Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Hohenwarsleben
Westarp-Wiss.
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 98 S. graph. Darst. 24 cm |
| ISBN: | 9783894321161 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV036468055 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 100525s2009 gw d||| m||| 00||| eng d | ||
| 015 | |a 09,N44,0669 |2 dnb | ||
| 015 | |a 10,A12 |2 dnb | ||
| 016 | 7 | |a 997399007 |2 DE-101 | |
| 020 | |a 9783894321161 |c kart. : EUR 19.95, sfr 35.00 (freier Pr.) |9 978-3-89432-116-1 | ||
| 024 | 3 | |a 9783894321161 | |
| 035 | |a (OCoLC)552476525 | ||
| 035 | |a (DE-599)BVBBV036468055 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-ST | ||
| 049 | |a DE-12 |a DE-188 | ||
| 082 | 0 | |a 616.07970724 |2 22/ger | |
| 082 | 1 | |a 616.07970724 |2 22//ger | |
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Lischke, Timo |d 1978- |e Verfasser |0 (DE-588)140320458 |4 aut | |
| 245 | 1 | 0 | |a Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo |c Timo Lischke |
| 264 | 1 | |a Hohenwarsleben |b Westarp-Wiss. |c 2009 | |
| 300 | |a 98 S. |b graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Zugl.: Potsdam, Univ., Diss., 2009 | ||
| 650 | 0 | 7 | |a T-Lymphozyt |0 (DE-588)4127387-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immuntoleranz |0 (DE-588)4161391-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Ovalbumin |0 (DE-588)4172997-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Tiermodell |0 (DE-588)4140660-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antigen CD4 |0 (DE-588)4385640-8 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Immuntoleranz |0 (DE-588)4161391-0 |D s |
| 689 | 0 | 1 | |a T-Lymphozyt |0 (DE-588)4127387-4 |D s |
| 689 | 0 | 2 | |a Antigen CD4 |0 (DE-588)4385640-8 |D s |
| 689 | 0 | 3 | |a Ovalbumin |0 (DE-588)4172997-3 |D s |
| 689 | 0 | 4 | |a Tiermodell |0 (DE-588)4140660-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020339795&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-020339795 | ||
Datensatz im Suchindex
| _version_ | 1804142962694684672 |
|---|---|
| adam_text | TABLE OF CONTENTS TABLE OF CONTENTS TABLE OF CONTENTS I LIST OF FIGURES
AND TABLES III LIST OF ABBREVIATIONS V 1 INTRODUCTION 1 1.1 TOLERANCE
AND IMMUNITY 1 1.2 THE THREE SIGNALS HYPOTHESIS AND COSTIMUUTION 2 U
MECHANISMSOFCD4 + T CELL TOLERANCE 4 1.4 CHARACTERISTICS OF CD4* T CCLL
TOLERANCE IN VIVO 6 1.5 TRACKING OF ANTIGEN-SPECIFIC CD4* T CELLS IN
VIVO 7 1.6 ADOPTIVE TRANSFER MODELS 8 1.7 OBJECTIVE 10 2 MATERIALS AND
METHODS 11 2.1 MICE 11 2.2 ANIMAL EXPERIMENTAL METHODS 11 2.2.1 ADOPTIVE
TRANSFER II 2.2.2 IMMUNIZATIONS 11 2.2.3 AIRWAY CHALLENGE 12 2.2.4 BLOOD
COLLECTION 12 2.3 CELL BIOLOGICAL METHODS 12 2.3.1 CELL JSOLATIONS 12
2.3.2 RESTIMULATION IN VITRO 13 2.3.3 MAGNETIC-ACTIVATED CELL SORTING 13
2.3.4 FIOW CYTOMETRY 13 2.3.5 FLUORESCENCEACTIVATED CELL SORTING 18 2.4
MOLECULAR BIOLOGICAL METHODS 18 2.4.1 RNA ISOLATION AND INTEGRITY
MEASUREMENT 18 2.4.2 MICROARRAYANALYSIS 18 2.4.3 TAQMAN* LOW DENSITY
ARRAYS 19 2.5 IMMUNOLOGICAL METHODS 20 2.5.1 SERUM PREPARATION 20 2.5.
