases 1177 Matthew K. Topham and Steve M. Prescott 146. Sphingosine-1-Phosphate Receptors: An Update 1183 Michael Maceyka and Sarah Spiegel 147. Lysophosphatidic Acid and Sphingosine 1 -Phosphate Activation of G-Protein- Coupled Receptors 1191 Tetsuji Mutoh andjerold Chun 148. The Role of Ceramide in Cell Regulation 1201 Leah]. Siskind, Thomas D. Mullen and Lina M. Obeid 149. Role of Phospholipase A2 Forms in Arachidonic Acid Mobilization and Eicosanoid Generation 1213 Jesús Balsinde and Edward A. Dennis 150. Prostaglandin Mediators 1219 EmerM. Smyth and Garret A. FitzGerald 151. Leukotriene Mediators 1229 Jesper Z. Haeggström and Anders Wetterholm 152. Lipoxins and Aspirin-Triggered 15-epi-Lipoxins: Pro-Resolving Mediators in Anti- Inflammation and Resolution 1235 Charles N. Serhan Section E - Protein Proximity Interactions 1243 John D. Scott 153. Protein Proximity Interactions Matthew G. Gold and John D. Scott 1245 154. Rapid Characterization of in vivo Phosphorylation Sites and the Protein Kinases and Phosphatases that Regulate them by Affinity Capture 1247 Timothy A.J. Haystead 155. FRET Analysis of Signaling Events in Cells 1253 Peter J. Verveer and Philippe I.H. Bastiaens Contents 156. The Focal Adhesion: A Network of Molecular Interactions 1259 Jianxin A. Yu, Nicholas O. Deakin and Christopher E. Turner 157. WASP and WAVE Family Protein Complexes 1265 Frank M. Mason and Scott H. Soderling 158. Synaptic NMDA-Receptor Signaling Complex 1271 Mary B. Kennedy 159. Toll Family Receptors 1277 Yann Hyvert and Jean-Luc Imler 160. Signaling and the Immunological Synapse 1283 Emanuele Ciurisato and Andrey S. Shaw 161. The Ubiquitin-Proteasome System 1293 Mark Hochstrasser 162. Caspases: Cell Signaling by Proteolysis 1297 Guy S. Salvesen 163. MAP Kinase in Yeast 1303 Rupam Sahoo, Am jad Húsain, and Elaine A. Elion 164. Mammalian MAP Kinases 1315 Norman J. Kennedy and Roger). Davis 165. Subcellular Targeting of PKA through AKAPs: Conserved Anchoring and Unique Targeting Domains 1329 Mathew D. Pink and Mark L Dell Acqua 166. AKAP Transduction Units: Context dependent Assembly of Signaling Complexes 1337 John D. Scott and Lorene K. Langeberg 167. Dendritic Protein Phosphatase Complexes 1343 Anthony J. Baucum II and Roger J. Colbran 168. Protein Phosphatase 2A 1353 Adam M. Silverstein, Anthony]. Davis, Vincent A. Bielinski, Edward D. Esplín, Nadir A. Mahmood and Marc C. Mumby 169. 14-3-3 Proteins 1367 Hubert Hondermarck 170. Protein Interaction Data Resources 1375 lan M. Donaldson Section F - Cyclic Nucleotides 1387 Jackie D. Corbin 171. Adenylyl Cyclases 1389 Adam]. Kuszák and Roger K. Sunahara 172. G uanylyl Cyclases 1399 Lincoln R. Potter 173. Phosphodiesterase Families 1409 James Surapisitchat and Joseph A. Beavo 174. The cAMP-Specific Phosphodiesterases: A Class of Diverse Enzymes that Define the Properties and Localization of cAMP Signals 1415 James L. Weeks II and Marco Conti 175. cAMP/cCMP Dual-Specificity Phosphodiesterases 1425 Lena Stenson, Eva Degerman and Vincent C. Manganiello 176. Phosphodiesterase-5 1439 Sharron H. Francis and Jackie D. Corbin Л77. Function and Regulation of Photoreceptor Phosphodiesterase (PDE6) in the Visual Signaling Pathway 1445 Rick H. Cote and Karyn B. Cahill 178. Regulation of Cyclic Nucleotide Levels by Sequestration 1453 Jackie D. Corbin, Jun Kotera, Venkatesh К. Gopal, Gary Z. Morris, Rick H. Cote and Sharron H. Francis 179. cAMP-Dependent Protein Kinase 1461 Susan S. Taylor and Elżbieta Radzio-Andzelm Contents 180. Cyclic GMP-Dependent Protein Kinase: Targeting and Control of Expression 1471 Thomas M. Lincoln, Hassan Sellak, Nupur