Chemo fog: cancer chemotherapy-related cognitive impairment
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer [u.a.]
2010
|
| Schriftenreihe: | Advances in experimental medicine and biology
678 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XXI, 216 S. Ill., graph. Darst. |
| ISBN: | 9781441963055 |
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Datensatz im Suchindex
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Titel: Chemo fog
Autor: Raffa, Robert B
Jahr: 2010
CONTENTS
1. SHORT INTRODUCTION AND HISTORY.1
Robert B. Raffa
Abstract_1
Introduction and History_._1
Conclusion._._._?._._.8
2. PATIENT'S PERSPECTIVE.11
Robert B. Raffa and Kathleen J. Martin
Abstract.11
Conclusion .---------._. 12
3. ONCOLOGY NURSE'S PERSPECTIVE.13
Jamie S. Myers
Abstract_13
Introduction: Personal ReOections of an Oncology Nursc--------------------------------13
Chemotherapy-Related Cognitive Impairment: The Oncology Nurse Perspective. 14
Oncology Nursing Research«._.-----------.?._.?._.14
Oncology Nursing Education------------------------------------------------------------------17
Conclusion .~?~_~.~~-------.?~.~.---------------.-.--------.?-17
4. ONCOLOGY PHARMACIST'S PERSPECTIVE.19
Rachel Clark-Vetri
Abstract_19
Conclusion ?.???.?_._._.??._.?.??.??.??----------.?_._?_._?._?20
xvi Contents
5. THE IMPACT OF CHEMO BRAIN ON THE PATIENT
WITH A HIGH GRADE GLIOMA.21
Michele R. Lucas
Abstract_21
Background_._.21
Brain Cancer_._._._._._._.?_.22
Impact of Chemo Brain on the Patient._._._._._._._._._23
Impact of Chemo Brain on the Family._._._?._._24
Impact of Chemo Brain on Society_24
Conclusion_25
6. NEUROCOGNITIVE EFFECTS OF CHILDHOOD CANCER
TREATMENT_26
Jennifer Costa
Abstract_._._._._?_?_?_._~_._?.?.26
Identified Risk Factors_27
Treatment of Childhood Leukemia: Pastand Present._._.??._._._?.?28
Treatment of Childhood Brain Tumors: Past and Present_.??._._.?28
Neurocognitive Effects of Chemotherapy----------------------------------------------------29
Cognitive Remediatton _?_.?_._?_~_.?_._?~~._.?._?.?._.-----30
Pharmacological Intervention: Methylphenidate.?-~.------31
Conclusion ._._.?_^.-._~_~~~»??.?.??~.?------31
7. THE ECONOMIC BÜRDEN_33
Albert I. Wertheimer
Epidemiology of Chemo Fog_.?33
Disease Impact_34
Economic Bürden of Chemo ?( ;_???-?-».??-.?34
Conclusion_36
8. DESIGNING CONCEPTUAL MODEL-BASED RESEARCH
IN CHEMOTHERAPY-RELATED CHANGES
IN COGNITIVE FUNCTION_37
Lisa M. Hess
Abstract--------------------------------------------------------------------------------------------37
Understand ing the Issue_._.?.?.?.?.?._._._.?. 37
Designing Research Trials_43
Conclusion_.?.?.??.??.?.?._._._.?.??.?.?_??.??? 53
Contents xvii
9. NEUROPSYCHOLOGIC TESTING FOR CHEMOTHERAPY-
RELATED COGNITIVE IMPAIRMENT.55
Jamie S. Myers
Abstract._._._._.55
Introduction.-------------55
Neuropsychologic Test Overview_._.?._.?._55
Issues Related to Neurocognitive Testing for CRCI_58
Conclusion ._._._._._._._.67
10. IMAGING AS A MEANS OF STUDYING CHEMOTHERAPY-
RELATED COGNITIVE IMPAIRMENT.70
Robert B. Raffa
Abstract.?.70
Introduction_70
Electrophysiological Studies_70
Neuroimaging Studies._.?.?._71
Conclusion.?.?.73
11. CHEMOTHERAPY ASSOCIATED CENTRAL NERVOUS
SYSTEM DAMAGE.77
Jörg Dietrich
Abstract._77
Introduction._~_?._._._._.?.------.-77
Stern Cells, Progenitor Cells and Lineage Systems with in the Central
Nervous System._._._.-----.?.?.?.? 78
Cell-Biological Analysis of Chemotherapy Associated Brain Damage------------------79
