From pathogenesis to therapy of autoimmune diseases: report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009
"In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not...
Gespeichert in:
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| Format: | Tagungsbericht Buch |
| Sprache: | English |
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Lengerich ; Berlin ; Bremen ; Miami, Fla. ; Riga ; Viernheim ; Wien ; Zagreb
Pabst Science Publ.
2009
|
| Schriftenreihe: | Autoimmunity, autoantigens, autoantibodies
6 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not only 'primary' autoimmune reactions but also other pathogenic mechanisms such as postinfectious and autoinflammatory processes. The heterogeneity within the immunological diseases may reflect the variable expression of autoinflammatory, autoimmune, and up to now unknown factors in disease development and manifestation. Based on histological and immunohistochemical examinations, IgG4-related sclerosing disease has been proposed as a novel clinicopathological entity with autoimmune phenomena but unknown etiology (chapter 1). The clarification of the etiopathological mechanisms is required to optimize prophylaxis, diagnostics and therapy Especially, the application of novel and designer biological therapies (chapter 8) requires a better understanding of the processes that are involved in the genesis of immunological diseases. In chapter 2, some aspects of the role of epigenetic mechanisms and innate immunity in the pathogenesis of autoimmune diseases are described. Regardless of the underlying pathology, disease-associated autoantibodies are important biomarkers for the vast majority of non-organ and organ specific autoimmune diseases. However, to improve our understanding of these diseases and serological diagnostics it is necessary to search for novel autoantibodies, to further evaluate the real clinical relevance of known autoantibodies and to further develop and standardize the detection methods (chapters 3-5) Pathogenetic aspects as well as aspects of the serological diagnostics, including novel autoantibody specificities, novel methodologies and evaluation studies are presented for rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic vasculitides, systemic sclerosis (chapter 6) and various organ specific diseases (chapter 7). In summary, the present volume highlights novel insights into the immune dysregulation, pathogenesis, serological diagnostics and biological therapies of autoimmune diseases."--Publisher's description |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XV, 567 S. Ill., graph. Darst. 21 cm, 960 gr. |
| ISBN: | 9783899675795 |
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| 245 | 1 | 0 | |a From pathogenesis to therapy of autoimmune diseases |b report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 |c K. Conrad ... (ed.) |
| 264 | 1 | |a Lengerich ; Berlin ; Bremen ; Miami, Fla. ; Riga ; Viernheim ; Wien ; Zagreb |b Pabst Science Publ. |c 2009 | |
| 300 | |a XV, 567 S. |b Ill., graph. Darst. |c 21 cm, 960 gr. | ||
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| 490 | 1 | |a Autoimmunity, autoantigens, autoantibodies |v 6 | |
| 500 | |a Literaturangaben | ||