Dey, Chung-Sik Choi, and Felricia Brown 181. Inhibitors of Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases 1479 Wolfgang R. Dostmann and Christian K. Nickl 182. Substrates of Cyclic Nucleotide- Dependent Protein Kinases 1489 NeilF.W. Saunders, Ross I. Brinkworth, Bruce E. Kemp and Bostjan Kobe 183. Physiological Substrates of PKA and PKG 1497 Anja Ruppelt, Nikolaus G. Oberprieler, George Magklaras and Kjetil Taskèn 184. Effects of cGMP-Dependent Protein Kinase Knockouts 1515 Franz Hofmann and Thomas Kleppisch 185. Cyclic Nucleotide-Regulated Cation Channels 1519 Martin Biel 186. Epac, cAMP-Regulated Guanine Nucleotide Exchange Factors for Rapi and Rap2 1525 Holger Rehmann, Johan de Rooij and Johannes L Bos 187. Cyclic Nucleotide-Binding GAF Domains in Phosphodiesterases and Adenylyl Cyclases 1531 Sergio E. Martinez, Clemens C. Heikaus and Joseph A. Beavo 188. Use of Chimeric Adenylyl Cyclases to Study Cyclic Nucleotide Signaling 1537 Jürgen U. Linder and Joachim E. Schultz 189. Cyclic Nucleotide Signaling in the Kinetoplastids 1543 Stefan Kunz, Mihaela Minca, Edith Luginbühl, Patrick Bregy and Thomas Seebeck 190. Cyclic Nucleotide Specificity and Cross-Activation of Cyclic Nucleotide Receptors 1549 John B. Shabb 191. Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling 1555 Anne Elisabeth Christensen, Kristin Viste and Stein Ove Dßskeland 192. cGMP and PKG Signaling in Platelets 1563 Stepán Gambaryan and Ulrich Walter 193. Use of siRNA and Antisense Knockdown to Study the Regulation ofPKAbyPKI 1569 Edward M . Greenfield and Xin Chen 194. Cyclic Nucleotide Signaling in the Central Nervous System 1573 Diego A. Golombek and Patricia V. Agostino 195. Compartmentation of cAMP in cardiomyocytes 1581 Grégoire Vandecasteele and Rodolphe Fischmeister 196. Phosphodiesterase^A: cGMP-Specific Enzyme 1589 Jun Kotera, Takashi Sasaki, and Kenji Omori Section G - G Proteins Heidi E. Hamm 1595 197. Signal Transduction by G Proteins: Basic Principles, Molecular Diversity, and Structural Basis of Their Actions 1597 Lutz Birnbaumer 198. Heterotrimeric G-Protein Signaling at Atomic Resolution 1615 David C. Lambright 199. In Vivo Functions of Heterotrimeric G Proteins 1621 Stefan Offermanns 200. Regulation of G Proteins by Covalent Modification 1629 Benjamin C.Jennings andMaurine E. Linder Contents 201. G-Protein-coupled Receptors, Signal Fidelity, and Cell Transformation 1635 Todd R. Palmby, Hans Rosenfeldt, and J. Silvio Gutkind 202. Signaling through Gz 1649 Michelle E. Kimple, Rainbo C. Hultman and Patrick J . Casey 203. Effectors of Goto 1655 Yana Torina, Ravi lyengar, and Kenneth D. Bromberg 204. Mono-ADP-ribosylation of Heterotrimeric G Proteins 1665 Maria Di Girolamo and Daniela Corda 205. Specificity of G Protein β-γ Dimer Signaling 1673 Carl A. Hansen, William F. Schwindinger and Janet D. Robishaw 206. The Superfamily of Regulator of G-protein Signaling (RGS) Proteins 1683 Melinda D. Willard, Francis S. Willard and David P. Siderovski 207. G-Protein Signaling in Chemotaxis 1705 Jonathan Franca-Koh, Stacey Sedore Willard and Peter N. Devreotes 208. Reversible Palmitoylation in G Protein Signaling 1713 Philip B. Wedegaertner 209. G Proteins in Gustatory Transduction 1721 Bedřich Mosinger, Sami Damak and Robert F. Margolskee 210. Regulation of Synaptic Fusion by Heterotrimeric G Proteins 1727 Simon Alford, Edaeni Hamid, Trillium Blackmer, and Tatyana Gerachshenko 211. G-protein Regulation of Channels Ofer Wiser and Lily Yeh Jan 1735 212. Ras and Cancer Frank McCormick 1741 213. The Influence of Intracellular Location on Function of Ras Proteins 1745 Jodi McKay and Janice