Signal transduction pathways in autoimmunity the latest research on intracellular signaling pathways
Signal transduction pathways in autoimmunity: the latest research on intracellular signaling pathways

An immensely complex network of interactions between multiple cell types and cytokines regulates the immune system. Ligand binding to antigen-specific, Fc, or cytokine receptors initiates differentiation, activation and proliferation of multiple immune system cell lineages. These activating pathways...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Weitere Verfasser: Altman, Amnon (HerausgeberIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Basel Karger 2002
Schriftenreihe:Current directions in autoimmunity Vol. 5
Schlagworte:
Immunology
Cell Biology
Immunosuppression
Leukemia
Immunozyt
Autoaggressionskrankheit
Zellkommunikation
Signaltransduktion
Aufsatzsammlung
Online-Zugang:DE-522
DE-12
DE-526
DE-521
DE-1102
DE-1046
DE-1028
DE-573
DE-M347
DE-92
DE-898
DE-859
DE-1049
DE-863
DE-862
DE-M382
DE-70
DE-128
DE-54
DE-22
DE-155
DE-150
DE-91
DE-384
DE-473
DE-19
DE-355
DE-703
DE-20
DE-29
DE-739
Volltext
Zusammenfassung:An immensely complex network of interactions between multiple cell types and cytokines regulates the immune system. Ligand binding to antigen-specific, Fc, or cytokine receptors initiates differentiation, activation and proliferation of multiple immune system cell lineages. These activating pathways are counteracted by inhibitory receptors. In the past two decades, considerable work on mechanistic and functional details of such intracellular signaling pathways has led to the realization that an excess of stimulatory/positive signals as well as a deficiency in inhibitory/negative signals can both result in a hyperactive immune system leading to autoimmunity.The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as well as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system
Beschreibung:1 Online-Ressource (VIII, 197 Seiten) Diagramme
ISBN:9783318007732
Login für die Nachverfolgung von Bestellungen und Vormerkungen
Volltext öffnen

Ähnliche Einträge