| 520 | 3 | |a "In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not only 'primary' autoimmune reactions but also other pathogenic mechanisms such as postinfectious and autoinflammatory processes. The heterogeneity within the immunological diseases may reflect the variable expression of autoinflammatory, autoimmune, and up to now unknown factors in disease development and manifestation. Based on histological and immunohistochemical examinations, IgG4-related sclerosing disease has been proposed as a novel clinicopathological entity with autoimmune phenomena but unknown etiology (chapter 1). The clarification of the etiopathological mechanisms is required to optimize prophylaxis, diagnostics and therapy | |
| 520 | 3 | |a Especially, the application of novel and designer biological therapies (chapter 8) requires a better understanding of the processes that are involved in the genesis of immunological diseases. In chapter 2, some aspects of the role of epigenetic mechanisms and innate immunity in the pathogenesis of autoimmune diseases are described. Regardless of the underlying pathology, disease-associated autoantibodies are important biomarkers for the vast majority of non-organ and organ specific autoimmune diseases. However, to improve our understanding of these diseases and serological diagnostics it is necessary to search for novel autoantibodies, to further evaluate the real clinical relevance of known autoantibodies and to further develop and standardize the detection methods (chapters 3-5) | |
| 520 | 3 | |a Pathogenetic aspects as well as aspects of the serological diagnostics, including novel autoantibody specificities, novel methodologies and evaluation studies are presented for rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic vasculitides, systemic sclerosis (chapter 6) and various organ specific diseases (chapter 7). In summary, the present volume highlights novel insights into the immune dysregulation, pathogenesis, serological diagnostics and biological therapies of autoimmune diseases."--Publisher's description | |
| 650 | 4 | |a Autoantibodies |v Congresses | |
| 650 | 4 | |a Autoimmune Diseases |x etiology |v Congresses | |
| 650 | 4 | |a Autoimmune Diseases |x therapy |v Congresses | |
| 650 | 4 | |a Autoimmune diseases |x Etiology |v Congresses | |
| 650 | 4 | |a Autoimmune diseases |x Treatment |v Congresses | |
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| 711 | 2 | |a Dresden Symposium on Autoantibodies |n 9 |d 2009 |c Dresden |j Sonstige |0 (DE-588)16024605-2 |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-018969784 | ||
Datensatz im Suchindex
| _version_ | 1804141134668103680 |
|---|---|
| adam_text | Titel: From pathogenesis to therapy of autoimmune diseases
Autor: Conrad, Karsten
Jahr: 2009
Contents
Preface XVII
Chapter 1
The Spectrum and Pathogenesis of Noninfectious Inflammatory
and Sclerosing Diseases
1 lgG4-related sclerosing disease 3
T. Kamisawa, K. Tsuruta, T. Sasaki
2 The autoinflammatory-autoimmune continuum 14
M. F. McDermott and D. McGonagle
Chapter 2
The Role of Epigenetics and Innate Immunity in the Pathogenesis
of Autoimmune Diseases
3 MicroRNA in the pathogenesis of systemic lupus: current status and future
perspectives 23
0. Sdnchez-Pernaute, J. Stanczyk, F. I. Romero-Bueno, S. Gay
4 Toll like receptors and autoimmunity 31
P. von Landenberg
5 Proteinase 3 and its receptors: linking innate immunity to autoimmunity in
ANCA-associated vasculitides 39
£ Csernok
6 Agonistic autoantibodies targeting innate immunity receptors:The example of TLR4
in systemic sclerosis 45
C. Chizzolini and P. L Meroni
7 Epigenetic regulation of IL-10 expression: Activation dependent changes in DNA
