Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-112133 Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Mechanismen des β-Zell-Verlustes bei männlichen Munich Ins2C95S Mausmutanten |
| Beschreibung: | 206 S. Ill., graph. Darst. 21 cm |
Internformat
MARC
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| 015 | |a 10,H04 |2 dnb | ||
| 016 | 7 | |a 1001018427 |2 DE-101 | |
| 035 | |a (OCoLC)644274521 | ||
| 035 | |a (DE-599)DNB1001018427 | ||
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| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 |a DE-188 | ||
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| 082 | 0 | |a 616.4 |2 22/ger | |
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Kautz, Sabine Martha |d 1982- |e Verfasser |0 (DE-588)140824537 |4 aut | |
| 245 | 1 | 0 | |a Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice |c by Sabine Martha Kautz |
| 264 | 1 | |c 2010 | |
| 300 | |a 206 S. |b Ill., graph. Darst. |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Nebentitel: Mechanismen des β-Zell-Verlustes bei männlichen Munich Ins2C95S Mausmutanten | ||
| 502 | |a München, Univ., Diss., 2010 (Nicht für den Austausch) | ||
| 650 | 7 | |a mice |2 cabt | |
| 650 | 7 | |a laboratory animals |2 cabt | |
| 650 | 7 | |a genes |2 cabt | |
| 650 | 7 | |a biotechnology |2 cabt | |
| 650 | 7 | |a nucleotide sequences |2 cabt | |
| 650 | 7 | |a immune response |2 cabt | |
| 650 | 7 | |a mutations |2 cabt | |
| 650 | 7 | |a mutants |2 cabt | |
| 650 | 7 | |a disease models |2 cabt | |
| 650 | 7 | |a diabetes mellitus |2 cabt | |
| 650 | 7 | |a diabetes |2 cabt | |
| 650 | 7 | |a insulin |2 cabt | |
| 650 | 7 | |a blood sugar |2 cabt | |
| 650 | 7 | |a metabolic disorders |2 cabt | |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:19-112133 |
| 856 | 4 | 1 | |u http://edoc.ub.uni-muenchen.de/11213/ |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | |u https://nbn-resolving.org/urn:nbn:de:bvb:19-112133 |x Resolving-System | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020299422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-020299422 | |
Datensatz im Suchindex
| _version_ | 1810361636500799488 |
|---|---|
| adam_text |
TABLE
OF
CONTENT
1
INTRODUCTION
1
2
LITERATURE
REVIEW
3
2.1
DIABETES
MELLITUS
3
2.1.1
PREVALENCE
3
2.1.2
COSTS
3
2.1.3
DEFINITION,
DESCRIPTION,
CLASSIFICATION
AND
DIAGNOSIS
OF
DIABETES
MELLITUS
4
2.1.3.1
DEFINITION
AND
DESCRIPTION
4
2.1.3.2
CLASSIFICATION
5
2.1.3.3
DIAGNOSIS
7
2.2
TYPES
OF
DIABETES
MELLITUS
8
2.2.1
DIABETES
TYPE
1
8
2.2.2
DIABETES
TYPE
2
9
2.2.3
MONOGENIC
FORMS
OF
DIABETES
MELLITUS
10
2.2.3.1
MATURITY-ONSET
DIABETES
OF
THE
YOUNG
(MODY)
10
2.2.3.2
NEONATAL
DIABETES
MELLITUS