E. Buss 214. Role of R-Ras in Cell Growth 1753 Gretchen A. Repasky, Adrienne D. Cox, Ariella В. Hanker, Natalia Mitin and ChanningJ. Der 215. The Ran GTPase: Cellular Roles and Regulation 1763 Mary Dasso 216. Regulation of NADPH Oxidases by Rac GTPase 1773 Gary M. Bokoch, Davide Gianni, Jun-Sub Kim and Yu-Ya Kao 217. The Role of Rac and Rho in Cell Cycle Progression 1781 Laura J. Taylor and Dafna Bar-Sagi 218. Cdc42 and its Cellular Functions 1785 Qiyu Feng and Richard A. Cerione 219. Tissue Transglutaminase: A Unique GTP-binding/GTPase 1795 Marc Antonyak and Richard A. Cerione 220. Roles for ADP-Ribosylation Factors in Membrane Traffic 1803 Amanda Caster and Richard A. Kahn 221. Yeast Small G Protein Function: Molecular Basis of Cell Polarity in Yeast 1813 Keith G. Kozminski and Hay-Oak Park 222. Farnesyltransferase Inhibitors 1819 James). Fiordalisi and Adrienne D. Сох 223. Structure of Rho Family Targets 1827 Helen R. Mott and Darerca Owen 224. Structural Features of RhoGEFs 1843 Jason T. Snyder, Kent L. Rossman, David K. Worthylake, and John Sondek 225. Structural Considerations of Small GTP-Binding Proteins 1849 Alfred Wittinghofer Contents 226. Mx Proteins: High Molecular Weight GTPases with Antiviral Activity 1855 Georg Kochs and Otto Haller Section H - Developmental Signaling 1865 Geraldine Weinmaster 227. Interactions between Wnt/ß-catenin/ Fgf and Chemokine Signaling in Lateral Line Morphogenesis 1867 Tatjana Piotrowski 228. Wnt Signaling in Development 1873 Stefan Rudloff, Daniel Messerschmidt and Rolf Kemier 229. Hedgehog Signaling in Development and Disease 1879 Frederic de Sauvage 230. Regulation of Vertebrate Left-Right Axis Development by Calcium 1885 Adam D. Langenbacherand Jau-Nian Chen 231. LlN-^/Notch Signaling: Induction, Lateral Specification and Interaction with the EGF/Ras Pathway 1891 Sophie Jarriault 232. Proteolytic Activation of Notch Signaling: Roles for Ligand Endocytosis and Mechanotransduction 1897 James T. Nichols and Gerry Weinmaster 233. BMPs in Development 1905 Kelsey N. Retting and Karen M. Lyons 234. Neurotrophin Signaling in Development 1913 Katrin Deinhardt and Moses V. Chao 235. Mechanisms Underlying Context-Dependent VEGF Signaling for Distinct Biological Responses 1919 M. Luisa Iruela-Arispe and Sunyoung Lee 236. Vascular Endothelial Growth Factors and Receptors: Signaling in Vascular Development 1927 Anna Dimberg, Charlotte Rolny, Laurens A. van Meeteren, and Lena Claesson-Welsh 237. Signaling from Fibroblast Growth Factor Receptors in Development and Disease 1939 Kristine A. Drafahl, Christopher W. McAndrew, and Daniel J. Donoghue 238. The Role of Receptor Protein Tyrosine Phosphatases in Axonal Pathfinding 1949 Andrew W. Stoker 239. Attractive and Repulsive Signaling in Nerve Growth Cone Navigation 1955 Guo-li Ming, and Mu-ming Poo 240. Semaphorins and their Receptors in Vertebrates and Invertebrates 1961 Eric F. Schmidt, Hideaki Togashi, and Stephen M. Strittmatter 241. Signaling Pathways that Regulate Cell Fate in the Embryonic Spinal Cord 1967 Matthew T. Pankratz and Samuel L Pfaff 242. Cadherin Regulation of Adhesive Interactions 1975 Barbara Ranscht 243. integration of BMP, RTK and Wnt Signaling through Smadi Phosphorylations 1989 Luis C. Fuentealba, Edward Eivers, Hojoon X. Lee and E. M. De Robertis XVI Contents VOLUME З Contributors xxi Preface to the Second Edition xliii Preface to the First Edition xlv Partili Transcription and Translation: Nuclear and Cytoplasmic Events 1995 Michael Karin Section A - Nuclear Receptors Michael G. Rosen feld 1997 244. Nuclear Receptor Coactivators 1999 Joshua D. Stender and