methylation patterns of CD4+ T cell subsets 59
C.M.HedrichJ.H. Bream
VI Contents
Chapter 3
Novel and Esoteric Autoantibodies
8 The clinical paradox of esoteric and novel autoantibodies 71
M.J.Fritzler
9 The UNIarray® technology platform for development of novel autoantibody
biomarkers in IVD applications 89
A. Kowald, G. Bartsch, H. Klocker, M. Schneider, P. Amersdorfer, 5. Mullner, A. Lueking
10 Autoantibodies to RNA helicase A as a new serological marker of early SLE 95
J.Y.F. Chan, H. Yoshida, A. Mizutani, Y. Yamasaki, Y. Li, M. R. Bubb, E. 5. Sobel, E. K. L. Chan,
W.H. Reeves, M.Satoh
11 Identification of inosine-1,2-monophosphate-dehydrogenase-2 as a novel
autoantigen 106
M. Bluthner, H. Appelhans, I. Moosbrugger, C Wiemann, D. Lenz, H. P. Seelig
12 Identification of Rho-GTPase-activating protein p26 as a novel autoantigen 108
M. Bluthner, H. Appelhans, I. Moosbrugger, C Wiemann, J. Ludwig, H. P. Seelig
13 The cell cycle protein Nop52 is a candidate target autoantigen 110
A. Swart, M. Mahler, M. J. f ritzier
14 Heterogeneous nuclear ribonucleoproteins, novel target antigens of autoantibodies
in autoimmune disease? 113
K. Op De Beeck, K. Van den Bergh, L Maes, G. Michiels, P. Verschueren, R. Westhovens,
D. Blockmans, X. Bossuyt
15 Sperm-associated antigen 16 isoform 2: a novel candidate autoantigen in multiple
sclerosis 116
K. Somers, R. Hupperts, C. Zwanikken, P. Stinissen and V. Somers
16 Identification of the f5- and y-subunits of FI-ATPase as target antigens in
anti-M2/PDC-E2 negative primary biliary cirrhosis (PBQ 118
ft Preuli, J. Dengjel, S. Stevanovic, /?. Klein
17 New autoantibodies in primary sclerosing cholangitis: reactivity with distinct
immunodominant epitopes of sulfite oxidase 120
ft PreuB, C. Berg, F. Altenberend, M. Gregor, 5. Stevanovic, R. Klein
18 Anti-p155/140 (anti-TIFly) autoantibodies in patients with cancer associated
myositis detected in a single centre ^22
J. Vencovsky, H. Mann, I. Putova, 1. Betteridge, H. Gunawardena, N. McHugh
Contents VII
Chapter 4
Biology of Autoantigen/Autoantibody Systems
19 Cytoplasmic rings/rods as autoimmune targets of emerging human autoantibodies
associated with HCV virus infection and interferon therapy 127
W. C. Carcamo, B. Yao, M. Satoh, W. H. Reeves, C Liu, 6. Covini, C.A. von Muhlen,
E. K.L.Chan
20 Autoantibodies to LEDGFp75/DFS70: natural autoantibodies or sensors of an
augmented state of cellular oxidative stress? 135
L 5. Leon, M. Mediavilla-Varela, A. Basu, C A. Casiano
21 Circulating proteasomes and autoantibodies 157
E. Feist
Chapter 5
Methodical Aspects and Diagnostic Strategies
22 Clinical performance characteristics of a laboratory test 163
X. Bossuyt
23 Recommendations of the ACR committee on the standardization of autoantibody
detection 171
P.L.Meroni
24 Laboratory policies on the management of autoimmune diseases in a cohort of
Italian laboratories 177
A. De Nicolo, M. Tampoia et al.
25 Novel recombinant antigenic targets for the determination of (auto)antibodies in
autoimmune dermatoses, neurological disorders and gastrointestinal diseases 179
K.-P. Wandinger, C Probst, L. Komorowski, S. Saschenbrecker, A. Rosemann, T. Mothes,
D. Zillikens, J. Dalmau, S. Jarius, W. Schlumberger, W. Stocker
26 Stratification of autoantibody signatures in human sera by peptide epitope profiling 191
P. Lorenz, 1. Qian, M. Hecker, M. Kreutzer, F. Steinbeck, Y. Li, M. 0. Glocker, H.-J. Thiesen