Conclusion._._._~.?_???.?.?.?.?.^?~.?.??.-------.82
12. IS SYSTEMIC ANTI-CANCER THERAPY NEUROTOXIC?
DOES CHEMO BRAIN EXIST? AND SHOULD
WE RENAME IT?-----------------------------------------------------------------86
Sophie Taillibert
Abstract.?.??._~.??.?._.-----.------_.?.-----86
Introduction._.?_?.---------.?-------.---------------.----------.86
Towards a Better Definition of Chemo Brain-----------------------------------------------------87
Towards a Better Understanding of Chemo Brain----------------------------------------------88
Does Chemo Brain Exist?---------------------------------------------------~~----------------------------92
Conclusion_92
xviii Contents
13. EVALUATION OF MULTIPLE NEUROTOXIC OUTCOMES
IN CANCER CHEMOTHERAPY.96
Bernard Weiss
Abstract_96
Introduction._._._._._._._._._._._96
Two Contrasting Views of Neurotoxicity._?_._._._98
Dimensions of Neurotoxicity_._._.?._._._._.?_.?.??.??_???99
Lessons Learned from Studies of Cognitive Dysfunction_._._.?._.??.99
Cognitive Function Approaches._?.?.?._.~._??.?.????_._???_. 100
Sensory Function.?.?.?._?._.?.?.~.?_._?._.?.????????_?_??.?»?.102
Motor Function ???.??_.?._??.?_._.?.????.?.?????_?._.?.?._. 105
Animal Models_._?._.?.?.?_.???.???.???.?.?.?.?.?_.??_._???_.??.?.-?_105
Alternative Approaches ?._???_?_._?.?.??_._.?_?????. 110
Conclusion_?_.?._._._._?._.?_~-?.?.~._???._._.?.?110
14. CHEMOTHERAPY-RELATED VISUAL SYSTEM TOXICITY_113
Robert B. Rafiä
Abstract_113
Introduction_?_113
Visual-System Deficits in Chemo Fog/'Chemo Brain' ?~~._.?._??. 113
Cbemotherapeutic Agent Toxicity on the Visual System---------------------------------114
Conclusion._????.?m.?_.?_????.????m?_116
15. THE POSSIBLE ROLE OF CYTOKINES
IN CHEMOTHERAPY-INDUCED COGNITIVE DEFICITS-------119
Jamie S. Myers
Abstract_119
The Role of Proinflammatory Cytokines_119
Overview of Cytokines_??_119
The Immune Response ?.¦¦¦?¦¦.?.?.?.?.?.119
Proinflammatory Cytokines and Cancer_. 120
Proinflammatory Cytokines and Antineoplastic Agents_121
Proinflammatory Cytokines and Sickness Behavior_121
Proinflammatory Cytokines and Other Symptoms_122
Future lmplications._.?.?.?._.??_m.?????.?.m_.?.??_.?._122
Conclusion ._.?.?.?.?._.?.???_?.?.??.?_._?.?_.??_.?.?_122
16. PHARMACOKINETICS OF ANTI-CANCER DRUGS USED
IN BREAST CANCER CHEMOTHERAPY------------------------------124
Swati Nagar
Abstract_124
Introduction---------------»_,-------------------------124
Pbarmacokinetics of Anticancer Drugs Used in Breast Cancer Chemotherapy. 124
Pharmacokinetics in Special Populations: Age and Menopause Status.?. 129
Contents xix
Pharmacokinetics of Anticancer Drugs and Memory Deficit
as a Pharmacodynamic Endpoint_.130
Conclusion.130
17. COMBINATION ANALYSIS.133
Ronald J. Tallarida
Abstract_.133
Introduction._.?.133
DrugAdditivity._133
Tests of Drug Combinations and the Isobole.135
Error Estimates._._._._. 136
Dose-Effect Relation of the Drug Combination_.?.136
Variable Potency Ratio_136
Conclusion_._._?._.?.?.?.??_._. 137
18. ANIMAL MODELS.138
Ellen A.Walker
Abstract.138
Introduction.?.138
Effects of Cancer Chemotherapeutic Agents on the Disruption of Sensory
Processing in Animal Models._._._._. 140
Effects of Cancer Chemotherapeutic Agents on the Disruption of Motor
and Spontaneous Behavior in Animal Models.140
Effects of Cancer Chemotherapeutic Agents on Motivational Behavior
in Animal Models .?.?.?.?_.?._.------.?.?-----. 141
Acute Effects of Cancer Chemotherapeutic Agents on Learning and Memory
in Animal Models .?.?.???.?_._._.?.------?--------------141
Repeated Treatment of Cancer Chemotherapeutics in Animal Models.?. 143
Potential Neural Mechanisms of Chemotherapy-Induced Learning
and Memory Impairments_.?_.??._._? 144
Conclusion ._.??.?.?.?_?.?-------._.------.???.?145
19. CHEMO BRAIN (CHEMO FOG) AS A POTENTIAL SIDE
EFFECT OF DOXORUBICIN ADMINISTRATION:
ROLE OFCYTOKINE-INDUCED,
OXIDATIVE/NITROSATIVE STRESS IN COGNITIVE
DYSFUNCTION_147
Christopher D. Aluise, Rukhsana Suitana, Jitbangjong Tangpong, Mary Vore,
Daret St. Ciair, Jeffrey A. Moscow and D. Allan Butterfield
Abstract_147
Introduction_.?.?.?.?_.????.?.?.?????.------------._.?.?.-----???147
Description of DOX and Mechanisms of Action------------------------------------------148
Toxicity of DOX_149
Description of Chemo Fog in Context of DOX--------------------------------------------152
Conclusion ?_.?????_.~?_??_.?.?_.???._.?.?.~.??-??.-??.~._?-----_~ 153
xx Contents
20. EFFECTS OF 5-FU.157