Christopher K. Glass 245. Corepressors in Mediating Repression by Nuclear Receptors 2005 Gratiën G. Prefontaine, Peter J. Cook and Michael G. Rosenfeld 251. The Multi-gene Family of Transcription Factor AP-1 2059 Peter Angel and jochen Hess 252. NFkB: a Key Integrator of Cell Signaling 2069 John K. Westwick, Klaus Schwambom, and Frank Mercurio 253. Transcriptional Regulation via the cAMP Responsive Activator CREB 2077 Paul K. Brindle 254. The NFAT Family: Structure, Regulation and Biological Functions 2083 Fernando Macian, Fernando Cruz-Guilloty , Sonia Sharma and An/ana Rao 255. Ubiquitination / Proteasome 2093 Daniel Kornitzer and Aaron Ciechanover 256. The Smads 2099 Malcolm Whitman 246. Steroid Hormone Receptor Signaling 2015 Vincent G i guère 247. Role of COUP-TFII in Congenital Diaphragmatic Hernia 2021 Sumiyasu Ishii, Sophia Y. Tsai and Ming-Jer Tsai 248. Nuclear Receptors in Drosophila Melanogaster 2027 Vincent С Henrich and Joshua M. Beatty Section В -Transcription Factors 2039 Marc Montminy 249. JAK-STAT Signaling 2041 Li Song and Christian Schindler 250. FOXO Transcription Factors: Key Targets of the РІЗК -Akt Pathway That Regulate Cell Proliferation, Survival, and Organismal Aging 2049 Anne Brunet, Hien Tran, and Michael E. Greenberg Section С - Damage/Stress Responses 2105 Albert J. Fornace, Jr. 257. Complexity of Stress Signaling 2107 Daniel R. Hyduke, Sally A. Amundson, and Albert J. Fornace, Jr. 258. Signal Transduction in the Escherichia coli SOS Response 2127 James J. Fotí, Lyle A. Simmons, Penny J. Beuning and Graham С Walker 259. Oxidative Stress and Free Radical Signal Transduction 2137 Bruce Demple 260. Screening Approaches to Identify Genes Required for DNA Double- Strand Break Damage Signaling in the Yeast Saccharomyces Cerevisiae 2145 Craig B. Bennett 261. Radiation Responses in Drosophila 2159 Wan-Jin Lu, Naoko Sogame and John M. Abrams Contents 262. Double-strand Break Recognition and its Repair by Non-homologous End-Joining 2165 Xiaopoing Cui and Michael R. Lieber 263. ATM Mediated Signaling Defends the Integrity of the Genome 2171 Martin F. Lavin, Magtouf Catei, Philip Chen, Amanda Kijas and Sergei Kozlov 264. Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses 2185 Carl W. Anderson and Ettore Appella 265. The p53 Master Regulator and Rules of Engagement with Target Sequences 2205 Alberto Inga, Jennifer J. Jordan, Daniel Menendez, Veronica De Sanctis and Michael A. Resnick 266. Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase 2217 Jean Y.J.Wang 267. Radiation Induced Cytoplasmic Signaling 2225 Frank-D. Böhmer, Carsten Weiss and Peter Herrlich 268. The Heat Shock Response and the Stress of Misfolded Proteins 2231 Richard I. Morimoto and Sandy D. Westerheide 269. Hypoxia Mediated Signaling Pathways 2241 Denise A. Chan, Albert С Koong, and Amato J. Giaccia 270. Regulation of mRNA Turnover by Cellular Stress 2247 Subramanya Srikantan and Myriam Gorospe 271. Oncogenic Stress Responses 2257 Dmitry V. Bulavin 272. Ubiquitin and FANC Stress Responses 2265 Siacy A. Williams and Gary M. Kupfer 273. Stress and Ч-Н2АХ 2273 Jennifers. Dickey, Christophe E. Redon, AsakoJ. Nakamura, Brandon J. Baird, Olga A. Sedelnikova, and William M. Bonner Section D - Post-transcriptional Control 2283 Nahum Sonenberg 274. Translational Control by Amino Acids and Energy 2285 Kathrin Thedieck and Michael N. Hall 275. Translation Control and Insulin Signaling 2295 Anand Selvaraj and George Thomas 276. ER and oxidative stress: Implications in disease 2301 Jyoti D. Malhotra and Randal J. Kaufman 277. Regulation of mRNA Turnover 2311 Ann-Bin Shyu and Chyi-Ying A. Chen 