Proteomics in nephrology:
The novel discipline of proteomics has experienced a rapid growth in the recent past and has a great potential for the future. Involving several fields, it offers various advantages: The study of proteins on a genomic scale allows to examine a large number of them simultaneously. Moreover, proteomic...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2004
|
| Schriftenreihe: | Contributions to nephrology
Vol. 141 |
| Schlagworte: | |
| Online-Zugang: | BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext |
| Zusammenfassung: | The novel discipline of proteomics has experienced a rapid growth in the recent past and has a great potential for the future. Involving several fields, it offers various advantages: The study of proteins on a genomic scale allows to examine a large number of them simultaneously. Moreover, proteomic analysis provides information about post-translational modifications and functions of gene products or proteins that cannot be obtained by genomic analysis. The knowledge thus gained is also important for a better understanding of renal physiology and pathophysiology, to identify disease biomarkers, and to develop new target therapies.This book is the first one that applies the science of proteomics to nephrology: It sets out to give an overview of the discipline, providing detailed background information and outlining scope, advantages, and limitations of proteomics.The second section reviews principles of commonly used proteomic techniques, including sample preparation, two-dimensional gel electrophoresis, various types of mass spectrometry, expression proteomics, quantitative proteomics, practical bioinformatics, and clinical proteomics. In the last section, examples and perspectives are provided of how proteomics can be applied to various fields in nephrology, including nephrotoxicity, sodium transport, diabetic nephropathy, renal Fanconi syndrome, IgA nephropathy, physiology of podocytes and mesangial cells, hypertension, urological malignancies, and dialysis. The publication ends with a discussion of biomarker discovery in glomerular diseases and drug discovery.Written by acclaimed experts in both proteomics and nephrology, this truly remarkable book is essential reading for students, residents, fellows, scientists, and nephrologists who are interested in or devoted to research, as well as for general health professionals and clinicians |
| Beschreibung: | an introduction to a coming field of science |
| Beschreibung: | 1 Online-Ressource (VIII, 336 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783318010145 |
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| 520 | |a The novel discipline of proteomics has experienced a rapid growth in the recent past and has a great potential for the future. Involving several fields, it offers various advantages: The study of proteins on a genomic scale allows to examine a large number of them simultaneously. Moreover, proteomic analysis provides information about post-translational modifications and functions of gene products or proteins that cannot be obtained by genomic analysis. The knowledge thus gained is also important for a better understanding of renal physiology and pathophysiology, to identify disease biomarkers, and to develop new target therapies.This book is the first one that applies the science of proteomics to nephrology: It sets out to give an overview of the discipline, providing detailed background information and outlining scope, advantages, and limitations of proteomics.The second section reviews principles of commonly used proteomic techniques, including sample preparation, two-dimensional gel electrophoresis, various types of mass spectrometry, expression proteomics, quantitative proteomics, practical bioinformatics, and clinical proteomics. In the last section, examples and perspectives are provided of how proteomics can be applied to various fields in nephrology, including nephrotoxicity, sodium transport, diabetic nephropathy, renal Fanconi syndrome, IgA nephropathy, physiology of podocytes and mesangial cells, hypertension, urological malignancies, and dialysis. The publication ends with a discussion of biomarker discovery in glomerular diseases and drug discovery.Written by acclaimed experts in both proteomics and nephrology, this truly remarkable book is essential reading for students, residents, fellows, scientists, and nephrologists who are interested in or devoted to research, as well as for general health professionals and clinicians | ||
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036069360 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:41:42Z |
| institution | BVB |
| isbn | 9783318010145 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018960665 |
| oclc_num | 837657239 |
| open_access_boolean | |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-578 DE-11 DE-1046 |
| physical | 1 Online-Ressource (VIII, 336 Seiten) Illustrationen, Diagramme |
| psigel | ZDB-1-KEB |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Karger |
| record_format | marc |
| series | Contributions to nephrology |
| series2 | Contributions to nephrology |
| spellingShingle | Proteomics in nephrology Contributions to nephrology Nephrology Biochemistry Biotechnology Genetics Internal Medicine Laboratory Proteomics Proteomanalyse (DE-588)4596545-6 gnd Nierenkrankheit (DE-588)4075399-2 gnd |
| subject_GND | (DE-588)4596545-6 (DE-588)4075399-2 (DE-588)4143413-4 |
| title | Proteomics in nephrology |
| title_auth | Proteomics in nephrology |
| title_exact_search | Proteomics in nephrology |
| title_full | Proteomics in nephrology volume editors: Visith Thongboonkerd, Jon B. Klein |
| title_fullStr | Proteomics in nephrology volume editors: Visith Thongboonkerd, Jon B. Klein |
| title_full_unstemmed | Proteomics in nephrology volume editors: Visith Thongboonkerd, Jon B. Klein |
| title_short | Proteomics in nephrology |
| title_sort | proteomics in nephrology |
| topic | Nephrology Biochemistry Biotechnology Genetics Internal Medicine Laboratory Proteomics Proteomanalyse (DE-588)4596545-6 gnd Nierenkrankheit (DE-588)4075399-2 gnd |
| topic_facet | Nephrology Biochemistry Biotechnology Genetics Internal Medicine Laboratory Proteomics Proteomanalyse Nierenkrankheit Aufsatzsammlung |
| url | https://karger.com/books/book/2464 |
| volume_link | (DE-604)BV039142755 |
| work_keys_str_mv | AT thongboonkerdvisith proteomicsinnephrology AT kleinjonb proteomicsinnephrology |