Peter M. Wigmore, Sarah Mustafa, Maha El-Beltagy, Laura Lyons,
Jariya Umka and Geoff Bennett
Abstract_157
Introduction_157
Animal Models_159
Conclusion ._._._._._.???.????.??_. 162
21. FUTURE DIRECTIONS_.165
Robert B. Raffa and Ronald J. Tallarida
Abstract-------------------------------------------------------------------------------------------165
Background_165
Chemo Fog/Chemo Brain: Current_._?._?.?._._?.?_165
Chemo Fog/Chemo Brain: Future-----------------------------------------------------------166
Conclusion ._?._.?._._?.?_??_?.???_167
SUGGESTED READING._169 |
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| spelling | Chemo fog cancer chemotherapy-related cognitive impairment ed. by Robert B. Raffa ... [Participants: Christopher D. Aluise ...] New York, NY Springer [u.a.] 2010 XXI, 216 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 678 Cognition Disorders chemically induced Neurotoxicity Syndromes Antineoplastic Agents pharmacokinetics Antineoplastic Agents toxicity Drug Therapy adverse effects Models, Animal Cytostatikum (DE-588)4068347-3 gnd rswk-swf Neurotoxizität (DE-588)4123836-9 gnd rswk-swf Kognitive Störung (DE-588)4164473-6 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Chemotherapie (DE-588)4127083-6 gnd rswk-swf Arzneimittelnebenwirkung (DE-588)4003134-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Cytostatikum (DE-588)4068347-3 s Neurotoxizität (DE-588)4123836-9 s DE-604 Krebs Medizin (DE-588)4073781-0 s Chemotherapie (DE-588)4127083-6 s Arzneimittelnebenwirkung (DE-588)4003134-2 s Kognitive Störung (DE-588)4164473-6 s b DE-604 Raffa, Robert B. Sonstige oth Aluise, Christopher D. Sonstige oth Advances in experimental medicine and biology 678 (DE-604)BV000003102 678 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3440282&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020588385&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemo fog cancer chemotherapy-related cognitive impairment Advances in experimental medicine and biology Cognition Disorders chemically induced Neurotoxicity Syndromes Antineoplastic Agents pharmacokinetics Antineoplastic Agents toxicity Drug Therapy adverse effects Models, Animal Cytostatikum (DE-588)4068347-3 gnd Neurotoxizität (DE-588)4123836-9 gnd Kognitive Störung (DE-588)4164473-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Chemotherapie (DE-588)4127083-6 gnd Arzneimittelnebenwirkung (DE-588)4003134-2 gnd |
| subject_GND | (DE-588)4068347-3 (DE-588)4123836-9 (DE-588)4164473-6 (DE-588)4073781-0 (DE-588)4127083-6 (DE-588)4003134-2 (DE-588)4143413-4 |
| title | Chemo fog cancer chemotherapy-related cognitive impairment |
| title_auth | Chemo fog cancer chemotherapy-related cognitive impairment |
| title_exact_search | Chemo fog cancer chemotherapy-related cognitive impairment |
| title_full | Chemo fog cancer chemotherapy-related cognitive impairment ed. by Robert B. Raffa ... [Participants: Christopher D. Aluise ...] |
| title_fullStr | Chemo fog cancer chemotherapy-related cognitive impairment ed. by Robert B. Raffa ... [Participants: Christopher D. Aluise ...] |
| title_full_unstemmed | Chemo fog cancer chemotherapy-related cognitive impairment ed. by Robert B. Raffa ... [Participants: Christopher D. Aluise ...] |
| title_short | Chemo fog |
| title_sort | chemo fog cancer chemotherapy related cognitive impairment |
| title_sub | cancer chemotherapy-related cognitive impairment |
| topic | Cognition Disorders chemically induced Neurotoxicity Syndromes Antineoplastic Agents pharmacokinetics Antineoplastic Agents toxicity Drug Therapy adverse effects Models, Animal Cytostatikum (DE-588)4068347-3 gnd Neurotoxizität (DE-588)4123836-9 gnd Kognitive Störung (DE-588)4164473-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Chemotherapie (DE-588)4127083-6 gnd Arzneimittelnebenwirkung (DE-588)4003134-2 gnd |
| topic_facet | Cognition Disorders chemically induced Neurotoxicity Syndromes Antineoplastic Agents pharmacokinetics Antineoplastic Agents toxicity Drug Therapy adverse effects Models, Animal Cytostatikum Neurotoxizität Kognitive Störung Krebs Medizin Chemotherapie Arzneimittelnebenwirkung Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3440282&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020588385&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT raffarobertb chemofogcancerchemotherapyrelatedcognitiveimpairment AT aluisechristopherd chemofogcancerchemotherapyrelatedcognitiveimpairment |