(NDM)
11
2.2.3.3
MUTATIONS
IN
THE
INSULIN
GENE
11
2.3
ANIMAL
MODELS
OF
DIABETES
MELLITUS
14
2.3.1
ENU
MOUSE
MUTAGENESIS
PROJECTS
15
2.3.1.1
ENU
MUTAGENESIS
15
2.3.1.2
MUNICH
ENU
MOUSE
MUTAGENESIS
PROJECT
15
2.3.1.3
PHENOTYPE
SCREEN
FOR
HYPERGLYCAEMIC
MOUSE
LINES
16
2.3.2
THE
MUNICH
INS2C95S
MUTANT
MOUSE
17
2.3.2.1
HETEROZYGOUS
MUTANT
MICE
17
2.3.2.2
HOMOZYGOUS
MUTANT
MICE
20
2.3.3
THE
AKITA
MOUSE
20
2.3.3.1
HETEROZYGOUS
MUTANT
MICE
20
2.3.3.2
HOMOZYGOUS
MUTANT
MICE
23
2.3.3.3
ER
STRESS
IN
THE
AKITA
MOUSE
23
2.3.4
INS1
AND
INS2
NULL
MUTANT
MICE
25
2.3.4.1
DOUBLE
HOMOZYGOUS
NULL
MUTANT
MICE
25
2.3.4.2
SINGLE
HOMOZYGOUS
NULL
MUTANT
MICE
26
2.4
ENDOPLASMIC
RETICULUM
STRESS
(ER
STRESS)
28
2.4.1
THE
ENDOPLASMIC
RETICULUM
28
2.4.2
ER
STRESS
AND
THE
UNFOLDED
PROTEIN
RESPONSE
(UPR)
29
2.4.2.1
SIGNAL
TRANSDUCTION
30
2.4.2.2
APOPTOTIC
PATHWAYS
34
2.4.3
DIABETES
MELLITUS
AND
ER
STRESS
36
2.4.3.1
PATHOPHYSIOLOGICAL
INDUCTION
OF
ER
STRESS
36
2.4.3.2
GENE
ALTERATIONS
IN
ANIMAL
MODELS
AND
MEN
37
2.4.3.3
THERAPEUTIC
STRATEGIES
FOR
REDUCING
ER
STRESS
39
2.5
GLUCOTOXICITY
AND
OXIDATIVE
STRESS
39
2.5.1
FREE
RADICALS
AND
OXIDATIVE
STRESS
40
2.5.2
ADVERSE
EFFECTS
OF
HYPERGLYCAEMIA-INDUCED
OXIDATIVE
STRESS
41
2.5.3
INSULIN
RESISTANCE,
3-CELL
DYSFUNCTION
AND
3-CELL
APOPTOSIS
43
2.5.3.1
INSULIN
RESISTANCE
43
2.5.3.2
3-CELL
DYSFUNCTION
45
2.5.3.3
3-CELL
APOPTOSIS
47
2.5.4
ANTIOXIDANTS
49
2.5.4.1
ANTIOXIDATIVE
DEFENCE
49
2.5.4.2
MEASUREMENT
OF
OXIDATIVE
STRESS
50
2.5.4.3
ANTIOXIDATIVE
TREATMENT
52
2.6
LINKAGE
BETWEEN
OXIDATIVE
AND
ER
STRESS
53
2.6.1
OXIDATIVE
PROTEIN
FOLDING
53
2.6.2
ER
STRESS
INDUCES
OXIDATIVE
STRESS
AND
VICE
VERSA
54
3
RESEARCH
DESIGN
AND
METHODS
56
3.1
TREATED
MALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
56
3.1.1
ANIMALS
56
3.1.2
GENOTYPING
58
3.1.3
TREATMENT
WITH
INSULIN
AND
PLACEBO-PELLETS
62
3.1.4
BODY
WEIGHT
63
3.1.5
BLOOD
GLUCOSE
CONCENTRATION
63
3.1.6
ORAL
GLUCOSE
TOLERANCE
TEST
(OGTT)
64
3.1.7
INSULIN
TOLERANCE
TEST
AND
PLACEBO-INSULIN
TOLERANCE
TEST
64
3.1.7.1
INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(IPITT)
64
3.1.7.2
PLACEBO-INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(PLACEBO-IPITT)
65
3.1.8
C-PEPTIDE
CONCENTRATION
IN
SERUM
AND
PANCREAS
65
3.1.8.1
SERUM
C-PEPTIDE
CONCENTRATION
65
3.1.8.2
PANCREATIC
C-PEPTIDE
CONTENT
65
3.1.9
SERUM
GLUCAGON
CONCENTRATION
67
3.1.10
SERUM
LIPID
PEROXIDATION
67
3.1.11
WESTERN
BLOT
ANALYSIS
OF
ISOLATED
ISLETS
67
3.1.11.1
ISLET
ISOLATION
67
3.1.11.2
ISLET
PROTEIN
CONTENT
70
3.1.11.3
SODIUM
DODECYL
SULFATE
POLYACRYLAMIDE
GEL
ELECTROPHORESIS
(SDS-PAGE)
70
3.1.11.4
WESTERN
BLOT
ANALYSIS
72
3.1.11.5
SILVER
STAINING
AND
DRYING
74
3.1.12
ORGAN
PREPARATION
AND
WEIGHING
76
3.1.12.1
PERFUSION
