Personal genomics and personalized medicine:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Introduction -- From DNA sequence to physiology -- DNA sequence variations, their prevalence, and effects on cellular biochemistry -- Environmental and life-history effects -- The impact of inter-individual biochemical differences on health outcomes -- DNA testing and sequencing technologies -- Measuring the impact of environmental factors on health -- Characterizing the effects of genetic and environmental factors on cellular function -- Translating personal genomics and personalized medicine into clinical practice -- Organizational, legal and ethical challenges -- Coda : engineering the future of medicine |
| Beschreibung: | IX, 259 S. Ill., graph. Darst. 23 cm |
Internformat
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| 500 | |a Introduction -- From DNA sequence to physiology -- DNA sequence variations, their prevalence, and effects on cellular biochemistry -- Environmental and life-history effects -- The impact of inter-individual biochemical differences on health outcomes -- DNA testing and sequencing technologies -- Measuring the impact of environmental factors on health -- Characterizing the effects of genetic and environmental factors on cellular function -- Translating personal genomics and personalized medicine into clinical practice -- Organizational, legal and ethical challenges -- Coda : engineering the future of medicine | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Personal genomics and personalized medicine
Autor: Bolouri, Hamid
Jahr: 2010
Contents
Chapter 1 Introduction 1
Why Now? 4
Biochemical Individuality: The Need for Personalized Medicine 9
The Demand for Individualized Medicine 11
Personalized Medicine: The Vision 14
The Aims of this Book 16
Who Should Read this Book 16
Organization of the Book 17
How to Read this Book 18
Acknowledgments 18
Chapter 2 From DNA Sequence to Physiology 21
Genetic Information Flow 21
DNA Organization 23
An Overview of Transcription and Translation 26
Condition-Specific Regulation of Gene Expression 29
Molecular Interaction Networks and Systems 36
Cross-Regulation and Physiology at the Organ Level 39
The Genome in its Environmental Context 41
Chapter 3 DNA Sequence Variations, their Prevalence, and Effects 43
on Cellular Biochemistry
Sources of DNA Sequence Variations 43
Observed Types of DNA Sequence Variation 47
Frequencies of DNA Sequence Variants 50
Effects of DNA Sequence Variation on Cellular Biochemistry 51
* iü Personal Genomics and Personalized Medicine
Chapter 4 Environmental and Life-History Effects 67
Somatic Mutations in Cancer 68
Epimutations 70
The Metagenome 74
Transient Physiological Effects 79
Cumulative Effects 82
Chapter 5 The Impact of Inter-individual Biochemical Differences 85
on Health Outcomes
Hierarchical System Modularity and Functional Building Blocks 85
The Dynamic Characteristics of Molecular Interaction Modules 86
Determine the Impact of Genetic and Environmental Factors
The Challenges of Establishing Cause-Effect Relationships 94
Making Predictive Systems Models of Cellular and Organ Function 110
Chapter 6 DNA Testing and Sequencing Technologies 111
Biochemical Tests 115
Cytogenetic Detection of Large-Scale Chromosomal Abnormalities 116
Targeted DNA Sequence Analysis 117
De novo Whole-Genome DNA Sequencing 119
Next Generation (Parallel) Re-sequencing Technologies 127
Sequencing Challenges for Personal Genomics 132
Chapter 7 Measuring the Impact of Environmental Factors on Health 135
Selecting Biomarkers 135
What should Biomarkers Predict? 137
The Multiple Roles of Biomarkers in Personalized Medicine 137
Imaging Anatomical and Physiological Biomarkers 138
Blood-Related Biomarkers 142
Saliva-Based Biomarkers 149
Biomarkers in Urine and Feces 150
Skin, Breath, Sweat and Tears 154
Challenges in Biomarker Development 159
Contents
Chapter 8 Characterizing the Effects of Genetic and Environmental Factors 163
on Cellular Function
How Completely Is the Reference Human Genome Characterized? 164
Functional Annotation of Genomic Sequences 173
Predicting the Effects of Sequence Variants 175
Characterizing Environmental and Life-History Effects 187
Chapter 9 Translating Personal Genomics and Personalized Medicine 193
into Clinical Practice
Interpreting Personal Genomes 193
Interpreting Biomarker Data 198
Electronic Health Records (EHRs) 199
Decision Support Systems for Diagnosis and Treatment Planning 209
From Bench to Bedside and from Bedside to Bench 213
Chapter 10 Organizational, Legal and Ethical Challenges 217
Privacy Considerations 217
Accuracy and Usefulness of Tests 221
Ethical Challenges 223
The Need for Patient Participation in Personalized Medicine 226
and its Challenges
Economic Considerations 227
Predictive and Preventive Medicine 235
Prolonging Life versus Promoting Quality of Life 237
Chapter 11 Coda - Engineering the Future of Medicine 241
Engaging and Educating the Stakeholders 244
Moving Beyond the One Treatment Fits All Approach 246
Are We There Yet? 248
Let the Revolution Begin 253
Index 255
|
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| spelling | Bolouri, Hamid Verfasser aut Personal genomics and personalized medicine Hamid Bolouri London Imperial College Press 2010 IX, 259 S. Ill., graph. Darst. 23 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Introduction -- From DNA sequence to physiology -- DNA sequence variations, their prevalence, and effects on cellular biochemistry -- Environmental and life-history effects -- The impact of inter-individual biochemical differences on health outcomes -- DNA testing and sequencing technologies -- Measuring the impact of environmental factors on health -- Characterizing the effects of genetic and environmental factors on cellular function -- Translating personal genomics and personalized medicine into clinical practice -- Organizational, legal and ethical challenges -- Coda : engineering the future of medicine Medical genetics Genomics Proteomics Genetics, Medical Individualisierte Medizin (DE-588)7660544-9 gnd rswk-swf Individualisierte Medizin (DE-588)7660544-9 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018983204&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bolouri, Hamid Personal genomics and personalized medicine Medical genetics Genomics Proteomics Genetics, Medical Individualisierte Medizin (DE-588)7660544-9 gnd |
| subject_GND | (DE-588)7660544-9 |
| title | Personal genomics and personalized medicine |
| title_auth | Personal genomics and personalized medicine |
| title_exact_search | Personal genomics and personalized medicine |
| title_full | Personal genomics and personalized medicine Hamid Bolouri |
| title_fullStr | Personal genomics and personalized medicine Hamid Bolouri |
| title_full_unstemmed | Personal genomics and personalized medicine Hamid Bolouri |
| title_short | Personal genomics and personalized medicine |
| title_sort | personal genomics and personalized medicine |
| topic | Medical genetics Genomics Proteomics Genetics, Medical Individualisierte Medizin (DE-588)7660544-9 gnd |
| topic_facet | Medical genetics Genomics Proteomics Genetics, Medical Individualisierte Medizin |
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