278. Signaling to Cytoplasmic Polyadenylation and Translation 2317 Jong Heon Kim and Joel D. Richter 279. Translational Control in Invertebrate Development 2323 Jocelyn Moore and Paul Lasko 280. The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death 2329 Xialu Li and James L. Manley 281. Signaling Pathways that Mediate Translational Control of Ribosome Recruitment to mRNA 2335 Ryan J. O. Dowling and Nahum Sonenberg Section E - Chromatin and its Modification 2343 Jerry L. Workman 282. The SWI/SNF and RSC Nucleosome Remodeling Complexes 2345 Nilanjana Chatterjee, Payel Sen, and Blaine Bartholomew XVIII Contents 283. ISWI Chromatin Remodeling Complexes 2357 Toshio Tsukiyama, Naomi Bogenschutz, Tracey Kwong,Jairo Rodriguez, Ashwin Unnikrishnan, and Adam Yadon 284. The INO80 Chromatin Remodeling Complex 2363 Mingming Chen and Xuetong Shen 285. Histone Acetylation Complexes Tara L Burke and Patrick A. Grant 2369 286. Regulation of Histone Deacetylase Activities and Functions by Phosphorylation and Dephosphorylation 2379 Edward Seto and Xiang-Jiao Yang 287. Histone Methylation: Chemically Inert But Chromatin Dynamic 2389 Johnathan R. Whetstine 288. Histone Phosphorylation: Chromatin Modifications that Link Cell Signaling Pathways to Nuclear Function Regulation 2399 Prisdlla Nga leng Lau and Peter Cheung 289. Histone Variants: Signaling or Structural Modules? 2409 Toyotaka Ishibashi, Andra Lì and Juan Ausìó 290. Silent Chromatin Formation and Regulation in the Yeast Saccharomyces cerevisiae 2427 Melissa R. Koch and Lorraine Pillus 291. Gene Silencing and Chromatin Modification by Polycomb Complexes in Flies and Humans 2437 Jeffrey A. Simon 292. Histone Ubiquitination 2449 Vikki M. Weake and Jerry L. Workman 293. Chromatin Mediated Control of Gene Expression in Innate Immunity and Inflammation 2461 Cioacchino Natoli Part IV Signaling From Intracellular Compartments 2467 Marilyn G. Farquhar and Suresh Subramani 294. Protein Quality Control in the Endoplasmic Reticulum 2471 Yuki Okuda-Shimizu, Ying Shen, and Linda Hendershot 295. Quality Control and Quality Assurance in the Mitochondrion 2477 Carolyn K. Suzuki 296. Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptors 2489 Chris Williams and Ben Distel 297. Mitochondrial Dynamics: Fusion and Division 2499 Yasushi lamura, Miho lijima and Hiromi Sesaki 298. The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking 2505 Arun Radhakrishnan, Li-Ping Sun, Peter J. Espenshade, Joseph L. Goldstein and Michael S. Brown 299. Regulating Endoplasmic Reticulum Function through the Unfolded Protein Response 2511 Alicia A. Bicknell and Maho Niwa 300. Signaling Pathways from Mitochondria to the Cytoplasm and Nucleus 2527 Immo E. Scheffler 301. Apoptosis Signaling: A Means to an End 2535 LisaJ. Pagliari, Michael J. Pinkoski, and Douglas R. Green 302. Regulation of Cell Cycle Progression 2545 Jennifer Scorah, and Claire H. McGowan Contents 303. Signaling During Organelle Division and Inheritance: Peroxisomes 2555 Andrei D. Fagarasaim and Richard A. Rachubinski 304. Signaling at the Nuclear Envelope Géza Ambrus and Larry Cerace 2563 305. Bidirectional Crosstalk between Actin Dynamics and Endocytosis 2571 Giorgio Scita and Pier Paolo Di Fiore 306. Signaling in Autophagy Related Pathways 2583 Patrice Codogno and Alfred J. Meijer PartV Cell-Cell and Cell-Matrix Interaction 2589 E. Brad Thompson 307. Overview of Cell-Cell and Cell-Matrix Interactions 2591 E. Brad Thompson and Ralph A. Bradshaw 308. Interactive Signaling Pathways in the Vasculature 2593 Igor Prudovsky, Volkhard Lindner, Calvin Vary and Robert E. Friesel 309. Signaling