Molecular pathology of type 1 diabetes mellitus:
Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusiv...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2001
|
| Schriftenreihe: | Current directions in autoimmunity
Vol. 4 |
| Schlagworte: | |
| Online-Zugang: | BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext |
| Zusammenfassung: | Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity |
| Beschreibung: | an authoritative and up-to-date overview |
| Beschreibung: | 1 Online-Ressource (X, 360 Seiten) Diagramme |
| ISBN: | 9783318007152 |
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| 520 | |a Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.All these findings are being discussed in this volume, which presents a state-of-the-art overview of the pathogenesis and intervention of type 1 diabetes. Authoritative and up-to-date, it will be of great value to any investigator interested in understanding autoimmunity | ||
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| id | DE-604.BV036069255 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:41:42Z |
| institution | BVB |
| isbn | 9783318007152 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018960559 |
| oclc_num | 837655607 |
| open_access_boolean | |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-11 DE-83 DE-M382 DE-70 DE-578 DE-1046 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-11 DE-83 DE-M382 DE-70 DE-578 DE-1046 |
| physical | 1 Online-Ressource (X, 360 Seiten) Diagramme |
| psigel | ZDB-1-KEB |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Karger |
| record_format | marc |
| series | Current directions in autoimmunity |
| series2 | Current directions in autoimmunity |
| spellingShingle | Molecular pathology of type 1 diabetes mellitus Current directions in autoimmunity Immunology Endocrinology Diabetes Genetics Molecular Biology Pathology Molekulare Medizin (DE-588)4543844-4 gnd Diabetes mellitus Typ 1 (DE-588)1194595685 gnd |
| subject_GND | (DE-588)4543844-4 (DE-588)1194595685 |
| title | Molecular pathology of type 1 diabetes mellitus |
| title_auth | Molecular pathology of type 1 diabetes mellitus |
| title_exact_search | Molecular pathology of type 1 diabetes mellitus |
| title_full | Molecular pathology of type 1 diabetes mellitus volume editor: Matthias G. von Herrath |
| title_fullStr | Molecular pathology of type 1 diabetes mellitus volume editor: Matthias G. von Herrath |
| title_full_unstemmed | Molecular pathology of type 1 diabetes mellitus volume editor: Matthias G. von Herrath |
| title_short | Molecular pathology of type 1 diabetes mellitus |
| title_sort | molecular pathology of type 1 diabetes mellitus |
| topic | Immunology Endocrinology Diabetes Genetics Molecular Biology Pathology Molekulare Medizin (DE-588)4543844-4 gnd Diabetes mellitus Typ 1 (DE-588)1194595685 gnd |
| topic_facet | Immunology Endocrinology Diabetes Genetics Molecular Biology Pathology Molekulare Medizin Diabetes mellitus Typ 1 |
| url | https://karger.com/books/book/2384 |
| volume_link | (DE-604)BV039142746 |
| work_keys_str_mv | AT vonherrathmatthiasg molecularpathologyoftype1diabetesmellitus |