76
3.1.12.2
ORGAN
WEIGHT
77
3.1.12.3
PANCREAS
PREPARATION
77
3.1.13
IMMUNOHISTOCHEMISTRY
OF
THE
PANCREAS
78
3.1.13.1
GLUCAGON,
SOMATOSTATIN
AND
PANCREATIC
POLYPEPTIDE
78
3.1.13.2
INSULIN
79
3.1.13.3
REPLICATING
CELLS
(BRDU)
80
3.1.13.4
APOPTOTIC
CELLS
(TUNEL)
81
3.1.14
QUANTITATIVE-STEREOLOGICAL
ANALYSES
82
3.1.14.1
PANCREAS
VOLUME
83
3.1.14.2
VOLUME
DENSITY
AND
TOTAL
VOLUME
OF
ISLETS,
3-CELLS,
NON-3-CELLS
AND
CAPILLARIES
83
3.1.14.3
VOLUME
DENSITY
AND
TOTAL
VOLUME
OF
ISOLATED
3-CELLS
85
3.1.14.4
3-CELL
REPLICATION
85
3.1.14.5
3-CELL
APOPTOSIS
86
3.1.15
TRANSMISSON
ELECTRON
MICROSCOPY
(TEM)
86
3.2
C-PEPTIDE
II
CONCENTRATION
IN
SERUM
AND
PANCREAS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
88
3.3
ADDITIONAL
INVESTIGATIONS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
89
3.3.1
ANIMALS
89
3.3.2
RANDOMLY
FED
BODY
WEIGHT
AND
BLOOD
GLUCOSE
CONCENTRATION
89
3.3.3
INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(IPITT)
89
3.3.4
SERUM
GLUCAGON
CONCENTRATION
90
3.4
STATISTICAL
ANALYSIS
AND
DATA
PRESENTATION
90
4
RESULTS
91
4.1
TREATED
MALE
MUNICH
INS2
C
^
MUTANT
AND
WILD-TYPE
MICE
91
4.1.1
BODY
WEIGHT
91
4.1.2
BLOOD
GLUCOSE
CONCENTRATION
91
4.1.3
ORAL
GLUCOSE
TOLERANCE
TEST
(OGTT)
92
4.1.4
INSULIN
TOLERANCE
TEST
AND
PLACEBO-INSULIN
TOLERANCE
TEST
95
4.1.4.1
INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(IPITT)
95
4.1.4.2
COMPARISON
BETWEEN
INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(IPITT)
AND
PLACEBO-INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(PLACEBO-IPITT)
96
4.1.5
SERUM
C-PEPTIDE
CONCENTRATION
98
4.1.6
PANCREATIC
C-PEPTIDE
CONTENT
100
4.1.7
SERUM
GLUCAGON
CONCENTRATION
100
4.1.8
SERUM
LIPID
PEROXIDATION
101
4.1.9
WESTERN
BLOT
ANALYSIS
OF
ISOLATED
ISLETS
102
4.1.9.1
BIP/ACTIN
103
4.1.9.2
PELF2A/ACTIN
104
4.1.9.3
CHOP/ACTIN
105
4.1.10
ORGAN
WEIGHT
105
4.1.11
QUALITATIVE-HISTOLOGICAL
FINDINGS
OF
THE
PANCREAS
107
4.1.11.1
EXOCRINE
PANCREAS
AND
PANCREATIC
ISLETS
107
4.1.11.2
ISOLATED
3-CELLS
109
4.1.12
QUANTITATIVE-STEREOLOGICAL
FINDINGS
OF
THE
PANCREAS
110
4.1.12.1
TOTAL
PANCREAS
VOLUME
110
4.1.12.2
VOLUME
DENSITY
OF
ISLETS
IN
THE
PANCREAS
110
4.1.12.3
TOTAL
ISLET
VOLUME
111
4.1.12.4
VOLUME
DENSITY
OF
3-CELLS
IN
THE
ENDOCRINE
COMPARTMENT
OFTHE
ISLETS
112
4.1.12.5
TOTAL
VOLUME
OF
3-CELLS
IN
THE
ISLETS
112
4.1.12.6
VOLUME
DENSITY
OF
NON-3-CELLS
IN
THE
ENDOCRINE
COMPARTMENT
OF
THE
ISLETS
113
4.1.12.7
TOTAL
VOLUME
OF
NON-3-CELLS
IN
THE
ISLETS
114
4.1.12.8
VOLUME
DENSITY
OF
CAPILLARIES
IN
THE
ISLETS
114
4.1.12.9
TOTAL
VOLUME
OF
CAPILLARIES
IN
THE
ISLETS
115
4.1.12.10
VOLUME
DENSITY
OF
ISOLATED
P-CELLS
IN
THE
PANCREAS
116
4.1.12.11
TOTAL
VOLUME
OF
ISOLATED
P-CELLS
IN
THE
PANCREAS
116
4.1.12.12
P-CELL
REPLICATION