Pathways Involved in Cardiogenesis 2601 Deepak Srivastava and Chulan Kwon 310. Regulatory Signaling in Pancreatic Organogénesis: Implications for Aberrant Signaling in Pancreatic Cancer 2611 Catherine Carrière and Murray Korc 311. Trophic Effects of Gut Hormones in the Gastrointestinal Tract 2621 Kanika A. Bowen and B. Mark Evers 312. The Neurotrophin Factors 2631 J. ReginoPerez-Polo 313. Cell to Cell and Cell-Matrix Interactions in Bone 2647 Lynda F. Bonewald 314. Cell-Cell Signaling in the Testis and Ovary 2663 Michael K. Skinner, Eric E. Nilsson and Ramji K. Bhandari 315. Signal Transduction in T Lymphocytes 2679 Rolf König 316. Signal Transduction via the В Cell Antigen Receptor: A Crucial Regulator of В Cell Biology 2689 Louis B. Justement 317. Signaling Pathways in the Normal and Neoplastic Breast 2699 Tushar B. Deb, Danica Ramljak, Robert B. Dickson2, Michael D. Johnson, and Robert Clarke 318. Kidney 2707 William J. Arendshorst and Elsa Bello-Reuss 319. Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis 2733 Fiona J. Pixley and E. Richard Stanley 320. Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells 2743 Larry Denner, Margaret Howe and Randall J. Urban 321. In Vivo Imaging of Cellular Network Signaling 2753 Werner Göbel, Björn M. Kampa and Fritjof Helmchen Part VI DISEASE PATHOPHYSIOLOGY: Translational Implications 2759 Murray Korc 322. The Roles of Ras Family Small GTPases in Breast Cancer 2763 Ariella В. Hanker and ChanningJ. Der Contents 323. Translational Implications of Stromal- Epithelial Interactions in Prostate Cancer and the Potential Role of Prostate Cancer Stem/Progenitor Cells 2773 Sophia L Maund and Scott D. Cramer 324. Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics 2783 AHxanna Norris and Murray Korc 325. The Evolution and Maintenance of the Multiple Myeloma Cell Clone within the Liquid Bone Marrow Compartment: Therapeutic Implications 2799 Klaus Podar and Kenneth C. Anderson 326. The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma 2811 Klaus Podar and Kenneth C. Anderson 327. Signaling Targets in Myeloid Leukémiás 2821 Muneyoshi Futami and Seth J. Corey 328. Signaling Targets in Lymphoid Leukémiás 2831 Muneyoshi Futami and Seth J. Corey 329. Targeting Ras for Anticancer Drug Discovery 2837 Jen Jen Yeh, James P. Madigan, Paul M. Campbell, Patrick J. Roberts, Lanika DeGraffenreid and ChanningJ. Der 330. Targeting EWS/FLI1 Driven Signaling Pathways as Therapy for Tumors of the Ewing s Sarcoma Family 2859 Vicente Notario, Silvia Mateo-Lozano, Joaquín Villar, and Oscar M. Tirado 331. IRS-Protein Scaffolds and Insulin/ IGF Action in Central and Peripheral Tissues 2873 Morris F. White 332. Adipokine Signaling: Implications for Obesity 2885 Rexford S. Ahima and Gladys M. Varela 333. Angiogenesis Signaling Pathways as Targets in Cancer Therapy 2895 CheryA. Whipple and Murray Korc 334. CXC Chemokine Signaling in Interstitial Lung Diseases 2907 Robert M. Strieter and Borna Mehrad 335. Systemic Sclerosis 2913 Carol A. Feghali-Bostwick, and John Varga 336. Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus 2919 Thomas Dömer, and Peter E. Lipsky 337. Translational Concepts in Vasculitis 2933 Daniel A. Albert and David B. Talmadge 338. Advances in Understanding the Pathogenesis of Inflammatory Bowel Disease 2945 David S. Kotlyar, Wojciech С. Błoński, and Gary R. Lichtenstein 339. Translational Implications of Proteomics 2959 Sam Hanash 340. Translational Implications of microRNAs in Clinical Diagnostics and Therapeutics 2965 Lorenzo F. Sempere and Sakari Kauppinen Index 2983
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