Cell therapy for lung disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XXIV, 504 S. Ill., graph. Darst. |
| ISBN: | 9781848164390 1848164394 |
Internformat
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| 245 | 1 | 0 | |a Cell therapy for lung disease |c ed.: Julia Polak |
| 264 | 1 | |a London |b Imperial College Press |c 2010 | |
| 300 | |a XXIV, 504 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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Datensatz im Suchindex
| _version_ | 1804143250675597312 |
|---|---|
| adam_text | Contents
List of Contributors
xiii
Foreword
xxi
Preface
xxiii
1.
A General Review of the Current Knowledge
1
of Stem Cell Therapy for Lung Disorders
Daniel J. Weiss
1.
Introduction and Terminology
2
2.
Endogenous Lung Stem and Progenitor Cells
7
3.
Endogenous Lung Progenitor Cells as Lung Cancer
11
Stem Cells
4.
Structural Engraftment of Circulating or Exogenously
12
Administered Stem or Progenitor Cells
5. Immunomodulation
of Lung Inflammatory
18
and Immune Pathways
6.
Lung Tissue Bioengineering^
21
7.
Clinical Trials in Lung
СеНЖіЕЯ-фу
24
8.
Conclusions
·
?
26
References
26
2.
Development of the Lung: Clues for Regeneration
53
and Repair
Sheila
G
Haworth and Alison A. Hislop
1.
Introduction
54
2.
Normal Development of the Airways and the Regulation
54
of Development
vi
Contents
3. Regulation
of Alveolar
Development 60
4. Development
of the Human Pulmonary Vasculature
61
5.
Regulation of Pulmonary Vascular Development
64
6.
Remodelling to Adapt to Extra-Uterine Life
67
7.
Interaction between Airways and Arteries
70
during Development
8.
Can the Adult Lung Begin to Grow Again?
72
9.
Lung Repair and Regeneration
73
10.
Will it be Possible to Regenerate or Grow a New Lung?
76
11.
Conclusion and the Way Forward
78
References
78
3.
Epithelial-Mesenchymal Interactions During Lung
91
Development and Their Potential Relevance
to Lung Repair
Alexandra Firsova, Tomoko Hyakumura, Timothy J. Cole
and Richard Mollard
1.
Formation of the Lung Epithelium and Mesenchyme
92
2.
Respiratory Endodermal Specification
93
and Primary Epithelial Bud Outgrowth
3.
Left and Right Bud Outgrowth and Left-Right Patterning
95
4.
Endodermal Specification and Left-Right Symmetry
97
5.
Secondary Branching and Branching Morphogenesis
98
6.
Fgf Signalling Within the Epithelium and Mesenchyme
100
During Lung Branching Morphogenesis
7.
Epithelial Shh Signalling Regulates Mesenchymal
104
Patterning and the Fgf
10
Signal
8.
Epithelial Dicer Signalling Regulates Mesenchymal
106
Fgf
10
Expression
9.
Epithelial Sprouty Modifies the Mesenchymal
106
Fgf
10
Signal
10.
Interaction of the Epithelial Bmp and Mesenchymal
107
Fgf Signals
11.
Wnt Signalling
109
12.
Conclusion and the Way Forward
112
References
112
Contents
vii
4.
Epithelial Progenitor Cells of the Mammalian Lung
125
Roxana M. Teisanu, Joshua C. Snyder and Barry R.
Stripp
1.
Introduction
126
2.
Progenitor Cells and Lineage
Specifícation
128
in the Developing Lung
3.
Adult Stem Cells and Tissue Maintenance
129
by a Stem Cell Hierarchy
4.
Approaches to Characterise and Hierarchically
130
Organise Progenitor Cells
5.
Progenitor Cells of Tracheobronchial Airways
133
6.
Progenitor Cells of Bronchiolar Airways
137
7.
Progenitor Cells of the Alveolar Compartment
142
8.
Conclusions and Future Directions
144
Acknowledgements
144
References
144
5.
Safety of Exogenous Stem Cells
155
Elizabeth K. Sage, Michael R. Loebinger
and Sam M. Janes
1.