27 Peptide resolved diagnostics in systemic autoimmune diseases: Potentials and
pitfalls 193
M. Mahler and M. Fritzler
X Contents
47 Corticosteroid-induced spinal epidural lipomatosis in the pediatric patients with
chronic autoimmune disorders 359
J. C. Moller, G. Hahn, F. Pessler
6.3
Anti-Phospholipid Syndrome and Systemic Vasculitides
48 Antiphospholipid antibodies affect the process of angiogenesis: novel mechanism
of placental damage 362
5. D ippolito, Ft. Marana, R. Castellani, C. Tersigni, A. Caruso, N. DiSimone
49 Gender differences in oxidative stress and apoptosis of vascular cells induced by
autoantibodies specific to RLIP76 364
£ Colasanti, P. Margutti, P. Matarrese, F. Delunardo, B. Ascione, D. Vacirca, W. Malorni, £
Ortona
50 Anti-Argonaute2 (Ago2/Su) and -Ro antibodies are the common autoantibody
specificities in primary anti-phospholipid syndrome (PAPS) 366
A. Ceribelli, I. Cavazzana, A. Tincani, F. Franceschini, B. A. Pauley, J.Y.F. Chan, E. K. L Chan,
M. Satoh
51 The antiphospholipid antibodies in patients with chronic heart failure 368
N. Virstyuk, V. Neyko, £ Cherkachuna, 0. Virstyuk
52 The antiphospholipid syndrome in acute ischemic stroke patients with insulin
resistance 370
0. Virstyuk, R. D. Gerasymchuk, N. Virstyuk, R. Portyuk
53 Performance evaluation of PR3-ANCA Eusas 372
M. W. Hayman, C Slade, K. Chamberlain, N. Cook, M. B. Spellerberg, J. L. O Donnell
54 Autoimmunity in patients with anti-neutrophil cytoplasmic antibodies: retrospective
analysis of an Italian cohort of ANCA positive patients 375
C Defendenti, M. F. Spina, M. Longo, S. Bollani, A. Cereda, S. Saibeni, A. Reina,
G. Guercilena, S. Bruno, M. Saudelli, F. Atzeni, P. Sarzi-Puttini
55 ANCA or other neutrophil specific antibodies (NSA) 378
L. Cebecauer, V. Ml, J. Lupac, I. Lochman
56 Clinical relevance of ANCA in routine care 380
Y. Ben Haj Hmida, D. Bouzid, S. Boukthir, M. Ben Ayed, H. Masmoudi
Contents XI
57 A novel PR3-ANCA Elisa with a mixture of human purified and recombinant PR3 as
solid-phase antigen 383
A. Radice, L. Bianchi, A. Palumbo, R. A. Sinico
58 High sensitive detection of autoantibodies to proteinase 3 (PR3) by a novel anchor
Elisa 386
D. Roggenbuck, T. Buttner, L Hoffmann, H. Schmechta, D. Reinhold, K. Conrad
59 A novel immunofluorescence assay for the Differentiation of pANCA and ANA 388
/. Kniitter, T. Buttner, J. Scholka, D. Roggenbuck, U. Anderer
6.4
Systemic Sclerosis
60 Anti-CENP-A and anti-CENP-B antibodies show high concordance and similar
clinical associations in patients with systemic sclerosis despite completely different
underlying protein sequences 392
K. Hanke, C. S. Bruckner, M. Becker, W. Meyer, W. Schlumberger, 6. Riemekasten
61 Evaluation of the in-house developed dot blot method and Elisa for the detection
of anti-PM/ScllOO autoantibodies in systemic autoimmune diseases. 395
L Maes, K. Op De Beeck, K. Van den Bergh, P. Verschueren, R. Westhovens, D. Blockmans,
M. Mahler, X.Bossuyt
62 Anti-PM/Scl-antibodies in systemic sclerosis: Comparison between PM1 -Alpha Elisa
and a line assay with recombinant PM/Scl-75c and PM/Sd-100 398
M. Mahler, M. Siegemund, W. Meyer, M. Petschinka, M.I. ritzier
63 Anti-IFI16 autoantibodies: a new marker in autoimmunity 400
S. Costa, M. Mondini, V. Caneparo, Italian FIRMA Group, S. Landolfo, M. Gariglio
64 Anti-Th/To antibodies in Italian scleroderma patients: clinical and immunological
correlations and comparison with patients with anti-centromere (ACA) antibodies 402