117
4.1.12.13
P-CELL
APOPTOSIS
118
4.1.13
TRANSMISSON
ELECTRON
MICROSCOPY
(TEM)
118
4.2
C-PEPTIDE
II
CONCENTRATION
IN
SERUM
AND
PANCREAS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
122
4.2.1
BLOOD
GLUCOSE
CONCENTRATION
122
4.2.2
SERUM
C-PEPTIDE
II
CONCENTRATION
123
4.2.3
C-PEPTIDE
II
CONTENT
IN
THE
PANCREAS
123
4.3
ADDITIONAL
INVESTIGATIONS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
124
4.3.1
BODY
WEIGHT
124
4.3.2
BLOOD
GLUCOSE
CONCENTRATION
125
4.3.3
INTRAPERITONEAL
INSULIN
TOLERANCE
TEST
(IPITT)
125
4.3.4
SERUM
GLUCAGON
AND
CORRESPONDING
BLOOD
GLUCOSE
CONCENTRATION
128
4.3.4.1
RANDOMLY
FED
SERUM
GLUCAGON
AND
GLUCAGON
CONCENTRATION
10
MINUTES
AFTER
INSULIN
INJECTION
128
4.3.4.2
FASTING
SERUM
GLUCAGON
AND
GLUCAGON
CONCENTRATION
10
MINUTES
AFTER
ORAL
GLUCOSE
APPLICATION
130
5
DISCUSSION
133
5.1
TREATED
MALE
MUNICH
/NS2
C95S
MUTANT
AND
WILD-TYPE
MICE
133
5.1.1
GLUCOSE
HOMEOSTASIS
133
5.1.2
LIPID
PEROXIDATION
141
5.1.3
ISLET
ISOLATION
AND
ER
STRESS
141
5.1.4
QUALITATIVE-HISTOLOGICAL
AND
QUANTITATIVE-STEREOLOGICAL
ANALYSIS
OFTHE
ENDOCRINE
PANCREAS
144
5.1.5
ELECTRON
MICROSCOPIC
FINDINGS
IN
P-CELLS
151
5.1.6
BODY
AND
ORGAN
WEIGHTS
155
5.2
C-PEPTIDE
II
CONCENTRATION
IN
SERUM
AND
PANCREAS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
157
5.3
ADDITIONAL
INVESTIGATIONS
OF
UNTREATED
MALE
AND
FEMALE
MUNICH
INS2C95S
MUTANT
AND
WILD-TYPE
MICE
159
5.4
SUMMARY
162
6
PERSPECTIVE
164
7
SUMMARY
165
8
ZUSAMMENFASSUNG
167
9
REFERENCES
169
10
APPENDIX
198
10.1
LIST
OF
ABBREVIATIONS
198
10.2
ASSAY
PROCEDURES
200
10.2.1
RADIOIMMUNOASSAY
(RIA)
10.2.1.1
C-PEPTIDE
10.2.1.2
GLUCAGON
200
200
201
10.2.2
C-PEPTIDE
II
ELISA
202
10.2.3
THIOBARBITURIC
ACID
REACTIVE
SUBSTANCES
(TBARS)
204
ACKNOWLEDGEMENTS
206 |
| any_adam_object | 1 |
| author | Kautz, Sabine Martha 1982- |
| author_GND | (DE-588)140824537 |
| author_facet | Kautz, Sabine Martha 1982- |
| author_role | aut |
| author_sort | Kautz, Sabine Martha 1982- |
| author_variant | s m k sm smk |
| building | Verbundindex |
| bvnumber | BV036426739 |
| collection | ebook |
| ctrlnum | (OCoLC)644274521 (DE-599)DNB1001018427 |
| dewey-full | 616.4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.4 |
| dewey-search | 616.4 |
| dewey-sort | 3616.4 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV036426739 |
| illustrated | Illustrated |
| indexdate | 2024-09-16T14:03:15Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020299422 |
| oclc_num | 644274521 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 DE-188 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 DE-188 |
| physical | 206 S. Ill., graph. Darst. 21 cm |
| psigel | ebook |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| record_format | marc |
