Organic synthesis: the disconnection approach
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2010
|
| Ausgabe: | 2. ed., reprint. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Hier auch später erschienene, unveränderte Nachdrucke Includes bibliographical references and index |
| Beschreibung: | VIII, 329 S. Ill. |
| ISBN: | 9780470712375 9780470712368 |
Internformat
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| 245 | 1 | 0 | |a Organic synthesis |b the disconnection approach |c Stuart Warren and Paul Wyatt |
| 250 | |a 2. ed., reprint. | ||
| 264 | 1 | |a Chichester |b Wiley |c 2010 | |
| 300 | |a VIII, 329 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Hier auch später erschienene, unveränderte Nachdrucke | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Organic compounds |x Synthesis | |
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Datensatz im Suchindex
| _version_ | 1804143078110396416 |
|---|---|
| adam_text | Contents
Preface ¡x
General
References
xi
1.
The Disconnection Approach
1
2.
Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds
7
3.
Strategy I: The Order of Events
17
4.
One-Group
C
-Х
Disconnections
23
5.
Strategy II: Chemoselectivity
29
6.
Two-Group
C
-Х
Disconnections
35
7.
Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy
45
8.
Amine
Synthesis
53
9.
Strategy IV: Protecting Groups
61
10.
One Group
C
-С
Disconnections I: Alcohols
69
11.
General Strategy A: Choosing a Disconnection
77
12.
Strategy V: Stereoselectivity A
83
13.
One Group
C
-С
Disconnections
Π:
Carbonyl Compounds
93
14.
Strategy VI: Regioselectivity
101
15.
Alkene Synthesis
107
16.
Strategy
VII: Use
of Acetylenes (Alkynes)
115
17.
Two-Group
C
-С
Disconnections I: Diels-Alder Reactions
121
18.
Strategy
VIII:
Introduction to Carbonyl Condensations
129
19.
Two-Group
C
-С
Disconnections
Π:
l^-Difunctionalised Compounds
133
20.
Strategy IX: Control in Carbonyl Condensations
139
21.
Two-Group
C
-С
Disconnections
ΙΠ:
l^-Difunctionalised Compounds
Conjugate (Michael) Addition and Robinson Annelation
151
22.
Strategy X: Aliphatic
Nitro
Compounds in Synthesis
161
23.
Two-Group Disconnections IV: l^-Difunctionalised Compounds
167
24.
Strategy XI: Radical Reactions in Synthesis
177
25.
Two-Group Disconnections V: l^-Difunctionalised Compounds
185
26.
Strategy
ΧΠ:
Reconnection
193
27.
Two-Group
C
-С
Disconnections VI: 1,6-diCarbonyl Compounds
199
28.
General Strategy B: Strategy of Carbonyl Disconnections
207
29.
Strategy
ΧΙΠ:
Introduction to Ring Synthesis: Saturated Heterocycles
217
30.
Three-Membered Rings
229
31.
Strategy
XIV:
Rearrangements in Synthesis
237
32.
Four-Membered Rings: Photochemistry in Synthesis
245
viii Contents
33.
Strategy XV: The Use of Ketenes in Synthesis
251
34.
Five-Membered Rings
255
35.
Strategy
XVI:
Pericyclic Reactions in Synthesis: Special Methods
for Five-Membered Rings
261
36.
Six-Membered Rings
269
37.
General Strategy C: Strategy of Ring Synthesis
279
38.
Strategy
XVII:
Stereoselectivity
В
289
39.
Aromatic Heterocycles
301
40.
General Strategy D: Advanced Strategy
313
Index
325
ORGANIC
SYNTHESIS
The Disconnection Approach
Second Edition
Stuart Warren
Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.
Paul Wyatt
Reader and Director of Undergraduate Studies,
School of Chemistry, University of Bristol, UK
One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will
start with the structure of their target molecule and progressively cut bonds to create simpler
molecules. Reversing this process gives a synthetic route to the target molecule from simpler
starting materials. This disconnection approach to synthesis is now a fundamental part of every
organic synthesis course.
Organic Synthesis: The Disconnedion Approach,
2nd
Edition introduces this important technique,
to help students to design their own organic syntheses. There are forty chapters: those on the
synthesis of given types of molecules alternate with strategy chapters in which the methods just
learnt are placed in a wider context. The synthesis chapters cover many ways of making each type
of molecule starting with simple aromatic and aliphatic compounds with one functional group
and progressing to molecules with many functional groups. The strategy chapters cover questions
of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents
specifically designed for difficult problems.
Examples are drawn from Pharmaceuticals, agrochemicals, natural products, pheromones,
perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more
advanced synthetic work. Reasons for wishing to synthesise each compound are given.
This second edition has been fully revised and updated with a modern look. Recent examples and
techniques are included and illustrated additional material has been added to take the student to
the level required by the sequel. Organic Synthesis: Strategyand Control. Several chapters contain
extensive new material based on courses that the authors give to chemists in the pharmaceutical
industry.
Organic Synthesis: The Disconnection Approach,
2nd
Edition provides a full course in retrosynthetic
analysis for chemistry and biochemistry students and a refresher for organic chemists working in
industry and
academia.
|
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| id | DE-604.BV036510337 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:41:56Z |
| institution | BVB |
| isbn | 9780470712375 9780470712368 |
| language | English |
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| physical | VIII, 329 S. Ill. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley |
| record_format | marc |
| spelling | Warren, Stuart G. 1938-2020 Verfasser (DE-588)136065775 aut Organic synthesis the disconnection approach Stuart Warren and Paul Wyatt 2. ed., reprint. Chichester Wiley 2010 VIII, 329 S. Ill. txt rdacontent n rdamedia nc rdacarrier Hier auch später erschienene, unveränderte Nachdrucke Includes bibliographical references and index Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd rswk-swf Organische Synthese (DE-588)4075695-6 s DE-604 Wyatt, Paul Verfasser aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020432555&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020432555&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Warren, Stuart G. 1938-2020 Wyatt, Paul Organic synthesis the disconnection approach Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd |
| subject_GND | (DE-588)4075695-6 |
| title | Organic synthesis the disconnection approach |
| title_auth | Organic synthesis the disconnection approach |
| title_exact_search | Organic synthesis the disconnection approach |
| title_full | Organic synthesis the disconnection approach Stuart Warren and Paul Wyatt |
| title_fullStr | Organic synthesis the disconnection approach Stuart Warren and Paul Wyatt |
| title_full_unstemmed | Organic synthesis the disconnection approach Stuart Warren and Paul Wyatt |
| title_short | Organic synthesis |
| title_sort | organic synthesis the disconnection approach |
| title_sub | the disconnection approach |
| topic | Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd |
| topic_facet | Organic compounds Synthesis Organische Synthese |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020432555&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020432555&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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