A. Ceribelli, I. Cavazzana, P. Aim, A. Tincani, F. Franceschini, B. A. Pauley, E. K. L Chan,
M. Satoh
XII Contents
Chapter 7
Pathogenetic Aspects and Serological Diagnostics of Organ Specific
Autoimmune Diseases
7.1
Autoimmune Neurological Diseases
65 Peripheral neuropathies and anti-glycolipid antibodies 409
H.J.Willison
66 Antiganglioside antibodies a very heterogeneous family of biomarkers 423
R. L Humbel, G. Foerster, I. Hila, M. Toussaint
67 Ganglioside antibodies in amyotrophic lateral sclerosis 426
U. Wurster, K. Kollewe, B. Mohammadi, T. Sinzenich, S. Petri
68 Co-Incidence of serum antiganglioside antibodies and microbial infection in
patients with inflammatory peripheral neuropathy 428
/. Janatkova, K. Malickova, A. Potmesilova, B. Potuznikova, T. Fucikova
69 Detection of antibodies to aquaporin-4 by indirect immunofluorescence employing
a standardized recombinant target antigen 430
S. Jarius, C Probst, K. Borowski, ft Franciotta, B. Wildemann, W. Stocker, K.-P. Wandinger
70 Antibodies against aquaporin-4 in neuromyelitis optica: cell-based assay vs.
immunoprecipitation assay 432
P. W. Modderman, I. Ketelslegers, R. Q. Hintzen, D. Hamann
71 Recombinant immunofluorescence assay for the detection of anti-glutamate
receptor (type NMDA) antibodies in the differential diagnosis of autoimmune
encephalopathies 434
K.-P. Wandinger, J. Dalmau, K. Borowski, C Probst, K. Fechner, W. Stocker
72 Immortalized B cell lines from multiple sclerosis patients produce antibodies that
bind an oligodendrocyte precursor cell line 436
J. Fraussen, K. Vrolix, P. Martinez-Martinez, M. Losen, R. Hupperts, A. Van Diepen,
R. Medaer, B. Van Wijmeersch, E. Meulemans, M. H. De Baets, P. Stinissen, V. Somers
73 Analysis of autoantibody profiles in cerebrospinal fluid and serum of a relaps-
ing-remitting MS patient with active disease using Serological Antigen Selection 438
C. Govarts, K. Somers, R. Hupperts, P. Jongen, P. Stinissen and V. Somers
Contents XIII
74 Anti-tau antibodies in patients with multiple sclerosis 440
J. Svarcovd, L Fialovd, A. Bartos, L Cechova, D. Dolezil, I. M. Malbohan
75 Avidity of antibodies against tau protein in patients with multiple sclerosis 443
L Fialovd, J. Svarcovd, A. Bartos, I. M. Malbohan
7.2
Gastrointestinal and Liver Diseases
76 The zymogen granule membrane glycoprotein GP2 is a major autoantigen of
pancreatic antibodies - relevance in diagnostics and pathogenesis of Crohn s
disease 449
D. Roggenbuck, G. Hausdorf, L. Martinez-Gamboa, D. Reinhold, T. Buttner, C Buning,
£ Feist, K. Conrad
77 CUZD1 and GP2 are the exocrine pancreas autoantigens in Crohn s disease 463
W. Stocker, B. Teegen, C. Probst, K. Aulinger-Stocker, D. Ludwig, M. 0. Glocker,
L Komorowski
78 Elisa for the detection of autoantibodies against DNA-bound lactoferrin in ulcerative
colitis 474
L Komorowski, B. Teegen, C. Probst, W. Schlumberger, W. Stocker
79 Antineutrophil cytoplasmic antibodies and HLA II in ulcerative colitis Tunisian
patients 476
D. Bouzid, Y. Ben Haj Hmida, A. Amouri, N. Mahfouth, A. Kammoun, M. Ben Ayed,
H. Makni, N. Tahri, H. Masmoudi
80 Diagnosis of IgA-deficient coeliac disease by assay of IgG antibodies against
deamidated gliadin (GAF3X) 478
D. Villalta, £ Tonutti, C. Prause, S. Koletzko, M. Stern, M. W. Laass, H. H. Uhlig, H. J. Ellis,
P.J. Ciclitira, T. Richter, C. Dahnrich, W. Schlumberger, T. Mothes
81 Antibodies against deamidated gliadin as a novel serologic marker for celiac disease 480
M. Miler, A. Tesija Kuna, 0. Zaja Franulovic, N. Vrkic
82 Deamidated gliadin antibodies facilitate diagnosis in celiac disease 482
£ Krieger, F. Haag
83 Validation of Bio-Rad gastrointestinal assays for use on the Evolis™ and Evolis™
twin plus systems 484
X. Guo, R. Lerner, L Sana, W. Kumfert and T. Prestigiacomo
XIV Contents
84 Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel Elisa -
revival of a disease-activity marker in autoimmune hepatitis (AIH) 486
G. Hausdorf, D. Roggenbuck, £ Feist, T. Buttner, K. Conrad, C Berg, R. Klein
85 Use of recombinant autoantigens in profiling of PBC associated antibodies 488
A. Neininger, J. Kaiser, J. Weyand, C. Berg, S. Buck, R. Klein, H. Haubruck, B. Liedvogel
7.3
Various Autoimmune Diseases and Cancer
