Transglutaminases: family of enzymes with diverse functions
Transglutaminases are a family of structurally and functionally related enzymes that are widely distributed and have been identified in a variety of organisms ranging from bacteria to mammals and plants. The reactions (isopeptide bonds) catalyzed by these enzymes are of great physiologic significanc...
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| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2005
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| Schriftenreihe: | Progress in experimental tumor research
Vol. 38 |
| Schlagworte: | |
| Online-Zugang: | BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext |
| Zusammenfassung: | Transglutaminases are a family of structurally and functionally related enzymes that are widely distributed and have been identified in a variety of organisms ranging from bacteria to mammals and plants. The reactions (isopeptide bonds) catalyzed by these enzymes are of great physiologic significance; they are highly stable and resistant to proteolytic degradation. Isopeptide bonds are commonly found in hair and skin, and they accumulate during wound healing, apoptosis, and blood clotting. Dysregulation of transglutaminase functions results in a number of pathologic conditions, such as neurodegeneration, autoimmune diseases, infectious diseases, progressive tissue fibrosis and diseases related to the assembly of the stratum corneum of the epidermis of the skin. The ability of transglutaminases to catalyze highly stable isopeptide bonds is also being exploited by the food processing and textile industries. Moreover, there has been a recent surge in findings indicating that transglutaminases are involved in various biological processes such as normal and neoplastic cell growth, reproduction, and cell death.As newer members of the transglutaminase family are being discovered and new functions for existing members are being described, it becomes imperative to collect all the findings in a book. This volume provides the most comprehensive single source of information and will appeal to both new investigators just entering the field and established researchers aiming to elucidate the biological relevance of these enzymes in cancer, inflammation, autoimmune diseases and related areas of research |
| Beschreibung: | 1 Online-Ressource (X, 254 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783318011982 |
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| 520 | |a Transglutaminases are a family of structurally and functionally related enzymes that are widely distributed and have been identified in a variety of organisms ranging from bacteria to mammals and plants. The reactions (isopeptide bonds) catalyzed by these enzymes are of great physiologic significance; they are highly stable and resistant to proteolytic degradation. Isopeptide bonds are commonly found in hair and skin, and they accumulate during wound healing, apoptosis, and blood clotting. Dysregulation of transglutaminase functions results in a number of pathologic conditions, such as neurodegeneration, autoimmune diseases, infectious diseases, progressive tissue fibrosis and diseases related to the assembly of the stratum corneum of the epidermis of the skin. The ability of transglutaminases to catalyze highly stable isopeptide bonds is also being exploited by the food processing and textile industries. Moreover, there has been a recent surge in findings indicating that transglutaminases are involved in various biological processes such as normal and neoplastic cell growth, reproduction, and cell death.As newer members of the transglutaminase family are being discovered and new functions for existing members are being described, it becomes imperative to collect all the findings in a book. This volume provides the most comprehensive single source of information and will appeal to both new investigators just entering the field and established researchers aiming to elucidate the biological relevance of these enzymes in cancer, inflammation, autoimmune diseases and related areas of research | ||
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036069414 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:41:42Z |
| institution | BVB |
| isbn | 9783318011982 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018960718 |
| oclc_num | 728412518 |
| open_access_boolean | |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| physical | 1 Online-Ressource (X, 254 Seiten) Illustrationen, Diagramme |
| psigel | ZDB-1-KEB |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Karger |
| record_format | marc |
| series | Progress in experimental tumor research |
| series2 | Progress in experimental tumor research |
| spellingShingle | Transglutaminases family of enzymes with diverse functions Progress in experimental tumor research Oncology Cell Biology Biochemistry Dermatology Enzymology Immunology Neurology Physiologie (DE-588)4045981-0 gnd Proteinglutamin-Glutamyltransferase Proteinglutamin-gamma-glutamyltransferase (DE-588)4389067-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4389067-2 (DE-588)4044898-8 (DE-588)4143413-4 |
| title | Transglutaminases family of enzymes with diverse functions |
| title_auth | Transglutaminases family of enzymes with diverse functions |
| title_exact_search | Transglutaminases family of enzymes with diverse functions |
| title_full | Transglutaminases family of enzymes with diverse functions volume editors: Kapil Mehta, Richard Eckert |
| title_fullStr | Transglutaminases family of enzymes with diverse functions volume editors: Kapil Mehta, Richard Eckert |
| title_full_unstemmed | Transglutaminases family of enzymes with diverse functions volume editors: Kapil Mehta, Richard Eckert |
| title_short | Transglutaminases |
| title_sort | transglutaminases family of enzymes with diverse functions |
| title_sub | family of enzymes with diverse functions |
| topic | Oncology Cell Biology Biochemistry Dermatology Enzymology Immunology Neurology Physiologie (DE-588)4045981-0 gnd Proteinglutamin-Glutamyltransferase Proteinglutamin-gamma-glutamyltransferase (DE-588)4389067-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Oncology Cell Biology Biochemistry Dermatology Enzymology Immunology Neurology Physiologie Proteinglutamin-Glutamyltransferase Proteinglutamin-gamma-glutamyltransferase Pathophysiologie Aufsatzsammlung |
| url | https://karger.com/books/book/2506 |
| volume_link | (DE-604)BV039163819 |
| work_keys_str_mv | AT mehtakapil transglutaminasesfamilyofenzymeswithdiversefunctions AT eckertrichard transglutaminasesfamilyofenzymeswithdiversefunctions |