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/997399007 DIGITALISIERT
DURCH TABLE OF CONTENTS 3 RESULTS 23 3.1 ESTABLISHMENT OFTHEDOL 1.10
ADOPTIVE TRANSFER MODEL 23 3.1.1 MACSOFDOLL.LOSPLENOCYTES 23 3.1.2
/NV/VOSTABILITYOFKJL-26 + CD4 + T CELLS 28 3.2 TITRATION OF ANTIGEN,
ADJUVANT AND TRANSFERRED T CELLS 29 3.3 KINETICS OF T CELL FREQUENCY AND
NUMBER 33 3.4 DIFFERENTIAL EXPRESSION OF ACTIVATION-DEPENDENT MOLECULES
35 3.5 ESTABLISHMENT OFA SORTING STRATEGY 39 3.6 MICROARRAYANALYSISOFCD4
+ T CELL GENE EXPRESSION 41 3.7 TAQMAN ANALYSIS OF CD4 + T CELL GENE
EXPRESSION 49 3.8 DECREASED PROLIFERATION IN CD4 + T CELL TOLERANCE 55
3.9 FAILNRE TO PRODUCE EFFECTOR CYTOKINES IN CD4 + TC TOLERANCE 58 3.10
LACK OFGERMINAL CENTER FORMATION IN TOLERANCE 61 3.11 ANTIGEN-SPECIFIC
IG PRODUCTION IS A FEATURE OF IMMUNITY 63 3.12 DEVELOPMENT OF T FH IS A
CRITERION FOR CD4* TC IMMUNITY 64 3.13 AG-SPECIFIC T EFF ARE PRESENT IN
TOLERANCE AND IMMUNITY 65 3.14 T REG DOMINATE THE AG-SPECIFIC TC
POPULATION IN TOLERANCE 66 3.15 TOLERIZED AG-SPECIFIC CD4 + T CELLS
POSSESS A REDUCED CAPACITY TO INFILTRATE THE LUNG UPON AIRWAY CHALLENGE
68 3.16 ICOS CONTROLS AG-SPECIFIC CD4 + T CEU DIFFERENTIATION 70 4
|
| any_adam_object | 1 |
| author | Lischke, Timo 1978- |
| author_GND | (DE-588)140320458 |
| author_facet | Lischke, Timo 1978- |
| author_role | aut |
| author_sort | Lischke, Timo 1978- |
| author_variant | t l tl |
| building | Verbundindex |
| bvnumber | BV036468055 |
| ctrlnum | (OCoLC)552476525 (DE-599)BVBBV036468055 |
| dewey-full | 616.07970724 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07970724 |
| dewey-search | 616.07970724 |
| dewey-sort | 3616.07970724 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02049nam a2200517 c 4500</leader><controlfield tag="001">BV036468055</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">100525s2009 gw d||| m||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">09,N44,0669</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">10,A12</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">997399007</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783894321161</subfield><subfield code="c">kart. : EUR 19.95, sfr 35.00 (freier Pr.)</subfield><subfield code="9">978-3-89432-116-1</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783894321161</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)552476525</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV036468055</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-ST</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.07970724</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="082" ind1="1" ind2=" "><subfield code="a">616.07970724</subfield><subfield code="2">22//ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lischke, Timo</subfield><subfield code="d">1978-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)140320458</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo</subfield><subfield code="c">Timo Lischke</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Hohenwarsleben</subfield><subfield code="b">Westarp-Wiss.</subfield><subfield code="c">2009</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">98 S.</subfield><subfield code="b">graph. Darst.</subfield><subfield code="c">24 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Zugl.: Potsdam, Univ., Diss., 2009</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">T-Lymphozyt</subfield><subfield code="0">(DE-588)4127387-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immuntoleranz</subfield><subfield code="0">(DE-588)4161391-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Ovalbumin</subfield><subfield code="0">(DE-588)4172997-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Tiermodell</subfield><subfield code="0">(DE-588)4140660-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Antigen CD4</subfield><subfield code="0">(DE-588)4385640-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immuntoleranz</subfield><subfield code="0">(DE-588)4161391-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">T-Lymphozyt</subfield><subfield code="0">(DE-588)4127387-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Antigen CD4</subfield><subfield code="0">(DE-588)4385640-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Ovalbumin</subfield><subfield code="0">(DE-588)4172997-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="4"><subfield code="a">Tiermodell</subfield><subfield code="0">(DE-588)4140660-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020339795&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-020339795</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV036468055 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:40:06Z |
| institution | BVB |
| isbn | 9783894321161 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020339795 |
| oclc_num | 552476525 |
| open_access_boolean | |
| owner | DE-12 DE-188 |
| owner_facet | DE-12 DE-188 |
| physical | 98 S. graph. Darst. 24 cm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Westarp-Wiss. |
| record_format | marc |
| spelling | Lischke, Timo 1978- Verfasser (DE-588)140320458 aut Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo Timo Lischke Hohenwarsleben Westarp-Wiss. 2009 98 S. graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Zugl.: Potsdam, Univ., Diss., 2009 T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf Immuntoleranz (DE-588)4161391-0 gnd rswk-swf Ovalbumin (DE-588)4172997-3 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Antigen CD4 (DE-588)4385640-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Immuntoleranz (DE-588)4161391-0 s T-Lymphozyt (DE-588)4127387-4 s Antigen CD4 (DE-588)4385640-8 s Ovalbumin (DE-588)4172997-3 s Tiermodell (DE-588)4140660-6 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020339795&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lischke, Timo 1978- Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo T-Lymphozyt (DE-588)4127387-4 gnd Immuntoleranz (DE-588)4161391-0 gnd Ovalbumin (DE-588)4172997-3 gnd Tiermodell (DE-588)4140660-6 gnd Antigen CD4 (DE-588)4385640-8 gnd |
| subject_GND | (DE-588)4127387-4 (DE-588)4161391-0 (DE-588)4172997-3 (DE-588)4140660-6 (DE-588)4385640-8 (DE-588)4113937-9 |
| title | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo |
| title_auth | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo |
| title_exact_search | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo |
| title_full | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo Timo Lischke |
| title_fullStr | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo Timo Lischke |
| title_full_unstemmed | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo Timo Lischke |
| title_short | Functional correlates of CD4+ T-cell tolerance and immunity to soluble protein antigen in vivo |
| title_sort | functional correlates of cd4 t cell tolerance and immunity to soluble protein antigen in vivo |
| topic | T-Lymphozyt (DE-588)4127387-4 gnd Immuntoleranz (DE-588)4161391-0 gnd Ovalbumin (DE-588)4172997-3 gnd Tiermodell (DE-588)4140660-6 gnd Antigen CD4 (DE-588)4385640-8 gnd |
| topic_facet | T-Lymphozyt Immuntoleranz Ovalbumin Tiermodell Antigen CD4 Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020339795&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lischketimo functionalcorrelatesofcd4tcelltoleranceandimmunitytosolubleproteinantigeninvivo |