The mitotic spindle assembly in C. elegans embryos:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
[2005]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 120 Bl. Ill., graph. Darst. 30 cm |
Internformat
MARC
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| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-355 |a DE-188 | ||
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| 100 | 1 | |a Özlü, Nurhan |d 1978- |e Verfasser |0 (DE-588)130485039 |4 aut | |
| 245 | 1 | 0 | |a The mitotic spindle assembly in C. elegans embryos |c von Nurhan Özlü |
| 264 | 1 | |c [2005] | |
| 300 | |a 120 Bl. |b Ill., graph. Darst. |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Dresden, Techn. Univ., Diss., 2005 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018979192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-018979192 | |
Datensatz im Suchindex
| _version_ | 1808135051818303488 |
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| adam_text |
TABLE
OF
CONTENTS:
1.
INTRODUCTION
4
SUMMARY
4
CELL
DIVISION
5
MITOTIC
SPINDLE
6
1)
SPINDLE
ASSEMBLY
PATHWAYS
7
A)
CELLS
CONTAINING
CENTROSOMES
8
B)
CELLS
LACKING
CENTROSOMES
9
2)
SPINDLE
DYNAMICS
12
3)
REGULATING
SPINDLE
LENGTH
13
4)
SPINDLE
POSITIONING
14
5)
MITOTIC
KINASE
AURORA-A
16
C.
ELEGANS
AS
A
MODEL
ORGANISM
TO
STUDY
CELL
DIVISION
18
THE
FIRST
CELL
DIVISION
OF
C.
ELEGANS
EMBRYOS
21
MITOTIC
SPINDLE
IN
EARLY
C.
ELEGANS
EMBRYOS
21
PROTEINS
IMPLICATED
IN
SPINDLE
ASSEMBLY
IN
C.
ELEGANS
EMBRYOS
22
1)
EFFECTORS
OF
CENTRIOLE
DUPLICATION
25
2)
EFFECTORS
OF
CENTROSOME
ASSEMBLY
AND
MATURATION
26
3)
EFFECTORS
OF
MICROTUBULE
STABILIZATION
28
4)
EFFECTORS
OF
MICROTUBULE
DESTABILIZATION
28
5)
KINETOCHORE
PROTEINS
30
GOAL
OF
MY
PHD
THESIS
31
FIGURES
1.1-1.3
33
2.
CHARACTERIZATION
OF
H38K22.2,
DCN-1
37
DCN-1
IS
REQUIRED
FOR
LONG
ASTER
MICROTUBULES
37
DCN-1
IS
INVOLVED
IN
THE
MEI-1
DEGRADATION
PATHWAY
38
FIGURES
2.1-2.2
41
3.
CHARACTERIZATION
OF
Y39G10AR.12,
TPXL-1
45
TPXL-1
IS
REQUIRED
TO
FORM
INTACT
MITOTIC
SPINDLE
45
TPXL-1
IS
REQUIRED
FOR
TARGETING
AIR-1
TO
THE
SPINDLE
45
COMMON
FEATURES
OF
TPXL-1
AND
VERTEBRATE
TPX2
46
TPXL-1
BINDS
TO
AND
STIMULATES
AIR-1
KINASE
47
INTERACTION
OF
TPXL-1
WITH
AIR-1
IS
REQUIRED
FOR
SPINDLE
ASSEMBLY
48
COMPARISON
BETWEEN
THE
PHENOTYPES
OF
AIR-1
AND
TPXL-1
50
ROLE
OF
TPXL-1
IS
INDEPENDENT
OF
CHROMATIN-STIMULATED
SPINDLE
ASSEMBLY
52
TPXL-1
IS
NOT
REQUIRED
FOR
GENERATION
OF
ASTRAL
FORCES
53
KINETOCHORE
MICROTUBULES
FORM
AFTER
RNAI
OF
TPXL-1
54
SPINDLE
COLLAPSE
IN
TPXL-L(RNAI)
EMBRYOS
DEPENDS
ON
KINETOCHORES
55
TPXL-1
IS
REQUIRED
TO
MAINTAIN
CHROMOSOME-SPINDLE
POLE
DISTANCE
IN
MONOPOLAR
SPINDLES
55
ABNORMAL
MICROTUBULE
BEHAVIOR
AT
SPINDLE
POLES
IN
TPXL-L(RNAI)
EMBRYOS
56
FIGURES
3.1-3.10
58
4.
DISCUSSION
81
4.1
C.
ELEGANS
IS
A
POWERFUL
MODEL
SYSTEM
TO
STUDY
CELL
DIVISION
81
4.2
CHARACTERIZATION
OF
A
NOVEL
FAMILY
PROTEIN
DCN-1
IN
C.
ELEGANS
EMBRYOS
82
FIGURE
4.1
4.3
CHARACTERIZATION
OF
TPXL-1
TO
DEFINE
THE
MECHANISM
OF
THE
TPX2
FUNCTION
IN
MITOTIC
CELLS
FIGURE
4.2
85
87
95
5.
EXPERIMENTAL
PROCEDURES
97
6.
APPENDIX
MOVIE
INFORMATION
ABBREVATIONS
107
107
110
7.
REFERENCES
111
8.
ACKNOWLEDGEMENTS
121
9.
ERKLARUNG
AND
VERSICHERUNG
122
3 |
| any_adam_object | 1 |
| author | Özlü, Nurhan 1978- |
| author_GND | (DE-588)130485039 |
| author_facet | Özlü, Nurhan 1978- |
| author_role | aut |
| author_sort | Özlü, Nurhan 1978- |
| author_variant | n ö nö |
| building | Verbundindex |
| bvnumber | BV036088536 |
| ctrlnum | (OCoLC)255062985 (DE-599)BVBBV036088536 |
| dewey-full | 571.8651257 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.8651257 |
| dewey-search | 571.8651257 |
| dewey-sort | 3571.8651257 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV036088536 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:12:38Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018979192 |
| oclc_num | 255062985 |
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| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | 120 Bl. Ill., graph. Darst. 30 cm |
| publishDate | 2005 |
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| publishDateSort | 2005 |
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| spelling | Özlü, Nurhan 1978- Verfasser (DE-588)130485039 aut The mitotic spindle assembly in C. elegans embryos von Nurhan Özlü [2005] 120 Bl. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Dresden, Techn. Univ., Diss., 2005 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018979192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Özlü, Nurhan 1978- The mitotic spindle assembly in C. elegans embryos |
| subject_GND | (DE-588)4113937-9 |
| title | The mitotic spindle assembly in C. elegans embryos |
| title_auth | The mitotic spindle assembly in C. elegans embryos |
| title_exact_search | The mitotic spindle assembly in C. elegans embryos |
| title_full | The mitotic spindle assembly in C. elegans embryos von Nurhan Özlü |
| title_fullStr | The mitotic spindle assembly in C. elegans embryos von Nurhan Özlü |
| title_full_unstemmed | The mitotic spindle assembly in C. elegans embryos von Nurhan Özlü |
| title_short | The mitotic spindle assembly in C. elegans embryos |
| title_sort | the mitotic spindle assembly in c elegans embryos |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018979192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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