| spelling | Kautz, Sabine Martha 1982- Verfasser (DE-588)140824537 aut Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice by Sabine Martha Kautz 2010 206 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Nebentitel: Mechanismen des β-Zell-Verlustes bei männlichen Munich Ins2C95S Mausmutanten München, Univ., Diss., 2010 (Nicht für den Austausch) mice cabt laboratory animals cabt genes cabt biotechnology cabt nucleotide sequences cabt immune response cabt mutations cabt mutants cabt disease models cabt diabetes mellitus cabt diabetes cabt insulin cabt blood sugar cabt metabolic disorders cabt (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-112133 http://edoc.ub.uni-muenchen.de/11213/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-112133 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020299422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kautz, Sabine Martha 1982- Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice mice cabt laboratory animals cabt genes cabt biotechnology cabt nucleotide sequences cabt immune response cabt mutations cabt mutants cabt disease models cabt diabetes mellitus cabt diabetes cabt insulin cabt blood sugar cabt metabolic disorders cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice |
| title_auth | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice |
| title_exact_search | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice |
| title_full | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice by Sabine Martha Kautz |
| title_fullStr | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice by Sabine Martha Kautz |
| title_full_unstemmed | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice by Sabine Martha Kautz |
| title_short | Mechanisms of b-cell [beta-cell] loss in male Munich Ins2C95S mutant mice |
| title_sort | mechanisms of b cell beta cell loss in male munich ins2c95s mutant mice |
| topic | mice cabt laboratory animals cabt genes cabt biotechnology cabt nucleotide sequences cabt immune response cabt mutations cabt mutants cabt disease models cabt diabetes mellitus cabt diabetes cabt insulin cabt blood sugar cabt metabolic disorders cabt |
| topic_facet | mice laboratory animals genes biotechnology nucleotide sequences immune response mutations mutants disease models diabetes mellitus diabetes insulin blood sugar metabolic disorders Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/11213/ https://nbn-resolving.org/urn:nbn:de:bvb:19-112133 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020299422&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kautzsabinemartha mechanismsofbcellbetacelllossinmalemunichins2c95smutantmice |