Hypopituitarism following traumatic brain injury: neuroendocrine dysfunction and head trauma
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
Saarbrücken
Lambert Acad. Publ.
2010
|
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | 191 S. Ill., graph. Darst. |
| ISBN: | 9783838304434 3838304438 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV036094852 | ||
| 003 | DE-604 | ||
| 005 | 20100511 | ||
| 007 | t | ||
| 008 | 100324s2010 ad|| |||| 00||| ger d | ||
| 020 | |a 9783838304434 |9 978-3-8383-0443-4 | ||
| 020 | |a 3838304438 |9 3-8383-0443-8 | ||
| 035 | |a (OCoLC)634213957 | ||
| 035 | |a (DE-599)BVBBV036094852 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a ger | |
| 049 | |a DE-355 | ||
| 084 | |a YC 3823 |0 (DE-625)153217:12929 |2 rvk | ||
| 084 | |a YG 3723 |0 (DE-625)153492:12929 |2 rvk | ||
| 084 | |a YG 5245 |0 (DE-625)153504:12952 |2 rvk | ||
| 100 | 1 | |a Agha, Amar |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Hypopituitarism following traumatic brain injury |b neuroendocrine dysfunction and head trauma |c Amar Agha |
| 264 | 1 | |a Saarbrücken |b Lambert Acad. Publ. |c 2010 | |
| 300 | |a 191 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |3 Klappentext |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-018985370 | ||
Datensatz im Suchindex
| _version_ | 1804141159924105216 |
|---|---|
| adam_text | Table
of
Contents
Summary
6
Table of figures
11
List Of Abbreviations
12
Chapter One: Introduction
1.1
Traumatic Brain Injury: Overview
14
1.2
Historical Perspective
16
1.3
Prevalence of Hypopituitarism Following TBI
16
1.3.1
Hypopituitarism in the Chronic Phase of TBI
16
1.3.2
Neuroendocrine
Dysfunction in the acute phase of TBI
18
1.3
J
Posterior Pituitary Dysfunction Following TBI
22
1.4
Anatomic Considerations
23
1.5
Autopsy Results
25
1.6
Clinical Imaging
26
1.7
Hypothesis
26
1.8
Objectives
26
Chapter Two: Methodology
2.1
Introduction
32
2.2
Assessment of Anterior Pituitary function
32
2.2.1
Somatotrophic Function
32
2.2.2
Corticotrophic Function
40
2.2
J
Definition of Normal GH and
Cortisol
Responses to the GST
44
2.2.4
Gonadotrophic and Thyrotrophic Function
47
2.3
Posterior
Pituitary Assessment
47
2
J.I Diabetes Insipidus
48
2.3.2
Syndrome of Inappropriate Anti-diuretic Hormone Secretion
52
(SIADH)
2.3.3
Cerebral Salt Wasting
52
2.4
Assessment of Severity of TBI
53
2.4.1
Clinical Methods
53
2.4.2
Computerised Tomography (CT) Morphology
55
2.5
Assessment of Functional Outcome Following TBI
57
2.6
Assessment of Quality of Life in Patients with GH Deficiency
57
2.7
Analytical Methods
58
2.8
Ethical Aspects of the Studies
59
Chapter Three: Anterior Pituitary Dysfunction
in Survivors of Traumatic Brain Injury (TBI)
3.1
Introduction
61
3.1.1
Illustrative Case History
61
3.1.2
Background
63
3.2
Patients and Methods
64
3.2.1
Patients
64
3.2.2
Methods
66
3.2
J
Laboratory Methods
67
3.2.4
Statistical Analysis
67
33
Results
68
3.3.1
GH-IGF-l Axis
69
3.3.2
The Corticotrophic-Adrenal Axis
72
3.3.3
Other Hormone Abnormalities
74
3.3.4
Overall Results
76
3.4
Discussion
79
Chapter Four: Posterior Pituitary Dysfunction
Following Traumatic Brain Injury
4.1
Introduction
90
4.2
Subjects and Methods
90
4.2.1
Subjects
90
4.2.2
Methods
91
4.2.3
Laboratory Methods
92
4.2.4
Statistical Analysis
93
43
Results
94
43.1
Posterior Pituitary Dysfunction in the Acute Post-TBI Period
94
43.2
Posterior Pituitary Dysfunction in the Chronic Phase of TBI
95
4.4
Discussion
102
Chapter Five:
Neuroendocrine
Dysfunction In
The Acute Phase of Traumatic Brain Injury
5.1
Introduction
108
5.1.1
Illustrative Case History
108
5.1.2
Background
111
5.2
Subjects And Method
111
5.2.1
Subjects
111
5.2.2
Method
113
5.2.3
Laboratory Methods
114
5.2.4
Statistical Analysis
114
5.3
Results
115
5.3.1
Somatotrophic-IGF-l Axis
115
5.3.2
Corticotrophic-Adrenal Axis
116
5.33
Other Pituitary Hormone Abnormalities
118
5.3.4
Posterior Pituitary Dysfunction
119
5.4
Discussion
120
Chapter Six: The Natural History of Post-
Traumatic Hypopituitarism: Implications For
Assessment And Treatment
6.1
Introduction
129
6.2
Subjects And Methods
130
6.2.1
Subjects
130
6.2.2
Method
130
6.2
J
Laboratory Methods
130
6.2.4
Statistical Analysis
131
63
Results
131
6
J.I The Somatotrophic Axis
132
6.3.2
The Corticotrophic Axis
133
633
The Gonadotrophic Axis
135
6.3.4
The Thyrotrophic Axis
136
6.3.5
Hyperprolactinaemia
136
6.3.6
Posterior Pituitary Dysfunction
136
6.4
Discussion
140
Chapter Seven: General Discussion And
Conclusion
7.1
Overview
147
7.2
Perspective
147
7.3
Significance
151
7.4
Who Should Be Tested
153
7.5
When And How Should the Assessment Be Performed?