Introduction
156
2.
Exogenous Stem Cells
156
3.
Potential Malignant Transformation
158
4.
Clinical Trials
161
5.
Conclusion
163
Acknowledgements
164
References
164
6.
Lung Stem Cell
Bioprocessing:
Fundamentals
169
of Producing Lung Cells
Siti
Norhayati Ismail, Julia M.
Polak
and
Anastasios
Mantalaris
1.
The Clinical Need
170
2.
Lung Architecture
170
3.
Cell Expansion and Sources
173
4.
Stem Cell
Bioprocessing
for Lung Cellular Therapies
178
viii Contents
5.
Integrated
3D
Bioprocessing
for Lung Cell
Production
185
6.
Conclusions and Future Prospects
187
Acknowledgements
187
References
188
7.
Lung Repair and Regeneration
—
Animal Models
199
Hiroshi
Kubo
1.
Lung Regeneration
200
2.
Repair Process after Acute Lung Injury
214
3.
Conclusion and the Way Forward
219
References
219
8.
Fibrocytes (Reactive or Reparative)
237
Alberto Bellini and
Sabrina Mattoli
1.
Introduction
238
2.
Mechanisms of Fibrocyte Development
238
and Differentiation
3.
Functional Consequences of Fibrocyte Accumulation
243
4.
Involvement of Fibrocytes in Lung Diseases
245
5.
Conclusions and Implications for Therapy
250
References
252
9.
Three-Dimensional Pulmonary Constructs
261
Christine M. Finck, Blair Roszell and Peter I.
Lelkes
1.
Introduction
262
2.
Culture of Distal Lung Cells In Vitro
263
3.
Two-Dimensional Models
263
4.
Three-Dimensional Growth
265
5.
Growth Factor Supplementation and Culture Media
269
Composition
6.
Importance of Endothelial-Epithelial Interactions
275
in Heterogeneous Co-Culture
7.
Conclusions and Future Challenges
279
References
280
Contents ix
10.
Stem Cells as Vehicles for Gene Therapy in Lung Repair
287
Shirley H. J.
Mei
and Duncan J. Stewart
1.
Introduction
288
2.
Types of Stem/Progenitor Cells Used as Vehicles
290
for Gene Therapy for Lung Diseases
3.
Pulmonary Diseases Targeted by Stem/Progenitor
293
Cells-Based Gene Therapy
4.
Conclusion and the Way Forward
301
References
302
11.
Repair of the Lung Epithelium in Cystic Fibrosis
313
Viranuj Sueblinvong and Daniel J. Weiss
1.
Introduction and Pathophysiology of Cystic Fibrosis
314
2.
Gene Therapy Approaches for Cystic Fibrosis
315
3.
Endogenous Lung Progenitor Cells in Cystic Fibrosis
316
4.
Cell-Based Therapies for CF Lung Disease
321
5.
Conclusion and the Way Forward
326
References
326
12.
Pulmonary Hypertension and Stem Cell Therapy
337
Manoj M. Lalu, Rohit Moudgil and Duncan J. Stewart
1.
Introduction
338
2.
Pulmonary Arterial Hypertension
—
A Brief Overview
338
3.
Pulmonary Arterial Hypertension
—
Evolution
342
of Treatments
4.
Pulmonary Arterial Hypertension
—
Endothelial
345
Progenitor Cell Therapy
5.
Preclinical Studies of Cellular Therapy for PAH
349
6.
Clinical Applications of Cell Therapy for PAH
351
7.
Conclusions and Future Directions
355
References
355
χ
Contents
13.
Molecular
Induction
of Alveolar
Regeneration 367
Matthew
Hind
and
Siân Stinchcombe
1.
Introduction
368
2.
Lung Development
368
3.
Retinoic Acid (RA) has a Master Role in Patterning the
369
Developing Lung
4.
RA has a Role in Alveolar Development
370
5.
The Adult Lung Structure Maintenance Programme
372
6.
RA in the Adult Structure Maintenance Programme
373
7.
Evidence of Molecular Plasticity: Endogenous
374
Programmed Alveolar Regression and Regeneration
8.