86 Prevalence of ovarian antibodies in women with unexplained recurrent pregnancy
loss 492
M. Cojocaru, I. M. Cojocaru, I. Silosi, S. Rogoz
87 TSH receptor antibody (TRAb) assays using human monoclonal autoantibody M22
are more sensitive than bovine TSH based assays 494
K. Zophel, P. von Landerberg, D. Roggenbuck, G. Wunderlich, T. Gruning, J. Kotzerke,
K. J. Lackner, B. Rees Smith
88 (31-adrenoreceptor autoantibodies in a Lewis rat model of dilated cardiomyopathy 496
V. Kocoski, N. Beyersdorf, A. Schlipp, V. Boivin, T. Kerkau, R. Jahns
89 Elisa using ectodomains of desmoglein 1 and 3 expressed in HEK293 for sensitive
and specific detection of pemphigus autoantibodies 498
C. Dahnrich, A. Rosemann, C. Probst, L Komorowski, W. Schlumberger, W. Stocker,
A. Recke, C. Rose, D. Zillikens, E. Schmidt
90 Fine specificity of serum IgA and IgG autoantibodies against Calreticulin in
oncological patients 500
D. Sanchez, A. Pekdrikovd, L Palova-Jelinkovd, T. Mothes, H. Tlaskalova-Hogenova,
L Tuckova
91 Occurrence of autoantibodies to calreticulin in oncological patients and patients
from risk groups 502
A. Pekdrikovd, D. Sanchez, L. Palovd-Jelinkovd, M. Simsovd, Z. Benes, I. Janatkovd,
I. Hoffmanovd, P. Drastich, T. Mothes, H. Tlaskalova-Hogenova, L. Tuikovd
Chapter 8
Biological Therapy of Autoimmune Diseases
92 Biological therapy of rheumatic diseases
M.Aringer,J.S.Smolen
Contents XV
93 The role of B cells in immunoregulation 521
A. Kessel, A. Snir, £ Toubi
94 Targeting of memory plasma cells as therapeutic option in autoimmune diseases 531
F. Hiepe, B. F. Hoyer, I. M. Mumtaz, T. Yoshida, A. Radbruch
95 Has B-cell depletion any effects on circulating autoantibody? 537
D. Cornec and P. Youinou
96 Immune reactions induced by therapeutic proteins 543
A. Kromminga
97 Measuring anti-adalimumab levels in the presence of adalimumab 553
P. van Schouwenburg, G. Wolbink, LAarden, D. Wouters
98 Peptide-based immunotherapy of dilated cardiomyopathy in a Lewis rat model 554
V. Kocoski, N. Beyersdorf, M. Merki, D. Schmidt, V. Boivin, I Kerkau, Ft. Jahns
Subject Index 557
Author Index 563
|
| any_adam_object | 1 |
| author2 | Conrad, Karsten 1956- |
| author2_role | edt |
| author2_variant | k c kc |
| author_GND | (DE-588)110452917 |
| author_facet | Conrad, Karsten 1956- |
| building | Verbundindex |
| bvnumber | BV036078676 |
| callnumber-first | R - Medicine |
| callnumber-label | RC600 |
| callnumber-raw | RC600 |
| callnumber-search | RC600 |
| callnumber-sort | RC 3600 |
| callnumber-subject | RC - Internal Medicine |
| ctrlnum | (OCoLC)614267197 (DE-599)DNB99669353X |
| dewey-full | 616.978 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.978 |
| dewey-search | 616.978 |
| dewey-sort | 3616.978 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Conference Proceeding Book |
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| genre | (DE-588)1071861417 Konferenzschrift 2009 Dresden gnd-content |
| genre_facet | Konferenzschrift 2009 Dresden |
| id | DE-604.BV036078676 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:11:03Z |
| institution | BVB |
| institution_GND | (DE-588)16024605-2 |
| isbn | 9783899675795 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018969784 |
| oclc_num | 614267197 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XV, 567 S. Ill., graph. Darst. 21 cm, 960 gr. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Pabst Science Publ. |
| record_format | marc |
| series | Autoimmunity, autoantigens, autoantibodies |
| series2 | Autoimmunity, autoantigens, autoantibodies |
| spelling | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 K. Conrad ... (ed.) Lengerich ; Berlin ; Bremen ; Miami, Fla. ; Riga ; Viernheim ; Wien ; Zagreb Pabst Science Publ. 2009 XV, 567 S. Ill., graph. Darst. 