153
7.6
Potential Effect of Hormone Replacement on Recovery And
155
Rehabilitation After
ТВ
I: Future Research
7.7
Public Health Implications
156
References 159
Neuroendocrine
derangements after traumatic brain injury (TBI) have
received increasing recognition in recent years. Marked changes of the
hypothalamo-pituitary axis have been documented in the acute phase of
TBI with as many as
80%
of patients showing evidence of gonadotropin
deficiency,
18%
of growth hormone deficiency,
16%
of corticotrophin
deficiency and
40%
of patients demonstrating vasopressin
abnormalities. Longitudinal prospective studies have shown that some
of the early abnormalities are transient, while new endocrine
dysfunction becomes apparent in the post acute phase. There remains a
high frequency of hypothalamic-pituitary hormone deficiencies among
long term survivors of TBI with approximately
28%
patients showing one
or more pituitary hormone deficiencies. This is a higher frequency than
previously thought and suggests that most cases of post traumatic
hypopituitarism (PTHP) remain undiagnosed and untreated. The data
underscore the need for the identification and appropriate timely
management of hormone deficiencies, in order to optimise patient
recovery from head trauma.
|
| any_adam_object | 1 |
| author | Agha, Amar |
| author_facet | Agha, Amar |
| author_role | aut |
| author_sort | Agha, Amar |
| author_variant | a a aa |
| building | Verbundindex |
| bvnumber | BV036094852 |
| classification_rvk | YC 3823 YG 3723 YG 5245 |
| ctrlnum | (OCoLC)634213957 (DE-599)BVBBV036094852 |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01471nam a2200325 c 4500</leader><controlfield tag="001">BV036094852</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20100511 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">100324s2010 ad|| |||| 00||| ger d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783838304434</subfield><subfield code="9">978-3-8383-0443-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3838304438</subfield><subfield code="9">3-8383-0443-8</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)634213957</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV036094852</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YC 3823</subfield><subfield code="0">(DE-625)153217:12929</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YG 3723</subfield><subfield code="0">(DE-625)153492:12929</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YG 5245</subfield><subfield code="0">(DE-625)153504:12952</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Agha, Amar</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypopituitarism following traumatic brain injury</subfield><subfield code="b">neuroendocrine dysfunction and head trauma</subfield><subfield code="c">Amar Agha</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Saarbrücken</subfield><subfield code="b">Lambert Acad. Publ.</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">191 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Klappentext</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-018985370</subfield></datafield></record></collection> |
| id | DE-604.BV036094852 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:11:27Z |
| institution | BVB |
| isbn | 9783838304434 3838304438 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018985370 |
| oclc_num | 634213957 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 191 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Lambert Acad. Publ. |
| record_format | marc |
| spelling | Agha, Amar Verfasser aut Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma Amar Agha Saarbrücken Lambert Acad. Publ. 2010 191 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Agha, Amar Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma |
| title | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma |
| title_auth | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma |
| title_exact_search | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma |
| title_full | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma Amar Agha |
| title_fullStr | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma Amar Agha |
| title_full_unstemmed | Hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma Amar Agha |
| title_short | Hypopituitarism following traumatic brain injury |
| title_sort | hypopituitarism following traumatic brain injury neuroendocrine dysfunction and head trauma |
| title_sub | neuroendocrine dysfunction and head trauma |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018985370&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT aghaamar hypopituitarismfollowingtraumaticbraininjuryneuroendocrinedysfunctionandheadtrauma |