Calorie Restriction
375
9.
Oestrogen
376
10.
Experimental Evidence of Alveolar Regeneration
378
11.
Cell Biology of Regeneration
383
12.
Bone Marrow-Derived Stem Cell Engraftment
384
13.
Intrinsic Alveolar Cell Response
387
14.
Alveolar Regeneration by Adrenomedullin
389
15.
Conclusion and the Way Forward
391
References
391
14.
Assessment of Cell Engraftment
405
Robert Zweigerdt and William Rust
1.
Introduction
406
2.
Visual Detection of Engrafted Cells
—
Mechanisms
407
Underlying Misleading Results
3.
In Vivo Monitoring of Cell Engraftment and Assessment
413
of Functional Improvement
4.
Conclusion and the Way Forward
417
References
417
15.
In Vivo Imaging for Cell Therapy
421
Richard Newton and Guang-Zhong Yang
1.
Introduction
422
2.
Imaging for Cell Repair
422
Contents xi
3. Biophotonics in Vivo 429
4.
Photogenic Small Animal
Models
and Cell Delivery
438
5.
Conclusion and the Way Forward
440
References
442
16.
Haematopoietic Transplantation and Pulmonary
453
Chimerism
Benjamin T. Suratt
1.
Introduction
454
2.
A Brief Review of HSCT Concepts and Techniques
454
3.
Techniques for the Detection of Pulmonary Chimerism
456
Following HSCT
4.
Evidence for Pulmonary Chimerism Following HSCT
462
5.
Possible Origins of Pulmonary Chimerism
465
6.
Conclusions and Future Perspectives
467
References
468
17.
Stem Cells and Lung Cancer
473
Arielle C.
Lebrenne,
Shahriar Islam and Malcolm R. Alison
I.
Stem Cells and the Origins of Lung Tumours
474
2.
Histogenesis and Molecular Pathogenesis
477
of Lung Tumours
3.
Cancer Stem Cells
483
4.
Conclusion and the Way Forward
490
References
491
Index
501
The use of stem cells to help with lung regeneration and repair is a
novel therapy which could help phase out the need for conventional
surgical or pharmacological approaches currently employed to
treat diseases of the lung or other organs. The present book explores
all avenues of this new form of medical care, moving swiftly, but in
depth,from the basic science of lung development, to the analyses
of different stem cell types available for regeneration and on to the
application of this knowledge base in initial clinical trials.
In this volume a stellar group of researchers converge, from different
angles, to help towards clarifying the basic mechanisms of lung
repair,These range from basic concepts of regeneration and lung
development, the analyses of a variety of cell types that may be
involved in lung repair, stem cell
bioprocessing,
to ways of creating
complex lung structures, including artificial and bioartificial lungs.
The book offers an insight into repair mechanisms of the diseased
lung, the role of specific lung niches and provides information on
initial clinical trials as well as the use of stem cells as vehicles for
gene therapy. Ingenious technological aspects of assessing stem
cell engraftment of stem cells are also included in this volume.
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| spelling | Cell therapy for lung disease ed.: Julia Polak London Imperial College Press 2010 XXIV, 504 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf Frischzellentherapie (DE-588)4067560-9 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 s Frischzellentherapie (DE-588)4067560-9 s DE-604 Polak, Julia M. 1939-2014 Sonstige (DE-588)121103536 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020554890&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020554890&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| subject_GND | (DE-588)4036660-1 (DE-588)4067560-9 |
| title | Cell therapy for lung disease |
| title_auth | Cell therapy for lung disease |
| title_exact_search | Cell therapy for lung disease |
| title_full | Cell therapy for lung disease ed.: Julia Polak |
| title_fullStr | Cell therapy for lung disease ed.: Julia Polak |
| title_full_unstemmed | Cell therapy for lung disease ed.: Julia Polak |
| title_short | Cell therapy for lung disease |
| title_sort | cell therapy for lung disease |
| topic | Lungenkrankheit (DE-588)4036660-1 gnd Frischzellentherapie (DE-588)4067560-9 gnd |
| topic_facet | Lungenkrankheit Frischzellentherapie |
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