21 cm, 960 gr. txt rdacontent n rdamedia nc rdacarrier Autoimmunity, autoantigens, autoantibodies 6 Literaturangaben "In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not only 'primary' autoimmune reactions but also other pathogenic mechanisms such as postinfectious and autoinflammatory processes. The heterogeneity within the immunological diseases may reflect the variable expression of autoinflammatory, autoimmune, and up to now unknown factors in disease development and manifestation. Based on histological and immunohistochemical examinations, IgG4-related sclerosing disease has been proposed as a novel clinicopathological entity with autoimmune phenomena but unknown etiology (chapter 1). The clarification of the etiopathological mechanisms is required to optimize prophylaxis, diagnostics and therapy Especially, the application of novel and designer biological therapies (chapter 8) requires a better understanding of the processes that are involved in the genesis of immunological diseases. In chapter 2, some aspects of the role of epigenetic mechanisms and innate immunity in the pathogenesis of autoimmune diseases are described. Regardless of the underlying pathology, disease-associated autoantibodies are important biomarkers for the vast majority of non-organ and organ specific autoimmune diseases. However, to improve our understanding of these diseases and serological diagnostics it is necessary to search for novel autoantibodies, to further evaluate the real clinical relevance of known autoantibodies and to further develop and standardize the detection methods (chapters 3-5) Pathogenetic aspects as well as aspects of the serological diagnostics, including novel autoantibody specificities, novel methodologies and evaluation studies are presented for rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic vasculitides, systemic sclerosis (chapter 6) and various organ specific diseases (chapter 7). In summary, the present volume highlights novel insights into the immune dysregulation, pathogenesis, serological diagnostics and biological therapies of autoimmune diseases."--Publisher's description Autoantibodies Congresses Autoimmune Diseases etiology Congresses Autoimmune Diseases therapy Congresses Autoimmune diseases Etiology Congresses Autoimmune diseases Treatment Congresses Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2009 Dresden gnd-content Autoaggressionskrankheit (DE-588)4003935-3 s DE-604 Conrad, Karsten 1956- (DE-588)110452917 edt Dresden Symposium on Autoantibodies 9 2009 Dresden Sonstige (DE-588)16024605-2 oth Autoimmunity, autoantigens, autoantibodies 6 (DE-604)BV014013293 6 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018969784&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 Autoimmunity, autoantigens, autoantibodies Autoantibodies Congresses Autoimmune Diseases etiology Congresses Autoimmune Diseases therapy Congresses Autoimmune diseases Etiology Congresses Autoimmune diseases Treatment Congresses Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| subject_GND | (DE-588)4003935-3 (DE-588)1071861417 |
| title | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 |
| title_auth | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 |
| title_exact_search | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 |
| title_full | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 K. Conrad ... (ed.) |
| title_fullStr | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 K. Conrad ... (ed.) |
| title_full_unstemmed | From pathogenesis to therapy of autoimmune diseases report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 K. Conrad ... (ed.) |
| title_short | From pathogenesis to therapy of autoimmune diseases |
| title_sort | from pathogenesis to therapy of autoimmune diseases report on the 9th dresden symposium on autoantibodies held in dresden on september 2 5 2009 |
| title_sub | report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2 - 5, 2009 |
| topic | Autoantibodies Congresses Autoimmune Diseases etiology Congresses Autoimmune Diseases therapy Congresses Autoimmune diseases Etiology Congresses Autoimmune diseases Treatment Congresses Autoaggressionskrankheit (DE-588)4003935-3 gnd |
| topic_facet | Autoantibodies Congresses Autoimmune Diseases etiology Congresses Autoimmune Diseases therapy Congresses Autoimmune diseases Etiology Congresses Autoimmune diseases Treatment Congresses Autoaggressionskrankheit Konferenzschrift 2009 Dresden |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018969784&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV014013293 |
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