The biochemistry of drug metabolism: [1] Principles, redox reactions, hydrolyses
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Zürich
Helvetica Chimica Acta [u.a.]
2008
Weinheim Wiley-VCH 2008 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIII, 319 S. Ill., graph. Darst. |
| ISBN: | 3906390535 9783906390536 |
Internformat
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Datensatz im Suchindex
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| adam_text |
CONTENTS PART 1 PRINCIPLES AND OVERVIEW 1 1.1. DRUGS AND XENOBIOTICS 4
1.1.1. PHYSIOLOGICAL METABOLISM 4 1.1.2. WHAT ABOUT XENOBIOTICS? 6 1.2.
WHAT ARE DRUG DISPOSITION AND METABOLISM? 9 1.2.1. HOW DO DRUGS INTERACT
WITH BIOLOGICAL SYSTEMS? 9 1.2.2. THE MAIN PHASES OF DRUG DISPOSITION
AND ACTION 10 1.2.3. PROCESSES OF DRUG DISPOSITION AND METABOLISM 12
1.3. WHERE DOES DRUG METABOLISM OCCUR? 18 1.3.1. A COMPARISON OF SIZES
18 1.3.2. THE METABOLISM OF DRUGS AND OTHER XENOBIOTICS IN THE BODY 19
1.3.3. MICROSCOPIC LOCATION OF DRUG METABOLISM 21 1.4. CONSEQUENCES OF
DRUG METABOLISM - AN OVERVIEW 24 1.4.1. CONSEQUENCES OF DRUG METABOLISM
FOR ACTIVITY 25 1.4.2. PHARMACOKINETIC ASPECTS OF DRUG METABOLISM 28
1.4.3. CLINICAL CONSEQUENCES OF DRUG METABOLISM 31 1.5. DRUG METABOLISM
AND DRUG RESEARCH 33 1.5.1. MAJOR PHASES IN DRUG DISCOVERY AND
DEVELOPMENT 33 1.5.2. METABOLISM IN DRUG RESEARCH 36 1.5.3. IN VITRO AND
IN SILICO TOOLS TO STUDY DRUG METABOLISM IN DRUG DISCOVERY AND EARLY
DEVELOPMENT 39 PART 2 REDOX REACTIONS AND THEIR ENZYMES 51 2.1. THE
BIOCHEMISTRY OF CYTOCHROMES P450 (CYPS) AND FLAVIN MONO- OXYGENASES
(FMOS) 55 2.1.1. THE STRUCTURE OF CYPS 55 2.1.2. THE MULTIPLICITY OF
CYPS 61 2.1.3. THE CATALYTIC MECHANISM OF CYPS 70 2.1.4.
FLAVIN-CONTAINING MONOOXYGENASES (FMOS) 74 2.2 BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/986187496 DIGITALISIERT DURCH XII
CONTENTS 2.3. CYP-CATALYZED SP 2 -C- AND SP-C-OXIDATIONS 92 2.3.1. THE
OXYGENATION OF ALDEHYDES TO CARBOXYLIC ACIDS 92 2.3.2. THE OXYGENATION
OF OLEFINIC BONDS 94 2.3.3. THE OXYGENATION OF AROMATIC RINGS 97 2.3.4.
REACTIONS OF SP-C-OXIDATION 107 2.4. OXIDATIONS OF N- AND S-ATOMS
CATALYZED BY CYPS AND/OR FMOS 109 2.4.1. AF-OXYGENATION OF BASIC OR
WEAKLY BASIC TERTIARY AMINES 110 2.4.2. N-OXIDATION OF SECONDARY AND
PRIMARY AMINES 113 2.4.3. TV-OXYGENATION OF AROMATIC AMIDES 117 2.4.4.
S-OXIDATIONS CATALYZED BY CYPS OR FMOS 119 2.5. OTHER REACTIONS
CATALYZED BY CYPS 127 2.5.1. OXIDATION OF O-ATOMS IN PHENOLS 127 2.5.2.
PEROXIDASE REACTIONS CATALYZED BY CYPS 130 2.5.3. REACTIONS OF REDUCTIVE
DEHALOGENATION CATALYZED BY CYPS 132 2.5.4. OTHER REDUCTIONS CATALYZED
BY CYPS AND/OR NADPH-CYP REDUCIASE 135 2.6. OTHER OXIDOREDUCTASES AND
THEIR REACTIONS 139 2.6.1. MONOAMINE OXIDASE AND OTHER AMINE OXIDASES
140 2.6.2. ALDEHYDE OXIDASE AND XANTHINE OXIDOREDUCTASE 147 2.6.3.
PEROXIDASES AND PROSTAGLANDIN G/H SYNTHASE 155 2.6.4.
DEHYDROGENASES/REDUCTASES 163 PART 3 REACTIONS OF HYDROLYSIS AND THEIR
ENZYMES 201 3.1. A SURVEY OF HYDROLASES 204 3.1.1. A SELECTION OF
HYDROLASES (EC 3) WITH KNOWN OR POTENTIAL ACTIVITY TOWARD XENOBIOTIC
SUBSTRATES 204 3.1.2. ESTERASES (EC 3.1) 207 3.1.3. GLYCOSYLASES (EC
3.2) 209 3.1.4. THE CLASSIFICATION OF PEPTIDASES (EC 3.4) 210 3.1.5
CONTENTS XIII 3.6.1. SULFATES, SULFAMATES, AND NITRATES 251 3.6.2.
PHOSPHATES AND ANALOGUES 253 3.7. THE HYDRATION OF EPOXIDES 258 3.7.1.
EPOXIDE HYDROLASES 258 3.7.2. ALKENE OXIDES 263 3.7.3. ARENE OXIDES 266
3.8. MISCELLANEOUS REACTIONS 268 3.8.1. THE HYDROLYSIS OF CARBOHYDRATE
CONJUGATES 268 3.8.2. THE HYDROLYSIS OF IMINES AND OXIMES 271 3.8.3. THE
HYDROLYSIS OF MANNICH BASES 273 3.8.4. HYDROLYTIC DEHALOGENATIONS 275
3.8.5. HYDRATION OF CISPLATIN AND ANALOGUES 277 INDEX 293 |
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| indexdate | 2024-07-20T10:39:05Z |
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| isbn | 3906390535 9783906390536 |
| language | English |
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| physical | XIII, 319 S. Ill., graph. Darst. |
| publishDate | 2008 |
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| spelling | Testa, Bernard Verfasser aut The biochemistry of drug metabolism [1] Principles, redox reactions, hydrolyses Bernard Testa ; Stefanie D. Krämer Zürich Helvetica Chimica Acta [u.a.] 2008 Weinheim Wiley-VCH 2008 XIII, 319 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Krämer, Stefanie D. Verfasser aut (DE-604)BV036498020 1 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020420508&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Testa, Bernard Krämer, Stefanie D. The biochemistry of drug metabolism |
| title | The biochemistry of drug metabolism |
| title_auth | The biochemistry of drug metabolism |
| title_exact_search | The biochemistry of drug metabolism |
| title_full | The biochemistry of drug metabolism [1] Principles, redox reactions, hydrolyses Bernard Testa ; Stefanie D. Krämer |
| title_fullStr | The biochemistry of drug metabolism [1] Principles, redox reactions, hydrolyses Bernard Testa ; Stefanie D. Krämer |
| title_full_unstemmed | The biochemistry of drug metabolism [1] Principles, redox reactions, hydrolyses Bernard Testa ; Stefanie D. Krämer |
| title_short | The biochemistry of drug metabolism |
| title_sort | the biochemistry of drug metabolism principles redox reactions hydrolyses |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020420508&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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