Type 2 diabetic nephropathy in Japan: from bench to bedside
Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date fin...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2001
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| Schriftenreihe: | Contributions to nephrology
Vol. 134 |
| Schlagworte: | |
| Online-Zugang: | BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext |
| Zusammenfassung: | Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan.The pathogenesis of diabetic nephropathy includes both metabolic and / or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy.Presenting clinical findings and issues related to laboratory analysis, this book will be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents |
| Beschreibung: | 1 Online-Ressource (VIII, 140 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783318007473 |
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| 520 | |a Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan.The pathogenesis of diabetic nephropathy includes both metabolic and / or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy.Presenting clinical findings and issues related to laboratory analysis, this book will be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents | ||
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| geographic | Japan (DE-588)4028495-5 gnd |
| geographic_facet | Japan |
| id | DE-604.BV036069416 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:41:42Z |
| institution | BVB |
| isbn | 9783318007473 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018960720 |
| oclc_num | 728412149 |
| open_access_boolean | |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| physical | 1 Online-Ressource (VIII, 140 Seiten) Illustrationen, Diagramme |
| psigel | ZDB-1-KEB |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Karger |
| record_format | marc |
| series | Contributions to nephrology |
| series2 | Contributions to nephrology |
| spellingShingle | Type 2 diabetic nephropathy in Japan from bench to bedside Contributions to nephrology Nephrology Cell Biology Endocrinology Genetics Pathology Nephropathia diabetica (DE-588)4136461-2 gnd |
| subject_GND | (DE-588)4136461-2 (DE-588)4028495-5 (DE-588)4143413-4 |
| title | Type 2 diabetic nephropathy in Japan from bench to bedside |
| title_auth | Type 2 diabetic nephropathy in Japan from bench to bedside |
| title_exact_search | Type 2 diabetic nephropathy in Japan from bench to bedside |
| title_full | Type 2 diabetic nephropathy in Japan from bench to bedside volume editor: Yasuhiko Tomino |
| title_fullStr | Type 2 diabetic nephropathy in Japan from bench to bedside volume editor: Yasuhiko Tomino |
| title_full_unstemmed | Type 2 diabetic nephropathy in Japan from bench to bedside volume editor: Yasuhiko Tomino |
| title_short | Type 2 diabetic nephropathy in Japan |
| title_sort | type 2 diabetic nephropathy in japan from bench to bedside |
| title_sub | from bench to bedside |
| topic | Nephrology Cell Biology Endocrinology Genetics Pathology Nephropathia diabetica (DE-588)4136461-2 gnd |
| topic_facet | Nephrology Cell Biology Endocrinology Genetics Pathology Nephropathia diabetica Japan Aufsatzsammlung |
| url | https://karger.com/books/book/2900 |
| volume_link | (DE-604)BV039142755 |
| work_keys_str_mv | AT tominoyasuhiko type2diabeticnephropathyinjapanfrombenchtobedside |